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WO/2022/166764A1 |
The present invention relates to the field of organic chemistry, and in particular, relates to a use of a silicon compound in a cyclization reaction. On one hand, the present invention provides a method for preparing 2-chloro-5-chloromet...
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WO/2022/163446A1 |
The present invention addresses the problem of providing a new compound that binds specifically to intracellular and/or extracellular vesicles, a cellular vesicle stain, and a method for fluorescent staining of cellular vesicles.　The p...
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WO/2022/149925A1 |
The present invention relates to a novel oxadiazole phenylalanine derivative and a medical use thereof. A novel tryptophan hydroxylase inhibitor and a pharmaceutical composition, which contain same, inhibit the synthesis of serotonin in ...
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WO/2022/129190A1 |
The present invention relates to the use of (hetero)aryl substituted 1,2,4-oxadiazole compounds for controlling harmful microorganisms, in particular phytopathogenic fungi, in crop protection (formula (I)). It also relates to novel (hete...
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WO/2022/023496A9 |
The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorop...
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WO/2022/122402A1 |
A dye encompassing a donor-acceptor-donor motif comprising a structure according to formulae (1), (2), (3), (4), (5), (6), (7) or (8). Further, a molecular probe, an analyte sensitive layer, a molecularly imprinted polymer, a sensor arra...
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WO/2022/111605A1 |
The present disclosure relates to an aryl or heteroaryl substituted 5-membered aromatic heterocyclic compound and the use thereof. In particular, provided is a compound as shown in formula I or a pharmaceutically acceptable salt thereof,...
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WO/2022/112139A1 |
The present invention provides novel compounds having the general formula (I) wherein R1 to R3 are as described herein, or a pharmaceutically acceptable salt thereof, compositions including the compounds and methods of using the compounds.
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WO/2022/064526A1 |
The present invention relates to solid state forms of Epacadostat of formula-1 which is chemically known as 4- ( { 2- [(amino sulfonyl) amino] ethyl} amino)-N-(3-bromo- 4 - fluoro phenyl) - N' - hydroxy- 1,2,5- oxa diazole- 3 - carboximi...
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WO/2022/055321A1 |
The present invention provides: a compound for a capping layer, represented by formula 1; and an organic light-emitting device including a first electrode, a second electrode, at least a single organic material layer interposed between t...
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WO/2022/050427A1 |
[Problem] To provide a novel method for producing a 1, 3, 4-oxadiazole-2-amine compound which is useful as a precursor of a heterocyclic amide compound that is useful as a herbicide. [Solution] A method for producing a 1, 3, 4-oxadiazole...
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WO/2022/035805A1 |
The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, and to a pharmaceutical composition comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The disclosure...
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WO/2022/028421A1 |
Provided by the present invention are a fluorescent traceable amino acid derivative, a preparation method therefor, and an application thereof, belonging to the technical field of biomedicine. The amino acid derivative provided by the pr...
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WO/2022/029438A1 |
The invention relates to compounds of formula (I): wherein A, RA1, RA2, RB, RC and RD are as defined herein, and associated aspects.
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WO/2022/017836A1 |
The present invention relates to fungicidal compositions comprising, as active components, (R)- 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1,2,4-t
riazol-1-yl)propan-2-ol (I) and N-(2- fluorophenyl)-4-[5-(trifluoromethyl)-1,2,4...
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WO/2022/015859A1 |
Among the various aspects of the present disclosure is the provision of compositions and methods for targeted treatment and detection of cancers. In particular, the present disclosure is directed to a compounds are from the benzofurazan,...
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WO/2022/008923A1 |
The present invention relates to the use of compounds of Formula (I) as herbicides, wherein Z, W, X1-X4, R1, F2, R3, R4, m and n are as defined herein. The invention further relates to agrochemical compositions comprising a compound of F...
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WO/2022/007461A1 |
Disclosed is an immunomodulator, and the present invention specifically relates to a compound for inhibiting IL-17A and an application of the compound serving as the immunomodulator in the preparation of a drug. Disclosed is an applicati...
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WO/2022/002078A1 |
The present invention relates to the fields of pharmaceutical chemistry and pharmacotherapeutics, and in particular to a compound as represented by general formula I, a racemate, an R-isomer, an S-isomer and a pharmaceutically acceptable...
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WO/2021/262311A1 |
The present disclosure is directed to a compound or compositions comprising the same for decreasing vascular permeability and the prevention or inhibition of metastasis in a cancer.
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WO/2021/247634A1 |
Provided herein are compounds of Formula (I''), Formula (I'), Formula (I), Formula (II'), and Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labele...
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WO/2021/244244A1 |
Disclosed is an oxadiazole compound having a novel structure and as represented by general formula I: a compound of the general formula I has excellent bactericidal activity, and has a good prevention and control effect for plant bacteri...
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WO/2021/247732A1 |
The present invention relates to compounds of formula I (I) as well as to the compounds of formula I for use as transmembrane serine protease 2 (TMPRSS2) inhibitors in the treatment of viral infections, such as e.g. corona virus infectio...
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WO/2021/243001A1 |
Provided are compounds of Formula (I): (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with TREX1.
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WO/2021/239568A1 |
The present invention relates to a process for the preparation of substituted 4-(N'-hydroxy- carbamimidoyl)benzoic acids, which can be obtained by nitrilase catalyzed hydration of substituted terephthalonitriles of formula (II) in an aqu...
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WO/2021/215393A1 |
Provided is the compound, or a salt thereof, represented in formula (I). (In formula (1): Ar indicates a C6-10 aryl group, etc.; R1 indicates a cyano group, a thiocarbamoyl group, etc.; R2 indicates a hydrogen atom, etc.; R 3 indicates a...
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WO/2021/209383A1 |
The present invention related to compounds of Formula (I) or an agronomically acceptable salt thereof, wherein Q, R2, R3, R4 and R5 are as described herein. The invention further relates to compositions comprising said compounds, to meth...
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WO/2021/204666A1 |
The invention relates to isophthalic acid diamides having general formula (I) as herbicides. In this formula (I), X and Y represent radicals such as hydrogen, alkyl and halogen. Z1 and Z2 represent radicals such as alkyl, cycloalkyl and ...
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WO/2021/204669A1 |
The invention relates to substituted isophthalic acid diamides and to their use as herbicides. Disclosed are isophthalic acid diamides having general formula (I) as herbicides. In this formula (I), Z1 and Z2 represent radicals such as al...
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WO/2021/204667A1 |
The invention relates to substituted isophthalic acid diamides and to their use as herbicides. Disclosed are isophthalic acid diamides having general formula (I) as herbicides. In this formula (I), Z1 and Z2 represent radicals such as al...
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WO/2021/204665A1 |
The invention relates to isophthalic acid diamides having general formula (I) as herbicides. In this formula (I), X, Y and Z represent radicals such as hydrogen, alkyl and halogen. Q represents a heterocyclic ring such as tetrazolyl.
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WO/2021/197852A1 |
The presented invention relates to crystalline form, Form A of Ozanimod hydrochloride, processes for preparation thereof and pharmaceutical compositions comprising the Ozanimod hydrochloride Form A.
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WO/2021/195413A1 |
Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable salt, homolog, hydrate or solvate thereof, wherein R is as defined herein. Such compounds serve as modulators of the sphingosine-1-phosphate rec...
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WO/2021/195397A1 |
Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable salt, homolog, hydrate or solvate thereof, wherein R is as defined herein. Such compounds serve as modulators of the sphingosine-1-phosphate rec...
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WO/2021/195396A1 |
Compounds are provided having the structure of Formula (I): (Formula (I)) or a pharmaceutically acceptable salt, homolog, hydrate or solvate thereof, wherein R is as defined herein. Such compounds serve as modulators of the sphingosine-1...
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WO/2021/187486A1 |
The present invention relates to the compound represented in formula (1) or a pharmaceutically acceptable salt thereof (in the formula, Q1 represents a halogen, Q2 represents a hydrogen, etc., X, Y and Z represent a nitrogen atom or an o...
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WO/2021/173930A1 |
The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-func...
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WO/2021/160470A1 |
The present invention relates to a process for the preparation of aromatic carbonyl compounds of formula I, which can be obtained through reaction of compounds of formula II with molecular oxygen in the presence of a solvent and a cataly...
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WO/2021/156175A1 |
The present invention relates to a process for the preparation of substituted 3-aryl-5- trifluoromethyl-1,2,4-oxadiazoles of formula (I), which can be obtained through reaction of amidoxime compounds of formula (II) with a haloacetic est...
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WO/2021/156174A1 |
The present invention relates to a process for the preparation of substituted 3-aryl-5-trifluoromethyl-1,2,4-oxadiazoles of formula I, which can be obtained through reaction of amidoxime compounds of formula II with a haloacetic ester in...
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WO/2021/142186A1 |
Discloased is a pharmaceutical composition comprising: an active ingredient of the following formula (I) or a pharmaceutically acceptable salt or solvate thereof: (I); and one or more excipient selected from the group consisting of a bin...
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WO/2021/130492A1 |
The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: (I) wherein, RA1, RA2, RC and RD are as defined herein.
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WO/2021/127301A1 |
4-phenyl-N-(phenyl)thiazol-2-amine and 4-(pyridin-3-yl)-N-( phenyl) thiazol-2-amine derivatives and the corresponding thiadiazole, thiophene, oxazole, oxadiazole, imidazole and triazole derivatives and related compounds as aryl hydrocarb...
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WO/2021/110498A1 |
The present invention relates to a process for the preparation of substituted aromatic carboxamides of formula I, (formula I) which can be obtained through reaction of an aromatic carboxylic acid halide and an amine, whereas the process ...
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WO/2021/102569A1 |
This disclosure relates generally to cannabinoid derivatives of formula (I), pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives for the treatment of conditions associated with cannabinoid receptor.
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WO/2021/102568A1 |
This disclosure relates generally to cannabinoid derivatives having the structural formula (I), pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives. In some embodiments, R1 is - CH2CH=C(CH3)2, R2...
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WO/2021/102204A1 |
Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction betw...
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WO/2021/094505A1 |
The present invention relates to compounds Formula (I) wherein Q, R2, R3 and R4 are as defined herein. The invention further relates to compositions comprising said compounds, and methods of controlling weeds using said compounds and/or ...
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WO/2021/092163A1 |
The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.
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WO/2021/090282A1 |
The present invention discloses a compound of formula (I), wherein, R1, R2, R3, R4, A1 and Q are as defined in the detailed description and a process for preparing the compound of formula (I). The present invention also discloses a metho...
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