Heterocyclic Compounds

Matches 151 - 200 out of 5,407	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/2003/053919A1	SUBSTITUTED CYCLOHEXANE DERIVATIVES The present invention relates to compounds of formula (I) wherein A?1¿, A?2¿, A?3¿, A?4¿, A?5¿, A?6¿, A?7¿, A?8¿, A?9¿, A?10¿, U, V, W, m, n and p are as defined in the description and claims, and pharmaceutically acceptable sa...
WO/2003/053939A1	BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS GNRH ANTAGONISTS The invention concerns novel benzimidazole derivatives of formula (I), wherein: A, Y, R1, R2, R3 and R4 represent diverse variable groups. Said products have a GnRH (Gonadotropin-Releasing Hormone) antagonist activity. The invention also...
WO/2003/051870A1	NOVEL COMPOUNDS The invention provides N-pyrazinyl-thienylsulphonamides of formula (I) for use in the treatment of chemokine mediated diseases. Particularly inflammatory diseases, such as asthma.
WO/2003/051869A1	3,4-DIHYDRO-1H-ISOQUINOLOIN-2-YL-DERIVATIVES The present invention relates to novel compounds of formula I wherein the variable groups are as defined in the claims or a pharmaceutically acceptable acid addition salt thereof. The compounds of the invention are NK2 antagonists.
WO/2003/051841A2	COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE Carbamates and related compounds of formula R1 R2NCO-Y or R1 R2NCS-Y wherein R1 and R2 are hydrogen, alkyl, aryl, heteroaryl or may together form a piperidine, piperazine, morpholine or other heterocyclic ring, are inhibitors of hormone ...
WO/2003/051842A2	COMPOSITIONS DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE Carbamates and related compounds of formula R1R2NCO-Y or R1R2NCS-Y wherein R1 and R2 may form a ring, are inhibitors of hormone sensitive lipase and are useful for the treatment of any disorder where it is desirable to modulate the plasm...
WO/2003/050261A2	(1-PHENYL-2-HETEROARYL)ETHYL-GUANIDINE COMPOUNDS AS INHIBITORS OF MITOCHONDRIAL F¿1?F¿0? ATP HYDROLASE Compounds having formula (I), and pharmaceutically acceptable salts thereof, are useful for modulating mitochondrial F¿1?F¿0? ATPase activity and treating ischemic conditions including myocardial infarction, congestive heart failure, a...
WO/2003/048137A1	METABOTROPIC GLUTAMATE RECEPTOR-5 MODULATORS Phenyl compounds substituted at the 1-position with a fused bicyclo moeity formed from a five-membered heterocycle fused to a six-membered carbocycle, to a six-membered aryl, or to a six-membered hetaryl, and further optionally substitut...
WO/2003/048078A2	PRODUCTION OF IONIC LIQUIDS A process for the manufacture of ionic liquids by an anion exchange reaction of a quaternary ammonium, phosphonium, imidazolium, or pyridinium halide, providing the appropriate cation component, with an acid or a salt thereof, providing ...
WO/2003/047512A2	COMPOUNDS DERIVED FROM AN AMINE NUCLEUS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME Compounds having the formula (I), are effective as inhibitors of IMPDH enzyme and/or serine protease Factor VIIa, wherein B is a monocyclic or bicyclic carbocyclic or heterocyclic ring, D is a monocyclic or bicyclic carbocyclic or hetero...
WO/2003/045925A1	1,2,4-TRIAZOLE DERIVATIVES CONTAINING A SULPHAMATE GROUP AS AROMATASE INHIBITORS There is provided a compound of Formula (I), wherein each T is independently selected from H, hydrocarbyl, -F-R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which...
WO/2003/045912A1	INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION CASCADE The present invention provides compounds of Formula (I), wherein A, B, C, G, and W?1¿ have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thrombotic disorders. Also...
WO/2003/045920A1	4-AMINOQUINOLINE COMPOUNDS The present invention is concerned with compounds of the general Formula I : and pharmaceutically acceptable salts thereof, which are useful as melanin concentrating hormone receptor antagonists, particularly MCH-1R antagonists. As such,...
WO/2003/045944A1	AROMATIC SULFONE HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS This invention is directed to aromatic sulfone hydroxamates (also known as aromatic sulfone hydroxamic acids) and salts thereof that, inter alia, tend to inhibit matrix metalloproteinase (also known as matrix metalloprotease or MMP) acti...
WO/2003/043999A1	INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 The present invention relates to compounds with the formula (I), and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on t...
WO/2003/043980A1	AZETIDINYL DIAMINES USEFUL AS LIGANDS OF THE NOCICEPTIN RECEPTOR ORL-1 Disclosed are nociceptin ORL-1 receptor agonists of formula (I) wherein; (a) R¿1? is optionally substituted alkyl, fluorenyl, pyrimidinyl or optionally substituted piperidinyl; R¿2? is H; and R¿3? is -C(H)(R)-NR¿7?R¿8?; R is H, opti...
WO/2003/044000A1	INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 The present invention relates to compounds with the formula (I), and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on t...
WO/2003/042188A1	TRIAZOLE DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THE SAME A compound usable in treatments for fungal infectious diseases. It is a compound represented by the following formula (I) or a pharmacologically acceptable salt or solvate thereof: (I) wherein A represents substituted phenyl or a 5− to...
WO/2003/039451A2	THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS A thiazole derivative of the formula (I):wherein R is 1-optiona lly substituted-6-oxo-1,6-dihydro-3-pyridazinyl, R' is an optionally substituted phenyl, and R?2¿ is hydrogen, a group of the formula (i): wherein R?4¿ is hydrogen, lower ...
WO/2003/039454A2	BETA-SECRETASE INHIBITORS AND METHODS OF USE Compounds inhibit memapsin 2 $g(b)-secretase activity and selectively inhibit memapsin 2 $g(b)-secretase activity relative to memapsin 1 $g(b)-secretase activity. The compounds are employed in methods to inhibit memapsin 2 $g(b)-secretas...
WO/2003/037871A1	THERAPEUTIC QUINOLONE COMPOUNDS WITH 5−HT−ANTAGONISTIC PROPERTIES Provided herein is a compound having the formula (I) (R2 is typically a tertiary nitrogen atom, being either alkyl−substituted or member of q heterocyclic ring&semi R7 is typically a monocyclic or bicyclic aromatic ring or a heterocycl...
WO/2003/037875A1	DEVELOPER CONSTITUENTS AND THEIR USE FOR DYING KERATIN FIBERS The invention relates to means for dying keratin fibers, particularly human hair, which contain, in a cosmetically acceptable carrier, at least one p-phenylenediamine derivative of formula (I), whereby: A represents a branched or unbranc...
WO/2003/035602A1	LIPID MODULATORS Compounds represented by the following general formula (I) and which have a PPAR&gammad modulator activity: (I) wherein A represents optionally substituted aryl&semi B represents optionally substituted aryl, optionally substituted cycloa...
WO/2003/035065A1	BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS The invention is directed to physiologically active compounds of the general formula (Ix) and compositions containing such compounds, and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prod...
WO/2003/035644A1	BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS KDR PROTEIN KINASE INHIBITORS The invention concerns novel products of formula (IA), wherein: A represents an optionally substituted cyclic or bicyclic saturated heterocycle, in particular pyrazole or imidazole, optionally substituted; A1, A2, A3 and A4, identical or...
WO/2003/035066A1	2-AMINOQUINOLONE DERIVATIVES FOR USE AS IMPDH INHIBITORS Quinolone derivatives of formula (1) are described; wherein: X is an O or S atom; R1 is an aliphatic, cycloaliphatic, or cycloalkyl-alkyl-group; R2 is a -CN group or an optionally substituted heteroaromatic group; R3 is a hydrogen atom o...
WO/2003/032980A1	5'−CARBAMOYL−1,1'−BIPHENYL−4−CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS Compounds of formula (I): wherein X is a bond or a phenyl group which may be optionally substituted&semi R1 is selected from an optionally substituted five− to seven−membered heterocyclic ring, an optionally substituted five− to se...
WO/2003/033477A1	ALKYNLATED FUSED RING PYRIMIDINE COMPOUNDS AS MATRIX METALLOPROTEASE-13 INHIBITOR A compound selected from those of formula (I) : wherein W¿1? represents O, S, or -NR¿3? in which R¿3? represents hydrogen, alkyl, OH or CN; W¿2? represents a group selected from hydrogen, CF¿3?, NH¿2?, monoalkylamino, dialkylamino,...
WO/2003/032997A1	PYRIMIDINE DERIVATIVES, PHARMACEUTICAL AGENT CONTAINING SAID COMPOUNDS, USE AND METHOD FOR MAKING SAME The invention concerns tri-substituted pyrimidines of formula (I), wherein Ra to Re are such as defined in the description, said compounds being used for treating diseases characterized by excessive or abnormal cell proliferation. The in...
WO/2003/032999A1	ALKYNE MATRIX METALLOPROTEINASE INHIBITORS A compound of Formula (I) or a pharmaceutical acceptable salt thereof, or a tautomer thereof, wherein G¿1?, G¿2?, and B are as defined in the application, are selective inhibitors of MMP-13. The compounds are useful for treating diseas...
WO/2003/032986A1	2' -METHYL-5-(1,3,4-OXADIAZOL-2-YL)-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS Compounds of formula (I), wherein R?1¿ is a phenyl group which may be optionally substituted; R?2¿ is selected from hydrogen, C¿1-6?alkyl and (CH¿2?)¿p?-C¿3-7?cycloalkyl; R?3¿ is the group: (Formula II), R?4¿ is selected from hyd...
WO/2003/033483A1	BIPHENYLCARBOXYLIC AMIDE DERIVATIVES AS P38 KINASE INHIBITORS Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
WO/2003/033482A1	OXADIAZOLYL−BIPHENYLCARBOXAMIDES AND THEIR USE AS P38 KINASE INHIBITORS Compounds of formula (I), wherein R3 is the group&semi or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
WO/2003/033478A1	ALKYNYLATED FUSED RING PYRIMIDINE COMPOUNDS AS MATRIX METALLOPROTEASE-13 INHIBITORS A compound selected from those of formula (I), wherein W¿1? represents O, S, or -NR¿3? in which R¿3? represents hydrogen, alkyl, OH or CN; W¿2? represents a group selected from hydrohen, CF¿3?, NH¿2?, monoalkylamino, dialkylamino, ...
WO/2003/031437A1	PROPYLCARBAMATE DERIVATIVES AS INHIBITORS OF SERINE AND CYSTEINE PROTEASES The present invention includes ketone derivatives (I) and (II), which are useful as cathepsin K inhibitors. The described invention also includes methods of making such ketone derivatives as well as methods of using the same in the treat...
WO/2003/030909A1	2− AND 4−AMINOPYRIMIDINES N−SUBSTTITUDED BY A BICYCLIC RING FOR USE AS KINASE INHIBITORS IN THE TREATMENT OF CANCER A coumpound of the formula (I) wherein each X is independently NR1R6, NR4R5, or R4, with the proviso that at least one X must be NR1R6&semi each R1 is independently an optionally substituted fused bicyclic unsaturated ring containing 9 o...
WO2001094341A9	QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS The invention concerns quinazoline derivatives of Formula (I) wherein each of Q<1>, Z, m, R<1>, R<2>, R<3> and Q<2> have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions contain...
WO/2003/031410A1	LIGANDS OF MELANOCORTIN RECEPTORS AND COMPOSITIONS AND METHODS RELATED THERETO Compounds which function as melanocortin receptor ligands and having utility in the treatment of melanocortin receptor-based disorders, and may be used to treat disorders or illnesses including eiating disorders, cachexia, obesity, diabe...
WO/2003/030902A1	IMIDAZOLE DERIVATES AS ANTI-INFLAMMATORY AGENTS Compounds (I), pharmaceutical compositions thereof are provided that are useful in the treatment of inflammatory and immune-related conditions or disorders. In particular, the invention provides compounds which modulate the expression an...
WO/2003/031448A1	REVERSE-TURN MIMETICS AND METHOD RELATING THERETO Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields,...
WO/2003/029244A1	PROCESS FOR PREPARING PYRIDYL-ALKYLSULFONYL PYRAZOLE DERIVATIVES The invention relates to processes for preparing compounds of formula (1) as well as intermediates useful in such processes, wherein R?1¿ - R?4¿ are as defined. The compounds of formula (I) are useful in the treatment or alleviation of...
WO/2003/026666A1	2-PHENYLAMINO-4- (5-PYRAZOLYLAMINO)-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS, IN PARTICULAR, AS SRC KINASE INHIBITORS The invention provides novel substituted 2,4-diaminopyrimidine compounds (I), in which L is a linker selected from: -O-(CH¿2?)¿1-4?- ; s(O)¿0-2?-(CH¿2?)¿1-4?- ; -N(R?1¿)-(CH¿2?)¿1-4?-(CH¿2?)¿1-4?-O-(CH¿2?)¿1-4?- ; -N(R?1¿)-C...
WO/2003/026665A1	2-PHENYLAMINO-4-(5-PYRAZOLYLAMINO)-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS, IN PARTICULAR, SRC KINASE INHIBITORS This application discloses and claims 5-substituted-2,4-diaminopyrimidines, (I) in which R?1¿ represents C¿1-6? alkyl, C¿3-6? cycloalkyl, adamantyl, phenyl, or a 5-membered heteroaromatic containing a single heteroatom selected from N...
WO/2003/026664A1	2−PHENYLAMINO−4− &lpar 5−PYRAZOLYLAMINO&rpar −PYRAMIDINE DERIVATIVES AS KINASE INHIBITORS, IN PARTICULAR, SRC KINASE INHIBITORS The invention provides novel substituted 2,4−diaminopyrimidine compounds (I). In formula (I), the variables are as follows. Y1 represents H or C 1−4 alkyl. Y2 represents CF3, C1−6 alkyl&semi C3−6 cycloalkyl&semi or phenyl optiona...
WO/2003/024448A2	INHIBITORS OF HISTONE DEACETYLASE The invention relates to the inhibition of histone deacetylase. The invention provides compounds e.g. (1) and methods for inhibiting deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell p...
WO/2003/022812A1	ORGANIC SULFATES AS IONIC LIQUIDS The invention relates to novel ionic liquids of general formula [cation] [R'-SO4], wherein R' represents a branched or linear, saturated or unsaturated, aliphatic or alicyclic, functionalised or unfunctionalised hydrocarbon chain having ...
WO/2003/022821A1	HETEROCYCLE DERIVATIVE HAVING 20−HETE−PRODUCING ENZYME INHIBITORY ACTIVITY A heterocycle derivative represented by the formula (I) (wherein Y is carbon or nitrogen&semi R1 is a heterocyclic group&semi R2 is hydrogen, C1−4 alkyl, C1−4 alkoxy, or halogeno&semi n is an integer of 1 to 4&semi and R3 is morpholi...
WO/2003/022274A2	2-AROYLIMIDAZOLE COMPOUNDS FOR TREATING CANCER Disclosed is a compound represented by Structural Formula (I). R¿1? is a substituted or unsubstituted 2-imidazolyl group which is optionally fused to a substituted or unsubstituted aryl group. Z¿l? is =0, =S, =NOR¿11?, or =NR¿11?. R ...
WO/2003/022280A2	3-GLYOXLYLAMIDEINDOLES FOR TREATING CANCER Disclosed is an anti-cancer compound represented by Structural Formula (I). The variables in Structural Formula (I) are described herein. Also disclosed is a pharmaceutical composition comprising a pharmaceutically acceptable carrier or ...
WO/2003/018543A1	NOVEL CYCLOHEXYL SULPHONES Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.

Matches 151 - 200 out of 5,407	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >