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WO/2005/063702A1 |
In the present invention, the process for the preparation of tamsulosin hydrochloride and subsequent purification with thermal crystallisation to provide essentially pure tamsulosin hydrochloride is disclosed.
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WO/2005/061447A2 |
The production of alkylaryl compounds comprises the following stages: a) reaction of a C4/C5 olefin mixture on a metathesis catalyst to produce a C4-8 olefin mixture containing 2-pentene and the optional isolation of the C4-8 olefin mixt...
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WO/2005/058806A1 |
A method for producing chlorosulfonyl isocyanate wherein chlorocyanogen is reacted with sulfur trioxide to form chlorosulfonyl isocyanate, characterized in that chlorosulfonyl isocyanate or a fluid containing chlorosulfonyl isocyanate is...
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WO/2005/058810A1 |
A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process.
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WO/2005/056521A1 |
Provided is a method of preparing an optically pure compound having formula 1 or its salts. The method includes: reacting ®-2-(4-methoxy-3-aminosulfonyl-phenyl)-1-methylethylamine or its salts with a compound selected form the group con...
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WO/2005/051897A1 |
There is provided a process for the preparation of tamsulosin of formula 5, involving a coupling reaction in the presence of an aluminum reagent between an ester of formula 2A and (R)-5-(2-amino)propyl-2-methoxy-benzenesulfonamide of for...
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WO/2005/049556A2 |
The subject matter of the invention is a process for the production of metal salts of trifluoromethane sulphonic acid by reacting trifluoromethane sulphonic acid with a metal alcoholate and the use thereof as esterification catalyst and/...
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WO/2005/044795A1 |
The present invention provides an efficient synthesis for the preparation of ((1R,3S)-3-isopropyl-3- &lcub [3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]c
arbonyl&rcub cyclopentyl)[(3S,4S)-3-m ethoxytetrahydro- 2H-pyran-4-yl...
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WO/2005/019164A2 |
The present invention relates to a novel process for the preparation of phenethanolamine derivatives, which process comprises the step of reacting a compound of formula RO(CH2)nBRaRb with a compound of formula (II).
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WO/2005/014539A2 |
HMGCo-A reductase inhibitor compounds of formula (I) useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compo...
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WO/2005/012238A1 |
A process for making a compound of formula (I) in which process the compound HC≡C-(CH2)n-NH2 is reacted with the compound R1-SO2Cl to produce an intermediate compound, which intermediate compound is then reacted with the compound of fo...
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WO/2005/012239A1 |
Provided are ionically dissociative functional molecules which are thermally and chemically stable under the conditions required for electrochemical equipment and useful as the material of protonic conductors of fuel cells; processes for...
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WO/2005/010011A2 |
Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in...
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WO/2005/007865A1 |
Optically active &agr -methylcysteine derivative is efficiently produced from an inexpensive raw material. An optically active 2-amino-2-methyl-1,3-propanediol derivative monoester is produced by esterifying one of the hydroxyls of 2-ami...
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WO/2005/007612A1 |
A process for the production of optically active 1-(2-trifluoromethylphenyl)ethylamine or salts thereof which comprises reacting 1-(2-trifluoromethylphenyl)ethyl alcohol with a sulfonylating agent in the presence of a base to obtain a su...
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WO/2005/004803A2 |
The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention ...
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WO/2005/003082A1 |
The invention provides a process for the production of fluorinated sulfonyl fluorides useful as the material of ion -exchange resins or the like and novel chemical substances useful as the intermediate in the process. Namely, a process w...
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WO/2005/003062A2 |
The invention aims at providing a process by which fluorinated sulfonyl fluorides having various molecular structures can be obtained efficiently and inexpensively with production problems solved. The invention provides a process which c...
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WO/2005/000797A1 |
The invention relates to a process for the preparation of a compound of formula (1) which comprises reaction of a compound of formula (II) with a compound of the formula (III) in the presence of a chlorinating agent, followed by reaction...
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WO/2004/113258A1 |
A process for the production of compounds represented by the general formula (I), salts of the same, or solvate thereof from compounds represented by the general formulae (II) and (III), salts of the same, or solvates thereof, comprising...
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WO/2004/113391A2 |
The present invention is directed to methods of preparation of sulfonate derivatized compounds, e.g., 3-amino-l-propanesulfonic acid and 1,3-propanedisulfonic acid disodium salt with increased purity, with reduced potential for toxic by-...
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WO/2004/110976A2 |
There is provided a process for the preparation of aromatic amines of Formula (1): where Rx is optionally substituted aryl and Ry is optionally substituted hydrocarbyl, which comprises: (a) reducing a compound of Formula (2): to give a c...
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WO/2004/108636A2 |
A radioisotope labeled reagent includes a compound having the general formula (I) where a in each occurrence independently is a carbon mass number between 11 and 14 inclusive, b in each occurrence independently is a hydrogen mass number ...
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WO/2004/101860A1 |
Disclosed is a solution for an electrochemical process, the solution containing a sulfonic acid and having a low concentration of sulfur compounds, either low or high valence, that are susceptible to reduction and which is intended for u...
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WO/2004/096759A1 |
A method for producing a perfluoroalkanesulfonyl fluoride represented by the general formula: Rf-CF2-SO2F (wherein Rf represents F, CF3 or C2F5) is characterized in that a monohydroperfluoroalkanesulfonyl fluoride represented by the gene...
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WO/2004/094366A1 |
The invention relates to a process for the preparation of a low-base number calcium sulfonate that is essentially chloride free. The process involves preparing a sulfonic acid solution by adding a solvent to a sulfonic acid, optionally r...
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WO/2004/094365A1 |
A method for producing a fluorine-containing sulfonyl fluoride compound which comprises oxidizing RB-E-RA-S-S-RA-E-RB to form XSO2-RA-E-RB (2), reacting the oxidation product with fluorine in a liquid phase to form FSO2-RAF-EF-RBF, and d...
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WO/2004/092096A2 |
The invention relates to a method for producing alkyl aromatic compounds by reacting C3-30 olefins or alcohols, from which C3-30 olefins are formed under the reaction conditions, with an aromatic hydrocarbon in the presence of an alkylat...
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WO/2004/087623A2 |
A process for the preparation of (R)(-) Tamsulosin hydrochloride [(R)(-)-5-[2-[[2-(o-ethoxy-phenoxy)ethyl]amino]-2-methylethy
l]-2-methoxybenzenesulfonamide hydrochloride] of formula (III), The (R)(-) Tamsulosin hydrochloride of formula ...
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WO/2004/087881A2 |
The present invention is directed to processes for the synthesis of intermediates useful in the preparation of non-nucleoside reverse transcriptase inhibitors.
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WO/2004/085489A2 |
Disclosed herein is a process for preparing 4-(2-sulfoethylcyclohexane)-1,2 diol, at ambient condition and in the presence of a buffer and an initiator, from vinylcyclohexane-1,2-diol.
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WO/2004/083166A1 |
The invention provides processes by which (R)-3-[4- (trifluoromethyl)phenylamino]pentanamide derivatives useful as intermediates of drugs, particularly, cholesteryl ester transfer protein (CETP) inhibitor can be easily and simply produce...
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WO/2004/080974A1 |
Disclosed is an ionic liquid purification method for preparing high purity ionic liquids which can be used as solvents for organic, inorganic and biochemical reactions or as electrolytic solutions of storage batteries, secondary batterie...
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WO/2004/069789A1 |
A solid acid or a composite solid strong acid comprising the solid acid and a carbon material which is prepared by subjecting a polycyclic aromatic hydrocarbon or a polycyclic aromatic hydrocarbon in combination with the carbon material ...
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WO/2004/067492A1 |
The invention relates to a method for the production of $g(b)-ketocarboxylic acid derivatives of formula (I) or the salts thereof, where X = NR', O or S, R, R', R1-R4 independently = H, alkyl, alkenyl, aryl or heteroaryl, by reaction of ...
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WO/2004/060857A1 |
A method is provided for making a perfluorinated vinyl ether having a sulfonyl fluoride end-group according to the formula FSO?2#191-(CF?2#191)?n#191-O-CF&equals CF?2#191, where n is 2-5, comprising the steps of: a) fluorination of: (PLE...
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WO/2004/060849A1 |
A method is provided for reacting hexafluoropropylene oxide (HFPO) with a perfluoroacyl fluorides according to the formula X-Rf-COF (II) to selectively produce a monoaddition product according to the formula X- Rf- CF2-O-CF(CF3)COF (I), ...
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WO/2004/058694A1 |
The invention relates to a process for the manufacture of optically pure (R) or (S)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide with D-i.e. (2S, 3S) or L-i.e. (2R, 3R)-tartaric acid to form a mixture of diastereomeric salts, separating...
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WO/2004/058693A1 |
The present invention relates to a process for the production of alkanesulfonic acid. More particularly, the present invention relates to a process for the production of alkanesulfonic acid from alkyl mercaptan effluents generated in che...
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WO/2004/058695A1 |
A novel 4−halo−2−oxyimino−3−oxo butyric acid−N, N−dimethyl formiminium chloride chlorosulfate of formula (I) useful in the preparation of cephalosporin antibiotics, wherein X is chlorine or bromine&semi R is hydrogen, C1−...
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WO/2004/054960A1 |
The invention relates to a process for the preparation of acyloxybenzenesulfonates starting from carbonyl halides and salts of phenolsulfonic acid which have a low water content. Surprisingly, it was discovered that acyloxybenzenesulfona...
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WO/2004/050606A1 |
The present invention comprises the simultaneous ring opening and concomitan N-substitution of various N-tosyl aziridines with different aliphatic and aromatic nitriles in presence of catalytic amount of metal triflates to afford differe...
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WO/2004/041399A2 |
Reagents and methods with low thermodynamic barriers can convert lower alkanes such as methane into methanol or other derivatives. One system uses a small quantity of a non-salt radical initiator such as Marshall's acid, a di-acid peroxi...
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WO/2004/039768A1 |
The invention relates to a method for producing phenyliso(thio)cyanates of general formula (I) according to which a compound of general formula (II) or the HCl adduct thereof is reacted with a phosgenating agent, wherein W represents oxy...
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WO/2004/035531A1 |
A process for producing an aminoalkylsulfonic acid represented by the general formula [2]: [2] (wherein R1 and R2 each represents hydrogen, aryl, etc.; and R3 and R4 each represents hydrogen or alkyl), characterized by reacting a solutio...
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WO/2004/035530A2 |
The invention relates to a method for producing alkylaryl sulfonates, the alkylaryl sulfonates obtained according to said method, alcohol mixtures and olefin mixtures obtained as intermediate products, alkylaromatic compounds obtained th...
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WO/2004/035532A1 |
A process for easily and efficiently producing an aminoalkylsulfonic acid salt on an industrial scale. The process, which is for producing an aminoalkylsulfonic acid salt represented by the general formula [3]: [3] (wherein R1 and R2 eac...
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WO/2004/031134A1 |
A process for making substituted aryl sulfonamides by sulfamoylation of an activated aromatic compound using an indium compound as a catalyst.
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WO/2004/029006A2 |
The invention provides a process for preparation of a fluorohaloalkane, preferably an [18F]fluorohaloalkane of formula (I) wherein X is halo and n is an integer of from 1 to 6; which comprises: reaction of the corresponding organosilicon...
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WO/2004/026808A1 |
The present invention relates to a new process for the preparation of NO-donating compounds using a sulfonated intermediate. The invention relates to new intermediates prepared therein suitable for large scale manufacturing of NO-donatin...
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