| Document |
Document Title |
|
WO/2024/001668A1 |
The present invention provides a DNA methylation molecular marker for detecting benign and malignant pulmonary nodules. The DNA methylation molecular marker comprises SEQ ID NO. 6 or a complete complementary sequence thereof, or a contin...
|
|
WO/2024/006908A1 |
Provided herein are methods of analyzing DNA comprising degrading forms of DNA sequences that are prevalent in healthy subjects; and detecting sequences that are not degraded. Some such methods facilitate detection of aberrant forms of DNA.
|
|
WO/2024/006991A1 |
A reverse transcription (RT) assay to directly detect chemical adducts on RNA. A fluorescence quenching assay to detect RT polymerization was optimized and employed to detect N 1 -alkylation of inosine, an important post-transcriptional ...
|
|
WO/2024/003114A1 |
The present invention relates to a method for determining the concentration of at least one target analyte in a sample comprising: a. providing at least a binding agent of a first type and a binding agent of a second type, each comprisin...
|
|
WO/2024/006765A2 |
The present invention provides methods for detecting eukaryotic endosymbionts in a sample. Primer sets, guide RNAs, and mock communities of eukaryotic endosymbionts for use in these methods are also provided. Further, methods for diagnos...
|
|
WO/2024/002165A1 |
Provided are a DNA methylation biomarker for diagnosis of a gastric cancer, a kit, and a use. Provided is a methylation biomarker for diagnosis of a gastric cancer, wherein the methylation biomarker comprises a fragment that is equivalen...
|
|
WO/2024/005523A1 |
The present invention relates to an RNA library construction method comprising a ligation step of a first adapter nucleic acid molecule and a second adapter nucleic acid molecule. Furthermore, by adding a guide nucleic acid molecule, the...
|
|
WO/2024/006799A1 |
Provided in some aspects are methods for light-controlled ?>? situ surface patterning of a substrate. Compositions such as nucleic acid arrays produced by the methods are also disclosed. In some embodiments, a method disclosed herein com...
|
|
WO/2024/005008A1 |
The present disclosure provides a method for determining whether or not a subject is suffering from synucleinopathy on the basis of a level of ApoA1 that is bonded to α-synuclein in a sample which has been taken from the subject.
|
|
WO/2023/245827A1 |
Provided are a method for constructing a model for identifying tissue sources of mesenchymal stem cells (MSCs), a method and device for identifying tissue sources of MSCs in a sample, and the use of a reagent, which is useful for determi...
|
|
WO/2023/249941A1 |
Disclosed is a method of determining ceruloplasmin activity using a mass spectrometry technique. The method comprises reacting a biological sample containing ceruloplasmin with a compound of formula I to produce an oxidized product of th...
|
|
WO/2023/246032A1 |
Disclosed is a one-pot single-stranded DNA cyclization and amplification and CRISPR/Cas-mediated nucleic acid molecule detection method. The method comprises: single-stranded DNA probe cyclization, rolling circle amplification, double-pr...
|
|
WO/2023/250524A1 |
Disclosed are methods, compositions, systems, and protein compounds for the directed evolution of enzymes and proteins. The method comprising generating variant protein with a desired functionality, comprising one or more DNA expression ...
|
|
WO/2023/247628A1 |
The invention relates to a method and kit for extraction of high molecular weight DNA from a biological sample and/or clean-up of a DNA library, wherein after optional lysis of the biological sample and/or after preparation of the DNA li...
|
|
WO/2023/245259A1 |
The present invention relates to plant growth promoting endophytes, preferably of plants of the Glycine genus, particularly plant growth promoting Curtobacterium sp. endophytes. The present invention also relates to seeds, plants, and pa...
|
|
WO/2023/246733A1 |
Disclosed herein include highly sensitive methods and systems for nucleic acid detection.
|
|
WO/2023/247567A1 |
The present invention relates to a method for predicting alcohol use disorder. The objective of this study was to validate the possibility of performing a plasma assay and to quantify the value of four plasmatic biomarkers of brain damag...
|
|
WO/2023/248310A1 |
The present invention relates to: a primer for a nucleic acid amplification reaction, in particular, an asymmetric nucleic acid amplification reaction; a DNA detection method; and a DNA detection kit. Specifically, the present invention ...
|
|
WO/2023/250419A1 |
The present disclosure provides methods of identifying a subject as suitable for the treatment or prevention of asthma exacerbation induced by a cat allergen with at least one antibody to the cat allergen. The present disclosure also pro...
|
|
WO/2023/247964A1 |
Provided herein are methods for improved polynucleotide detection.
|
|
WO/2023/247287A1 |
Device and method for demonstrating efficacy of oral care implements, and the plaque removal efficacy of a toothbrush, especially toothbrushes, wherein the device (1) comprises a body (2), said body (2) comprising: i) a holder (6) to sec...
|
|
WO/2023/250077A1 |
Provided herein are methods, kits, systems, and compositions for spatial analysis using one or more substrates (e.g., slides), wherein one of the substrates can have a spatial array. The methods disclosed herein include arrays having rel...
|
|
WO/2023/247502A1 |
Sterile sampling composition comprising a surfactant, one or more enzymes selected from the group consisting of a protease, a polysaccharidase, a laccase, a lipase, a cellulase and a mannanase, a sampling kit comprising this composition,...
|
|
WO/2023/250364A1 |
Methods of formation and detection of arrays of single analytes on enhanced substrates are described. The arrays may comprise pluralities of single analytes containing heterogeneity with respect to one or more properties. Enhanced substr...
|
|
WO/2023/246124A1 |
A reagent combination, a kit, a detection system and a detection method for detecting a target antibody. In the present application, when a solution to be tested contains a target antibody, an antibody-antigen complex is formed by means ...
|
|
WO/2023/248958A1 |
A microscope system (1) comprises: a microscope (100) that forms an image of a sample containing sperm; an imaging device (143) that acquires the image of the sample; a processing device (200) that generates, on the basis of the acquired...
|
|
WO/2023/247500A1 |
The invention also relates to a method for collecting microorganisms on surfaces for their subsequent detection and analysis in a laboratory.
|
|
WO/2023/246808A1 |
The present invention provides use of cancer-associated short exons to assist cancer diagnosis and prognosis prediction. Specifically, the present invention provides use of cancer-associated short exons (CASEs) or a detection reagent the...
|
|
WO/2023/250422A1 |
The present disclosure relates generally to compositions, methods, and systems for the characterization of antigen-binding molecules, e.g., multispecific T cell receptors, B cell receptors, antibodies, and antigen-binding fragments there...
|
|
WO/2023/245283A1 |
There is described herein methods of ameliorating, treating or preventing graft-versus- host disease, transplant rejection or an autoimmune disorder, or promoting transplant graft function in a human using innate lymphoid cells (ILCs), i...
|
|
WO/2023/250441A2 |
The present disclosure provides methods and systems for capture and enrichment of nucleic acid sequences. Probes or primer may be used to capture or enrich nucleic acids. The characteristics of the prober or primers may be tuned or modul...
|
|
WO/2023/248150A1 |
The invention relates to methods of identifying and characterizing a Cannabis spp. plant comprising a quantitative trait locus (QTL) or a causal polymorphism associated with a flower density trait, and to Cannabis spp. plants having a fl...
|
|
WO/2023/246033A1 |
Disclosed are a one-pot rolling circle transcription and CRISPR/Cas-mediated nucleic acid detection method and a kit. The nucleic acid detection method comprises: S1, extracting a total nucleic acid from a to-be-detected sample; S2, prep...
|
|
WO/2023/250418A2 |
The invention provides a system for evaluating gene expression levels from scRNA-Seq experiments. The system uses in silico cell calling tools for distinguishing between partitions that contain cells and background partitions that did no...
|
|
WO/2023/250476A2 |
Disclosed herein are methods and systems to generate novel nucleic acid sequences that bind to an allosteric transcription factor and novel nucleic acid sequences generated by said methods.
|
|
WO/2023/248934A1 |
A method for producing a cell support composite 10 includes: culturing renal cells in an aggregated state; separating the aggregates into individual cultured cells 16; seeding the cultured cells 16 onto a substrate 12 at a seeding densit...
|
|
WO/2022/261188A9 |
Disclosed herein are methods for analyzing one or more analytes of a cell by performing single-cell analysis. In one scenario, the one or more analytes are located on a surface of the cell. In one scenario, the one or more analytes are l...
|
|
WO/2023/247569A1 |
A method for sample preparation and/or DNA amplification from urine, saliva and/or mouthwash samples is disclosed. The method involves providing a sample preparation system comprising a filter and providing a urine, saliva and/or mouthwa...
|
|
WO/2023/245955A1 |
The present invention discloses an apparatus and method for nucleic acid detection. The apparatus comprises a substrate capable of rotating during nucleic acid detection. The interior of the substrate comprises the following chambers: a ...
|
|
WO/2023/245243A1 |
The present invention relates to the determination of menstrual cycle time point based on endometrial gene expression profile. In one embodiment, the present invention relates to the generation of endometrial gene expression profiles fro...
|
|
WO/2023/250482A1 |
Systems and methods that use machine learning models or deep learning models to learn a relationship of genotype by environment interactions with the phenotypic performance for a plurality of plant genotypes and predict, for one or more ...
|
|
WO/2023/246003A1 |
Provided are a chimeric antigen receptor macrophage, a method for preparing same, and use thereof. The chimeric antigen receptor macrophage is a mouse bone marrow-derived macrophage comprising a chimeric antigen receptor modification and...
|
|
WO/2023/249714A1 |
The present disclosure relates generally to methods for determining whether a cancer patient will benefit from treatment with a DNA methyltransferase 1 (DNMT1) inhibitor. These methods are based on screening a cancer patient for mutation...
|
|
WO/2023/249949A1 |
A method of detection of nucleic acids from a biological sample (molecular diagnostics) using a sample extraction tube without isolation or purification of the nucleic acids or the use of specialized equipment in the preparation of the b...
|
|
WO/2023/245401A1 |
The present invention provides a characteristic SNP marker-based method for identifying litopenaeus vannamei breeds. On the basis of providing a characteristic SNP marker set of different litopenaeus vannamei breeds and populations, a me...
|
|
WO/2023/246507A1 |
Disclosed is a cell-free reaction system, comprising a DNA/RNA template and a cell extract, the cell extract being a gene-knockdown cell extract. Further disclosed are multiple cell-free reaction systems for analysis and detection, which...
|
|
WO/2023/250397A1 |
The present disclosure encompasses methods for molecularly subtyping formalin-fixed paraffin-embedded tumor samples. The disclosure works particularly well for old and degraded (archival) samples for which standard methods are unfeasible...
|
|
WO/2023/248230A1 |
The techniques described herein disclose a method or a system for analyzing genomic data, calculating a predictor and making a quantitative assessment of a biological effect based on the predictor. A biological effect such as the pathoge...
|
|
WO/2023/228174A9 |
Various compositions and methods are disclosed in which a plurality of restriction enzymes, including methylation-sensitive and/or methylation-dependent restriction enzymes, are used for the analysis of cfDNA. Useful combinations can be ...
|
|
WO/2023/248568A1 |
Provided is a single-strand nucleotide that is a single-strand oligonucleotide labelled with a fluorescent substance and a quenching substance, wherein the 5' side forms a hairpin structure via self hybridization; when a single-strand ol...
|
