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WO/2019/006723A1 |
Provided is a mesophilic microorganism host cell that produces lysine, and is genetically modified to express a thermophilic lysine decarboxylase and to overexpress one or more lysine biosynthesis polypeptides. And provided are methods o...
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WO/2019/008110A1 |
The present invention relates to the preparation of amines from aldehydes and ketones by reductive amination with enzymes having a reductive aminase activity on aldehydes and ketones devoid of any carboxyl group gamma of the carbonyl gro...
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WO/2019/004780A2 |
The present application relates to an O-succinyl homoserine transferase mutant, a polynucleotide for coding same, a microorganism comprising the mutant, and a method for producing O-succinyl homoserine using the microorganism.
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WO/2019/004778A2 |
The present application relates to an aspartokinase mutant, a microorganism including the mutant, and a method for production of an aspartate-derived L-amino acid or homoserine derivative, using the microorganicm.
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WO/2019/004234A1 |
The present invention addresses the problem of providing a simple method for producing ergothioneine. Provided is an ergothioneine production method characterized by comprising a step for culturing a microorganism belonging to the genus ...
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WO/2019/004779A2 |
The present application relates to an O-succinyl homoserine transferase mutant, a polynucleotide for coding same, a microorganism comprising the mutant, and a method for producing O-succinyl homoserine using the microorganism.
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WO/2018/230977A1 |
The present application relates to a novel polypeptide having an ability to discharge an ornithine-based product, and a method for producing an ornithine-based product using same.
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WO/2018/230978A1 |
The present application relates to a novel polypeptide having an ability to discharge an ornithine-based product, and a method for producing an ornithine-based product using same.
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WO/2018/229208A1 |
A method for producing a compound of formula (III) or a salt thereof, wherein said process comprises the following steps: (a) forming a mixture comprising a compound of formula (II) by adding an organocatalyst to a compound of formula (I...
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WO/2018/228247A1 |
Disclosed in the present application are a method for producing an enzymatic reaction by using adenosine to replace adenosine triphosphate (ATP) and an application thereof. The method comprises the following steps: (1) in an enzymatic re...
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WO/2018/220228A1 |
The method relates to the production of dialdehyde dioxime precursors corresponding to medium chain linear α-, ω-dinitriles by means of an enzymatic conversion.
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WO/2018/219107A1 |
Provided are engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. The engineered polypeptides disclosed are developed through directed evolution based on ...
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WO/2018/217168A1 |
This invention relates to the bioproduction of substituted or unsubstituted phenylacetaldehyde, 2-phenylethanol, phenylacetic acid or phenylethylamine by subjecting a starting material comprising glucose, L-phenylalanine, substituted L-p...
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WO/2018/212626A1 |
The present invention relates to a recombinant microorganism having an enhanced ability to produce heme, coproporphyrin III (Copro III), and uroporphyrin III (Uro III), and a method for producing heme, coproporphyrin III, and uroporphyri...
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WO/2018/213796A1 |
The disclosure relates to host cells having altered NADPH availability, allowing for increased production of compounds produced using NADPH, and methods of use thereof. NADPH availability is altered by one or more of: expressing an alter...
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WO/2018/211051A1 |
The present invention is directed to microbial production of nicotinamide mononucleotide using a genetically modified fungus.
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WO/2018/209563A1 |
Provided are CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. Methods of generating such mutant polypeptides, microorganisms genetically modified to overexpress the mu...
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WO/2018/210359A1 |
The invention relates to pyruvate carboxylase and a pyruvate carboxylase-encoding DNA, a plasmid containing said DNA and a microorganism for the production thereof, and to methods for the production of products the biosynthesis of which ...
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WO/2018/206027A1 |
It has been determined that the yeast Kazachstania slooffiae, which occurs endemically in hog-gut, is capable of utilising a plurality of L-amino acids, peptone, ammonium sulfate or urea as an individual N-source and in so doing, does no...
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WO/2018/202688A1 |
The present invention relates to a process for preparing a natural flavor base and a flavor base obtainable by such process. A further aspect of the invention is a method for providing a natural pistachio, a natural malty, a natural hone...
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WO/2018/202683A1 |
The present invention relates to a process for preparing a natural flavor base and a flavor base obtainable by such process. A further aspect of the invention is a method for providing a natural malty, a natural tropic fruit, a natural c...
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WO/2018/202686A1 |
The present invention relates to a process for preparing a natural flavor base and a flavor base obtainable by such process. A further aspect of the invention is a nnethod for providing a natural milky, a natural caramel, a natural pop-c...
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WO/2018/202684A1 |
The present invention relates to a process for preparing a natural flavor base and a flavor base obtainable by such process. A further aspect of the invention is a method for providing a natural nutty, a natural roasty, and/or a natural ...
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WO/2018/197608A1 |
The present invention provides a method of producing astaxanthin and lysine in recombinant gram-positive bacteria comprising a nucleic acid sequence encoding for a crtZ-protein from F. pelagi and comprises a nucleic acid sequenceencoding...
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WO/2018/190398A1 |
According to the present invention, it becomes possible to produce theanine with high efficiency without requiring adding ethylamine from the outside and without accumulating or remaining ethylamine as a by-product, by using a microorgan...
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WO/2018/185084A1 |
The present invention relates to a method of producing vinylglycine and/or derivatives thereof, the method comprising, - contacting glutamic acid and/or derivatives thereof with an electrolysis medium; and - subjecting the glutamic acid ...
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WO/2018/181774A1 |
The purpose of the present invention is to provide a novel enzymatic protein that makes it possible to produce an optically active β-hydroxy amino acid. The present invention solves the aforementioned problem by providing a monooxygenas...
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WO/2018/182361A1 |
The present invention relates to a method for preparing a bacteria mutant strain, comprising the steps of: (a) primarily transforming a normal bacteria into an enzyme-expressing vector which has temperature sensitivity or antibiotic sens...
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WO/2018/171488A1 |
Provided is a method for screening a corynebacterium constitutive expression vector promoter on the basis of transcriptome sequencing; and further provided are the corynebacterium constitutive expression vector promoter screened on the b...
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WO/2018/168525A1 |
The present invention provides a polyamine-rich yeast mutant that is mutated in comparison to the Sake yeast kyokai No. 7 in that, in the amino acid sequence of any one of leucine synthase, aconitic acid synthase, S-adenosyl-L-methionine...
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WO/2018/165325A1 |
Provided herein are methods for producing an organoboron product. The methods include combining a boron-containing reagent and a carbene precursor in the presence of a heme protein, e.g., a cytochrome c, a cytochrome P450, a globin, a pr...
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WO/2018/157942A1 |
Process of cell-free synthesis of a target protein, comprising at least the following steps: a. providing at least one precursor of an amino-acid, a cell-free extract comprising means for transforming said precursor of an amino-acid into...
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WO/2018/160103A1 |
A group of inventions relates to biotechnology, in particular a method for producing L-asparaginic acid. For this purpose, a recombinant strain of Escherichia coli that produces aspartase was produced by introducing a recombinant plasmid...
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WO/2018/152918A1 |
Provided is an L-homoserine-producing bacterial strain. One or more genes of the bacterial strain related to an L-homoserine metabolic pathway are knocked out or weakened, and/or one or more genes related to the L-homoserine metabolic pa...
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WO/2018/144965A1 |
Microorganisms and bioprocesses are provided that convert gaseous substrates, such as renewable H2 and waste CO2 producer gas, or syngas into high-protein biomass that may be used directly for human nutrition, or as a nutrient for plants...
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WO/2018/127143A1 |
The invention provides a highly active S-cyanohydrin lyase obtained by mutating an amino acid residue at position 103 of a wild-type cassava S-cyanohydrin lyase. The mutation can significantly increase an expression of a mutant enzyme in...
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WO/2018/124440A2 |
The present application relates to novel mutant polypeptide having isopropylmalate synthase activity, a polynucleotide coding for the same, a microorganism including the polypeptide, and a method for producing L-leucine by culturing the ...
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WO/2018/124247A1 |
A nitrile hydratase that is derived from Pseudonocardia thermopila and has an α subunit and a β subunit, wherein a specific amino acid residue has been substituted for the amino acid residue in at least one position selected from the g...
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WO/2018/124475A2 |
The present invention relates to a recombinant microorganism having a xenogeneic gene introduced thereto and a method for producing a useful material from formic acid and carbon dioxide using the microorganism. The present invention prov...
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WO/2018/120025A1 |
The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms gene...
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WO/2018/122511A1 |
The invention relates to the field of organic polysulphides, more particularly to a method for synthetising functionalised organic polysulphides of formula (I): R2-X-(NR1R7)C*H-(CH2)n-Sa-(CH2)n-C*H(NR1R7)-X-R2, in which the various subst...
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WO/2018/124778A1 |
The present application relates to a microorganism producing O-phosphoserine and a method for producing O-phosphoserine, cysteine or a cysteine derivative using same.
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WO/2018/124533A1 |
The present application relates to a Corynebacterium sp. microorganism for producing L-lysine and a method for producing L-lysine by using the same.
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WO/2018/120026A1 |
The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms gene...
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WO/2018/116203A1 |
The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, ...
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WO/2018/114841A1 |
The present invention relates to a process for preparing aminobenzoic acid or an aminobenzoic acid conversion product, comprising the steps of: (I) providing an aqueous solution of aminobenzoic acid using a fermentation process; (II) ads...
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WO/2018/115538A1 |
The invention relates to a method for obtaining biogenic polyamines from a protein material with a protein richness of approximately 10% by weight, the method including the following steps: (i) performing hydrolysis of a protein material...
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WO/2018/114575A1 |
The present invention relates to a method for the enzymatic reduction of cystine to cysteine comprising contacting cystine with a reduction solution comprising: (i) an active glutathione reductase (EC1.8.1.7); (ii) a cofactor; and (iii) ...
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WO/2018/104143A1 |
The present invention relates to a method for the biocatalytic synthesis of proteinogenic L-amino acids, such as L-alanine, L-valine, L-methionine, L-leucine, L-isoleucine or L-phenylalanine from a respective aldehyde and carbon dioxide ...
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WO/2018/099452A1 |
Disclosed is a L-isoleucine-producing Corynebacterium glutamicum fermentation medium, comprising a basal medium and a growth factor, wherein the growth factor consists of choline, betaine and vitamin B6, and the contents of each ingredie...
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