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WO/2005/016867A2 |
Therapeutically active anthranilic acid derivatives of Formula (I) wherein R1, R2 and Z are as defined in the specification, processes for the preparation of said derivatives, pharmaceutical formulations containing the active compounds a...
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WO/2005/016862A1 |
A compound represented by the formula (I)[In the formula, Link represents a saturated or unsaturated straight hydrocarbon chain having 1 to 3 carbon atoms, C2 to C6 in the aromatic ring (E) independently represent a ring-constituting car...
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WO/2005/013928A1 |
The present invention provides a method and composition for promoting hair growth in a mammal which comprises a prostaglandin compound having two hetero atoms at the 15 position as an active ingredient thereof.
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WO/2005/012280A1 |
The present invention is related to alkynyl aryl carboxamides of Formula (I’) and use thereof for the treatment and/or prevention of an inflammatory disorder, obesity and/or metabolic disorders mediated by insulin resistance or hypergl...
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WO/2005/009981A1 |
The invention relates to surface-functionalized support materials, respectively comprising a polymer surface and at least one linker compound which is bonded to said surface in a covalent manner, as well as to the production and use ther...
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WO/2005/009984A1 |
An acetal of formula (I) is disclosed, whereby the groups R1 to R6, independently = H, methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec-butyl or tert.-butyl, n = 0 or 1 and, in the location of a dotted line between two C atom...
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WO/2005/009940A1 |
The invention provides novel compounds according to formula I relates to compounds with the general formula I said compounds being useful, e.g. in the treatment of inflammatory, ophthalmic diseases or cancer.
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WO/2005/010131A1 |
The invention concerns a method for producing an oxygen-containing compound used as fuel additive, in particular in diesel fuels, gasoline and rapeseed methyl ester. Said method consists in a) reacting a polyvalent alcohol with an aldehy...
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WO/2005/007621A2 |
This invention describes compounds useful as ubiquitin ligase inhibitors. The compounds of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. The invention also provides f...
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WO/2005/000777A2 |
A process for the preparation of cinnamaldehyde, a,ß-unsaturated cyanoester, and cyanoamide compounds using a Heck reaction is described. Methods for further elaboration of these aldehydes are also provided.
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WO/2005/000804A2 |
The instant invention is directed to novel compounds of Formulae (I) and (II), as wells a process for preparing compounds of Formula (II). The process comprises a palladium-catalyzed reductive cyclization of a compound of Formula (I) to ...
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WO/2005/000233A2 |
The present invention is directed to compounds having the structure (I) wherein R1, R2, R3, R4, R5 and m are as defined herein. The compounds of this invention are novel therapeutic agents for the treatment of cancer, metabolic diseases ...
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WO/2005/000406A2 |
Methods of treating or preventing an amyloid-related disease in a subject by administering to a subject a therapeutic amount of a compound of the invention are described. Also included are methods for inhibiting epileptogenesis in a subj...
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WO/2004/110986A1 |
A compound which functions to inhibit capsaicin receptor VR1 activation and is useful as a therapeutic agent for, e.g., various pains including inflammatory pain and neurogenic pain, migraine, cluster headache, and bladder diseases inclu...
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WO/2004/110973A1 |
The present invention discloses platinum (II) complexes with effective anticancer activity, characterized in that the new platinum (II) complexes are formed by reacting the anionic ligand of Camphoric radicals with the cationic ligand of...
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WO/2004/108696A1 |
A method of manufacturing an alkylene carbonate capable of providing a reactive mixture containing the alkylene carbonate in a reactor by reacting alkylene oxide with carbon dioxide under the presence of a catalyst in the reactor. The re...
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WO/2004/108673A2 |
The use of a compound of formula (II): or its enantiomers or diastereoisomers thereof, or salts or pharmaceutically-acceptable esters thereof, in the treatment or prevention of a papilloma virus infection, particularly human papilloma vi...
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WO/2004/106289A1 |
A monoacyl semicarbazide of the general formula (I): (I), or a pharmaceutically acceptable salt or ester thereof, is capable of selectively inhibiting dipeptidyl-peptidase I (DPP-I), also known as cathepsin C. A compound of the invention...
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WO/2004/101476A1 |
The invention relates to a process for amino acid synthesis, i.e., the preparation of side chain unsaturated &agr ,&agr -disubstituted-&agr -amino acid derivatives with formula (1) wherein: * denotes a stereogenic C-atom PG represents an...
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WO/2004/099171A2 |
Disclosed are compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include...
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WO2004072091B1 |
Novel glycolipid derivatives wherein the substituent of the sphingosine base moiety is alkyl having a shorter carbon chain, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted aralk...
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WO/2004/096771A1 |
Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed, wherein one of Ar1 and Ar2 is phenyl linked in a 1,4-relationship, and the other is phenyl linked in a 1,4-relationship or a 6 membered heteroaryl ring...
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WO/2004/093781A2 |
The invention refers to new compounds, e.g. podophyllotoxin derivatives, as well as to the use thereof and of known compounds as specific inhibitors of the insulin-like growth factor-1 receptor (IGF-1R). Said compounds can be used for tr...
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WO/2004/092115A2 |
The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associ...
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WO/2004/092106A2 |
Process for preparing alkoxy- and aryloxy-phenols, comprising oxidizing the ketone of formula (I) with peracids to give the corresponding ester of formula (II) which is then hydrolysed to give the corresponding aryloxy- or alkoxy-phenol.
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WO/2004/092100A1 |
Compounds of formula (Ia): wherein R1, R2, R3, R4a, R4b, R5 and R6 are defined herein, as well as other indene derivatives are disclosed herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are ...
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WO/2004/092116A1 |
Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical...
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WO/2004/089927A1 |
Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases o...
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WO/2004/089922A2 |
Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
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WO/2004/089377A1 |
Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
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WO/2004/089928A1 |
A process for producing a 3-cyclopropyl-3-oxopropanal acetal compound represented by the general formula (I-1), characterized by reacting cyclopropyl methyl ketone with a formic ester in tetrahydrofuran and then reacting the reaction mix...
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WO2004071481B1 |
A melanogenesis inhibitor characterized by containing at least one kind of piperonyl alcohol represented by the following general formula (1) wherein R is a straight chain or branched chain alkyl group having 13 to 18 carbon atoms, a str...
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WO/2004/089885A1 |
The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
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WO/2004/087634A1 |
A process for the production of carbonyl compounds, characterized by reacting a diol represented by the general formula (1): (1) [wherein R1, R2, R3 and R4 are each independently hydrogen, substituted or unsubstituted alkyl, substituted ...
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WO/2004/085373A1 |
A compound highly active in, e.g., the inhibition of tyrosinase activity which is of the same class as shogaol and zingerol, which are useful in the fields of foods, medicines, quasi-drug preparations, cosmetics, etc. It is a compound re...
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WO/2004/085375A1 |
Process for the preparation of propylene glycol from propylene oxide, which process comprises: (a) contacting propylene oxide with carbon dioxide in the presence of catalyst to obtain a first reaction mixture containing propylene carbona...
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WO/2004/083153A1 |
A process for production of an allyl and/or methallyl ether of a tri or polyhydric alcohol is disclosed. Said process comprises (i) subjecting at least one cyclic formal of a tri or polyhydric alcohol to allylation, (ii) subjecting obtai...
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WO/2004/082677A1 |
The present invention relates to aniline derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.
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WO/2004/080480A1 |
Novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer that are capable of prolonging the action of insulin preparations are disclosed.
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WO/2004/080377A2 |
This invention relates to compounds of the general formula (I) useful as modulators of the KCNQ channel, to pharmaceutical compositions comprising these compounds, and to methods of treatment herewith.
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WO/2004/080492A1 |
The invention relates to conjugates of formula (V) or (VI): wherein X is -CO-NH-, -NH-, -O-, -NHCONH-, or -NHCSNH-; their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.
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WO2004064972A9 |
Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the p...
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WO/2004/078144A2 |
The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering...
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WO/2004/077511A2 |
The present invention provides novel (meth)acrylic and (meth)acrylamide monomers and polymers produced from those monomers. The monomers of the invention each include only a single vinyl functionality and at least one non-vinyl functiona...
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WO/2004/076433A1 |
The present invention relates to novel inhibitors of serine type peptidases in general and of serine type dipeptidyl peptidases in particular. The present invention further relates to the use of the dipeptidyl peptidase inhibitors for se...
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WO/2004/076423A1 |
The present invention relates to a method of promoting growth comprising the step of administering an effective amount of a compound of formula (I); in which X and Y are either the same or different and selected from a heteroatom; (a) is...
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WO/2004/076434A1 |
The present invention relates to novel inhibitors of serine type peptidases in general and of serine type dipeptidyl peptidases in particular. The present invention further relates to the use of the dipeptidyl peptidase inhibitors for se...
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WO/2004/076439A1 |
The invention relates to a method for producing 4-fluoro-1,3-dioxolan-2-one. According to the invention, ethylene carbonate is reacted with 3 to 20 % by weight of 4-fluoro-1,3-dioxolan-2-one (with regard to ethylene carbonate) serving as...
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WO/2004/073709A1 |
Compounds of formula (I) are antibacterial agents: wherein B represents R2R3N-, R2NH-C(=NR3)-, or R2NH-C(=NR3)-NR4- wherein each of R2, R3 and R4 represents hydrogen or a C1-C6 alkyl, phenyl, phenyl(C1-C6 alkyl)-, monocyclic heteroaryl, ...
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WO/2004/072087A2 |
The invention relates to novel metal complexes for optical data carriers, whereby the latter is preferably a transparent substrate which is, optionally already covered with one or several reflective layers. A light-inscriptible informati...
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