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WO/2018/028557A1 |
The present invention relates to a series of tricyclic compounds and the use thereof as receptor agonists of 1-phosphate sphingosine 1 subtype (S1P1), and in particular to the compounds shown in formula (I), and tautomers or pharmaceutic...
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WO/2018/029242A1 |
Compounds of formula (I), wherein the substituents are as defined in claim 1, useful as a pesticides, especially as fungicides.
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WO/2018/024208A1 |
A compound as an indoleamine-2,3-dioxygenase 1(IDO1) inhibitor, and an application thereof in the field of IDO1-related diseases, and in particular a compound as shown in formula (I) and a pharmaceutically acceptable salts thereof.
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WO/2018/024188A1 |
Provided are a polycyclic compound and a manufacturing method, pharmaceutical composition, and application thereof. The structure of the polycyclic compound and an isomer, prodrug, solvate, hydrate, stable isotopic derivative, or pharmac...
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WO/2018/022802A1 |
The invention provides antifungal compounds, antifungal compositions, and intermediates for the preparation of antifungal compounds and antifungal compositions. The invention also provides methods of inhibiting fungi and methods of treat...
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WO/2018/015449A1 |
Compounds of the formula (I), wherein the substituents are as defined in claim 1, useful as a pesticides, especially as fungicides.
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WO/2018/015447A1 |
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as fungicides.
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WO/2018/015458A1 |
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as fungicides.
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WO/2018/011746A1 |
The present invention provides compounds which are modulators of RORγ and their use for the treatment of diseases or conditions mediated by RORγ. Further, the present invention relates to processes of preparing such compounds, their ta...
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WO/2018/011747A1 |
The present invention provides compounds which are modulators of RORγ and their use for the treatment of diseases or conditions mediated by RORγ. Further, the present invention relates to processes of preparing such compounds, their ta...
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WO/2018/009256A1 |
The present invention relates to ampakines, including low impact ampakines, and pharmaceutical compositions and methods employing ampakines for treating central nervous system (CNS) disorders, including attention deficit disorders. Novel...
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WO/2017/222474A1 |
The present invention provides processes for the preparation of ataluren. Intermediates for preparing ataluren are also provided.
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WO/2017/219083A1 |
The present invention relates to novel compounds which active HIV expression in latently infected cells. More particularly, the invention relates to pharmaceutical compositions comprising the novel compounds and their use in activating H...
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WO/2017/220485A1 |
Compounds of the Formula (I), wherein the substituents are as defined in claim 1, useful as pesticides, especially as fungicides.
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WO/2017/215617A1 |
Disclosed are a crystal form of ozanimod, a crystal form of a hydrochloride thereof, and a preparation method therefor. The crystal form of ozanimod and the crystal form of a hydrochloride thereof can be applied to treatment for autoimmu...
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WO/2017/211649A1 |
The present invention relates to novel trifluoromethyl oxadiazoles of the formula (I), or an N-oxide, and/or their agriculturally useful salts; to their use for controlling phytopathogenic fungi; to a method for combating phytopathogenic...
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WO/2017/211652A1 |
The present invention relates to novel trifluoromethyloxadiazoles of the formula (I), or an N-oxide, or their agriculturally useful salts; to their use for controlling phytopathogenic fungi; to a method for combating phytopathogenic harm...
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WO/2017/213252A1 |
The present invention provides a compound having excellent control efficacies against pests. Specifically, the present invention provides a compound represented by formula (I): (wherein: A is a single bond, etc.; m is any one integer of ...
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WO/2017/211650A1 |
The present invention relates to novel trifluoromethyloxadiazoles of the formula I, or an N-oxide, and/or their agriculturally useful salts; to their use for controlling phytopathogenic fungi; to a method for combating phytopathogenic ha...
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WO/2017/209155A1 |
Provided are: a novel sulfonamide compound having ribonucleotide reductase inhibitory activity or a salt thereof; and a pharmaceutical composition which contains this sulfonamide compound or a salt thereof as an active ingredient. A comp...
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WO/2017/207757A1 |
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as pesticides, especially as fungicides.
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WO/2017/198700A1 |
The present invention relates to treatment of cancer, in particular to methods of sensitising cancer cells to an anti-cancer therapy by administering an effective amount of a modulator of Volume Regulated Anion Channels, i.e. a VRAC modu...
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WO/2017/198852A1 |
Compounds of Formula (IA) or Formula (IB): (IA/IB) wherein the substituents are as defined in claim 1, useful as pesticides, especially as fungicides.
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WO/2017/195149A1 |
Provided are IDO inhibitor compounds of Formula I and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of diseases.
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WO/2017/196544A1 |
The present invention includes novel compounds useful for labeling biomolecules. The present invention further includes a novel method of labeling a biomolecule using a compound of the invention. The present invention further includes a ...
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WO/2017/193034A1 |
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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WO/2017/193030A1 |
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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WO/2017/193041A1 |
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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WO/2017/192304A1 |
The present disclosure is directed to compounds of formula (I): or a pharmaceutically acceptable salt, solvate or solvate of the salt thereof. Compounds of formula (I) are inhibitors of NOX4 and are useful in the treatment of fibrotic di...
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WO/2017/181849A1 |
The present invention relates to an indoleamine 2,3-dioxygenase inhibitor having the structure of formula (I), a preparation method therefor, and an application. The IDO inhibitor is an N'-hydroxyl-N-phenylformamidine derivative, has hig...
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WO/2017/184662A1 |
Disclosed are compounds of Formula (I), or a salt thereof, wherein: X is CR4 or N; Y is CR4 or N, provided that Y is N only if X is N; R1 is Formulae (A) or (B); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, R3, R4...
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WO/2017/178245A1 |
The present invention relates to novel trifluoromethyloxadiazoles of the formula I, or an N-oxide and/or their agriculturally useful salts and to their use for controlling phytopathogenic fungi; to a method for combating phytopathogenic ...
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WO/2017/178549A1 |
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially fungicides.
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WO/2017/177896A1 |
Disclosed in the present invention are a compound represented by formula (I), a geometric or optical isomer, a pharmaceutically acceptable salt, a solvate or a polymorph thereof. Also disclosed in the present invention is a composition o...
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WO/2017/174158A1 |
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides and especially as fungicides.
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WO/2017/169893A1 |
An oxadiazole compound represented by formula (I) [wherein R1 represents a halogen atom or a C1-C2 alkyl group; n represents an integer of 0 to 2; and R2 represents a C2-C6 alkyl group or a C3-C4 alkenyl group] has an excellent controlli...
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WO/2017/170826A1 |
The purpose of the invention is to provide a compound useful in the prevention or treatment of diabetes, obesity, and conditions related thereto. The present invention relates to an enhancing agent for glucagon-like peptide-1 receptor ac...
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WO/2017/165256A1 |
The present disclosure relates to compounds of formula (I) that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly ...
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WO/2017/160922A1 |
Disclosed herein are compounds of Formula (I), methods of synthesizing compounds of Formula (I), and methods of using compounds of Formula (I) as an analgesic.
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WO/2017/157962A1 |
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially fungicides.
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WO/2017/152857A1 |
Disclosed in the present invention are an indoleamine-2,3-dioxygenase inhibitor and a preparation method therefor. The structure of the inhibitor of the present invention is shown in general formula (I), wherein the definitions of X, R1,...
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WO/2017/148797A1 |
Substituted oxadiazoles for combating phytopathogenic fungi The present invention relates the use of the compounds of the formula I, or the N-oxides, or the agriculturally acceptable salts thereof for combating phytopathogenic harmful fu...
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WO/2017/143874A1 |
Provided are a substituted oxadiazole chemical compound and composition containing said chemical compound and use thereof; said substituted oxadiazole chemical compound is the oxadiazole chemical compound as represented by formula (I), o...
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WO/2017/146400A1 |
The present invention relates to a compound for detecting phosgene and DCP (diethyl chlorophosphate) and a composition for detecting phosgene and DCP (diethyl chlorophosphate) comprising the said compound. More precisely, the compound fo...
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WO/2017/144402A1 |
The invention relates to N-(5-halogen-1,3,4-oxadiazol-2-yl)aryl carboxylic acid amides of general formula (I) and their use as herbicides. In formula (I), A means nitrogen or CY. R, V, W, X, Y and Z stand for groups such as hydrogen, org...
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WO/2017/129139A1 |
Provided in the present invention are a sulfamic acid ester as an indoleamine-2,3-dioxygenase inhibitor, a preparation method therefor and a use thereof. The structure of the inhibitor in the present invention is shown in general structu...
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WO/2017/124822A1 |
Provided is a method for preparing IDO inhibitor epacadostat. The whole reaction route is simple, easy to control and has high yield.
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WO/2017/110865A1 |
Oxadiazole compounds indicated by formula (I) and the use of said oxadiazole compounds in plant disease control. [In the formula, Z represents OC(=X)NR2R3, OC(=X)YR4, or the like, R1 represents a halogen atom, a C1-4 alkoxy group, or the...
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WO/2017/110861A1 |
Provided is a plant disease control agent that contains a compound indicated by formula (I). [In the formula, G represents a benzene ring, a thiophene ring, a furan ring, a pyrazole ring, an imidazole ring, an oxazole ring, an isoxazole ...
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WO/2017/110862A1 |
The oxadiazole compound represented in expression (1) exhibits an excellent effect in controlling plant disease. (In the expression, G represents a benzene ring, a thiophene ring, a furan ring, etc., R1 represents a C1-C6 alkyl group, a ...
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