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WO/2009/089210A1 |
The present invention is directed to novel processes for the preparation of sulfamide derivatves, useful in the treatment of epilepsy and related disorders.
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WO/2009/087395A1 |
The present invention relates to compounds which find use as weight reducing agents, and find use in treating obesity and/or excess adiposity.
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WO/2009/083451A1 |
The invention pertains to a process for preparing compounds of formula (I-A) or (I-B) here below: by reaction of perfluoroallylfluorosulfate (FAFS) of formula (II): with at least one hypofluorite of formula (II-A) or (II-B): wherein: RF ...
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WO/2009/085033A1 |
Provided herein are blends oils or fatty acids comprising more than 50% medium chain fatty acids, or the fatty acid alkyl esters thereof, and having low melting points. Such blends are useful as a fuel or as a starting material for the p...
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WO/2009/080446A1 |
The object of the invention is a chemical compound of the general formula (I) or (II), where X = O or NR and R = H, an optionally branched C1-C6-alkyl, C3-C6-cycloalkyl, aryl, in particular phenyl, or aralkyl, in particular benzyl, and w...
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WO/2009/079907A1 |
The invention discloses a novel method for preparing and purifying 4-[9-(6-aminopurine)]-2-(S)-hydroxyl-butyric acid methyl ester. The said method starts with cheap and easily available L-malic acid, both of 1-carboxyl and 2-hydroxyl are...
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WO/2009/077385A1 |
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing...
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WO/2009/075818A1 |
Disclosed herein are methods and intermediates useful in the preparation of macrolides, e.g., compounds of formula (IV) wherein R1-R12 are as defined herein.
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WO/2009/075823A1 |
Disclosed herein are methods and intermediates useful in the preparation of macrolides, e.g., compounds of formula (IV), wherein R1-R12 are as defined herein.
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WO/2009/071651A1 |
The invention provides a process and a reactor for the preparation of an alkylene glycol from an alkylene oxide. Alkylene oxide, water, a homogeneous carboxylation catalyst and a homogenous hydrolysis catalyst are supplied to a reactor c...
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WO/2009/072502A1 |
Disclosed is a method by which various fluorine-containing carbonate compounds can be freely produced with high yield without using phosgene and without by-producing hydrogen chloride. Specifically disclosed is a method wherein a fluorin...
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WO/2009/071528A2 |
The invention relates to a process for the synthesis of moguisteine that is ethyl ester of (R,S)-3-[2-[(2-methoxyphenoxy)methyl]-1,3-thiazolidin-3-yl]-
3-oxypropanoic acid which comprises the steps of forming a new cyclic intermediate of...
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WO/2009/070873A1 |
Substituted 2-naphthoic acids of structural formula I are effective as antagonists of the biological activity of GPR105 protein. They are useful for the treatment, control or prevention of disorders responsive to antagonism of this recep...
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WO/2009/072501A1 |
Disclosed is a novel method by which various carbonate compounds can be freely produced with high yield without using phosgene and without by-producing hydrogen chloride. Specifically disclosed is a method wherein a compound having a car...
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WO/2009/066072A2 |
There is provided a compound having Formula (I), wherein each of R1, R2, R3, R4, R5, R6, R7, R8 and R9 are independently selected from (a) H, (b) R13, -OC(R13)3, -OCH(R13)2, -OCH2R13, -C(R13)3, -CH(R13)2, or -CH2R13 wherein R13 is a halo...
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WO/2009/062933A1 |
The invention provides a process for the preparation of an alkylene glycol from an alkene. The gas composition from an alkylene oxide reactor is contacted with lean absorbent in an alkylene oxide absorber in the presence of one or more c...
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WO/2009/064249A1 |
The present invention is directed to a process for the preparation of a diastereomerically pure dibenzoyl-L-tartrate salt of a compound of formula (III) and to products of said process.
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WO/2009/059941A1 |
The invention relates to a method for producing benzyl alkyl ethers of general formula (I) wherein R1, R2, R3, R4 and R5 are the same or different, and are hydrogen, linear or branched C1-C10alkyl or C1-C10 alkoxy, C3-C10cycloalkyl, C3-C...
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WO/2009/056233A1 |
The present invention relates to a method for the production and isolation of known substituted and unsubstituted 1,4-cyclohexanone monoketals of the formula (I). The compounds (I) are produced by the hydrogenation of compounds of the fo...
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WO/2009/052191A1 |
Internally masked neopentyl sulfonyl ester prodrugs of acamprosate, pharmaceutical compositions comprising such prodrugs, and methods of using such prodrugs and compositions thereof for treating diseases are disclosed. In particular, aca...
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WO/2009/050352A2 |
The invention relates to imidazolone derivatives and the use thereof as drugs, having formula (I), wherein: R1 = H, alkyl at C1 to C5, aryl, or a heterocyclic group with 5 or 6 elements; Ar1 = aryl, optionally substituted, or an aromatic...
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WO/2009/050365A2 |
The invention relates to a novel method for preparing (poly)aminoalkylaminoacetamide derivatives of epipodophyllotoxin and the salts thereof. The invention is characterised in that it includes a step comprising the peptide coupling of 4 ...
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WO/2009/047613A2 |
The present invention relates to an improved process for the preparation of Tadalafil intermediate (1R,3R)Methyl-1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl
)-9H-pyrido[3,4-b]indole-3-carboxylate of formula III comprising a modified P...
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WO/2009/037111A2 |
The invention relates to a method for producing 1,3-dioxolane-2-ones of general formula (3) in basic reaction conditions by reesterifying the respective ester of general formula (1) in which R1 to R5 have the meanings indicated in the cl...
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WO/2009/035269A2 |
Disclosed is a method of manufacturing a glycerol carbonate (GC). The method includes a bio-catalyst reaction for generating the GC and byproducts generated by reacting a reactant solution using a lipase of a bio-catalyst. In this instan...
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WO/2009/035951A2 |
Disclosed are amide, thioamide, urea and thiourea compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and co...
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WO/2009/035652A1 |
The present invention provides a convenient and efficient process for the synthesis of d 2-benzo[d][l,3]dioxoles.
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WO/2009/035407A1 |
The present invention relates to novel processes for the preparation of intermediate compounds which can be used to prepare therapeutic agents. The present invention also relates to novel intermediate compounds which can be used to prepa...
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WO/2009/026961A1 |
Processes for the preparation of pancratistatin and pancratistatin analogues. The key step is the reaction of a 1,3-dioxan-5-one and a nitroolefine in the presence of an amine. The process may take place in an enantioselective way when a...
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WO/2009/026658A1 |
The present invention relates to PPAR agonists and their use in therapy, including the treatment of disease. In particular, the invention relates to compounds which are PPAR-gamma agonists and/or PPAR alpha/gamma dual agonists.
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WO/2009/026348A2 |
A Streptomycete bacteria associated with the Southern Pine Beetle (SPB) has been found to synthesize a potent antifungal compound. The spectrum of activity of the isolated antifungal compound is similar to that of amphotericin, and the c...
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WO/2009/024550A1 |
The present invention relates to N-benzyl,N' -arylcarbonylpiperazine derivatives having the general Formula (I) to pharmaceutical compositions comprising the same, and to the use of a these N-benzyl,N' -arylcarbonylpiperazine derivatives...
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WO/2009/024492A1 |
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing...
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WO/2009/016087A1 |
The present invention relates to compounds of formula (I), wherein Ar is aryl or heteroaryl; R1 is hydrogen, halogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy, lower alkoxy substituted by halogen, cyano, SO2-lower al...
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WO/2008/145941A9 |
The invention relates to a conjugated process for the production of nitriles and/or of fatty amines and of polyol carbonates from a natural oil, comprising the following zones: I) zone of methanolysis or hydrolysis of a natural oil conta...
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WO/2009/010554A1 |
The invention provides a new enantioselective process for the preparation of (S) -pregabalin, or a pharmaceutical acceptable addition acid salt comprising: acid hydrolysis of the dioxolan ring of a chiral compound of general formula (I) ...
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WO/2009/010527A1 |
The present invention relates to a process for preparing cyclic glycerol acetals or cyclic glycerol ketals or mixtures thereof and cyclic glycerol monoester acetals or monoether acetals or cyclic glycerol monoester ketals or monoether ke...
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WO/2009/011225A1 |
A process in which 4-chloro-1,3-dioxolan-2-one as a starting substance is fluorinated with a fluorinating agent. By the process, high-purity 4-fluoro-1,3-dioxolan-2-one can be produced in a short time while maintaining high yield. A fluo...
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WO/2009/010260A2 |
An insecticidal compound of formula (I) in which G1, G2, and G3 together with the two carbon atoms to which G1 and G3 are attached, form a non-aromatic 4- or 5-membered ring system; wherein G1 is sulfur, SO, SO2, oxygen, a direct bond, N...
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WO/2009/004990A1 |
It is intended to provide a prostaglandin F2α receptor agonist (FP receptor agonist), which comprises a biphenyl derivative represented by the following general formula (I) (wherein m represents an integer of 0 to 2; n represents an int...
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WO/2009/005110A2 |
There is provided a halogen-containing organosulfur compound having an excellent controlling effect on arthropod pests represented by the formula (I): wherein, m represents 0, 1 or 2, n represents 0, 1 or 2, A represents optionally subst...
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WO/2008/153159A1 |
It is intended to provide a novel amine compound represented by the following general formula (I), a pharmaceutically acceptable acid addition salt thereof, a hydrate thereof or a solvate thereof, which has an excellent peripheral blood ...
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WO/2008/148853A1 |
The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein: each R1 is independently selected from the group consisting of Cl, Br, CH3 and CF3; X is carbon or nitroge...
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WO/2008/142100A1 |
The invention relates to an improved method for producing carbonate-terminated urethanes using isocyanates. The method according to the invention is characterized by high yields with no phenol being produced as a secondary component.
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WO/2008/143293A1 |
Disclosed is a carbonate compound represented by the following general formula (I) (In the formula, R represents an alkyl group having 1-6 carbon atoms or an alkoxyalkyl group having 1-6 carbon atoms.). This carbonate compound is useful,...
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WO/2008/142097A2 |
The invention relates to an improved method for producing carbonate-terminated compounds using amines. The method according to the invention is characterized by high yields with no phenol being produced as a secondary component.
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WO/2008/142101A1 |
The invention relates to an improved method for producing carbonate-terminated urethanes using di- or polyisocyanates. The method according to the invention is characterized by high yields with no phenol being produced as a secondary com...
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WO/2008/139315A2 |
Polycyclic aromatic compounds of formula (I) having at least two conjugated aromatic rings at least one of which has a substituent comprising a cyclic carbonate group can be used as sensitisers for cationic photoinitiators, especially io...
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WO/2008/139079A2 |
The invention relates to a conjugated method for the production of ω-amino-alkanoic acids and polyol carbonates from a natural monounsaturated fatty acid, comprising the following zones: I) zone for methanolysis of a natural oil contain...
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WO/2008/138639A1 |
This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper- proliferative and/or angiogenesis disorde...
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