| Document |
Document Title |
|
WO/2005/070864A1 |
A method of enantiometrically selective nucleophilic addition reaction to carbonyl, which enables asymmetric synthesis of optically active &agr -hydroxy-&gammad -keto acid esters, optically active &agr -hydroxy-&gammad -amino acid esters...
|
|
WO/2005/070876A1 |
An asymmetric synthesis of amino acid compound that is useful as a starting material or synthetic intermediate for production of medicinal products, agrichemicals, perfumes, functional polymers, etc. There is provided a method of enanthi...
|
|
WO/2005/063698A1 |
A process for the preparation of carbamates from organic urea and organic carbonate in presence of a solid base catalyst is disclosed. The process works at the milder reaction conditions and utilizes inexpensive catalysts that can be rec...
|
|
WO/2005/062811A2 |
One aspect of the present invention relates to a method of preparing allylic carboxylate compounds comprising the step of contacting a compound comprising an allylic hydrogen atom with a carboxylic acid in the presence of palladium, a su...
|
|
WO/2005/061446A2 |
The present invention relates to a process for preparing an aminoalkyl phenylcarbamate (4), comprising the steps of converting a hydroxy phenyl ketone (2) to a phenylcarbamate ketone (3), and converting the phenylcarbamate ketone (3) to ...
|
|
WO/2005/061445A1 |
Methods and reagents for rhodium-promoted carbonylation via isocyanate using carbon-isotope labeled carbon monoxide are provided. The resultant carbon isotope labeled compounds are useful as radiopharmaceuticals, especially for use in ...
|
|
WO/2005/061434A1 |
The invention relates to a novel method for producing dendritic trimesic acid triamides.
|
|
WO/2005/058804A1 |
There is provided a process for the preparation of a compound of Formula: (1) wherein Ar represents an optionally substituted hydrocarbyl or an optionally substituted heterocyclyl group comprising an aromatic moiety; and R1, R2 and R3 ea...
|
|
WO/2005/058805A1 |
A process for producing an optically active amine compound (IV), characterized in that nucleophilic addition of nucleophilic agent (III) to imine compound (II) is carried out in the presence of asymmetric urea compound (I). An advantageo...
|
|
WO/2005/054186A2 |
The present invention relates to methods of preparing a stereoisomerically enriched compound of formula (I), wherein R6 is hydrogen, comprising treating a compound of formula (I), wherein R6 is chosen from C1-C10 alkyl, C2-C10 alkenyl, C...
|
|
WO/2005/047234A1 |
The invention relates to a method for producing carbamate group-containing (meth)acrylic esters. The inventive method is characterized by reacting at least one carbamate group-containing hydroxy compound with (meth)acrylic anhydride in t...
|
|
WO/2005/040099A1 |
Processes for efficiently producing a 3-substituted (2R,3R)-2-(protected amino)-3-hydroxypropionic acid derivative from a 3-substituted (2S*,3R*)-2,3-epoxypropionic acid. The processes are the following (1) to (3): (1) a process which co...
|
|
WO/2005/033180A1 |
The present invention relates to novel aspartates, their method of production and the use of these mono and polyaspartates as reactive components for polyisocyanates in two-component polyurethane coating compositions and for preparing po...
|
|
WO/2005/033064A1 |
A process for preparing O-carbamoyl aminoalcohols represented by Formula(I) wherein: n is an integer from 0 and 5; R1, R2, R3 and R4 are individually selected from the group consisting of hydrogen, alkyl, cycloalkyl, substituted or unsub...
|
|
WO/2005/016866A2 |
The present invention is to provide a method for producing the desired optically active β-amino acid derivatives of high optical purities in high yields, without requiring a step of deprotection. More particularly, the present invention...
|
|
WO/2005/016871A1 |
A process for the manufacture of iodopropynyl butylcarbamate (IPBC) is disclosed wherein the subject reaction is carried out in an aqueous solution of a suitable surfactant. The iodination reactant is metallic iodide salt which serves as...
|
|
WO/2005/009928A2 |
The present disclosure provides methods of synthesizing alkylating agents and methods of use.
|
|
WO/2005/010011A2 |
Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in...
|
|
WO/2005/000803A2 |
A process for producing an asymmetric compound (IV), characterized by causing a compound (II) to add a nucleophilic reagent (III) through conjugate addition in the presence of an asymmetric urea compound (I). Also provided is a nonmetall...
|
|
WO/2004/101476A1 |
The invention relates to a process for amino acid synthesis, i.e., the preparation of side chain unsaturated &agr ,&agr -disubstituted-&agr -amino acid derivatives with formula (1) wherein: * denotes a stereogenic C-atom PG represents an...
|
|
WO/2004/067498A2 |
The invention relates to compounds of general formula (I), where n = a whole number from 1 to 7, A is selected from one or several groups X, Y and/or Z, X = C1-2 alkylene, optionally substituted by one or more C1-12 alkyl, C3-7 cycloalky...
|
|
WO/2004/058681A1 |
A process for producing a benzylamine derivative represented by the general formula (3): (3) (wherein X1 represents halogeno; R1 represents acyl; and R2 represents acyl), characterized by reacting a benzyl compound represented by the gen...
|
|
WO/2004/052844A1 |
The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA anal...
|
|
WO/2004/052843A1 |
The invention relates to a process for producing carbamoyloxy (meth)acrylates which comprises transesterification of hydroxyalkyl carbamates with an (meth)acrylate of formula CH2=CR29-COOR30 wherein R29 is hydrogen or methyl and R30 repr...
|
|
WO/2004/046089A1 |
Novel methods for synthesizing a functional PNA monomer unit and functional PNA oligomer which are for incorporating functional molecules in any desired positions directly or postsynthetically through linkers having various lengths under...
|
|
WO/2004/037772A1 |
The present invention discloses an improved synthesis of ethyl N-[(2-Boc-amino)ethyl]glycinate and its hydrochloride salt. The synthesis is based on the reductive alkylation of Boc-ethylenediamine with ethyl glyoxylate hydrate and furnis...
|
|
WO/2004/026814A2 |
The invention is a process for the preparation of compounds of the Formula (I): where R1, R2, R3, R4 and R5 are defined in the specification, which are intermediates useful for the preparation of tubulin inhibitors useful in the treatmen...
|
|
WO/2004/024737A1 |
The invention relates to a method for binding heteroatom-carbon bonds. According to said method, a lithium compound (II) is first generated by reacting aliphatic or aromatic halogen compounds (I) with lithium metal, said compound is then...
|
|
WO/2004/020384A1 |
The present invention refers to a process for preparing a compound of general formula (A), wherein R is a radical of naproxen or bromonaproxen and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer...
|
|
WO/2004/020385A1 |
The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independent...
|
|
WO/2004/011523A2 |
Phase change solvents for thermoplastic polymers to provide blended compositions. Above the phase change temperature of the solvent, the phase change solvent solubilizes or intimately mixes with the thermoplastic polymer. Below the phase...
|
|
WO/2004/002939A2 |
The present invention relates to a compound formula [I]: Y is bond, -0-(CH2)n- (in which n is 1, 2, 3 or 4), etc., Z is cyano, tetrazolyl, etc., R1 is hydrogen, lower alkyl, etc., R2 is hydrogen or an amino protective group, R3 is hydrog...
|
|
WO/2004/000794A1 |
Allyl carbamates are disclosed. The allyl carbamates are prepared by reacting an isocyanate with an allylic alcohol or alkoxylated allylic alcohol. Suitable isocyanates are selected from hexamethylene diisocyanate (HDI), HDI biuret, dime...
|
|
WO/2003/106399A2 |
The invention provides processes for preparing N-protected β-amino aldehyde compounds which are useful as synthetic intermediates for preparing glycopeptide antibiotic derivatives. The processes include cleaving a carbon-carbon double b...
|
|
WO/2003/104184A1 |
The synthesis of 1-(acyloxy)-alkyl carbamates of GABA analogs from 1-haloalkyl carbamates of GABA analogs are described. Also described are new 1-haloalkyl carbamates of GABA analogs.
|
|
WO/2003/101917A2 |
A process for the preparation of compound of formula (I); wherein R1 is hydrogen, linear, branched or cyclic lower alkyl, cyclohexyl, allyl, propargyl or benzyl; R2 is hydrogen, methyl, ethyl or propyl; or R1 and R2 together with the nit...
|
|
WO2002088069A9 |
This invention relates compounds of formulae Wherein A is CN,CONH>2< OR CONHCOOR, R being methyl or optionally substituted benzyl, useful as intermediates for cholesteryl ester transfer protein (CETP) inhibitors and methods for the prepa...
|
|
WO2003014102B1 |
The present invention relates to certain substituted polyketides of formula (I), wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds in treating tumors.
|
|
WO/2003/076396A1 |
A novel process for synthesizing a ß-aminoketone which comprises reacting an &agr ,ß-unsaturated ketone compound with a carbamate compound through conjugate addition, in which a salt or hydrated salt of a transition metal belonging to ...
|
|
WO/2003/076451A1 |
The invention relates to bidentate organophosphorous ferrocenyl ligands containing ligands of formula (I), to their complex compounds and to their utilization in catalytic processes.
|
|
WO/2003/074478A1 |
A process for the preparation of optically active biaryl compounds represented by the general formula (4): (4) [wherein R*s are each independently a substituent having at least one asymmetric carbon atom; R2s are each independently fluor...
|
|
WO/2003/072597A1 |
More efficient and/or economical methods for synthesizing heptap eptide alcohol analogs of oxytocin are provided along with novel intermediates which are useful in synthesizing such oxytocin analogs. Efficient and economical methods for ...
|
|
WO/2003/066549A2 |
A regio- and stereoselective two-stage synthesis of β-aminoalcohols employs a key transformation, viz., the creation of a cyclic sulfamidate from a precursor diol, mediated by Burgess-type reagents. The generality and scope of this appr...
|
|
WO/2003/066580A1 |
The present invention relates to a process wherein a cyclic carbonate compound is reacted with a compound containing a nucleophilic group, especially an amine group, in the presence of a catalyst comprising a lithium compound. Such react...
|
|
WO/2003/066578A1 |
A pinene derivative represented by the general formula (I) or a salt thereof; and a process for producing the derivative or salt or a process for producing from the derivative or salt an optionally active 2-(t-butoxycarbonyl)amino-3-hydr...
|
|
WO/2003/064432A1 |
Intermediates for the total synthesis of ecteinascidins which are represented by the general formula (2) and bear the skeletal pentacyclic structure of ecteinascidins, characterized in that the 4-position OH group and trichloroethoxycarb...
|
|
WO/2003/053919A1 |
The present invention relates to compounds of formula (I) wherein A?1¿, A?2¿, A?3¿, A?4¿, A?5¿, A?6¿, A?7¿, A?8¿, A?9¿, A?10¿, U, V, W, m, n and p are as defined in the description and claims, and pharmaceutically acceptable sa...
|
|
WO/2003/053885A1 |
The invention concerns a method for generating a carbon-carbon or carbon-heteroatom linkage by reacting an unsaturated compound bearing a leaving group and a nucleophilic compound. The invention also concerns generating a carbon-nitrogen...
|
|
WO/2003/053916A1 |
The invention concerns a new process for preparing (S)-(+)-2-(substituted phenyl)-2-hydroxy-ethyl carbamates and to novel intermediates used in this process. It further relates to polymorphic forms of said carbamates and to processes for...
|
|
WO/2003/051841A2 |
Carbamates and related compounds of formula R1 R2NCO-Y or R1 R2NCS-Y wherein R1 and R2 are hydrogen, alkyl, aryl, heteroaryl or may together form a piperidine, piperazine, morpholine or other heterocyclic ring, are inhibitors of hormone ...
|
