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WO/2005/115972A1 |
Compounds of formula I or pharmaceutically acceptable salts thereof: (I) wherein R1, R2, R3, R4, m and n are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are ...
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WO/2005/115983A1 |
Aryl sulfonamide and sulfonyl compounds of formula (I) as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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WO/2005/112538A2 |
The present invention describes phenylpiperazinyl alpha adrenergic antagonists that corresponds to the formula (I) which selectively act on the alpha 1A/alpha 1D subtypes, where its selectivity index in comparison to alpha 1B subtype is,...
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WO/2005/113527A1 |
The present invention relates to novel tetrahydronaphthylpiperazines derivatives, that are compounds of the formula (I) wherein R1, R2 and R6 are as defined herein, X is CH2 or O, A is a group of the formula (G1, G2, G2a, G3, G4, G5 or G...
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WO/2005/108347A2 |
The invention relates to substituted enaminones of Formula (I) and their derivatives and the discovery that these compounds modulate the effect of &gammad -aminobutyric acid (GABA) on the GABAA receptor complex in a therapeutically relev...
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WO/2005/108385A1 |
The invention relates to a method for producing optionally substituted methylenedioxybenzene. The invention particularly relates to the production of methylenedioxybenzene. The inventive production method is characterized by the fact tha...
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WO/2005/105774A1 |
Process for the preparation of 3-(3,4-methylenedioxyphenyl)-2-methylpropanal (I) comprising the following steps: a) reacting 5-propanoyl-1,3- benzodioxol (III) with the Vilsmeier reagent at temperatures ranging between 0° and 40°C and ...
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WO/2005/105744A1 |
This invention is directed to a compound of the formula (I) as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a method of treatment of a disorder or conditi...
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WO/2005/105764A1 |
Compounds of the formula (I): in which R, R1 and R2 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and . processes for the...
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WO/2005/103033A1 |
The invention relates to 1-amino-phthalazine derivatives of general formula (I), wherein A, B = possibly substituted C1-4-alkylene; L = a simple bond or C1-2-alkylene, possibly substituted -CH=CH-, or -C=C- or cycloprop-1,2--diyl; R1 = p...
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WO/2005/102977A1 |
The present invention relates to the compounds of general formula (I): wherein R, R1, R2 are as defined in claim 1. Compounds of formula (I) are particularly useful for preparing 3,3-dimethyl-5-formyl-2,3-dihydrobenzoxepines derivatives.
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WO/2005/100305A1 |
The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess...
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WO/2005/100308A1 |
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl ace...
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WO/2005/100303A1 |
The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and...
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WO/2005/100301A1 |
The present invention relates to certain 2-aryloxyethyl glycine derivatives that exhibit activity as inhibitors of the glycine type-1 transporter, to pharmaceutical compositions containing them and to their use in the treatment of neurol...
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WO/2005/100337A1 |
The present invention relates to the dioxolane derivatives of general formula (I), which have nerve nutrition effects, or to the pharmaceutical acceptable salts or hydrate thereof. Each group of general formula (I) is defined as the spec...
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WO/2005/097100A2 |
Use of compounds of formula (I) as antibacterial agents: Formula (I), wherein Z is a carboxyl radical HOC (∼O)-, a carboxyl ester radical, or a carboxyl isostere radical; ring A is an optionally substituted monocyclic aryl, heteroaryl ...
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WO/2005/097779A1 |
N-diarylaminoalkyl-substituted piperazine/4-aminopiperidine compounds of formula (1) are disclosed, wherein each of A and B is independently a 6-membered aromatic or nonaromatic, carbocyclic or heterocyclic moiety or is an aminoalkyl and...
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WO/2005/094805A1 |
A medicine having prostaglandin D2 (PGD2) production inhibitory activity and having as an active ingredient a substance selected from compounds represented by the general formula (I): A-Y-B &lcub wherein A and B each independently repres...
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WO/2005/095326A2 |
Disclosed are compounds of the formula: where variables Q, Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer’s di...
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WO/2005/095327A1 |
Novel compounds having kininogenase-inhibitory activity and medicinal uses thereof, specifically, compounds represented by the general formulae (A), (B), (C), (E) and (H) or medicinally acceptable salts thereof: (A) (C) (B) (E) (H) where...
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WO/2005/095377A1 |
The present invention provides a process for the preparation of a compound of formula (I): wherein R1 is C1-6 alkyl; R2 and R3 are, independently, C1-6 alkyl; and R4 is C1-6 alkyl or benzyl (wherein the phenyl ring of benzyl is optionall...
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WO/2005/096422A1 |
An electrolyte material for a solid polymer type fuel cell which comprises a polymer containing a recurring unit derived from a fluorine-containing monomer having radical polymerizability, wherein said recurring unit contains an ionic gr...
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WO/2005/092337A1 |
A composition comprising optically pure 6&agr -oxymorphol is disclosed. Also disclosed is a method of treating pain, in a patient in need of pain relief, by administering to the individual an amount of optically pure 6&agr -oxymorphol or...
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WO/2005/092904A1 |
Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.
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WO/2005/092934A1 |
The invention relates to a coating composition wherein orthoester groups block the hydroxyl groups of the poly(meth)acrylate wherein the orthoester groups can be removed through hydrolysis in order to facilitate cross-linking through rea...
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WO/2005/090297A1 |
The invention relates to sulphonamide derivatives of formula (I), where RC is optionally substituted 4-6-membered heterocyclic ring containing one or more N atoms, or RC is -NR1R2, RA is a group having the formula (A), (B) or (C) RB is h...
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WO/2005/089815A2 |
This invention relates to new radiohalogenated benzamide derivatives and their use in tumor diagnosis and tumor therapy. The radiohalogenated benzamide derivatives according to the invention exhibit novel and especially advantageous prop...
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WO/2005/090294A2 |
The present invention is directed to a process of making &agr -aminooxyketone and &agr -hydroxyketone compounds. The synthetic pathway generally involves reacting an aldehyde or ketone substrate and a nitroso substrate in the presence ...
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WO/2005/090298A1 |
The invention relates to sulphonamide derivatives of formula (I), where RC is optionally substituted 4-6-membered heterocyclic ring containing one or more N atoms, or RC forms together with the phenyl ring to which it is attached a benzo...
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WO/2005/090274A1 |
Disclosed is a process for regioselective preparation of l-palmitoyl-2-linoleoyl-3-acetylglycerol which is known as having activities for proliferation of hematopoietic stem cells and megakaryocytes, and an intermediate for the same. The...
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WO/2005/087236A1 |
Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
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WO/2005/087215A1 |
The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating at least one disease, disorder, and condition associated with amyloidosis. Amyloidosis refers to a collection of d...
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WO/2005/085224A1 |
The invention provides a process for the production of cyclic carbonates which is applicable to various fields including organic solvents, finishing agents for synthetic fibers, raw materials of drugs, solvents for the electrolytic solut...
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WO/2005/085171A1 |
A process for producing an optically active fluorochemical represented by the general formula (3), which comprises reacting a specific fluoroamine with an optically active diol; and a process for producing an optically active fluoroalcoh...
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WO/2005/084801A1 |
Disclosed is a solid catalyst used for synthesizing a cyclic carbonate with high yield and high selectivity, which is excellent in stability and easily separated after the synthesizing reaction. Specifically disclosed is a catalyst which...
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WO/2005/083045A1 |
The present invention relates to the field of perfumery and concerns a diether or a 1,3-dioxolane derivative of 1,8a-methano-2,4a,8,8-tetramethyldecahydro-2,3-naphthalenedi
ol and its use as perfuming ingredient. The present invention co...
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WO2005063665B1 |
The invention provides para substituted dialkylphenol derivatives of propofol. The invention further provides pharmaceutical compositions comprising such analogs, methods for preparing such analogs, and methods of using such analogs to i...
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WO/2005/080318A1 |
The invention provides a process permitting easy production in high yield of &agr -aminooxyketones, which are equivalents for the synthesis of monosaccharides or pentoses and equivalents of &agr -hydroxyketones serving as intermediates i...
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WO/2005/080304A1 |
Disclosed is an organic semiconductor material which exhibits a high mobility and is excellent in solubility in solvents and oxidation resistance. Also disclosed are an organic semiconductor thin film having a high mobility and an organi...
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WO/2005/080305A1 |
A compound satisfying both annealing properties and lubricating properties. It is an alkyl acetal compound having a structure represented by the following general formula (1) or (2). In the formulae, R1 and R2 each represents a hydrocarb...
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WO/2005/080322A1 |
A novel fluorene characterized by having a fluorene skeleton to which a functional group such as a guanidino group is attached via a carbonyl group, or its salt. This compound has such an advantage as showing a high affinity particularly...
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WO/2005/080317A2 |
The present invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein: A and B independently represent CH2 or O, with the proviso that A and B are not simultaneously O; Cy repres...
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WO/2005/075401A1 |
The invention relates to a method for producing 2,5-dimethylphenyl acetic acid by reacting p-xylol with chloroacetyl chloride to form 2-chloro-1-(2,5-dimethylphenyl) ethanone, which reacts with the compound of formula (II) to form the co...
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WO/2005/075450A2 |
The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5 and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof, for use as therapeutically active substances. The com...
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WO/2005/073165A1 |
The invention aims at providing highly effective insecticides. Compounds represented by the general formula (1); insecticides containing the same as the active ingredient; and a process for the production thereof: (1) wherein A1, A2, A3 ...
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WO/2005/073213A2 |
The invention relates to a method for the production of acetals and ketals of 3-amino-5-(hydroxymethyl)cyclopentane-1,2-diols of formula (I) (and/or the enantiomer), where Rl = H, C1-6 alkyl, C3-8 cycloalkyl or benzyl and i) R2 = methyl ...
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WO/2005/070860A1 |
The present invention relates to substituted bicyclo[3.3.1]nonanes and bicyclo[3.3.1]nonenes of formula (I) wherein R, and R1 to R5 have the same meaning as described in the specification.
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WO/2005/070915A1 |
The present invention relates to novel compounds, 1,3-benzodioxol-5-ylmethyl methyl sulfone and its derivatives and to preparation method thereof. In detail, 1,3-benzodioxol-5-ylmethyl methyl sulfone and its derivatives have strong tyros...
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WO/2005/070910A2 |
The invention relates to a compound having general formula (I), wherein: m represents an integer equal to 1 or 2; R1 represents an aryl- or heteroaryl-type group that is optionally substituted by one or more R3 or R4 groups; R2 represent...
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