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WO/2010/044581A2 |
The present invention relates to an N1-benzo[1,3]dioxol-5-ylmethyl-N2-substituted biguanide derivative expressed in chemical formula 1, to a pharmaceutically acceptable salt thereof, to a preparation method thereof, and to a pharmaceutic...
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WO/2010/043581A1 |
The invention relates to a method for producing cyclic carbonates by reacting a multivalent alcohol with a dialkyl carbonate in the presence of a heterogeneous catalyst, characterized in that the heterogeneous catalyst is a basic mixed o...
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WO/2010/042867A2 |
Disclosed are pyruvate kinase M2 activators, which are, bis sulfonamide piperazinyl compounds of Formula (I) and 2,4-disubstituted 4H-thieno[3,2-b]pyrrole-2-(substituted benzyl)pyridazin-3(2H)ones of Formula (II), wherein L and R1 to R16...
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WO/2010/040460A2 |
The invention relates to novel compounds of formula (I) in which X, Y, Z, A, B, and G have the meanings indicated above, several methods and intermediate products for the production thereof, and the use thereof as pesticides and/or herbi...
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WO/2010/040786A2 |
The present invention relates to a synthesis process of polyol carbonate, such as glycerol carbonate, from polyols such as glycerol, propylene glycol or ethylene glycol and urea conducted in using a solvent selective for polyols ( glycer...
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WO/2010/037190A1 |
The present invention describes a series of derivatives of 2-(3-methylenedioxy)-benzoyl indol, their mixtures, their pharmaceutically acceptable salts, their enantiomers, pharmaceutical compositions comprising them, processes for prepari...
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WO/2010/036884A1 |
The present disclosure relates to the preparation of acrylate, alkacrylate, allyl, and polycarbonate derivatives of hydroxy ketal esters, and uses thereof.
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WO/2010/029379A1 |
The present invention relates to compounds of general formula (i) having an oxime moiety or a pharmaceutically acceptable salt, hydrate or solvate thereof and its use for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also know...
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WO/2010/030224A1 |
The present invention is directed to a process for preparing [1S-[1α,2α,3β(1S*,2R*),5β]]- 3-[7-[2-(3,4-difluorophenyl)-cyclopropylamino]-5-(propylthio
)-3H-1,2,3-triazolo[4,5- d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-l,2-dio...
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WO/2010/027424A2 |
The present invention provides compounds of Formula I: compositions containing the same, and methods of use thereof such as for the treatment of cancer.
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WO/2010/022634A1 |
The present invention provides ethylenediamine derivatives of formula (I), its pharmaceutically acceptable salts, its preparation method and uses for the treatment of infectious diseases induced by mycobacterium tuberculosis, especially ...
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WO/2010/023448A1 |
The present invention provides a compound of formula (I) or its salts or pharmaceutically acceptable derivatives thereof wherein; X1 is selected from a group consisting of CH2, C(=O), C(=NH), NC(=O), R1 is selected from the group consist...
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WO/2010/025448A2 |
Compounds of formula (I) and (II) are provided as modulators of Rb:Raf-1 interactions which are potent, selective disruptors of Rb:Raf-1 binding. Therapeutic methods of using the compounds, for example for treating or ameliorating a cell...
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WO/2010/017323A1 |
The present invention provides novel methylenedioxy phenolic compounds and their derivatives, methods of making them and methods of using them to treat or prevent cardiovascular disease, vascular disease and/or inflammatory disease, as w...
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WO/2010/013510A1 |
A 2-aryl-2-halomethyl-4-chloromethyl-1,3-dioxolane (A) can be produced conveniently without decreasing its optical purity by reacting an optically active monochlorohydrin and an aryl (halomethyl) ketone (starting materials) with each oth...
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WO/2010/009508A1 |
A compound of Formula (A) wherein Z is an aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein the heteroaryl or substituted heteroaryl connected to a 2,4-dinito-6-(trifluoromethyl)phenyl ring via a carbon-carbon bond.
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WO/2010/003929A1 |
The invention pertains to a method for making a fluoropolymer comprising an aqueous emulsion polymerization of one or more fluorinated monomers wherein said aqueous emulsion polymerization is carried out in the presence of at least one c...
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WO/2010/000083A1 |
The present invention refers to 5,7-dioxatetracyclo[9.2.1.01,9,04,8]tetradecane derivatives of formula I,wherein R1 - R3 have the same meaning as given in the description. The invention furthermore refers to their preparation and to perf...
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WO/2010/001673A1 |
Disclosed is a manufacturing method for fluoropropylene carbonate that is safe and produces a high yield in one step (one pot), wherein a fluorinating agent is caused to act on a propylene carbonate derivative having groups separated in ...
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WO/2009/155362A1 |
Compounds with physiological effects, such as the activation of hematopoietic growth factor receptors, are disclosed. These compounds can be used to treat a variety of conditions, diseases and ailments, including hematopoietic conditions...
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WO/2009/154154A1 |
Disclosed is a process for producing a benzaldehyde compound represented by formula (3) [wherein Q represents a hydrogen atom or a halogen atom; and Ar represents a phenyl group which may be substituted by at least one group selected fro...
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WO/2009/150248A1 |
The present invention relates to a compound of general formula (I) : and also to the pharmaceutically acceptable salts thereof, to the isomers or isomer mixtures thereof in all proportions, in particular to an enantiomer mixture, and esp...
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WO/2009/147217A1 |
The present invention relates to compounds of formula (I) below in which: - R1 and R3 represent, independently of one another, a methoxy group optionally substituted by one or more fluorine atoms, - R2 and R4 represent, independently of ...
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WO/2009/147632A2 |
The invention provides a method of preparing the stereoisomers of 1,11-diamino-6-aza- undecane-2,4,8,10-tetraol.
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WO/2009/146202A2 |
The present disclosure relates to the preparation of ketal compounds from polyols and oxocarboxylates, and uses thereof.
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WO/2009/141377A1 |
The invention relates to a process for producing an 1,2-alkylene carbonate comprising (i) transporting liquid carbon dioxide to an 1,2-alkylene carbonate production plant; (ii) feeding the liquid carbon dioxide to an evaporation vessel; ...
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WO/2009/142184A1 |
A production method which comprises a step of reacting a compound represented by formula (II) with an acyl donor in the presence of an enzyme originating in a microorganism to thereby convert into a compound represented by formula (III)....
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WO/2009/141361A2 |
The invention relates to a process for the production of an alkylene carbonate by the reaction of an alkylene oxide with carbon dioxide in the presence of a phosphonium catalyst in which process (a) the alkylene oxide, carbon dioxide and...
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WO/2009/137916A1 |
The present application relates to processes for the preparation of oseltamivir and the H3PO4 salt of oseltamivir, Tamiflu®. The application further relates to novel intermediate compounds and to pharmaceutical compositions containing s...
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WO/2009/140318A1 |
The invention provides a reaction system for the production of an alkylene carbonate comprising: - an epoxidation zone containing an epoxidation catalyst located within an epoxidation reactor; - a carboxylation zone containing an bromide...
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WO/2009/140319A1 |
The invention provides a reaction system for the production of an alkylene carbonate and/or an alkylene glycol comprising: an epoxidation zone containing an epoxidation catalyst located within an epoxidation reactor; a carboxylation zone...
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WO/2009/135979A1 |
The invention relates to a method for obtaining zaragozic acid and derivatives thereof, to the intermediate compounds of this synthesis and to the use of said intermediate compounds in the preparation of zaragozic acid.
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WO/2009/132131A1 |
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and...
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WO/2009/130422A2 |
The present invention relates to the use of acylthiourea or acylurea derivatives of formula (I) for the treatment of pathologies involving a tissue dysfunction associated with a deregulation of the Hedgehog protein signalling pathway, an...
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WO/2009/129938A1 |
The present invention relates to substituted phenoxybenzamide compounds of general formula (I) : in which R1, R2, R3, R4, R5, X, R6 and q are as defined in the claims, to methods of preparing said compounds, to pharmaceutical composition...
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WO/2009/124987A1 |
The invention provides a process for the preparation of an alkylene glycol from an alkene wherein conversion of alkylene oxide to alkylene glycol occurs in an alkylene oxide absorber and optionally in further reactors, and alkylene glyco...
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WO/2009/125606A1 |
Provided is a compound represented by formula (I) having a PAI-1 inhibiting action. [In formula (I), R1 represents an optionally substituted C6-10 aryl group etc., T represents a single bond etc., m is 0 or 1, when m is 0 G represents -N...
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WO/2009/125861A1 |
Disclosed are a compound having an outstanding cysteine protease inhibiting action, and medicaments for treating or preventing a disorder selected from a set comprising osteoporosis, osteoarthrosis deformans, rheumatoid arthritis, Paget'...
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WO/2009/125594A1 |
Novel optically active dibenzazepine derivatives having high utility value as chiral phase-transfer catalyst, more specifically, optically active 6,7-dihydro-5H-dibenz- [c,e]azepine derivatives represented by general formula (1') [wherei...
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WO/2009/123355A2 |
The invention relates to a cooling sensation agent composition with a prolonged cool sensation effect comprising at least one compound selected from Formula (1) wherein each of A and B is a hydrogen atom or a hydrocarbon group which may ...
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WO/2009/123241A1 |
Disclosed is a novel compound having an inhibitory activity on a plasminogen activator inhibitor-1 (PAI-1). Also disclosed is a PAI-1 inhibitor comprising the compound as an active ingredient. Further disclosed is a pharmaceutical compos...
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WO/2009/118369A1 |
Mixtures comprising organic carbonates (carbonates not substituted by fluorine, but especially fluorosubstituted organic carbonates) depleted in HF can be obtained from respective mixtures with a higher HF content by a step of stripping ...
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WO/2009/120191A1 |
The present invention is directed to a process for the preparation of benzo-fused heteroaryl sulfamates, useful for the treatment of epilepsy and related disorders according to formula (IA) and to a crystalline compound of formula (I-S)....
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WO/2009/118580A2 |
The invention provides novel compounds of Formula (I), pharmaceutical compositions and methods of synthesis thereof.
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WO/2009/118368A1 |
The content of hydrogen fluorides in fluorosubstituted organic carbonates can be reduced by contact with SiO2 containing agents, especially silica gel. The process is especially suitable to reduce the hydrogen fluoride content in fluoroe...
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WO/2009/110609A1 |
Disclosed is a method for producing a phosphoroamide compound, which is useful for synthesis of an optically active alcohol and enables production of a sterically bulky phosphoroamide compound with high yield. Specifically, a phosphoroam...
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WO/2009/109765A1 |
A dimeric aluminium(salen) catalyst of formula I: herein: Y-Q is CRC1=N or CRC1RC2-NRN1, where RC1, RC2 and RN1 are independently selected from H, halo, optionally substituted C1-20 alkyl, optionally substituted C5-20 aryl, ether and nit...
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WO/2009/106605A1 |
The invention relates to a method for the continuous production of a 1,3-dioxolane-2-one of formula (I) where R1 represents hydrogen or an organic radical comprising 1 to 40 carbon atoms and R2 and R3, which can also be bonded to one ano...
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WO/2009/107449A1 |
Disclosed is a method for producing fluorinated 1,3-dioxolan-2-one by a liquid-liquid reaction in a short time with high yield, wherein a 1,3-dioxolan-2-one derivative having a halogen atom other than fluorine is used as a starting mater...
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WO/2009/089640A1 |
Compounds of formula (I) wherein n is selected from 0, 1 and 2; and R1 is selected from hydrogen, methyl, ethyl, an propyl. A process of the production of compounds of formula (I) and flavour products comprising them. The prefered embodi...
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