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WO/2023/245245A1 |
Epigenetic modifications play an important role in regulating cell-specific expression patterns. Different DNA methylation signatures, for example, can be found in different tissues and even between different cell types within a particul...
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WO/2023/246860A1 |
The present invention provides an initially capped oligonucleotide primer, a method for preparing same, and use thereof, and particularly, provides an initially capped oligonucleotide primer comprising a hexose ring, a morpholine ring or...
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WO/2023/246485A1 |
Disclosed are a construction method for a 3D stratum corneum-like model and use thereof. The 3D stratum corneum-like model is composed of a top surface, an intermediate layer, and a bottom surface. The top and bottom surfaces are uneven ...
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WO/2023/248635A1 |
Provided is a substrate for an inspection device, the substrate having an average thickness of 250 µm to 350 µm and a density of 0.25×106g/m3 to 0.40×106g/m3.
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WO/2023/248997A1 |
The problem addressed by the present invention is to provide a method for determining haplotype based on a combination of multiple single nucleotide polymorphisms (SNP) in the human STING1 gene. As a result of in-depth studies by the p...
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WO/2023/248567A1 |
A single-stranded oligonucleotide labeled by a fluorophore and a quencher, wherein the 5' side forms a hairpin structure by self-hybridization, a triple-stranded structure is formed at the 5' end upon hybridization with a single-stranded...
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WO/2023/246266A1 |
Provided is a method for simultaneously preparing a single cell suspension and a single cell nucleus suspension in the same mouse kidney tissue sample, and simultaneously performing single cell sequencing and single cell nucleus sequenci...
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WO/2023/246935A1 |
The present invention relates to the field of biomedicines. Specifically, the present invention relates to a target-specific nucleic acid molecule having a quinoline modification, the quinoline modification being capable of improving the...
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WO/2023/247658A1 |
In an aspect, the invention relates to methods of library preparation and compositions suitable for use in methods of library preparation. The invention also relates to methods of sequencing and to uses of libraries in sequencing.
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WO/2023/250398A1 |
In some embodiments, a computer-implemented method of predicting a molecule type using segment read information is provided. A computing device receives a segment read for a molecule. The computing device determines one or more k-mers fo...
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WO/2023/240563A1 |
A sequencing kit containing a thiol blocking reagent, and a use of the sequencing kit. Further disclosed is a method for reducing a sequencing background signal, comprising the following steps: (1) opening a three-dimensional spatial str...
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WO/2023/243147A1 |
The present invention relates to: a gene analysis method for performing the quantitative analysis of a gene mutation using a single-base extension reaction; and a gene analysis apparatus and a gene analysis kit which are based on said me...
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WO/2023/240500A1 |
Provided in the present invention is a preservation reagent for dNTP. The preservation reagent for dNTP comprises one or more of dimethyl sulfoxide, sulfolane, tetrahydrofuran, dimethylformamide, dimethylacetamide, N,N-dimethylformamide,...
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WO/2023/244127A1 |
The present invention is concerned with novel CRISPR-Cas systems which are configured to detect the presence of a target nucleic acid in a sample through activation of secondary nucleases which bind and cleave a nucleic acid probe modifi...
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WO/2023/245165A1 |
Disclosed herein are methods for performing in situ sequencing of RNA transcripts with non-uniform 5' ends. During reverse transcription (RT) of RNA transcripts, RT enzyme is induced to "template-switch" to a separate oligonucleotide pro...
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WO/2023/244129A1 |
Type 2 diabetes mellitus (T2DM) is a prevalent public health problem that leads to long-term and costly complications to the afflicted. Thus, prevention of the condition by predicting at-risk individuals make it possible for the latter t...
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WO/2023/244680A2 |
Disclosed are peptides that differentially bind to analytes, and methods for obtaining the peptides. Disclosed are methods for determining binding of peptides to analytes by detecting nucleic acids that are associated with the peptides. ...
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WO/2023/243694A1 |
The present invention pertains to a method for detecting an analyte contained in a sample, the method comprising: (1) mixing the sample and salt with a gold-nanoparticle-labeled aptamer in which gold nanoparticles are bound to an aptamer...
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WO/2023/241076A1 |
A hyperspectral sequencing method and system and a gene sequencer. The method comprises: emitting laser light to a sample to be tested, so that a base in the sample generates excitation fluorescence; collecting the excitation fluorescenc...
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WO/2023/240627A1 |
The present invention relates to a multi-detection kit for a respiratory tract target nucleic acid, and a use method of the multi-detection kit. The multi-detection kit comprises specific primers and probes for genes of influenza A virus...
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WO/2023/243495A1 |
Provided is a method capable of expressing and activating the function of a G-protein conjugated receptor (GPCR). A method for expressing a GPCR polypeptide comprises expressing, in a cell, a GPCR polypeptide comprising an amino acid seq...
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WO/2023/242602A1 |
The subject of the present invention is a molecular biology method, by which relative (normalized to an internal control) N6-methyladenine (6mA) level at a selected site of the mitochondrial (mt) DNA (deoxyribonucleic acid) (mtDNA) in a ...
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WO/2023/244016A1 |
The present invention relates to novel long non-coding RNAs (lncRNA) involved in the regulation of chondrocyte hypertrophy. Together with the finding that RUNX2 was regulated at the post-translational level during the hypertrophic differ...
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WO/2023/244582A1 |
This application relates generally to lung cancer-related biomarkers, such as aggressive lung cancer-related molecules, which can be used to predict clinical outcomes, such as patient overall survival and/or metastasis-free survival, and...
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WO/2023/240610A1 |
Provided is a method for constructing a single-stranded nucleic acid molecule sequencing library. The method comprises: (1) connecting the 3' end of a single-stranded nucleic acid molecule to a 3' end linker, so as to obtain a connection...
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WO/2022/263496A9 |
Nanopores having charged polymers linked thereto are provided. At least one end of the charged polymer is fixed to or near one end of the channel of the nanopore in a position that enables the charged polymer to enter into the channel. T...
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WO/2023/243759A1 |
The present invention relates to a pharmaceutical composition for preventing or treating cancer caused by overexpression of β-catenin, comprising an expression vector comprising a NEURL gene or a NEURL protein as an active ingredient, w...
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WO/2023/245207A2 |
The present disclosure relates to methods of selecting and/or treating a subject for treatment of a cancer with a G4-stabilizing ligand based on expression of oncogene with a G4 motif comprising GxN1-7GxN1-7 GxN1-7 GxN1-7 (SEQ ID NO: 15)...
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WO/2022/256229A9 |
The disclosed technology relates to the field of nucleic acid sequencing, and more particularly, to systems and methods for DNA sequencing utilizing a single optical excitation and at least three fluorescent labels. In some embodiments, ...
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WO/2023/245190A1 |
The present disclosure relates in some aspects to methods and compositions for in situ analysis involving catalytic de-crosslinking of biological samples.
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WO/2023/244669A1 |
There is a tremendous need for advanced human model systems to screen new immunomodulatory candidates in an economical and robust manner, which is addressed by the present disclosure. Compositions and methods are provided for in vitro im...
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WO/2023/242964A1 |
The present invention improves the recovery rate of nucleic acid bonded to a nucleic acid capturing carrier, and recovers the nucleic acid at a high concentration. In the present invention, nucleic acid bonded to a nucleic acid capturing...
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WO/2023/243152A1 |
The present invention relates to a container for single cell analysis and a single cell analysis method using the same. The present invention also relates to an automated device for performing single cell analysis using such a container ...
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WO/2023/240564A1 |
Provided are an excision reagent containing a glycine-NaOH buffer and the use thereof in nucleic acid sequencing. Further provided are a sequencing kit containing the excision reagent, a method for excising a blocking group at the 3' end...
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WO/2023/245158A2 |
A method of selecting a recombinant microorganism is described. The method includes providing a genetically modified microorganism that includes an antibiotic selection marker; contacting the genetically modified microorganism with an ef...
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WO/2023/245122A2 |
An exemplary embodiment of the present disclosure provides a system for determining a minimum inhibitory concentration of an antimicrobial agent. The system can include a plurality of containers, a light source disposed on a first side o...
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WO/2023/241701A1 |
Provided are a sequencing kit containing a sulfydryl blocking reagent and an application of the sequencing kit. Also disclosed is a method for reducing a sequencing background signal. The method comprises the following steps: (1) opening...
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WO/2023/245203A1 |
The present disclosure in some aspects relates to real-time nucleic acid sequencing, including real-time sequencing, single molecule sequencing, long-read sequencing, and/or single-cell sequencing. Also described herein are methods of er...
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WO/2023/244046A1 |
Disclosed is a method of diagnosing cancer and predicting the type of cancer based on a single nucleotide variant in a cell-free nucleic acid including extracting nucleic acids from a biological sample to obtain sequence information, ext...
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WO/2023/243749A1 |
The present invention provides a composition and a kit for diagnosis or prognosis of diffuse type gastric cancer, each comprising an agent for measuring an expression level of SYT11 gene. Also provided in the present invention is a metho...
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WO/2023/244632A1 |
The invention relates to a gene expression based biomarker that is predictive of patient clinical need for treatment that includes a PD-1 antagonist, wherein the gene expression based biomarker comprises five or more genes selected from ...
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WO/2023/240755A1 |
Disclosed are a kit for detecting chromosome aneuploidy and single gene mutations and a use: comprising: preparing a plasma free DNA library of a pregnant woman to be detected; hybridizing the plasma free DNA library of said pregnant wom...
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WO/2023/245056A1 |
Provided herein is a method for generating a strand of DNA. In some embodiments, this method may comprise: (a) ligating a hairpin adaptor to a double-stranded fragment of DNA to produce a ligation product; (b) enzymatically generating a ...
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WO/2023/245172A1 |
The present disclosure provides methods, systems, and devices for the in situ labeling of complex environmental samples, specifically mixed populations of total live bacteria, using D-amino acid analogs, such as fluorescent D-amino acids...
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WO/2023/243732A1 |
The objective of the present invention is to provide a biomarker for use in determination of skin aging, comprising a protein or a fragment thereof. Alternatively, the objective of the present invention is to provide a method for determi...
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WO/2023/244699A1 |
Provided are methods for detecting cell viability and proliferation in a single sample. A cell or tissue sample is treated, incubated with a glycosylamine, and subsequently washed. The sample is then permeabilized, and a first detectable...
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WO/2023/240494A1 |
A sequencing buffer and a method for improving the stability of dNTP modified with a reversible blocking group. The sequencing buffer comprises: a competing reagent, which can compete with dNTP modified with a reversible blocking group i...
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WO/2023/244963A2 |
The present disclosure provides compounds and methods to prepare an antibody conjugate with a fluorophore, as well as the methods of using these conjugates for cellular imaging. In one example, the conjugate may be coupled with a quenche...
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WO/2023/244760A1 |
Disclosed herein are protein-RNA display constructs that couple a protein of interest to its encoding mRNA. An example protein-RNA display construct includes a first nucleotide portion including an RNA that forms hairpin structures; a se...
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WO/2023/241721A1 |
The present application discloses a cDNA synthesis method having improved high-throughput reverse transcription, template conversion and pre-amplification, so as to increase the yield and average length of cDNA libraries generated from s...
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