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Matches 701 - 750 out of 3,496

Document Document Title
WO/1996/009283A1
(S)-2-aryl-1,3-propanediol monocarbamate and its intermediate, (S)-3-acetoxy-2-aryl-propanol carbamate, represented by formulae (I) and (II), respectively, have pharmaceutically useful activity against central nervous system disorders in...  
WO1996001788A3  
WO/1996/009284A1
(R)-2-aryl-1,3-propanediol monocarbamate and its intermediate, (R)-3-acetoxy-2-arylpropanol carbamate, represented by formulae (I) and (II), respectively, have pharmaceutically useful activity against central nervous system disorders inc...  
WO/1996/007642A1
A process for producing 2-[3(S)-amino-2-(R)-hydroxyl-4-phenyl butyl]-N-tert.butyl decahydro-(4aS, 8aS)-isoquinoline-e(S)-carboxamide of the formula (I) via 3(S)-[lower alkoxy carbonyl amino, phenoxy carbonyl amino or benzyl oxycarbonyl a...  
WO/1996/007637A1
O-carbamoyl-(D/L)-phenylalaninol represented by structural formula (I) is pharmaceutically useful to treat diseases of the central nervous system, which is prepared by a characteristic process comprising the steps of: treating phenylalan...  
WO/1996/002498A1
Carbamic acid vinyl ester compounds are produced by the reaction of corresponding secondary amines with carbon dioxides and acetylenically unsaturated compounds in the presence of a compound of a metal of the platinum group, especially a...  
WO/1996/002497A1
The novel compounds of formula (I) (the meanings of A and R1 to R4 are given in the description) may be produced by conventional methods and therapeutically used as, for example, LTB4 antagonists.  
WO/1996/002499A1
The present invention provides novel difluorostatone derivatives of general formula (I), which are useful as antiviral agents. More specifically, these novel compounds are useful as inhibitors of retroviral proteases required for replica...  
WO/1996/001788A2
The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized...  
WO/1996/000718A1
The invention relates to novel amino acid derivatives, a process for their production and their use as pesticides, especially as fungicides, and as intermediate products for the production of prior art fungicidal substituted amino acid d...  
WO/1995/033710A1
Disclosed are carbamoyl carboxylic acid hydrazides (I) and their salts, wherein: R1 is optionally substitued alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aryl or heteroaryl or an optionally substituted non-aromatic carbo- or hetero...  
WO/1995/032180A1
A process for producing N-protected N-alkylated amino acids of formula (I) is described in which the components have the meaning given in the description. In the process, to a compound of formula (II) is added a solution of potassium-ter...  
WO/1995/029975A1
Poly(oxyalkylene) hydroxy and amino aromatic carbamates having formula (I) or a fuel-soluble salt thereof; wherein X is hydroxy or amino; R is hydrogen or lower alkyl having 1 to 6 carbon atoms; R1 and R2 are each independently hydrogen,...  
WO/1995/029150A1
Prototype renin inhibitors having general structure (I), where n is 0-3 inclusive, A are either both hydrogen atoms or together are a single carbon-nitrogen bond, R1 is hydrogen, or hydrocarbylcarboxy wherein the hydrocarbyl entity is se...  
WO/1995/029171A1
A method for making arthropodicidal oxadiazines and intermediates which are racemic or enantiomerically enriched at their chiral center, the method for making the oxadiazines comprising reaction of an intermediate selected from (II) or (...  
WO/1995/028385A1
A method is described for synthesis of N-protected amino acids, especially N-Boc-L-propargylglycine, a key intermediate used in the preparation of high-potency, orally-active renin inhibitors. This method involves reaction of an organic ...  
WO/1995/024384A1
Polycarbamates of a polyisocyanate and secondary alcohols are disclosed. These carbamates are characterized in being readily pyrolyzed to form the corresponding polyisocyanate and alcohol with low formation of tars and other by-products....  
WO/1995/023793A1
An intermediate useful for synthesizing a 2,5-diamino-1,6-diphenyl-3-hydroxyhexane derivative serving as an intermediate for preparing medicines such as retrovirus protease inhibitors including human immunodeficiency virus (HIV) protease...  
WO/1995/021155A1
A process for preparing N,N-substituted carbamoyl halides comprising (a) contacting carbon dioxide and a secondary amine in the presence of an aprotic organic solvent and a base selected from the group consisting of a phosphazene compoun...  
WO/1995/014653A1
A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide of cyanohydrin from a...  
WO/1995/012574A1
The description relates to a process for producing N-protected N-alkylated amino acids of formula (1), in which Rs and R1 to R3 have the meanings given in the description, in which a compound of said formula (1), wherein R3 is a hydrogen...  
WO/1995/011226A1
A substituted benzene derivative of formula (I), wherein A is an aryloxy group which may be substituted, an arylthio group which may be substituted or -ON=C(R1)R2, each of R1 and R2 which are independent of each other is an alkyl group w...  
WO/1995/011224A1
Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are i...  
WO/1995/008529A1
Chiral surfactants, methods for their synthesis and use, and apparatus designed to facilitate chiral separations using micellar capillary electrophoresis is disclosed. A chiral surfactant having general formula (I) is described. R1 is th...  
WO/1995/002576A1
Process for the preparation of N-carbonylarylimines of general formula (I) by desulphonating a sulphone of general formula (II). The N-carbonylarylimines of general formula (I) are particularly useful for the preparation of therapeutical...  
WO/1995/001323A1
A process for producing a 3-amino-1-nitro-4-phenyl-2-butanol derivative represented by general formula (1) and a 3-amino-2-hydroxy-4-phenyl-butyric acid derivative derived therefrom. In said formula, R1 and R2 represent each independentl...  
WO/1994/027941A1
A process for preparing felbamate and a key intermediate, 2-phenyl-1,3-propanediol (PPD) is disclosed. PPD can be prepared by cleaving a borate ester, a boric acid ester or a mixture thereof, with an anion exchange resin in the presence ...  
WO/1994/022813A1
Method for the preparation of beta-phenylisoserine derivatives of general formula (I) involving the action of an anhydride and hydrogen with a product of general formula (II). The products of general formula (I) are especially useful in ...  
WO/1994/018181A1
A process for preparing N-substituted-oxazolidine-2,4-diones comprising (a) contacting carbon dioxide and a primary amine or ammonia in the presence of an aprotic organic solvent and an organic, nitrogenous base to produce the correspond...  
WO/1994/017034A1
Compounds are disclosed having the general formula (I) R1-(A)a-(B)b-(D)c-(CH2)m-N(R2)-(CH2)n-R3, in which A, B, D, R1 to R3 and a, b, c, m and n have the definitions given in the description, as well as a process for preparing the same a...  
WO/1994/017033A1
A process for preparing C-substituted diethylene triamines having general formula (I) is characterized in that a nitrogen-protected aminoethyl alcohol having general formula (II) is reacted with methane sulphonic acid chloride, tosyl chl...  
WO/1994/013627A1
The invention concerns iodoalkinyl carbamates of general formula (I) I-C = C-C(R1R2)-O-[C(R3R4)-C(R5R6)-O]n-CONHR7, in which R1 and R2, independently of each other, are hydrogen or straight-chain or branched-chain alkyl groups with 1 to ...  
WO/1994/007847A1
Method of stereoselective preparation of a derivative of beta-phenylisoserine of formula (I) by the action of an N-carbonylbenzylimine of formula (II) on an optically active amide of a protected hydroxyacetic acid of formula (III), follo...  
WO/1994/006737A1
A process for preparing felbamate and a key intermediate, 2-phenyl-1, 3-propanediol (PPD) is disclosed. PPD can be prepared by contacting (i) the enolate salt of formyl phenyl acid ester (VIII), (ii) an E-enol (X), a Z-enol (XII) or form...  
WO/1994/002450A1
Prodrugs, of generic formula (I), are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 cat...  
WO/1993/024263A1
Novel zerovalent metal species and organometallic reagents are disclosed. The zerovalent metal species are directly produced by reaction of a reducing agent on a metal cyanide salt. Preferably, the zerovalent metal species are directly p...  
WO/1993/023361A1
A process is disclosed for the preparation of a substituted diaminodiol. These compounds are HIV protease inhibitors.  
WO/1993/020044A1
Compounds of general formula (II) wherein R3 is C1-35 hydrocarbyl group optionally substituted by one to five substituents, selected from halo, C1-6alkoxy, hydroxy, amino, and mono- or di-C1-4alkyl-amino; and either the dotted line repre...  
WO/1993/016058A1
Novel anhydrides of general formula (I), wherein Ar is an aryl radical, and either R1 is C6H5-CO or (CH3)3C-O-CO, R2 is a hydrogen atom and R3 is a hydroxy function protective grouping, or R1 is (CH3)3C-O-CO and R2 and R3 together form a...  
WO/1993/007116A1
Fungicidal compounds having formula (I), wherein W is CH3O.CH=CCO2CH3, CH3ON=CCONR3R4 or CH3ON=CCO2CH3 and stereoisomers thereof; n is 0 or 1; X is oxygen or sulphur; Z is oxygen, sulphur or NR1; R1 is hydrogen or alkyl optionally substi...  
WO/1993/004038A1
Process for the preparation of novel beta-phenylisoserine derivatives of general formula (I) and use thereof in the preparation of biologically active taxane derivaties.  
WO/1992/019623A1
A novel zerovalent copper species and an organocopper reagent are disclosed. The zerovalent copper species is directly produced by reaction of a reducing agent with a combination of copper cyanide or halide and an alkali metal halide sal...  
WO/1992/017442A1
The present invention relates to a process for producing isocyanates which comprises reacting an N-halogenated amide with an organic base in an essentially water-free modified Hofmann reaction using a soluble silver salt promoter in the ...  
WO/1992/013827A1
A process for producing compounds represented by general formulae (III) and (IV), which are useful as intermediates for the production of amino acid derivatives which have a renin inhibitory activity and are useful as a hypotensive, ster...  
WO/1992/010467A1
The object of the invention is a method for obtaining of N-phenylcarbamic acid esters in a liquid phase on the way pressure carbonylation of nitrobenzene at the presence of alcohols. The product can be a raw material basis for production...  
WO/1992/000957A1
A method for preparing deferoxamine and a composition of formula (I): X-Ph-CH¿2?-O-C(O)-NH-(CH¿2?)¿4?-CH=NOR, wherein X is a C¿1?-C¿4? alkyl, -O(C¿1?-C¿4? alkyl), a halogen or hydrogen; R is X-Ph-CH¿2?- or hydrogen for preparing ...  
WO/1991/017977A1
Process for the stereoselective preparation of phenylisoserin derivatives of general formula (I) from benzylamine. In the general formula (I), R is a phenyl radical or tert.butoxy and R1 is a hydroxy function protective group.  
WO/1991/017976A1
Process for the enantioselective preparation of phenylisoserin derivatives of general formula (I) from phenylglycine S(+). In the general formula (I), R is a phenyl radical or tert.butoxy and R1 is an alcohol function protective group. T...  
WO/1991/008197A1
The present invention relates to an improved method for the preparation of an intermediate for bambuterol, i.e. for the preparation of 2'-bromo-3,5-di[N,N-dimethylcarbamoyloxy]acetophenone (1), by reacting 3,5-dihydroxyacetophenone with ...  
WO/1991/002016A1
New monomeric units obtained from hydroxy fatty acids, which are suitable for manufacturing plastics, are obtained by reacting esters of fatty acids containing hydroxyl groups or esters or salts of fatty acids containing amino groups wit...  

Matches 701 - 750 out of 3,496