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JP2008115116A |
To provide a method for efficiently producing an -hydroxy--trifluoromethyl--lactam derivative.The method for producing an -hydroxy--trifluoromethyl--lactam derivative comprises subjecting an enamine compound and a trifluoropyruvic acid e...
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JP2008516989A |
The present invention provides novel compounds and pharmaceutical compositions thereof, as well as methods for using the compounds and pharmaceutical compositions for treating tumors. Examples of specific tumor types that the compounds m...
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JP4076709B2 |
To obtain a red-luminescent organic luminescent element material with a high color purity. This luminescent element material is a compound represented by formula (I) [wherein R1, R2, and R3 are each an aryl, a heterocyclic or an aliphati...
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JP2008509176A |
The invention relates to compounds of the formula (I) or (II), to compositions which comprise such compounds, to corresponding processes for the preparation of the compounds or the compositions comprising same, and to the use thereof as ...
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JP4064471B2 |
PCT No. PCT/EP98/03558 Sec. 371 Date Dec. 8, 1999 Sec. 102(e) Date Dec. 8, 1999 PCT Filed Jun. 12, 1998 PCT Pub. No. WO98/58913 PCT Pub. Date Dec. 30, 1998The invention relates to a novel class of compounds that have structures related t...
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JP2008050361A |
To provide pharmaceuticals in treating or preventing a disease or condition in which cannobinoid receptor activation plays a role.The present invention relates to naphthalene derivatives of formula (I), wherein X is S, S(O), S(O)2, S(O)2...
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JP4045364B2 |
The present invention relates to a compound of the general formula wherein m is 0 to 9, and R<1a>, R<2a>, R<3a> and R<4a> are the same or different and each is a hydrogen or an acyl, with the proviso that m is not 4; a pharmaceutically a...
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JP4043046B2 |
PCT No. PCT/EP95/01233 Sec. 371 Date Mar. 6, 1997 Sec. 102(e) Date Mar. 6, 1997 PCT Filed Apr. 4, 1995 PCT Pub. No. WO95/30641 PCT Pub. Date Nov. 16, 1995New compounds and their compositions having anti-inflammatory, analgesic and anti-t...
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JP4034366B2 |
3-Phenyl-N,N-dimethyl-propylamine derivs. of formula (I) and their isomers and acid-addn. salts are new; X = H, OH, F, Cl or 2-4C alkanoyloxy; R1 = 1-4C alkyl; R2 = H or 1-4C alkyl; R3 = H or 1-4C n-alkyl; or CR2R3 = 4-7C cycloalkylidene...
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JP4024149B2 |
The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an —S(O)z(C1-C4)alkyl group, an —NHSO2(C1-C4)alkyl group, an —SO2NH(C1-C4)...
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JP2007536399A |
In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a pi-donor conjugated to a pi-acceptor through a pi-electron conjugated bridge. ...
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JP2007314365A |
To provide a method for forming a large-size organic single crystal excellent in crystallinity and to provide the organic single crystal. Gel 3 is formed by charging a gelling agent 2 into a solution 1 in which organic matter constitutin...
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JP4013320B2 |
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JP4012823B2 |
Compounds of formula I wherein m, R, R1 and R3 to R6 are as defined in the specification, m, is 1, 2 or 3 and X is O or a direct bond, and the corresponding unphosporylated compounds have interesting properties, e.g. immunosuppressive pr...
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JP4002338B2 |
Inorganic ion receptor modulating cpds. of formulae (I), (II) and (III) and their salts and complexes in the case of (I) and (II) are new, in which Ar2 = naphthyl or phenyl which are opt. substd. with 0-5 substits. X1 ; X1 = lower alkyl,...
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JP3998903B2 |
A novel arylamine compound represented by the following general formula (1): wherein R<1> and R<2> each independently represent an alkyl group, an alkoxyl group, an aryl group, an arylalkyl group or an aryloxyl group, Ar<1> to Ar<4> each...
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JP4001321B2 |
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JP2007529569A |
Methods and intermediates for the preparation of Fenoldopam mesylate and intermediates thereof are provided.
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JP2007269709A |
To provide a method for producing amino ketones or salts thereof, using a new reaction. The method for producing amino ketones or salts thereof comprises reacting a salt of ≥3C secondary amines (such as dipropylamine, buthylethylamine ...
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JP2007528400A |
The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and condit...
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JP3976503B2 |
The invention provides a microencapsulated Lewis acid characterized in that a Lewis acid is supported through coordinate bonds on microcapsules formed of an organic polymer as a novel Lewis acid supported on a polymer in order to overcom...
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JPWO2005070875A1 |
In the present invention, an imine compound and a nucleophilic compound (excluding trialkylsilyl vinyl ethers) are subjected to the general formula (1) [Chemical formula 1].(In the formula, A1Indicates a spacer, X1And X2Independently ind...
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JP2007525148A |
This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains...
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JP2007523899A |
Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y 1 and Y 2 fonn various tricyclic cores, and R x is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for tr...
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JP3958851B2 |
To obtain the subject new compound, useful as an intermediate for crop-selective herbicides, e.g. 1-{[o-(cyclopropylcarbonyl)phenyl]-sulfamoyl}-3-(4,6- dimethoxy-2-pyrimidinyl)urea. This compound is shown by formula I [R is a 1-6C alkyl ...
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JP2007522194A |
A process for the preparation of compound AQ4N of formula (2) or a salt or solvate thereof wherein the said process includes the reaction step: Formula (1), Formula (2), where compound AQ4 of formula (1) is oxidised to compound AQ4N of f...
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JP3955180B2 |
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, ...
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JP2007153772A |
To provide a new method for producing a 3-substituted α,β-unsaturated carboxylic ester useful as an intermediate for pharmaceuticals and agrochemicals.The method for producing the 3-substituted α,β-unsaturated carboxylic ester of for...
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JP3935199B2 |
The present invention relates to novel 5-HT4 receptor ligands which are 1-(5-halo-4-aminophenyl) (C2-6)alkan-1-one derivatives in which the 5-halo-4-aminophenyl group is substituted at its 2-position with (C1-4)alkyloxy or phenyl(C1-4)al...
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JP2007145867A |
To provide a compound modulating an inorganic ion receptor or its activity.The invention relates to the molecules modulating the inorganic ion receptor or its activity, represented by general formula (I) or (II). Preferably the molecule ...
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JP3927630B2 |
To obtain a new benzene derivative, having selective strong antiviral activities against only viruses without affecting a host cell, and useful as a preventing and therapeutic agent for viral diseases (e.g. a hepatitis C virus). This com...
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JP2007514709A |
Described are merocyanine derivatives of formula wherein R2 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; a cyano group; or R1 and R2 together with the nitrogen atom linki...
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JP3927232B2 |
Terpene-quinones with antitumour activity, defined from a Diels-Alder cyclocondensation reaction, thereby achieving families or series of said compounds of new structure which have cytotoxic activity against cell cultures P-388, A-549, H...
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JP3924124B2 |
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, ...
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JP2007126460A |
To provide a compound and a composition effective for inhibiting the activity of a CETP [cholesterol ester transfer protein (plasma lipid transfer protein-1)] and useful for treating especially atherosclerosis and other coronary arterial...
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JP2007118254A |
To provide a "write once"-type optical recording medium using a recording layer containing organic coloring matter with excellent light resistance and absorption in 600 to 700 nm or 350 to 520 nm wavelength range.This "write once"-type o...
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JP2007112804A |
To provide substituted aryl and heteroaryl (R)-chiral halogenated 1-substituted amino-(n+1)-alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and a composition of the com...
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JP2007509116A |
Treatment of Diseases caused by Disturbances of the Activity of the Androgen Receptor uses of compounds of Formula (I): (as defined herein), for the treatment of diseases caused by disturbances of the activity of androgen receptor are pr...
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JP2007509116A5 |
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JP3904599B2 |
Novel amine derivatives of the following general formula (I): (wherei A may denote -(CH2)-O-, -(CH2)2-O-, or -(CH2)2-NH-; B may denote -(CH2)2-; R1 may denote a hydrogen atom, a halogen atom, a nitro group, a 1-pyrrolyl group, an acetami...
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JP3901945B2 |
The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonist and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides phar...
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JP2007070300A |
To provide a process for producing 2,5-diamino-1,4-benzenediol and/or a salt thereof as a monomer of high performance fibers.A process for producing 2,5-diamino-1,4-benzoquinone comprises allowing 2,5-dialkoxy-1,4-benzoquinone and ammoni...
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JP3897363B2 |
The present invention describes certain alkyloxyamino-substituted fluorenones which inhibit protein kinase C, as well as pharmaceutical compositions including these compounds and methods of using these compounds to control protein kinase...
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JP3895795B2 |
To provide a method for the control of phytopathogenic bacteria, fungi and diseases caused thereby by using a benzophenone compound having a specific structure, capable of selectively controlling the phytopathogenic bacteria, fungi and d...
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JP3891840B2 |
The invention relates to a process for the preparation of substituted 2-vinyl-2-arylmorpholine derivatives as described herein. This invention also relates to 2-vinyl-2-arylmorpholine derivatives as well as intermediates therefor.
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JP2007055957A |
To provide a new tolan type compound which can be used for pigments or fluorescent materials, and to provide a thin film.This tolan type compound obtained by binding one compound selected from tropolone and its derivatives, tropone deriv...
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JP2007500610A |
The invention relates to novel optical recording materials that comprise specific and in some cases novel diketone enamines or metal chelates thereof and that have excellent recording and playback quality especially at a wavelength of 35...
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JP3868096B2 |
To produce the subject new derivative, comprising a specific amine derivative containing an aromatic ring, having inhibiting actions on the amyloid β protein production and secretion and useful for the prophylaxis, therapy or the like o...
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JP3870419B2 |
A benzene compound of the formula wherein each symbol is as defined in the specification; an optically active isomer or salt thereof, a medicinal composition containing the same, and an immunosuppressant containing the same as the active...
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JP2007500245A |
This invention relates to non-steroidal compounds that are or are believed to be modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.
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