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Matches 1 - 50 out of 11,226

Document Document Title
WO/2019/172184A1
Provided is a metal imide complex which has a stable structure and is able to be easily synthesized, while being capable of efficiently oxidizing various substrates. A metal imide complex which contains a metal and an imide that serves a...  
WO/2019/166633A1
The present invention relates to compounds of formula (I) : (I) wherein Q is selected from O or S; R1 is an optionally substituted hydrocarbyl group which may optionally include one or more heteroatoms N, O or S in its carbon skeleton, p...  
WO/2019/166621A1
The present invention relates to phenylsulfonylureas and phenylsulfonylthioureas, wherein the phenyl ring is substituted either (i) at the ortho-position with a halo group, or (ii) at the meta- and para-positions, and wherein the group a...  
WO/2019/166623A1
The present invention relates to phenylsulfonylureas and phenylsulfonylthioureas, wherein the phenyl ring is substituted with a monovalent group comprising either (i) an aryl or a heteroaryl group, or (ii) a nitrogen-containing heterocyc...  
WO/2019/166608A1
The presently claimed invention relates to a color developer, a process for its manufacture and its use as a component in heat sensitive recording material. The heat sensitive recording material is useful for thermographic printing.  
WO/2019/167949A1
The present invention addresses the problem of providing a method for producing a high-purity bis(fluorosulfonyl)amide alkali metal salt powder, wherein the reduction of the yield due to pyrolysis etc., is inhibited. The method for produ...  
WO/2019/165232A1
Inhibitors of Glycerol 3-Phosphate Acyltransferase (GPAT) are provided; and methods of use in the treatment of cancer; and treatment of conditions relating to metabolic syndrome and hyperlipidemia.  
WO/2019/160037A1
The purpose of the present invention is to provide methods for producing a carboxamide compound, a sulfonamide compound, and an ester compound using an acid halide. The methods for producing a carboxamide compound, a sulfonamide compound...  
WO/2019/153088A1
A composition for oral administration comprising a cannabinoid in combination with a stilbenoid or derivative thereof and a solubility enhancing agent is described. Oral dosage forms, in the form of dissolvable tablet or capsule with enh...  
WO/2019/154795A1
The present invention relates to 3-(benzylamino)-4-(cyclohexylamino)-N-(2-(piperazin-1-yl)eth yl)benzenesulfonamide derivatives and related ferrostatin-1 (Fer-1) analogues as cell death inhibitors by inhibition of ferroptosis and/or oxyt...  
WO/2019/152536A1
The present disclosure relates to compounds that are capable of modulating the WNT/Beta-Catenin pathway. The disclosure further relates to methods of treating colorectal cancer and other WNT/Beta-Catenin mediated cancers.  
WO/2019/130866A1
Provided is an active ray- or radiation-sensitive resin composition which has excellent storage stability and can enable a pattern with excellent LWR performance to be obtained. Also provided are a resist film, a pattern forming method, ...  
WO/2019/131922A1
The present invention provides a compound that has β2-adrenergic receptor antagonist activity and carbonic anhydrase-inhibitory activity, and that exhibits excellent ocular antihypertensive activity. Specifically provided is a compound ...  
WO/2019/111225A1
Compounds and compositions are provided having the structure of Formula (I) or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein T, T', U, U', V, W, R1, R2, R3', n, o, o', o'', and o''' are as defined herein....  
WO/2019/102054A1
Non-glycosidic analogues of alpha-galactosylceramide of formula (I), wherein A, Z, Ra, Rb and Rc have the meaning indicated in the description, as NKT cell activators.  
WO/2019/104030A1
Provided are compounds of Formula I, or pharmaceutically acceptable salts thereof, and methods for their use as Nrf2 activators and for their production.  
WO/2018/067638A3
Compounds, pharmaceutically acceptable salts, and pharmaceutical compositions thereof are disclosed that are useful for inhibition of the biological activity of HMGB1, as well as methods of treatment for diseases involving the inflammati...  
WO/2019/090069A1
Provided herein are compounds, compositions, and methods useful for the modulation of elF2B, for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.  
WO/2019/085847A1
Disclosed are a Piper laetispicum extract and a preparation method therefor and a use thereof. The Piper laetispicum extract comprises any one of sesamin, (2E, 6E)-N-isobutyl-7-(3,4-methylenedioxyphenyl)heptadienamide, (2E, 4E)-N-isobuty...  
WO/2018/026811A3
Described herein are methods employing substituted phenyl-heteroaryl-aryl compounds, and corresponding kits directed to antifungal therapy. The antifungal activity is tolerant of a wide diversity of fungal species, being effective agains...  
WO/2019/079119A1
In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: wherein the variables shown in Formula AA can be as defined anywhere herein. Compounds AA are modulators of NLRP1 and/or NLRP3  
WO/2019/068772A1
The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R1 is a saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include cyclic ...  
WO/2019/060994A1
Compounds, compositions and their use in the treatment or prevention of symptoms of Lowe Syndrome and Dent disease 2 are described, for instance, the use of such compounds in the treatment of Lowe Syndrome and Dent disease 2, or in the t...  
WO/2019/060210A1
The present disclosure relates to compounds of formula I that are useful as modulators of 7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly diso...  
WO/2019/056120A1
The present application relates to sulfonamide containing compounds of Formulae (I) and (II) and compositions containing said compounds effective in the treatment of cell proliferative disorders, in particular cancer, and various methods...  
WO/2019/053634A1
The invention discloses compounds of Formula (I), wherein A1, R1, R2, R3, R4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharma...  
WO/2019/051222A1
The present disclosure provides a benzene fused heterocyclic derivative of Formula (I): --̅-̅-̅ is a single or double bond; n is an integer of 0 or 1; A is -CH2-, -CH(OH)-, or - C(O)-; G is C or N; X is -CH2-, O, or -C(O)-; Y is alkyl...  
WO/2019/046931A1
Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions invol...  
WO/2019/044476A1
This fluorine-containing bissulfonylimide compound is represented by general formula (1). In general formula (1), Rf1 represents an ether-bond-containing perfluoroalkyl group in which an ether bond is present and the number of carbon ato...  
WO/2019/045035A1
The present invention relates to biaryloxy derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage ...  
WO/2019/046287A1
The present invention includes compositions and methods for treating or preventing hepatitis B virus (HBV) infections in a patient.  
WO/2019/044286A1
Provided is an efficient method for producing a perfluoroalkane sulfonylimide acid metal salt. The perfluoroalkane sulfonylimide acid metal salt is produced by: reacting a perfluoroalkane sulfonyl halide with an organic base and ammonia ...  
WO/2019/043610A1
The present invention relates to novel heterocyclic compounds of the general formula (I) their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers and polymorphs. The invention also relates...  
WO/2019/040122A1
This invention is directed to compositions, methods and kits that can be used for the treatment or amelioration of pain.  
WO/2019/040380A1
Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction betw...  
WO/2019/034697A1
The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R1 is a saturated or unsaturated, optionally substituted C1-C15 hydrocarbyl group, wherein the atom of R1 which is attached to the sulfur atom ...  
WO/2019/031472A1
[Problem] The purpose of the invention is to develop, as drug-candidate compounds, a group of novel compounds having the activity of inhibiting functions of Pin1. [Solution] The invention provides: a compound represented by formula (I) o...  
WO/2019/029211A1
Disclosed by the present invention are an SIRT6 small-molecule allosteric activator and the application thereof, and provided is an SIRT6 small-molecule allosteric activator that contains a derivative as shown in formula (1) or a pharmac...  
WO/2019/017814A9
The present invention relates to novel hepatitis B virus (HBV) inhibitors for use as chemotherapeutic agents for treating HBV. The compounds bind to HBV core-antigen and trigger the formation of aberrant virus capsids not carrying the vi...  
WO/2019/032739A1
The present disclosure is directed to method of treatment for treating or ameliorating various conditions caused by radiation exposure such as RIGS, enteritis, mucositis, e.g., oral mucositis, and proctitis by the administration of compo...  
WO/2019/028343A1
Methods of treating or preventing cancer, diabetes, and/or obesity in a subject are provided. The methods comprise administering to a subject a therapeutically effective amount of an SLC25A1 inhibitor as described herein. Also provided h...  
WO/2019/025153A1
The invention relates to the use of substituted N-sulfonyl-N'-aryl diaminoalkanes and N-sulfonyl-N'-heteroaryl diaminoalkanes of general formula (I), or the salts thereof, formula (I), wherein the groups in general formula (I) are define...  
WO/2019/026994A1
The present invention provides a pharmaceutical composition for the treatment or prevention of cognitive function diseases or disorders, wherein the pharmaceutical composition contains a compound represented by formula (I), an enantiomer...  
WO/2019/022097A1
[Problem] To provide a sulfonyl azide benzoic acid derivative that can be used in a bioorthogonal click reaction. [Solution] The following sulfonyl azide benzoic acid derivative was developed as a compound to be used in a highly versatil...  
WO/2019/009759A1
The present invention relates to a novel combined medicinal preparation having a solid oral dosage form and comprising as one of three active ingredients elsulfavirine sodium, which could be used in medicine for treating viral infections...  
WO/2019/008061A1
The present invention relates to asymmetric sulfonamide compounds comprising at least: • one polycyclic group, Ar, formed of two to six rings, at least one of which is aromatic, • a linear or branched, saturated or unsaturated alipha...  
WO/2017/191000A9
Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a di...  
WO/2018/237163A1
Disclosed herein, are 5-Aminolevulinate synthase inhibitors and methods for their use in the treatment of porphyria. In at least one specific embodiment, the 5-Aminolevulinate synthase inhibitors can include compounds or salts thereof of...  
WO/2018/228857A1
The invention relates to novel laser markable compositions comprising developing agent precursors according to formula (I).  
WO/2018/224560A1
The present invention concerns a compound having the following formula (I): wherein: - A is in particular -N(R'a)-C(=O)-R, R'a being H or a (C1-C6)alkyl group, and R being preferably a group having the following formula (II): - X is in p...  

Matches 1 - 50 out of 11,226