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WO/2024/020410A1 |
Provided are systems and compositions for dual-end sequencing.
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WO/2024/019166A1 |
The present invention addresses the problem of providing a simple method and a simple kit both for detecting a microorganism or a cell in a solution. Provided are: a method for detecting a microorganism or a cell in a solution, the met...
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WO/2024/019556A1 |
The present invention relates to a composition, kit, and method for predicting the risk of progression of Alzheimer's disease by detecting the methylation level of the CpG region of a Keratin 32 (KRT32) gene promoter, and has the effect ...
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WO/2024/015621A1 |
A method for assessing a lupus nephritis disease state of a patient, the method comprising: analyzing a data set comprising or derived from gene expression measurement data of at least 2 genes or human orthologs thereof selected from the...
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WO/2024/014834A1 |
The present invention relates to a biomarker for the early diagnosis of Alzheimer's disease and a use thereof, and more particularly, the present invention relates to: a biomarker composition for the early diagnosis of Alzheimer's diseas...
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WO/2024/015624A1 |
Methods and devices for determining the hematocrit of blood samples.
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WO/2024/015766A1 |
Scalable stamping methods to replicate a template microarray are provided.
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WO/2024/015999A1 |
The present disclosure provides methods, systems, and compositions for the multiplexed detection and quantification of multiple analytes from a sample. Analytes may be nucleic acid analytes. Detection of analytes may comprise contacting ...
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WO/2024/015952A1 |
Current immuno-PCR methods are limited in the number or antigens that can be assayed, the ability to quantitate those antigens, and the ability to detect antigens across multiple samples in a single detection step. Provided herein are me...
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WO/2024/015879A1 |
The present disclosure relates to measuring gene expression of cells of a blood sample obtained from a mammalian subject suspected of having a tick-borne disease. In particular, the present disclosure provides tools for determining wheth...
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WO/2024/013271A1 |
The application, inter alia, provides a method for detecting a target nucleic acid, the method comprising the steps of (a) amplifying a target nucleic acid providing an amplified nucleic acid; (b) bringing the amplified nucleic acid in c...
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WO/2024/015843A1 |
Provided herein are quantitative assays to evaluate duplex unwinding efficiency or strand exchange efficiency during isothermal amplification.
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WO/2024/012467A1 |
A method for detecting nucleic acids by fluorescent PCR, combining primer-activated polymerization reaction and specific fluorescence-labeled probe, which detects the target nucleic acid with high selectivity and high specificity.
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WO/2024/015992A1 |
The present disclosure provides methods and compositions for detection of multiple nucleic acid target variations in a single optical channel in a digital assay. In some cases, three or more nucleic acid target variations may be detected...
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WO/2024/014536A1 |
The present invention relates to a compound represented by a general formula (1) or a salt or a solvate thereof. [In the formula, R1, R2, and R3 are as defined in the description.]
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WO/2024/012418A1 |
A chromatin three-dimensional conformation capture method, comprising: performing chromatin proximity ligation in situ, and performing spatial location information specific labelling on a proximity ligation product, such that chromatin t...
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WO/2024/015966A2 |
Novel AAV capsids and recombinant AAV vectors comprising the same are provided.
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WO/2024/014580A1 |
The present invention relates to a method for providing information for cancer diagnosis, the method comprising the steps of: isolating an exosome fraction from a biological sample isolated from an individual of interest; and measuring t...
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WO/2024/014502A1 |
The purpose of the present invention is to provide a novel antibody production method. Provided is a method for producing an antibody capable of binding to an extracellular vesicle, the method comprising: (1) a step for bringing an antib...
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WO/2024/015875A2 |
The present disclosure relates to compositions of matter, methods, and systems for analyzing polymeric macromolecules, including polymeric macromolecules such as peptides, polypeptides, and proteins.
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WO/2024/012600A1 |
Provided in the present invention is a biomarker miR-25802 cluster for inflammation-related diseases, wherein the miR-25802 cluster can also be used as a target for treating inflammation-related diseases.
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WO/2024/015762A1 |
The present disclosure is directed to methods of treating Allan-Herndon-Dudley syndrome comprising administering 3,5-diiodothyropropionic acid (DITPA) to a subject in need thereof, and to administering gene therapy to the subject by intr...
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WO/2024/013241A1 |
The present disclosure provides a method for enrichment of at least one target nucleic acid in a library of nucleic acids. This present disclosure is also directed to a faster and easier method of target capture using primer extension re...
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WO/2024/014137A1 |
The present disclosure includes, inter alia, a composition for inducing immunotolerance, the composition containing laeverin.
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WO/2024/014734A1 |
The present invention relates to a method for adding a com probe, which is a non-amplified non-fluorescent probe (combination or competition probe) through a method for controlling non-specific signals generated by the non-specific bindi...
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WO/2024/015997A2 |
Disclosures herein are directed to methods for classifying and characterizing cancer epithelial cells and analyzing their level of interaction with secondary cell populations in order to identify, modify or otherwise tailor immunotherapy...
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WO/2024/015331A1 |
The present invention is directed to methods of treating subjects suffering from multiple sclerosis (MS). The methods of the invention include administering a therapy (e.g., an immunomodulatory disease-modifying therapeutic (DMT) agent) ...
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WO/2024/011360A1 |
The present disclosure relates to a survival stress-based screening system and a high-throughput screening device. Particularly, the present disclosure relates to a fusion protein composition, fusion proteins, a recombinant nucleic acid ...
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WO/2024/015792A2 |
Separation constructs such as membranes, porous beads, etc. are modified with a plurality of oligomeric ligands. The ligands are bound to the surface of the separation substrates via linker constructs such as acrylate groups or azide gro...
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WO/2024/013229A1 |
Provided herein is a method of diagnosing or prognosing advanced liver fibrosis or liver cirrhosis in a patient. The method is accomplished by determining a score based on the circulating levels in serum of two markers.
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WO/2024/011822A1 |
Disclosed in the present invention are a primer pair for quantitative detection of DNA fragment size distribution in an MDCK cell, a detection reagent, and a detection method. The primer pair at least comprises four primer pairs. The pre...
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WO/2024/015963A2 |
A new class of molecular probes is provided for real, efficient, stable, and selective capture of protein-nucleic acid complexes inside cells. The molecular probes have a nucleic acid-binding functional group and a photo-reactive diaziri...
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WO/2024/013228A1 |
Provided herein is a method of diagnosing or prognosing advanced liver fibrosis or liver cirrhosis in a patient. The method is accomplished by determining a score based on the circulating levels in serum of three markers.
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WO/2024/015962A1 |
Disclosed herein are blocked asymmetric hairpin adaptors that include a spacer that prevents extension by a strand-displacing polymerase. Such adaptors can be utilized for creating libraries of templates that can be processed into templa...
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WO/2024/015577A1 |
Systems and methods for the treatment of infectious diseases and cancers is provided. Aspects of the invention include a method comprising collecting a small stool sample from a human patient using noninvasive means, isolating the gut ce...
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WO/2024/015919A1 |
The present disclosure provides methods of using specific combinations of fluorophores to reduce cross-channel interference, thereby enabling highly multiplexed assays. In reducing signal interference, the present disclosure enables high...
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WO/2024/015640A2 |
The present disclosure provides methods and kits for evaluating and risk stratifying subjects with HFpEF. Specifically, the present disclosure provides methods and kits for determining an expression profile of small, non-coding RNA bioma...
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WO/2024/011311A1 |
The present disclosure relates to compounds of Formula (I) which are incorporated into DNA for on-DNA aldehyde capture and use as fluorescent molecular rotors.
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WO/2024/015561A1 |
Techniques for determining whether a sample obtained from a subject includes cells having homologous recombination deficiency (HRD). The techniques include: obtaining data about segments of the subject's genome; identifying a first subse...
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WO/2024/015378A1 |
The present disclosure relates generally to methods and systems for the characterization of antigen-binding molecules, e.g., B cell receptors, antibodies, and antigen-binding fragments thereof, using single-cell immune profiling methodol...
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WO/2024/015760A2 |
The present disclosure is directed to antibodies binding to and neutralizing the coronavirus designated SARS-CoV-2 and methods for use thereof.
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WO/2024/012958A1 |
The present invention relates to a method of certifying a test animal-derived product sample, the method comprising the steps of: (a) determining a test methylation profile of one or more pre-selected methylation sites within the genomic...
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WO/2024/015486A1 |
Biomarkers, methods, devices, reagents, systems, and kits used to assess the quality of a sample collected from a subject are provided. Such biomarkers, methods, devices, reagents, systems, and kits may be useful in evaluating acceptabil...
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WO/2024/013218A1 |
The present invention concerns a labelling solution on or into a biological sample which allows identification tags to be assigned to areas of the biological sample comprising a single or plurality of cells or organelles, e.g. about two ...
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WO/2024/015138A1 |
This patent application relates generally to mixture deconvolution systems and methods for identifying DNA profiles. Various embodiments of the present invention concern the deconvolution of unknown DNA profiles in a two-person DNA mixtu...
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WO/2024/014439A1 |
Provided is a novel quantitative method capable of accurately evaluating the dynamics, etc. of a target gene in the body without being affected by the amount of genomic DNA (gDNA). This problem was solved by the following method. A met...
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WO/2024/015828A2 |
Systems and methods for analyzing micro-ribonucleic acid (miRNA) signature profiles in a biological sample to identify profiles of a subject to biotic and abiotic agents are disclosed. A system comprises an extractor unit and a nucleic a...
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WO/2024/015800A2 |
Disclosed herein are methods and compositions for 5mC modification, detection, sequencing, and analysis. Certain aspects of the disclosure are directed to methods for modification of a 5mC in a nucleic acid molecule, including oxidation,...
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WO/2024/015860A2 |
Provided herein is technology relating to detecting analytes and particularly, but not exclusively, to methods, compositions, systems, and kits for detecting analytes using fluorogenic probes and multiplex technologies.
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WO/2024/012073A1 |
Provided are an osteosarcoma organoid model and a construction method therefor. The osteosarcoma organoid model at least comprises a biological scaffold, osteosarcoma cells, and exosomes derived from mesenchymal stem cells, wherein the o...
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