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WO/2006/076350A2 |
The present invention provides processes and intermediates for the preparation of aminoethoxybenzyl alcohols of Formula (I) useful in the production of pharmaceutically useful compounds. Formula (I)
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WO/2006/068662A1 |
Provided are processes for preparing tomoxetine comprising reacting Nmethyl-3-hydroxy-3-phenylpropylamine with dimethylsulfoxide (DMSO) and 2-fluorotoluene in the presence of an alkali base to form tomoxetine. Also provided is the co...
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WO/2006/067808A1 |
The present invention discloses a process for the preparation of substituted aryl alkylamine compounds comprising the steps of, reducing the substituted aryl acetonitrile substrate using Raney nickel catalyst at lower substrate/catalyst ...
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WO/2006/064283A1 |
The invention provides three polymorphic forms of crystalline levosalbutamol sulphate designated herein as Forms (I), (II) and (III). Crystalline levosalbutamol sulphate Form I is characterised by a powder XRD pattern with peaks at 10.8,...
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WO/2006/056098A1 |
The invention relates to the process for resolving DL-ephedrine, DL-pseudoephedrine or the derivatives thereof and to the corresponding resolving agents. The D-(+)- or L-(-)-tartaric acid derivatives of formula (I) are the resolving agen...
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WO/2006/050633A1 |
The invention relates to the process for resolving DL-ephedrine or the derivatives thereof and to the corresponding resolving agents. The L-(-)-dibenzoyl-tartaric acid or its derivatives of formula (I) are the resolving agents for DL-eph...
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WO/2006/049182A1 |
Disclosed is a novel hydroxyalkylated polyalkylenepolyamine composition. Also disclosed is a method for producing such a hydroxyalkylated polyalkylenepolyamine composition at low cost. Further disclosed is a method for producing a polyur...
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WO/2006/049014A1 |
An industrially practicable process for producing an &agr ,&agr -difluoroamine, which comprises using specific amounts of hydrogen fluoride and a Lewis base in a halogen-fluorine exchange reaction in which an &agr ,&agr -dihaloamine is u...
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WO/2006/045519A1 |
The present invention relates to an improved process for the preparation of substituted 2-(4-carbonylmethoxy-optionally 2,5-disubstituted-phenyl)-acetaldehydes, in particular 2-(4-alkoxycarbonylmethoxy- optionally 2,5-disubstituted-pheny...
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WO/2006/045852A1 |
The invention relates to a novel method of synthesising phenolic amino acids from industrial products with a high degree of purity and a good yield, which can be used to obtain chelates of metals such as iron, for subsequent use in agric...
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WO/2006/043577A1 |
Disclosed is a novel method for producing a phenylethanolamine compound represented by the following general formula (III) (wherein R1 represents a hydrogen atom or a halogen atom, and R2 represents an alkyl group which may be substitute...
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WO/2006/040332A1 |
The instant invention relates to the use of compounds derived from the esterification reaction of alkoxylated amines and fatty acids, optionally quaternised with an alkylating agent, and of the cationic surfactants and esterquats obtaina...
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WO/2006/040470A1 |
The invention concerns a method for preparing (meth)acrylic esters or anhydrides from acrylic acid of formulae (I), wherein R is H or Me, and R' is alkyl and R'' is alkyl or ethyl substituted by dialkylamino whereof the alkyls can form w...
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WO/2006/037950A1 |
The invention provides a method for the synthesis of an 18F-labelled product comprising deprotected of a protected 18F-labelled compound using a deprotection agent comprising a weak acid and wherein neutralisation and buffering of the de...
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WO/2006/035685A1 |
Disclosed are novel production intermediates (IIa) and (III) of a 6-substituted-1-methyl-1-H-benzimidazole derivative (I) as a publicly-known pharmaceutically active ingredient. Also disclosed is a production method suitable for mass syn...
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WO/2006/037055A1 |
(±)-Atomoxetine oxalate having crystalline Form II and a solid (±)-atomoxetine free base are useful in preparing atomoxetine hydrochloride.
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WO/2006/035457A1 |
The present invention provides an improved process for the preparation of Venlafaxine and the intermediates thereof. The present invention provides a process for preparing compound of formula (IV), an intermediate for preparing Venlafaxi...
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WO/2006/034459A1 |
The present invention generally relates to a process for preparing the alkoxylated alkylamines and/or alkyl ether amines. The process consists of three stages, and utilizes an alkali catalyst. The alkoxylated alkyl amines and alkoxylated...
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WO/2006/027077A1 |
The invention relates to a method for producing triethanolamine, according to which a phosphane or a phosphane-releasing compound is added to the triethanolamine.
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WO/2006/024358A1 |
The invention relates to a triethanolamin production method consisting in adding a phosphorous and/or hypophosphorous acid and a basic compound selected from an alkali metal hydroxide, alkali-earth metal hydroxide and [R1R2R3(2-hydroxyet...
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WO/2006/020348A2 |
The present invention provides novel crystalline polymorph forms of atomoxetine hydrochloride denominated Forms B and C and methods for their preparation, as well as methods for the preparation of Form A. The present invention provides p...
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WO/2006/011696A1 |
The present invention relates to a novel method for preparing an itopride·hydrochloride mediate of the formula 1, which is useful for digestive tract activator, and more particularly, the present invention provides with a method for pre...
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WO/2006/009884A1 |
A process for preparing a 3-aryloxy-3-arylpropylamine comprises reacting a 3-hydroxy-3-arylpropylamine with a substituted aryl compound, in a solvent comprising N-N-dimethylacetamide or hexamethylphosphorous triamide.
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WO/2006/005476A1 |
The invention relates to an improved method for producing enantiomers 3-hydroxy-3-phenyl-propylamines on the industrial scale while using an asymmetric hydrogenation as a key step and, optionally, a special sequence of consecutive steps,...
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WO/2006/005692A1 |
The present invention relates to a composition comprising choline hydroxide, a solvent, and one or more stabilizers selected from the group consisting of a hydride and choline sulfite.
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WO/2006/004976A2 |
The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to th...
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WO/2006/003194A1 |
Chiral, secondary amines of the formula (I) or (II), where R01, R02 and R03 are each, independently of one another, C1-C4-alkyl, R04 is C1-C4-alkyl, C1-C4-alkoxymethyl or C1-C4-alkoxyethyl, and * indicates predominantly one configuration...
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WO/2006/004977A2 |
The present invention provides a process for the optical resolution of racemic tomoxetine under reaction conditions that improve reaction yields and optical purity. The invention also provides an epimerization process for the (S)-(+) ena...
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WO/2005/123659A1 |
The invention relates to a method of synthesising a compound having formula (I) and to the use thereof for the synthesis of ivabradine and the pharmaceutically-acceptable acid addition salts and hydrates of same.
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WO/2005/121066A1 |
IN this invention, (1 R,2S)-(-)-ephedrine is obtained by reacting, [(S)-(-)-&agr -methylaminophenylacetone]2 . (2R,3R)-tartaric acid derivatives or the salts of (S)-(-)-&agr -methylaminophenylacetone and other organic acids with metal bo...
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WO/2005/115969A1 |
The inventive method for producing quaternary ammonium compounds consists in reacting compounds containing an sp3 hybridised nitrogen atom with dialkyl sulphate or trialkyl phosphate and in exposing the thus obtained ammonium compound to...
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WO/2005/113481A1 |
Provided are processes for the preparation of (R)-SLB.D-DBTA salt and levalbuterol hydrochloride. Also provided are levalbuterol hydrochloride degradation products and processes for preparing them. Pharmaceutical compositions comprising ...
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WO/2005/113559A1 |
The invention relates to a method for the production of a compound of general formula (Ia), wherein X represents a halogen atom or a pharmaceutically acceptable salt thereof, wherein a compound of formula (II), in which X is defined as a...
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WO/2005/113482A1 |
The invention is directed to levalbuterol HC1 Form B and methods of making the same.
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WO/2005/113483A2 |
The invention is directed to processes for making levalbuterol HC1 Polymorph A from by suspending or forming a first slurry of (R)-SLB(D)-DBTA in at least a first organic solvent, adding HC1 to the suspension or slurry of the solid (R)-S...
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WO/2005/110969A1 |
The invention relates to a method for the continuous production of an amine by reacting a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound, selected from the group containing ammonia and primary ...
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WO/2005/111050A2 |
This invention relates to phosphoramidite compounds and catalyst complexes which can be used to provide enantioselective reactions including hydroamination reactions, etherification reactions and conjugate addition reactions and allylic ...
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WO/2005/111009A2 |
This invention relate to methods for the preparation of amino acid keto-epoxides according to scheme (I). Specifically, allylic ketones are stereoselectively converted to the desired keto epoxides.
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WO/2005/108409A2 |
Compounds of the formula (I) or (I'), where R1 is a hydrogen atom or C1-C4-alkyl and R'1 is C1-C4-alkyl; X1 and X2 are each, independently of one another, a secondary phosphine group; R2 is hydrogen, R01R02R03Si-, C1-C18 -acyl substitu...
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WO/2005/103280A1 |
A process for producing either a 3-benzamido-2-hydroxycarboxylic acid represented by 3-benzamido-2-hydroxy-3-phenylpropionic acid or a salt thereof. The process is safe and suitable for industrial production, and the target compound havi...
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WO/2005/100299A1 |
An efficient cost-effective process for preparation of l-erythro-2-amino-1-phenyl-1-propanol from l-1-phenyl-1-hydroxy-2-propanone, which comprises converting l-1-phenyl-1-hydroxy-2-propanone to l-1-phenyl-1-hydroxy-2-propanone oxime and...
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WO/2005/097318A1 |
A process for preparing a catalyst comprising silver, a rhenium component, and a rhenium co-promoter on a support, which process comprises - depositing the rhenium co-promoter on the support prior to or simultaneously with depositing sil...
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WO/2005/097316A1 |
A process for preparing an epoxidation catalyst comprising silver and a high-selectivity dopant on a support, which process comprises - depositing a base having a pKb of at most 3.5 when measured in water at 25 °C, on the support prior ...
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WO/2005/095324A1 |
A quaternary ammonium compound represented by the general formula (I) or (I'): (I) or (I') wherein A represents C1-4 linear alkyl, C2-4 branched alkyl, hydroxylated C1-4 linear alkyl, or hydroxylated C2-4 branched alkyl; R1 to R3 are the...
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WO/2005/092833A1 |
A production process by which a 1,2-ethanediamine derivative for use as a raw material in producing useful chemical substances including medicines can be industrially advantageously produced at low cost. The process, which is for produci...
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WO/2005/092834A1 |
Processes for the purification of voglibose are provided. Also provided are processes for the purification of substituted or unsubstituted 5-oxo-1,2,3,4-cyclohexanetetrol and substituted 5-amino-1,2,3,4-cyclohexanetetrol, which compounds...
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WO/2005/092832A1 |
The present invention provides an industrially advantageous method of producing aminophenol compounds represented by the formula (1) by a simple and easy procedure at a high yield and a high purity. The present invention provides a metho...
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WO/2005/090283A1 |
A method of synthesising a compound of formula I: comprising the step of reacting a moiety of formula II: with a moiety of formula III: in compressed carbon dioxide in the presence of a transition metal catalyst and a base, wherein L is ...
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WO/2005/084803A1 |
[PROBLEMS] To provide an asymmetric reaction catalyst which is excellent in yield and stereoselectivity and easy of handling and a process for the production of optically active compounds with the same. [MEANS FOR SOLVING PROBLEMS] An as...
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WO/2005/081778A2 |
The present invention relates to a process for preparing severely sterically hindered secondary amine ether alcohols and diamine polyalkenyl ethers by reacting a primary amino compound with a polyalkenylether glycol in the presence of a ...
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