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WO/2014/086712A1 |
The present invention relates to compounds of general formula I, wherein the groups (Het)Ar and R1 are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activ...
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WO/2014/086865A1 |
The present invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to 1-phenyl-2-pyridinyl alkyl alcohol derivatives, to processes for the preparation thereof, compositions comp...
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WO/2014/086284A1 |
Disclosed in the invention are a deuterated 3-cyano quinoline compound or pharmaceutically acceptable salts, solvates, prodrugs, stereoisomers, tautomers, polymorphic substances, metabolites etc., and a pharmaceutical composition contain...
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WO/2014/086894A1 |
The present invention relates to novel retinoid-related orphan receptor gamma (RORϒ) modulators and their use in the treatment of diseases mediated by RORϒ.
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WO/2014/082889A1 |
Disclosed are compounds of Formula I or pharmaceutically acceptable salts thereof, wherein X1, X2, X3, R1, R2 and R3 are as described in this application, methods for making said compounds as well as methods of using them in the treatmen...
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WO/2014/084407A1 |
The present invention provides a compound having an excellent efficacy for controlling weeds. A dihydropyrone compound of formula (I): wherein m is 1, 2 or 3; n is an integer of any one of 1 to 5; X represents O, S, S(O) or S(O)2; R1 rep...
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WO/2014/079803A1 |
The present invention relates to compounds of formula (la) or (lb) or pharmaceutically acceptable salts thereof for use in the treatment or prevention of hairloss, formula (Ia), (Ib) wherein Ra, Rb, Rc, Rd, Y1, Y2, Y3, Y4, Y5, Z, R1, R2,...
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WO/2014/074675A1 |
Compounds having the following formula (I) or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R2 is a monocyclic heteroaryl group, and R1, R3, R4, R5 and R6 are as defined herein, are useful as kinase modulators, in...
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WO/2014/071044A1 |
The invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R', R1 through R7 and Ar are as defined herein. These compounds are useful as inhibitors of phosphodiesterase 10 (PDE10A) which are ...
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WO/2014/065209A1 |
Provided are: a pyridine compound or a salt thereof that has excellent insecticidal activity and/or acaricidal activity, is highly safe, and can be synthesized industrially advantageously; and a pest control agent including the same as a...
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WO/2014/064149A1 |
There are provided substituted 4-carboxamido-isoindolinone derivatives which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of this invention are...
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WO/2014/062732A1 |
The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutic...
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WO/2014/061764A1 |
A compound having an exceptional blood-sugar-reducing effect and represented by general formula (I), and a pharmaceutically acceptable salt thereof. In the formula, X is =C(R8)-, -CH(R8)-, =N-, or -O-; Y is =C(R9)-, -CH(R9)-, or =N-; Z i...
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WO/2014/058037A1 |
The present invention provides a compound having an excellent efficacy for controlling weeds. A pyrone compound of formula (I): wherein m is 1, 2 or 3; n is an integer of any one of 1 to 5; X represents O, S, S(O) or S(O)2; R1 represents...
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WO/2014/058078A1 |
Disclosed is a process for preparing dihydro-2H-pyran derivatives of formula I: wherein R1 and R2 are defined herein. The process of the invention provides the compound of formula I in concise cascade reactions and in one pot. The compou...
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WO/2014/056938A1 |
The present invention relates to pyrrolidinone derivatives of formula (I). The pyrrolidinone derivatives of formula (I) are GPR119 modulators and useful for the prevention and/or treatment of diabetes, obesity, dyslipidemia and related d...
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WO/2014/049488A1 |
This invention relates to compounds of general formula (I), in which R1, R2, R6, U, V, W, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, pharmaceutical compositions containing such compounds and salt...
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WO/2014/050894A1 |
The present invention provides the compound represented by formula (1) (in the formula: X1 and X2 each independently represent -OR1, -NR2R3, -CR4R5R6, or the like; R1, R2, R3, R4, R5, and R6 each independently represent a glycosyl group ...
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WO/2014/044757A1 |
The present invention relates to cationic triphenylamines derivatives compounds having a common structure presenting the following general formula (I) activable by visible and infra-red light for inducing and imaging apoptosis in cancer ...
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WO/2014/044488A2 |
The invention relates to ester and ester mixtures with at least one epoxide ring and at least one carbonate group on the acid chain. The invention also relates to a method for producing said type of ester and to the use of the ester as a...
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WO/2014/037327A1 |
The present invention relates to compounds of general formula (I), wherein R1, LP, LQ, (Het)Ar, m and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR1 19 receptor and...
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WO/2014/031784A1 |
Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating...
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WO/2014/030822A1 |
Provided are a compound for an organic optoelectronic element represented by chemical formula 1, an organic light-emitting element comprising same and a display device comprising the organic light-emitting element. The structure of chemi...
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WO/2014/029193A1 |
Provided herein are dihydropyrimidine compounds and their pharmaceutical applications, especially for use in treating and preventing HBV diseases. Specifically,provided herein are compounds having Formula (I) or (Ia), or an enantiomer,...
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WO/2014/028669A1 |
The present invention relates to aryl sulfones and related compounds that are modulators of ROR-gamma receptors. The invention also provides pharmaceutical compositions comprising these modulators, and methods of modulating ROR-gamma rec...
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WO/2014/020105A1 |
The present invention relates to compounds of the following general formula (I), or to a pharmaceutically acceptable salt thereof, as well as to the uses thereof as a drug, in particular for treating cancerous or precancerous hyperprolif...
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WO/2014/020101A1 |
The present invention relates to compounds of the following general formula (I), or to a pharmaceutically acceptable salt thereof, as well as to the uses thereof as a drug, in particular in the treatment of cancerous or precancerous hype...
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WO/2014/010737A1 |
Provided is a novel pest control agent, particularly a fungicide and nematicide. An oxime-substituted amide compound represented by formula (I) [where G1 represents a structure represented by G1-1 or the like; G2 represents a structure r...
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WO/2014/010823A1 |
The present specification provides a novel compound which can significantly lengthen the life span and improve efficacy, electrochemical stability, and thermal stability of an organic heterocyclic element, and an organic heterocyclic ele...
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WO/2014/008992A1 |
The present invention provides compounds of Formula (I) for the treatment of cancer, rheumatoid arthritis and other diseases (I).
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WO/2014/010824A1 |
The present specification provides a novel compound which can significantly lengthen the life span and improve efficacy, electrochemical stability, and thermal stability of an organic heterocyclic element, and an organic heterocyclic ele...
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WO/2014/008197A1 |
Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a f...
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WO/2014/002105A1 |
The present invention relates to compounds of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use ...
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WO/2014/004064A1 |
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, wherein L is C(R12a)R12b-C(R13a)R13b-, wherein the carbon atom bonded to R12a and R12b is also bonded to the carboxamide nitrogen atom in For...
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WO/2013/189237A1 |
Disclosed are a novel andrographolide derivative and analogue as well as a preparation method of the novel andrographolide derivative and analogue and an application to the treatment, the prevention and the relief on human viruses and ne...
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WO/2013/192352A1 |
The invention provides compounds of formula la, lb and Ic: [Formula Ia, Ib, and Ic] and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of ma...
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WO/2013/188381A1 |
The present invention provides for compounds of formula (I) Wherein J is a group of formula lla or llb: A', A2, A3, A4, J, and X 3have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof...
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WO/2013/188253A1 |
An improved, high yielding process is disclosed for making bisglycidyl ether derivatives of isosorbide, isomannide and/or isoidide, wherein up to quantitative yields overall are demonstrated. In another related aspect, a process is discl...
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WO/2013/182263A1 |
The invention relates to specific phenanthrenes, the use of the compound in an electronic device, and an electronic device containing at least one of said compounds. The invention further relates to a method for producing the compound an...
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WO/2013/180375A1 |
The present invention relates to: a composition and a cured article comprising inorganic particles together with an alkoxysilyl-based epoxy compound which does not require a separate silane coupling agent and exhibits outstanding heat re...
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WO/2013/177243A1 |
A process for making the compound of Formula I utilizes the starting compound, together with sulfilimine and sulfoxide process steps later on.
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WO/2013/175388A1 |
The present invention provides a compound of formula (A): I as described herein, and pharmaceutically acceptable salts, enantiomers, rotamers, tautomers, or racemates thereof. Also provided are methods of treating a disease or condition ...
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WO/2013/174485A1 |
The present invention relates to compounds of formula 1 that are useful as an active ingredient of a medicament for preventive and/or therapeutic treatment of diseases caused by abnormal activation of CXCR3 chemokines. The invention rela...
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WO/2013/171092A1 |
The present invention relates to novel strigolactam derivatives, to processes and intermediates for preparing them, to plant growth regulator compositions comprising them and to methods of using them for controlling the growth of plants ...
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WO/2013/171641A1 |
The present invention relates to compounds of formula I: in which Y, Y1, Y 4, Y5, Y 6, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention furth...
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WO/2013/170155A2 |
The invention provides methods of purifying and quantifying procyanidin oligomers from cocoa-containing sources. The methods advantageously provide ways to isolate commercially useful quantities of a range of procyanidin oligomers.
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WO/2013/164321A1 |
Pyrazole compounds that are modulators of LRRK2, methods of making the compounds, and methods for using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
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WO/2013/163835A1 |
A (E)-1-[8-(5-methoxyl-2, 2-dimethyl-2H-benzopyranyl)]-3-(4-methoxyphenyl) -2-propylene-1-ketone as represented by formula I and derivatives thereof, as well as preparation method and uses thereof, the compounds having a tumor inhibition...
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WO/2013/163262A1 |
The invention provides compounds of formula (I) wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of replication of the hepatitis C virus. The invention also provid...
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WO/2013/162757A1 |
The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as CDM-Hs, function through orthogonal pathways, by inhibiting the gp120-CD4...
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