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WO/1995/032180A1 |
A process for producing N-protected N-alkylated amino acids of formula (I) is described in which the components have the meaning given in the description. In the process, to a compound of formula (II) is added a solution of potassium-ter...
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WO/1995/029975A1 |
Poly(oxyalkylene) hydroxy and amino aromatic carbamates having formula (I) or a fuel-soluble salt thereof; wherein X is hydroxy or amino; R is hydrogen or lower alkyl having 1 to 6 carbon atoms; R1 and R2 are each independently hydrogen,...
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WO/1995/029150A1 |
Prototype renin inhibitors having general structure (I), where n is 0-3 inclusive, A are either both hydrogen atoms or together are a single carbon-nitrogen bond, R1 is hydrogen, or hydrocarbylcarboxy wherein the hydrocarbyl entity is se...
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WO/1995/029171A1 |
A method for making arthropodicidal oxadiazines and intermediates which are racemic or enantiomerically enriched at their chiral center, the method for making the oxadiazines comprising reaction of an intermediate selected from (II) or (...
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WO/1995/028385A1 |
A method is described for synthesis of N-protected amino acids, especially N-Boc-L-propargylglycine, a key intermediate used in the preparation of high-potency, orally-active renin inhibitors. This method involves reaction of an organic ...
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WO/1995/024384A1 |
Polycarbamates of a polyisocyanate and secondary alcohols are disclosed. These carbamates are characterized in being readily pyrolyzed to form the corresponding polyisocyanate and alcohol with low formation of tars and other by-products....
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WO/1995/023793A1 |
An intermediate useful for synthesizing a 2,5-diamino-1,6-diphenyl-3-hydroxyhexane derivative serving as an intermediate for preparing medicines such as retrovirus protease inhibitors including human immunodeficiency virus (HIV) protease...
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WO/1995/021155A1 |
A process for preparing N,N-substituted carbamoyl halides comprising (a) contacting carbon dioxide and a secondary amine in the presence of an aprotic organic solvent and a base selected from the group consisting of a phosphazene compoun...
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WO/1995/014653A1 |
A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide of cyanohydrin from a...
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WO/1995/012574A1 |
The description relates to a process for producing N-protected N-alkylated amino acids of formula (1), in which Rs and R1 to R3 have the meanings given in the description, in which a compound of said formula (1), wherein R3 is a hydrogen...
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WO/1995/011226A1 |
A substituted benzene derivative of formula (I), wherein A is an aryloxy group which may be substituted, an arylthio group which may be substituted or -ON=C(R1)R2, each of R1 and R2 which are independent of each other is an alkyl group w...
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WO/1995/011224A1 |
Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are i...
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WO/1995/008529A1 |
Chiral surfactants, methods for their synthesis and use, and apparatus designed to facilitate chiral separations using micellar capillary electrophoresis is disclosed. A chiral surfactant having general formula (I) is described. R1 is th...
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WO/1995/002576A1 |
Process for the preparation of N-carbonylarylimines of general formula (I) by desulphonating a sulphone of general formula (II). The N-carbonylarylimines of general formula (I) are particularly useful for the preparation of therapeutical...
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WO/1995/001323A1 |
A process for producing a 3-amino-1-nitro-4-phenyl-2-butanol derivative represented by general formula (1) and a 3-amino-2-hydroxy-4-phenyl-butyric acid derivative derived therefrom. In said formula, R1 and R2 represent each independentl...
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WO/1994/027941A1 |
A process for preparing felbamate and a key intermediate, 2-phenyl-1,3-propanediol (PPD) is disclosed. PPD can be prepared by cleaving a borate ester, a boric acid ester or a mixture thereof, with an anion exchange resin in the presence ...
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WO/1994/022813A1 |
Method for the preparation of beta-phenylisoserine derivatives of general formula (I) involving the action of an anhydride and hydrogen with a product of general formula (II). The products of general formula (I) are especially useful in ...
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WO/1994/018181A1 |
A process for preparing N-substituted-oxazolidine-2,4-diones comprising (a) contacting carbon dioxide and a primary amine or ammonia in the presence of an aprotic organic solvent and an organic, nitrogenous base to produce the correspond...
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WO/1994/017034A1 |
Compounds are disclosed having the general formula (I) R1-(A)a-(B)b-(D)c-(CH2)m-N(R2)-(CH2)n-R3, in which A, B, D, R1 to R3 and a, b, c, m and n have the definitions given in the description, as well as a process for preparing the same a...
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WO/1994/017033A1 |
A process for preparing C-substituted diethylene triamines having general formula (I) is characterized in that a nitrogen-protected aminoethyl alcohol having general formula (II) is reacted with methane sulphonic acid chloride, tosyl chl...
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WO/1994/013627A1 |
The invention concerns iodoalkinyl carbamates of general formula (I) I-C = C-C(R1R2)-O-[C(R3R4)-C(R5R6)-O]n-CONHR7, in which R1 and R2, independently of each other, are hydrogen or straight-chain or branched-chain alkyl groups with 1 to ...
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WO/1994/007847A1 |
Method of stereoselective preparation of a derivative of beta-phenylisoserine of formula (I) by the action of an N-carbonylbenzylimine of formula (II) on an optically active amide of a protected hydroxyacetic acid of formula (III), follo...
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WO/1994/006737A1 |
A process for preparing felbamate and a key intermediate, 2-phenyl-1, 3-propanediol (PPD) is disclosed. PPD can be prepared by contacting (i) the enolate salt of formyl phenyl acid ester (VIII), (ii) an E-enol (X), a Z-enol (XII) or form...
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WO/1994/002450A1 |
Prodrugs, of generic formula (I), are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 cat...
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WO/1993/024263A1 |
Novel zerovalent metal species and organometallic reagents are disclosed. The zerovalent metal species are directly produced by reaction of a reducing agent on a metal cyanide salt. Preferably, the zerovalent metal species are directly p...
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WO/1993/023361A1 |
A process is disclosed for the preparation of a substituted diaminodiol. These compounds are HIV protease inhibitors.
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WO/1993/020044A1 |
Compounds of general formula (II) wherein R3 is C1-35 hydrocarbyl group optionally substituted by one to five substituents, selected from halo, C1-6alkoxy, hydroxy, amino, and mono- or di-C1-4alkyl-amino; and either the dotted line repre...
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WO/1993/016058A1 |
Novel anhydrides of general formula (I), wherein Ar is an aryl radical, and either R1 is C6H5-CO or (CH3)3C-O-CO, R2 is a hydrogen atom and R3 is a hydroxy function protective grouping, or R1 is (CH3)3C-O-CO and R2 and R3 together form a...
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WO/1993/007116A1 |
Fungicidal compounds having formula (I), wherein W is CH3O.CH=CCO2CH3, CH3ON=CCONR3R4 or CH3ON=CCO2CH3 and stereoisomers thereof; n is 0 or 1; X is oxygen or sulphur; Z is oxygen, sulphur or NR1; R1 is hydrogen or alkyl optionally substi...
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WO/1993/004038A1 |
Process for the preparation of novel beta-phenylisoserine derivatives of general formula (I) and use thereof in the preparation of biologically active taxane derivaties.
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WO/1992/019623A1 |
A novel zerovalent copper species and an organocopper reagent are disclosed. The zerovalent copper species is directly produced by reaction of a reducing agent with a combination of copper cyanide or halide and an alkali metal halide sal...
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WO/1992/017442A1 |
The present invention relates to a process for producing isocyanates which comprises reacting an N-halogenated amide with an organic base in an essentially water-free modified Hofmann reaction using a soluble silver salt promoter in the ...
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WO/1992/013827A1 |
A process for producing compounds represented by general formulae (III) and (IV), which are useful as intermediates for the production of amino acid derivatives which have a renin inhibitory activity and are useful as a hypotensive, ster...
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WO/1992/010467A1 |
The object of the invention is a method for obtaining of N-phenylcarbamic acid esters in a liquid phase on the way pressure carbonylation of nitrobenzene at the presence of alcohols. The product can be a raw material basis for production...
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WO/1992/000957A1 |
A method for preparing deferoxamine and a composition of formula (I): X-Ph-CH¿2?-O-C(O)-NH-(CH¿2?)¿4?-CH=NOR, wherein X is a C¿1?-C¿4? alkyl, -O(C¿1?-C¿4? alkyl), a halogen or hydrogen; R is X-Ph-CH¿2?- or hydrogen for preparing ...
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WO/1991/017977A1 |
Process for the stereoselective preparation of phenylisoserin derivatives of general formula (I) from benzylamine. In the general formula (I), R is a phenyl radical or tert.butoxy and R1 is a hydroxy function protective group.
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WO/1991/017976A1 |
Process for the enantioselective preparation of phenylisoserin derivatives of general formula (I) from phenylglycine S(+). In the general formula (I), R is a phenyl radical or tert.butoxy and R1 is an alcohol function protective group. T...
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WO/1991/008197A1 |
The present invention relates to an improved method for the preparation of an intermediate for bambuterol, i.e. for the preparation of 2'-bromo-3,5-di[N,N-dimethylcarbamoyloxy]acetophenone (1), by reacting 3,5-dihydroxyacetophenone with ...
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WO/1991/002016A1 |
New monomeric units obtained from hydroxy fatty acids, which are suitable for manufacturing plastics, are obtained by reacting esters of fatty acids containing hydroxyl groups or esters or salts of fatty acids containing amino groups wit...
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WO/1990/006914A1 |
The present invention provides a novel process for Nalpha-alkylating an amino acid comprising the use of a hindered alkoxide base and an alkylhalide in an inert solvent.
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WO/1988/010250A1 |
A process for the production of a carbamate having formula (I), wherein X and Y are independently either hydrogen, a hydrocarbyl group or a hetero-substituted hydrocarbyl group or the group of formula (II), wherein Z is either a divalent...
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WO/1986/005178A1 |
Process for preparing urethanes by reacting a solution of a nitrogen-containing organic compound and a hydroxyl-containing organic compound with carbon monoxide in the presence of a ruthenium catalyst. The selectivity of this process is ...
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WO/1986/005179A1 |
Process for carbonylating a nitrogen-containing organic compound, selected from the group consisting of nitro, nitroso, azo, and azoxy compounds, by reacting said nitrogen-containing organic compound, with carbon monoxide, wherein the im...
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WO/1980/002686A1 |
A process for preparing aromatic urethane by reacting an aromatic nitro compound, a hydroxy group-containing organic compound having at least one hydroxy group, and carbon monoxide at elevated temperatures under high pressure in the pres...
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JP7472101B2 |
The present invention provides methods of efficiently producing various optically active aromatic amino acid derivatives by reacting, using an additive, a specific ester compound with an aromatic halide and zinc in the presence of a cata...
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JP2024516114A |
The present invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof that are melatonin MT2 agonists, as well as pharmaceutical compositions containing such compounds. The present invention manages or trea...
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JP2024515451A |
The present invention relates to improved methods for preparing cyclooctenes and conjugates thereof. In particular, methods for regioselectively modifying and/or enantiomerically enriched compounds are disclosed. Additionally, compounds ...
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JP7458058B2 |
To provide a method that can produce carbamate with high yield and high selectivity, and excellent economical efficiency, using more different kinds of amines.A method for producing carbamate has a reaction step where, in the presence of...
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JP7446221B2 |
The present invention provides a method for producing a carbamate that includes a step (1) and a step (2) described below:(1) a step of producing a compound (A) having a urea linkage, using an organic primary amine having at least one pr...
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JP7441181B2 |
Crystalline forms of the drug conjugate (S)-3-((((R)-1-((S)-2-(6-methoxynaphthalen-2-yl)propanoyloxy
)ethoxy)carbonyl-amino)methyl)-5-methylhexanoic acid and their pharmaceutical compositions are described herein. Also described are meth...
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