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WO/2024/015733A1 |
The present disclosure relates generally to the field of immunology, and particularly relates to improved methods and systems useful for identification and characterization of antigen-binding molecules (ABMs) obtained from biological sam...
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WO/2024/013770A1 |
The present invention relates to substituted 3-methylbenzo[d]thiazol-3-ium compounds, their nucleic acid conjugates, complexes, salts which are potentially useful for cell imaging applications, diagnostics, fluorescent tags, pharmaceutic...
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WO/2024/015578A1 |
The present disclosure relates to methods, compositions, and kits for determining the location of target RNA in a biological sample and/or rescuing target RNA, from which spatial gene expression analysis is difficult to determine, from f...
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WO/2024/011056A2 |
The present disclosure relates to compositions and methods for identifying, selecting and/or producing soybean plants having determinate stem termination and late maturity. The present disclosure also relates to compositions and methods ...
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WO/2024/010526A1 |
A method of identifying one or more bacteria from a sample, wherein the one or more bacteria is suspected to be present in the sample, is provided. The method may include providing an aqueous suspension comprising a bacteria-SERS nanopar...
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WO/2024/008040A1 |
Provided are a methylation marker specific for specific cancers, such as colorectal cancer, and the use thereof. The present invention relates the use of a reagent or component in the preparation of a kit or device. The kit or device is ...
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WO/2024/008735A1 |
The present invention is related to a method of determining if a test animal and/or a test animal from which a product is derived has been treated and/or is currently undergoing treatment with at least one antibiotic and/or veterinary ch...
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WO/2024/010020A1 |
The present invention addresses the problem of providing: a matured cultured cell sheet which is constructed from cardiac myocytes without using a specific medical agent; and a method for producing the same. The present invention also ad...
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WO/2024/008145A1 |
A novel Cas enzyme, which belongs to a novel type of Cas protein and has a broad application prospect.
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WO/2024/010976A1 |
Disclosed are biosensors for detecting an analyte of interest. These biosensors can comprise one or more electrochemical sensors disposed on a flexible substrate. Each of the one or more electrochemical sensors can comprise a first elect...
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WO/2024/008260A1 |
A method of detecting an analyte in a sample, a versatile and/or relatively low cost electrochemical biosensor, a biosensor system and an electrochemical biosensor production method are disclosed. The biosensor production method comprise...
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WO/2024/008955A1 |
The present invention relates generally to methods of screening for susceptibility to severe COVID-19, as well as kits for screening for susceptibility to severe COVID-19. More particularly, the invention relates to a method of screening...
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WO/2024/010465A1 |
The present invention broadly relates to methods for determining the presence of and/or quantifying micoorganisms present in a sample, for example in a sample obtained from a subject for diagnostic purposes. In particular, the invention ...
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WO/2024/008779A1 |
The invention relates to an in vitro or ex vivo determination method for determining the risk of death of a patient infected by a respiratory virus, said method comprising the steps of measuring, in a biological sample from said patient,...
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WO/2024/010993A1 |
The present disclosure generally relates to the use of linear nucleic acid primers for the amplification of a target nucleic acid sequence, for example, in a cell-free environment. In some embodiments, compositions of the linear nucleic ...
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WO/2024/009946A1 |
The present invention addresses the problem of providing a method for testing the effectiveness of a PARP inhibitor against ovarian cancer. Said problem is solved by a method for testing the effectiveness of a PARP inhibitor against ovar...
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WO/2024/007071A1 |
Some pathological conditions are accompanied by the increase in dimers of free light chains (FLCs) kappa and/or lambda. For instance, high levels of FLC dimers are found in AL amyloidosis, multiple myeloma, and multiple sclerosis. There ...
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WO/2024/010162A1 |
The present invention relates to a composition for preventing or diagnosing glaucoma, comprising a protein as an active ingredient. The present invention put efforts into research for the development of more effective and novel diagnosis...
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WO/2024/010424A1 |
The present invention relates to a method for screening a therapeutic agent for atherosclerosis, a method for providing information necessary for predicting therapeutic reactivity, a biomarker, a composition, and a kit. Specifically, at ...
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WO/2024/007629A1 |
The present invention relates to the field of plant trypsin inhibitors, and provides a polysaccharide trypsin inhibitor and a preparation method therefor. The polysaccharide trypsin inhibitor is obtained by separating and purifying massa...
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WO/2024/011098A1 |
A flexible strategy for assembling luminescent and colorimetric quantum dot/nucleic acid hairpin (QD-HP) molecular beacons for use in CRISPR/Cas diagnostics uses chimeric peptide/peptide nucleic acid (PNA) to conjugate fluorescently labe...
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WO/2024/010416A1 |
The present invention relates to a method for discovering cell surface antigens for novel antibodies. A screening method according to an aspect can accurately screen for cell surface antigens that bind to novel antibodies. Moreover, the ...
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WO/2024/008759A1 |
It is provided a method for identifying dementia with Lewy bodies (DLB) in a subject, comprising determining in a sample of the subject comprising mitochondrial DNA, the methylation pattern in the D- loop region and/or ND1 gene of the mi...
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WO/2024/010753A1 |
Provided herein are methods for diagnosing and staging fibrosis associated with a disease state in a subject, such as liver disease or cancer. Also provided are methods for monitoring treatment efficacy. The methods include measuring the...
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WO/2024/009873A1 |
The purpose of the present invention is to provide a nucleic acid polymerase having high reverse transcription activity.　The present inventor found that reverse transcription can be performed efficiently by modifying the amino acid cor...
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WO/2024/010134A1 |
The present invention relates to a method for discovering a biomarker for diagnosing fatty liver disease and, more specifically, to a method for discovering a biomarker for diagnosing fatty liver disease, comprising: a first step of sele...
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WO/2024/007971A1 |
Various embodiments are directed to detecting infection-causing microbial cell-free DNA from a biological sample based on their size profiles and/or end signatures, in which the detection of infection-causing microbial DNA can be perform...
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WO/2024/010875A1 |
Disclosed herein are methods and systems of analyzing cell-free RNA (cfRNA) that comprises sequencing the cfRNA from a biological sample from a subject to produce cfRNA sequence reads; and aligning and quantifying the cfRNA sequence read...
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WO/2024/010036A1 |
The present invention provides an antiviral agent containing, as an active ingredient, a protein having a disulfide bond cleavage action. The present invention also provides a pharmaceutical composition for treating or preventing viral i...
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WO/2024/009947A1 |
The present disclosure, at least in part, relates to methods of sequencing low abundance aptamers from an aptamer library, the method comprising: (i) amplifying a plurality of aptamers capable of binding to one or more target molecules i...
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WO/2024/009074A1 |
An electrochemical system comprising an electrode (D) having a porous layer and plural enzymes and a cofactor (ATP) located within the pores of the porous layer, a first of said plural enzymes (E1) being operable to recycle nicotinamide ...
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WO/2024/010609A1 |
Provided herein are graphene biosensors and related core particles, compositions methods and systems in which more than one pristine graphene sheet is coated with a coating layer of an organic or inorganic material to provide a core grap...
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WO/2024/011226A1 |
In aspects, the disclosure provides devices and methods for linking omics datasets associated with a reusable single cell or nucleus.
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WO/2024/007079A1 |
Probiotic bacteria isolated from phytoplankton biomass are provided. The probiotic bacteria may be in the form of at least one isolated strain. In some embodiments, the probiotic bacteria are for use as probiotics in mammals, including h...
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WO/2024/011145A1 |
The present disclosure provides compositions comprising nucleic acid double-stranded splint adaptors, including kits, and methods that employ the double-stranded splint adaptors, e.g., PCR-free workflows. The double-stranded splint adapt...
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WO/2024/009960A1 |
The present disclosure, at least in part, provides methods for generating aptamer libraries capable from binding to multiple target molecules (e.g., one or more biomolecules) in a complexed sample (e.g., biological sample) using electrop...
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WO/2024/010351A1 |
Provided is a method for obtaining an approximate signal for a target analyte, the method comprising the step of obtaining, from a signal generation reaction of multiple cycles targeting a first target analyte and a second target analyte...
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WO/2024/011121A2 |
The present invention relates to systems and methods for tissue processing and imaging including simultaneous dehydration and staining with fluorescent nuclear and protein dyes followed by optical sectioning microscopy.
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WO/2024/011249A1 |
The present disclosure provides compositions, methods, and kits for detecting guaiacol-producing microorganisms, in particular, Thermophilic Acidophilic Bacteria (TAB) in foodstuff. In one example, a method comprises: (a) contacting a se...
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WO/2024/008782A1 |
The invention relates to an in vitro or ex vivo method for determining the risk of death in a subject infected with a respiratory virus, for example SARS-CoV-2, comprising a measurement, in a biological sample of said subject, of the lev...
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WO/2024/011184A1 |
The present disclosure provides methods, systems, and compositions for the multiplexed detection and quantification of multiple analytes from a sample. Analytes may be nucleic acid analytes. Detection of analytes may comprise contacting ...
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WO/2024/007757A1 |
Disclosed is use of a prokaryotic Argonaute protein only having RNA target cleavage activity in RNA editing. The Argonaute protein is derived from a mesophilic prokaryote Verrucomicrobia bacterium, the amino acid sequence thereof is set ...
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WO/2024/011208A1 |
The present disclosure relates to methods using CRISPR-Cas13 enzyme, complexed with Influenza A or B crRNA guide RNAs to detect and quantify the presence of Influenza A or B RNA in a sample with enhanced specificity and sensitivity. Thes...
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WO/2024/008344A1 |
The invention relates to the use of an E. coli bacterial strain, for detecting in a liquid up to 50 mM, in condition of anaerobiosis, the presence, the absence or the amount of chlorate ions of formula ClO3 -, wherein said E. coli bacter...
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WO/2024/008891A1 |
This invention relates to mapping the binding sites of a test compound within a nucleic acid. The nucleic acid is contacted with a tagged test compound that binds to the nucleic acid or to protein associated with the nucleic acid at one ...
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WO/2024/008780A1 |
The invention relates to an in vitro or ex vivo method for determining the risk of death for a subject infected with a respiratory virus, said method comprising the steps of measuring, in a biological sample from said subject, the expres...
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WO/2024/008090A1 |
Provided are a monoclonal antibody of an anti-BCMA antibody and a use thereof. The monoclonal antibody of a BCMA antibody has high specificity and strong affinity. Further provided is a BCMA CAR-T cell detection reagent, which can be use...
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WO/2024/008787A1 |
The invention relates to a method for determining a production capacity of multiple bacterial metabolites in a subject by quantifying an expression level and an abundance of each of multiple bacterial genes, said genes encoding enzymes a...
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WO/2024/010812A2 |
Disclosed herein are systems, devices, and methods for identifying recombinant variants (such as deletion or duplication variants) of genes such as HBA1 gene and HBA2 gene, the copy numbers of HBA1 and/or HBA2, and a copy number variant ...
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WO/2024/010907A1 |
In one aspect the present disclosure relates to a molecular tension sensor including: a first nucleic acid strand nucleic acid; a second nucleic acid strand nucleic acid, wherein the second nucleic acid strand includes a region of at lea...
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