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Matches 1 - 50 out of 5,404

Document Document Title
WO/2022/006457A1
The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.  
WO/2022/006456A1
The present application provides tricyclic pyridone compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.  
WO/2021/252644A1
The disclosure provides compounds of formula II with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provid...  
WO/2021/111351A1
The present invention relates to novel heterocyclic compounds of general formula (I) their tautomers, stereoisomers, enantiomers, pharmaceutically acceptable salts and pharmaceutical composition. The compounds of general formula (I) belo...  
WO/2021/094269A1
The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.  
WO/2021/066873A1
The disclosure includes compounds of Formula (A) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11, h, j, m, n, k, v, s, g, V, W, L, Z1 Q1, Q2, Q3, Q4, Q5, Q6, and Q7, are defined herein. Also disclosed is a method for treating a ...  
WO/2020/082656A1
The prevent invention provides a macromolecule Thermally Activated Delayed Fluorescence (TADF) material, and further provides a TADF monomolecular white light material, which is synthesized from raw materials of first groups and second g...  
WO/2019/234075A1
The invention relates to 4-(1-hydroxy-3,4-dihydro-1H-benzo[c][1,2]oxaborinin-3-yl)ben zimidamide derivatives and their use in treating diseases and conditions of the skin (for example, Netherton syndrome, rosacea, atopic dermatitis, psor...  
WO/2019/084271A1
The disclosure relates to compounds that are, e.g., PAP Associated Domain Containing 5 (PAPD5) inhibitors and methods of use thereof.  
WO/2018/078657A1
The present invention discloses a simple, economic, consistent, commercially viable and industrially applicable process for preparation of Glipizide in high yield and highly pure Glipizide having purity more than 95%, preferably more tha...  
WO/2016/201354A1
Described are compositions and methods for treating cancer. Some methods comprise the administration of an effective amount of at least one inhibitor of tryptophan 2, 3-dioxygenase (TDO) and/or indoleamine 2, 3-dioxygenase (IDO), optiona...  
WO/2015/111943A1
The present invention relates to an organic compound, and an organic electroluminescent device containing the same. The luminescence efficiency, driving voltage, lifetime and the like of an organic electroluminescent device can be improv...  
WO/2013/072896A1
The present invention is related to variants of mycolactones of formula (I), processes for the preparation thereof, pharmaceutical compositions thereof and their use in modulating inflammation, immunity and pain. Y-O-W (I), wherein Y and...  
WO/2012/174564A1
Methods of preparing hetero ionic complexes, and ionic liquids from bisulfate salts of heteroatomic compounds using dialkylcarbonates as a primary quaternizing reactant are disclosed. Also disclosed are methods of making electrochemical ...  
WO/2010/063069A1
The present invention relates to compounds that are useful as metal ligands and which either contain a molecular recognition moiety or can be bound to a molecular recognition moiety and methods of making these compounds. Once the compoun...  
WO/2009/089482A1
Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein R1 is H or optionally substituted alkyl; R2, R3, R4 are each independently selecte...  
WO/2008/122115A1
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable ...  
WO/2007/138307A2
A sulfur-containing acid removal process for deacidifying a crude oil and/or crude oil distillate containing sulfur-containing acids comprising the steps of: (a) contacting the crude oil and/or crude oil distillate containing sulfur-cont...  
WO/2007/134958A1
There are presented compounds of the formula (I) wherein R1, R2, R3 and R4 are as defined in the description and claims, or a pharmaceutically acceptable salt thereof, which are active adenosine A2B receptor antagonists and useful in the...  
WO/2007/108742A1
The present invention relates to new compounds of formula I, or salts, solvates or solvated salts thereof, wherein Q, R1, R2, R3, R4 and n are defined as in claim 1, processes for their preparation and to new intermediates used in the pr...  
WO/2007/087684A1
The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerisation inhibitors.  
WO/2006/073967A1
Compounds useful as prodrugs of potassium channel inhibitor compounds, in particular as prodrugs of Kv1.5 channel inhibitors.  
WO/2005/116020A1
Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them...  
WO/2005/100370A1
The present invention refers to new compounds derived from artesunate salts with quinolines represented by the general formula (I) where X is represented by the general formula (II) and Y is represented by the general formula (III) depen...  
WO/2005/075422A1
The invention relates to a process for the manufacture of an 1,2,4-triazol-1-yl compound of the formula [A], or a salt thereof, wherein each of R3 and R4 is hydrogen or lower alkyl, said process comprising reacting a hydrazine compound o...  
WO/2005/070896A1
The invention relates to a method for producing ionic liquids consisting first in reacting an ionic liquid with an alkylate, a hydrogencarbonate, a carbonate, a carboxylate or a hydroxide and, afterwards in neutralising with an acid. The...  
WO/2005/070923A1
A crystalline polymorph of a bislulfate salt of a thrombin receptor antagonist compound, which exhibits a powder x-ray diffraction profile substantially the same as that shown in FIG. 1, or which exhibits a differential scanning calorimt...  
WO/2005/068404A1
The invention relates to a method for the distillation of ionic liquids. According to said method, in one step the pressure is set to a value below the ambient pressure and in a subsequent step, the ionic liquid is heated to a temperatur...  
WO/2005/058916A2
The present invention relates to organometallic transition metal compounds of formula (I) where M1, X, n, Z, R1-R8 and A are as defined in the claims, biscyclopentadienyl ligand systems having such a substitution pattern, catalyst system...  
WO/2005/046688A2
A method of treating a therapeutic condition comprising administering to a mammal in need of such treatment an effective amount of at least one compound of the formulas (I) and (II) or a pharmaceutically acceptable isomer, salt, solvate ...  
WO/2005/040121A2
The present invention relates to compounds of formula (I), that are novel VR1 antagonists useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or bladder overactivity.  
WO/2005/037954A1
Disclosed is a compound represented by formula 1: wherein each of A, X, Y, Y’, and Y’’ has the same meaning as described herein. When used in an organic light emitting device, the compound represented by formula 1 has at least one ...  
WO/2005/030712A2
A series of compounds represented by the structural formulas and pharmaceutically acceptable isomers, salts, solvates and polymorphs thereof are disclosed. Also disclosed are pharmaceutical compositions containing said compounds and thei...  
WO/2005/023235A1
The invention aims at providing novel low-molecular compounds which have G-CSF-like activities and can substitute for G-CSF preparations. The invention relates to G-CSF-like agonists containing as the active ingredient benzyl alcohol der...  
WO/2005/019183A1
Disclosed is a method for producing purified 1,3-substituted imidazolium salts of general formula (I) by reacting a 1,3-substituted imidazolium salt of general formula (II) with a strong base at a temperature ranging between 20 and 250 ...  
WO/2005/016890A1
Compounds of Formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.  
WO/2005/014583A1
An azole derivative of formula (I) having a fluorovinyl moiety or a pharmaceutically acceptable salt thereof is superior to the conventional antifungal drugs in antifungal activity against a wide spectrum of pathogenic fungi, and has adv...  
WO/2004/093828A2
Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, ...  
WO/2004/089914A1
The invention relates to benzenesulphonamide derivatives of formula (I), methods and intermediate products for production thereof and use of said compounds, or means comprising said compounds for the control of undesired plants and for t...  
WO/2004/084901A1
This invention generally relates to methods for treating or preventing a condition responsive to JNK inhibition, such as a metabolic condition, comprising administering to a patient in need thereof an effective amount of an Anilinopyrimi...  
WO/2004/083208A1
The present invention relates to novel substituted piperidine and piperazine derivatives as melanocortin-4 receptor (MC-4R) modulators. MC-4R agonists of the invention can be used for the treatment of disorders and diseases such as obesi...  
WO/2004/080973A1
Compounds having the formula (I) (I), are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.  
WO/2004/080974A1
Disclosed is an ionic liquid purification method for preparing high purity ionic liquids which can be used as solvents for organic, inorganic and biochemical reactions or as electrolytic solutions of storage batteries, secondary batterie...  
WO/2004/072031A2
Compounds of Formula (I): or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.  
WO/2004/071390A2
The present invention is related to piperazine -2-carboxamide derivatives of formula (I) for the treatment and/or prophylaxis of preterm labor, premature birth, dysmenorrhea and for stopping labor prior to cesarean delivery. Wherein A, X...  
WO/2004/069823A1
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell pr...  
WO/2004/069797A1
The invention relates to novel heteroaryl-substituted acetone derivatives, which inhibit the enzyme phospholipase A2, to pharmaceutical agents that contain said compounds and to a method for producing said compounds.  
WO/2004/069846A1
The invention relates to pyrimidines of formula (I), wherein Ln have the meaning indicated in the description while the substituents R1, R2, and R3 have the following meaning: R1 represents C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkinyl, C...  
WO/2004/067537A1
It is intended to provide a compound represented by the following general formula (I) (wherein n represents an integer of 0 or 1; R1 represents hydrogen or alkyl; and A represents an optionally substituted imidazo[2,1-b]thiazole ring) or...  
WO/2004/065381A1
The invention relates to a process for producing a compound of formula (I), wherein a carbazolone of formula II, formaldehyde or a formaldehyde precursor, an amine of formula III or a salt thereof wherein R1 and R2 each independently rep...  

Matches 1 - 50 out of 5,404