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WO/2020/048523A1 |
Provided are a baicalein- and wild baicalein-synthesizing microorganism, a preparation method for same, and applications thereof. By modifying a heterologous metabolic pathway of a host cell per a genetic engineering method, acquired is ...
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WO/2020/041851A2 |
The present invention relates to a pharmaceutical composition comprising secondary metabolites produced by the fungus Exserohilum rostratum for cell regeneration. Particularly, the present invention relates to a pharmaceutical compositio...
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WO/2019/113710A9 |
Disclosed are methods for converting a substrate into a product benzylisoquinoline compound in a biosynthetic system involving the culturing of cells in a medium. The cells comprise a benzylisoquinoline uptake permease and a biosynthetic...
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WO/2020/034660A1 |
Disclosed in the present invention is a method for preparing (S)-1,2,3,4-tetrahydroisoquinoline-1-formic acid and derivatives thereof, comprising: using a raceme of a compound represented by formula (I) or a raceme of a salt of the compo...
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WO/2020/030755A1 |
A method for the production of a chemical compound derived from oxaloacetate using genetically modified microorganismsis disclosed. The chemical compound can for example be ectoine or the ectoine precursor NADA. The genetic modifications...
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WO/2020/030820A1 |
The present invention relates to a method of production of a nutrient or a nutraceutical compound, a method for the generation of an improved nutrient-producing or nutraceutical compound-producing organism or community of organisms, and ...
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WO/2020/028795A1 |
Enzymes and methods are described herein for manufacturing terpenes, including terpenes.
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WO/2020/027251A1 |
A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective ...
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WO/2020/019066A1 |
Described herein is a polypeptide comprising the sequence of SEQ ID NO:3 (CsPT3), a variant thereof having at least 80% sequence identity to SEQ ID NO:3, or a fragment of the polypeptide or the variant thereof. Also described herein is a...
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WO/2020/018905A1 |
Disclosed herein is a yeast strain capable of fermenting high maltose syrups into ethanol in the presence of glucose. In commercially important fuel ethanol yeast strains, the presence of glucose prevents robust maltose fermentation. Thi...
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WO/2020/018833A1 |
The disclosure provides biocatalysts that halogenate complex chemical compounds in specific and predictable ways. Also disclosed are halogenated complex organic compounds. The disclosure further provides methods for the halogenation of c...
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WO/2020/012681A1 |
The present invention addresses the problem of providing a novel method for producing 8-prenylnaringenin. The present invention solves said problem by providing a method for producing 8-prenylnaringenin which includes a step for causing ...
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WO/2020/013027A1 |
The present invention addresses the problem of providing a novel method for producing 8-prenylnaringenin. The present invention solves said problem by providing a method for producing 8-prenylnaringenin which includes a step for causing ...
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WO/2020/004936A1 |
The present invention relates to a multiplex expression inhibition system based on a synthesis regulator sRNA and a method of producing same, and more specifically, to a combination of vectors comprising a variety of antibiotic-resistanc...
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WO/2019/243624A1 |
The invention relates to recombinant microorganisms and methods for producing benzylisoquinoline alkaloids and precursors thereof.
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WO/2019/240579A1 |
The invention provides a production process for the production of an aromatic epoxide derived compound, the production process comprising: (i) an epoxidation stage comprising: reacting an aromatic compound and a peroxide in the presence ...
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WO/2019/240243A1 |
The purpose of the present invention is to provide a selenoneine production method with which selenoneine can be produced at high yields even if an inorganic selenium compound is used as the selenium compound. This purpose is achieved by...
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WO/2019/235688A1 |
The present invention relates to: a recombinant microorganism for malonyl-CoA detection which has a gene, coding type III polyketide synthase, inserted in the genome thereof or has a recombinant vector, comprising the gene, transferred t...
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WO/2019/233367A1 |
A streptomyces strain and an application thereof, and a method for preparing staurosporine by culturing the strain. The strain is named as streptomyces sp. HS-HY-153, and the preservation number thereof is CGMCC NO. 14806.
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WO/2019/227969A1 |
An ansamycin all-carbon cycle polyketide-type antibiotic and uses thereof in preparing antimicrobial medications or anti-tumor medications. Verrucosispora sp. SCSIO 07399 preserved on 22 October 2018 at Guangdong Microbial Culture Collec...
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WO/2019/228947A1 |
The invention relates to the cultivation of URA for producing biomass for the production of products of interest, such as dry biomass or compounds or mixtures of compounds of interest extracted from the biomass produced, particularly foo...
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WO/2019/220093A1 |
The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 110, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound, wherein the amino acid residue at positio...
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WO/2019/213754A1 |
Methods for in-situ enzymatic transformation of petroleum hydrocarbons into value-added products, using downhole injection of at least one hydrolytic enzyme and optional additives.
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WO/2019/175607A9 |
The complex chemistry underlying the extensive transformations involved in terpene indole alkaloid synthesis makes identification of the biosynthetic genes challenging. The present invention relates to methods for producing a terpene ind...
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WO/2019/202038A2 |
Isosorbide-5-methacrylate was obtained by enzymatic catalysis with Lipozyme RM IM in a highly regioselective manner in up to 87% yield. The process uses readily available acyl donors (methacrylic anydride or vinyl methacrylate), is easil...
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WO/2019/204787A1 |
The present disclosure describes the engineering of microbial cells for fermentative production of histamine and provides novel engineered microbial cells and cultures, as well as related histamine production methods.
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WO/2019/197334A1 |
The present invention relates to a process for the production of a dyed biopolymer comprising the steps of providing at least one biopolymer-producing microorganism, providing at least one dye-producing microorganism, culturing said at l...
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WO/2019/197571A1 |
The present invention is directed to a process for the enantioselective biocatalytic preparation of 4-substituted 1-aminoindanes of general formula (S)-I: (l) and a process for the preparation of Ozanimod, preferably involving the enanti...
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WO/2019/196262A1 |
The present invention relates to the field of pharmaceutical synthesis, and in particularly relates to a preparation method for a hexahydrofuro-furan-ol derivative, and an intermediate of the derivative and a preparation method therefor....
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WO/2019/194287A1 |
The present invention provides a method for producing 13-hydroxy-9(Z)-octadecenoic acid, which is improved in productivity. More specifically, the present invention provides a method for producing 13-hydroxy-9(Z)-octadecenoic acid, which...
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WO/2019/194309A1 |
Provided is a novel production method that can produce alkaloids at higher efficiencies than conventional methods. The method for producing alkaloids comprising a step for expressing, in a Catharanthus plant of the family Apocynaceae and...
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WO/2019/191772A1 |
This disclosure relates to strategies for in vivo production of certain carbon-based products, for example, aminated aliphatic compounds having a carbon chain length of C5-C19. Specifically, 7-aminoheptanoic acid is produced using a tran...
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WO/2019/189388A1 |
Provided is a culturing method for efficiently proliferating equol-producing bacteria belonging to Coriobacteriaceae. The present invention relates to a method for culturing equol -producing bacteria belonging to Coriobacteriaceae in an ...
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WO/2019/185646A2 |
A process for oxidising a substrate selected from hydroxymethylfurfural (HMF), diformylfuran (DFF), hydroxymethylfurancarboxylic acid (HMFCA) and formylfurancarboxylic acid (FFCA). Said process comprises mixing said substrate with catala...
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WO/2019/182440A1 |
The present invention is in the field of a method for producing engineered microorganisms, a method for producing cell wall-targeting antibiotics using said engineered microorganisms, and a product obtainable by said methods. The microor...
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WO/2019/174176A1 |
The present invention relates to the field of pharmaceutical synthesis, and in particularly relates to a preparation method for a hexahydrofuro-furan-ol derivative, and an intermediate of the derivative and a preparation method therefor....
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WO/2019/176732A1 |
[Problem] To provide a production method capable of easily synthesizing a compound having a structure in which a plurality of tetrahydroisoquinoline rings are linked together, using a reduced number of steps. [Solution] It was found that...
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WO/2019/175171A1 |
The present disclosure relates to a process for converting atranol and/or its derivatives into hydrosoluble compound(s). In particular, the present disclosure relates to a process for converting atranol and/or its derivative(s), said pro...
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WO/2019/169695A1 |
A bradyrhizobium monooxygenase, a gene for encoding the monooxygenase, a recombinant expression vector comprising the gene, a recombinant expression transformant, a method for preparing the monooxygenase by using the recombinant expressi...
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WO/2019/173797A1 |
Disclosed herein are prokaryotic and eukaryotic microbes, including E. coli and S. cerevisiae, genetically altered to biosynthesize tryptamine and tryptamine derivatives. The microbes of the disclosure may be engineered to contain plasmi...
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WO/2019/166093A1 |
A method for increased and permanent production of a natural compound by a microorganism during an exponential growth and during a stationary phase of a culture of the microorganism, the method comprising: enhancing a translation of a ta...
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WO/2019/165551A1 |
Disclosed are methods for converting a substrate into a product alkaloid, including a benzylisoquinoline compound or benzylisoquinoline precursor compound, in a biosynthetic system involving the growth of host cells. The cells comprise a...
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WO/2019/169334A1 |
The present disclosure provides methods for preparing tryptophans and tryptophan derivatives. The methods include: combining i) an indole substrate or azulene substrate, ii) a serine substrate, and iii) an engineered tryptophan synthase ...
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WO/2019/158513A1 |
The present invention is directed to methods for catalyzing a chemical reaction by retroaldolases, corresponding uses of retroaldolases and to novel retroaldolases. The methods and retroaldolases have utility in (i) preparing tertiary al...
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WO/2019/153633A1 |
Provided are an alcohol dehydrogenase mutant and an application thereof in synthesis of diaryl chiral alcohol, belonging to the technical field of the biological engineering. The alcohol dehydrogenase mutant has good catalytic activity a...
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WO/2019/157383A2 |
A method of producing promorphinan, morphinan, nal-opioid, and nor-opioid alkaloid products through the increased conversion of a promorphinan alkaloid to a morphinan alkaloid. The method comprises contacting the promorphinan alkaloid wi...
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WO/2019/153183A1 |
The present invention relates to the technical field of genetic engineering, and provides a monooxygenase mutant, a preparation method therefor and an application thereof. The monooxygenase mutant has any one of the amino acid sequences ...
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WO/2019/153634A1 |
An alcohol dehydrogenase mutant and an application thereof in the synthesis of biaryl chiral alcohol. The alcohol dehydrogenase in the present invention is coupled to glucose dehydrogenase or formate dehydrogenase, and may be used for th...
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WO/2019/153632A1 |
Provided are an alcohol dehydrogenase mutant and an application thereof in synthesis of diaryl chiral alcohol, belonging to the technical field of the biological engineering. The alcohol dehydrogenase mutant has good catalytic activity a...
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WO/2019/150564A1 |
The present invention pertains to a method for synthesizing an oligodeoxynucleotide (ODN), said method comprising synthesizing an ODN which has a sulfonamide bonded thereto via a non-natural internucleotide linkage and using the thus syn...
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