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WO/2019/125686A1 |
Described are methods for improving the production of the amino acids glutamate and lysine in submerged Corynebacterium culture comprising adding to a submerged Corynebacterium culture a non- enzymatic fraction of spent Trichoderma ferme...
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WO/2019/121876A1 |
The present invention relates to the production of organic acids by anaerobic fermentation of molasses and/or pulp, residues of the sugar industry, in which the molasses and/or the pulp are fermented in an aqueous medium containing vinasse.
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WO/2019/123311A1 |
Subject-matter of the present invention is a process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction of the corresponding beta-amino ketones. Subject-matter of the invention ar...
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WO/2019/118548A1 |
This disclosure provides engineered strains of Corynebacteria for the cost-effective production of lysine, tools and methods used to produce the engineered strains, and methods of using the engineered strains to produce lysine.
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WO/2019/104518A1 |
Provided microorganisms genetically modified to overexpress an imine/enamine deaminase to enhance the production of lysine and lysine derivatives by the microorganism. Also provided a method of generating such microorganism, and methods ...
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WO/2019/104179A1 |
This disclosure relates to deuterated D-serine, pharmaceutically acceptable salts thereof, analogs and prodrugs thereof, pharmaceutical compositions thereof, and methods of use.
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WO/2019/097123A1 |
The present invention relates to a process for producing aqueous acrylamide solution by hydrating acrylonitrile in an aqueous solution in the presence of a biocatalyst. The present invention further relates to aqueous acrylamide solution...
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WO/2019/095161A1 |
A transaminase mutant and an application thereof, the amino acid sequence of the transaminase mutant is an amino acid sequence in which the amino acid sequence as represented by SEQ ID NO: 1 is mutated, the mutated amino acid position be...
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WO/2019/096727A1 |
The invention relates to the biotechnological production of tryptophan and derivatives thereof. The invention provides means for an enhanced microbial L-tryptophan synthesis. In one aspect the invention provides a bacterial cell being ge...
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WO/2019/096973A1 |
The present invention relates to a method for preparing an amino salt compound comprising: i) providing a carbonyl compound; ii) reacting the carbonyl compound provided according to (i) in the presence of a transaminase with ii-a) at lea...
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WO/2019/096677A1 |
A microbiological process for the preparation of amides from the corresponding nitriles by enzymatic hydrolysis with nitrile hydratase enzyme from a bacterial strain of Rhodococcus biphenylivorans species is described.
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WO/2019/091366A1 |
Disclosed is a method for preparing an optically pure L-tertiary leucine by using an active inclusion body, the method comprising the following steps: (1) preparing a bifunctional enzyme active inclusion body, wherein the active ingredie...
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WO/2019/092054A1 |
Described is a novel micro-organism, having a nitrite tolerance of at least 200 mg/l and a nitrite clearance rate of at least 100 mg/l/d nitrite, as well as a method for the preparation of a monoculture of a micro-organism having such ni...
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WO/2019/094752A1 |
This disclosure provides a non-genetic, high-throughput method of introducing and assaying effects of amino acid substitutions at a plurality of positions in a target protein. Mistranslation events are imposed stochastically during the t...
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WO/2019/085445A1 |
A recombinant bacterium for producing L-lysine, a construction method thereof, and a method for producing L-lysine by using the recombinant bacterium. The recombinant bacterium has increased expression and/or activity of asparaginase com...
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WO/2019/084950A1 |
Disclosed are a transaminase mutant and a use thereof. The amino acid sequence of the transaminase mutant is obtained by the mutation of the amino acid sequence as shown in SEQ ID NO: 1, and the mutation at least comprises one of the fol...
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WO/2019/081004A1 |
Process for producing aqueous polyacrylamide solutions by polymerizing an aqueous solution comprising at least acrylamide thereby obtaining an aqueous polyacrylamide gel and dissolving said aqueous polyacrylamide gel in water, wherein th...
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WO/2019/081319A1 |
Process for producing aqueous polyacrylamide solutions by polymerizing an aqueous solution comprising at least acrylamide thereby obtaining an aqueous polyacrylamide gel and dissolving said aqueous polyacrylamide gel in water, wherein th...
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WO/2019/081318A1 |
Process for producing aqueous polyacrylamide solutions by polymerizing an aqueous solution comprising at least acrylamide obtained by hydrolyzing acrylonitrile in water in the presence of a biocatalyst capable of converting acrylonitrile...
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WO/2019/081008A1 |
The present invention relates to methods for preparing aqueous acrylamide solutions having a low acrylic acid concentration, aqueous acrylamide solutions obtainable by such methods, and acrylamide homopolymers or copolymers obtainable by...
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WO/2019/081331A1 |
The present invention relates to methods for preparing aqueous acrylamide solutions having a low acrylic acid concentration, aqueous acrylamide solutions obtainable by such methods, and acrylamide homopolymers or copolymers obtainable by...
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WO/2019/081327A1 |
Process for producing aqueous polyacrylamide solutions by polymerizing an aqueous solution comprising at least acrylamide thereby obtaining an aqueous polyacrylamide gel and dissolving said aqueous polyacrylamide gel in water, wherein th...
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WO/2019/081323A1 |
Process for producing aqueous polyacrylamide solutions by polymerizing an aqueous solution comprising at least acrylamide thereby obtaining an aqueous polyacrylamide gel and dissolving said aqueous polyacrylamide gel in water, wherein th...
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WO/2019/081330A1 |
Process for producing aqueous polyacrylamide solutions by polymerizing an aqueous solution comprising at least acrylamide thereby obtaining an aqueous polyacrylamide gel and dissolving said aqueous polyacrylamide gel in water, wherein th...
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WO/2019/081321A1 |
Process for producing aqueous polyacrylamide solutions by polymerizing an aqueous solution comprising at least acrylamide thereby obtaining an aqueous polyacrylamide gel and dissolving said aqueous polyacrylamide gel in water, wherein th...
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WO/2019/081320A1 |
Process for producing aqueous polyacrylamide solutions by polymerizing an aqueous solution comprising at least acrylamide thereby obtaining an aqueous polyacrylamide gel and dissolving said aqueous polyacrylamide gel in water, wherein th...
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WO/2019/081003A1 |
Process for producing aqueous polyacrylamide solutions by polymerizing an aqueous solution comprising at least acrylamide thereby obtaining an aqueous polyacrylamide gel and dissolving said aqueous polyacrylamide gel in water, wherein th...
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WO/2019/078528A2 |
Provided is a method for purifying 1,5-diaminopentane, the method comprising the steps of: preparing a fermentation broth comprising a carbonate of 1,5-diaminopentane; heating the fermentation broth to prepare a first composition; evapor...
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WO/2019/071668A1 |
Provided is an L-homoserine producing strain, which has a single and stable chromosome and does not contain any plasmids or other free DNA vectors. One or more genes related with L-threonine synthesis on the chromosome DNA are knocked ou...
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WO/2019/073035A1 |
The present invention relates to methods for increasing the concentration of anthranilic acid tolerated by a given microbial cell by limiting the concentration of ammonia in the culture medium.
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WO/2019/073033A1 |
The present invention relates to the production of o-aminobenzoic acid from fermentable substrates using microbial cells and alkali-containing bases during fermentation.
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WO/2019/062222A1 |
An R-3-aminobutyric acid preparation method with high efficiency and high stereoselectivity. The method comprises using aspartase with stereoisomeric catalytic activity derived from Escherichia coli to efficiently convert butenoic acid i...
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WO/2019/060963A1 |
The present invention relates to methods for producing isothiocyanate containing products from Brassicaceae material and lactic acid bacteria for use in such methods. The present invention also relates to isothiocyanate containing produc...
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WO/2019/056285A1 |
Provided are microorganisms genetically modified to co-overexpress a carbohydrate binding module and lysine decarboxylase polypeptides in a mesophilic host to enhance the production of lysine derivatives by the microorganism, method of g...
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WO/2019/055498A1 |
The present invention provides enzymes that have been optimized by implementation of Protein Repair One Stop Shop (PROSS), an algorithm that generates protein design(s) for enhanced stability without changing either enzymatic properties ...
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WO/2019/051069A1 |
The invention is directed to a process for producing one or more fermentation product in a multi-stage process including an inoculation reactor and at least one bioreactor. The inoculation reactor is fed a C1-containing gaseous substrate...
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WO/2019/048438A1 |
Method of obtaining a compound and corresponding apparatus. The method comprises adding a substrate (14) to a medium (132) comprised in a reactor (13, 33), and reacting the substrate in the reactor to form the compound. A first stream (1...
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WO/2019/043186A1 |
The present invention relates to a method for producinga chiral amine, performing a transamination reaction of a prochiral amino acceptor and an amino donor in a first solution in the presence of a transaminase, thereby forming a chiral ...
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WO/2019/039544A1 |
The present invention provides: a compound having a structure represented by general formula (1) (in the formula, n is 2-100, P represents a (C1-C5) alkylene group substituted with one amino group, Q is general formula (2) (in general fo...
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WO/2019/035612A1 |
The present application relates to a microorganism producing a mycosporine-like amino acid and a mycosporine-like amino acid production method using the same microorganism. Being enhanced in the productive potential of mycosporine-like a...
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WO/2019/031575A1 |
An enzyme having features (a) and (b). (a) Has D-amino acid reversible dehydrogenating activity. (b) Is a hexamer of a polypeptide having an amino acid sequence that identifies at least 80% with a SEQ ID No. 2 amino acid sequence.
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WO/2019/030808A1 |
Provided is a microorganism which is plasmid-free and has improved productivity. In one aspect, the present disclosure relates to a transgenic microorganism belonging to the genus Escherichia, in which at least five genes shown below are...
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WO/2019/031574A1 |
An enzyme having features (a) and (b). (a) Has D-amino acid reversible dehydrogenating activity. (b) Is a hexamer of a polypeptide having an amino acid sequence that identifies at least 80% with a SEQ ID No. 2 amino acid sequence.
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WO/2019/024706A1 |
An aspartase variant, a preparation method therefor, and an application thereof are provided. The amino acid sequence of the aspartase variant has 96% or higher identity with sequence 2 in the sequence listing, comprises T187I and N326C ...
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WO/2019/023796A1 |
Disclosed are methods for converting an alkaloid substrate compound into a N- alkylated alkaloid product compound in the presence of an alkyl donor compound and catalytic quantities of an N-alkyltransferase enzyme capable of converting t...
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WO/2019/027267A2 |
The present application relates to an ATP phosphoribosyltransferase (HisG) protein, and a histidine production method using same.
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WO/2019/022375A1 |
Provided are: an L-lysine-producing microorganism having been transformed with a polynucleotide comprising an L-lysine-inducible promoter; and a method for producing L-lysine by using the same.
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WO/2018/219619A9 |
The invention relates to a method of producing a modified non-ribosomal peptide, e.g. a modified microcystin and/or modified nodularin (together CA), comprising the steps of: a) growing a modified non-ribosomal peptide producing cyanobac...
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WO/2019/017706A2 |
The present application relates to a genus Corynebacterium microorganism producing putrescine and a method for producing putrescine using the same
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WO/2019/011236A1 |
Use of a stereoselective transaminase in the asymmetric synthesis of a chiral amine. In particular, provided is use of a polypeptide in the production of a chiral amine or a downstream product using a chiral amine as a precursor. Further...
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