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Matches 1,101 - 1,150 out of 12,335

Document Document Title
WO/2010/026153A1
Compounds of structural formula (I): and pharmaceutically acceptable salts thereof; wherein R1; R2; R3;Q1and Q2 are as defined herein, processes for their preparation; pharmaceutical compositions containing them and their use in medicine...  
WO/2010/026439A1
Single enantionmers of compounds of formula (B), in either the cis or trans configuration, (B) wherein R1 and R2 are as defined herein, can be separated from enantiomeric mixtures thereof by reacting the compound with an acid to produce ...  
WO/2010/025584A1
DNA molecule for expressing hairpin RNA, the constructing method and the use thereof are provided. The DNA molecule is a closed circular single-stranded DNA molecule which is constructed by linking four fragments A,B,C and D as following...  
WO/2010/023457A1
The invention provides compounds that comprise a 4'-thio nucleoside that is a derivative of 4'-thiothymidine or 4'-thio-2'-deoxyuridine comprising a positron or single photon emitting radioisotope or corresponding non-radioactive isotope...  
WO/2010/021897A1
The instant invention provides for novel nucleosidic phosphoramidite crystalline material and crystallization processes for purifying the same, useful for the synthesis of oligonucleotides.  
WO/2010/021344A1
Disclosed is a method for preparing a nuclease-resistant nucleic acid, which comprises the steps of mixing a nucleic acid composed of at least three nucleotides, a terminal deoxynucleotide transferase and a 2’,4’-crosslinked nucleosi...  
WO/2010/015637A1
This invention relates to novel compounds that have various medicinal applications, e.g. for the treatment and/or prevention of viral infections.  
WO/2010/017547A1
A process of synthesizing a 5-azacytosine nucleoside, such as azacitidine and decitabine, comprises coupling a silylated 5-azacytosine with a protected D-ribofuranose of formula in the presence of a sulfonic acid catalyst.  
WO/2010/017374A1
The present invention provides a processes for preparing 5 -Azacytidine, and intermediates thereof, said process Comprising reacting a silylated 5-azacytosine of the formula (II), a sugar moiety having of the formula (III): and a protic ...  
WO/2010/015643A1
This invention relates to novel compounds that have various medicinal applications, e.g. for the treatment and/or prevention of viral infections. wherein: X is CH or CR6; R1 is halogen, NR7R8 or OR9; R2 is H, halogen, or NR7R8; R3 is H, ...  
WO/2010/015245A1
The invention relates to a method for producing phosphate-bridged nucleoside conjugates. According to the method, a nucleophile is first dissolved in a non-aqueous solvent and dried, and a cyclosaligenyl phosphate compound is subsequentl...  
WO/2010/013442A1
Disclosed are: a method for producing a long-chain light-responsive modified nucleic acid without the need of employing any DNA synthesizer; and a light-responsive artificial nucleotide molecule for use in the method. Specifically disclo...  
WO/2010/014134A1
Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alon...  
WO/2010/010966A1
Disclosed are: a novel nucleoside triphosphate derivative; a nucleic acid probe; a multilabeled nucleic acid probe which enables the detection of a target nucleic acid conveniently and with high sensitivity; a method for producing the mu...  
WO/2010/011312A1
This invention provides methods of derivatizing a double-stranded DNA comprising contacting double-stranded DNA with a CpG methyltransf erase and an s-adenosylmethionine analog. This invention also provides methods of sequencing DNA to d...  
WO/2009/098404A8
The invention relates to a method for preparing nanoparticles based on functional amphiphilic molecules or macromolecules, optionally in the presence of at least one colipide, enabling the encapsulation of therapeutic agents, especially ...  
WO/2009/115927A3
The present invention comprises compounds useful as antiviral or antitumor agents. The compounds comprise nucleotide analogues that comprise tetrahydrofuranyl or tetrahydrothienyl moeities with quaternary centers at the 3' position. The ...  
WO/2010/005986A1
The invention is related to salts of anti-viral compounds, compositions containing such salts, and therapeutic methods that include the administration of such salts, as well as to processes and intermediates useful for preparing such salts.  
WO/2010/003540A2
The present invention relates to an in-vitro method for the formation of megamitochondria in cells, wherein the cells are grown in a suitable fermentation medium acidulated with lactic acid to pH values between 5.3 and 6.7. The invention...  
WO/2009/135455A3
The invention relates to methods for producing gemcitabine derivatives of the general formula 6, or gemcitabine hydrochloride 7 (2'-desoxy-2',2'-difluorocytidine hydrochloride), to the silylated cytosine analogs 4c and 4d as intermediate...  
WO/2010/002877A2
The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.  
WO/2010/000459A1
Compounds of formula I: wherein: R2 is hydrogen or C1-C4alkyl; R3 and R4 are hydrogen, -C(=O)R5, or -C(=O)CHR6-NH2; or R3 is hydrogen and R4 is a monophosphate-, diphosphate-, or triphosphate ester; or R3 is hydrogen, -C(=O)CHR5, or -C(=...  
WO/2009/105077A3
A novel and efficient single pot synthetic schemes are disclosed for preparing modified nucleotides, nucleotide analogs, nucleotide polyphosphates, and nucleotide polyphosphate analogs. The novel method is used to prepare nucleotides, nu...  
WO/2008/154639A3
The current invention provides methods (e.g., large-scale processes) for the production of nucleotide sugars, which are modified with a polymeric modifying group, such as poly(alkylene oxide) moieties (e.g., poly(ethylene glycol) or poly...  
WO/2009/154276A1
Disclosed is a process for producing a spiroketal derivative through a compound represented by formula (VI) [wherein the variable groups and the variable numbers are as defined in the description] which can be produced from a dihalobenzy...  
WO/2009/069095A3
Compounds having the formula (I) or (II) wherein R1, R2, B, and V are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replic...  
WO/2009/152421A1
The present application provides several crystalline forms of gemcitabine base and methods of making the same.  
WO/2009/151921A1
Provided herein are methods and compositions for nucleic acid amplification. These methods involve the use of 3'-substituted nucleoside 5'-triphosphates or 3'-substituted terminated primers in nucleic acid amplification reactions. In cer...  
WO/2009/152353A2
The present invention relates generally to labeled and unlabled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention relates in part to nucleotides and nucleosides ...  
WO/2009/152431A1
The invention provides P2Y1 receptor antagonists of Formula (I); wherein R1-R3 are as defined in the specification, pharmaceutical compositions comprising the same, and the use of such antagonists in the treatment of a disease or conditi...  
WO/2009/144418A1
The invention relates to a method for the chemical synthesis of RNA, comprising the following steps: a) bonding to a solid support of a monomer having formula (II) in which - X1 is a dimethoxytrityl group, - X6 is H or an OAc group or OX...  
WO/2009/143519A2
This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial ischemia; (b) determining in the sample the am...  
WO/2009/116044A3
The present invention relates to a novel class of guanine nucleotide analogs of formula (I) which inhibit Re1A and Relseq synthetic activity and which possess anti -bacterial activity. The present invention also relates to pharmaceutical...  
WO/2009/074253A3
The subject of the present invention are specific phospholipidesters of clofarabine and the use of such lipidesters in the treatment of tumors.  
WO/2009/139719A1
The present invention relates to novel synthesis routes for preparation of thiodigalactosides of the general formula (12). The method comprises the use of a 3-azido-galactosyl thiouronium salt derivative, which is activated to the corres...  
WO/2009/120878A3
One aspect of the present invention relates to modified nucleosides and oligonucleotides comprising such modified nucleosides. Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method...  
WO/2009/139856A1
Vesicles for use in biosensors that have both high specificity and high sensitivity, where the vesicles include a receptor specific for the intended analyte and a signal generating component.  
WO/2009/136162A1
The present invention relates to a process for preparing a compound of formula (682-6'), said process comprising the steps of: formula (682-4), (682-5), (682-6'): (i) converting a compound of formula (682-4) into a compound of formula (6...  
WO/2009/098404A3
The invention relates to a method for preparing nanoparticles based on functional amphiphilic molecules or macromolecules, optionally in the presence of at least one colipide, enabling the encapsulation of therapeutic agents, especially ...  
WO/2009/135455A2
The invention relates to methods for producing gemcitabine derivatives of the general formula 6, or gemcitabine hydrochloride 7 (2'-desoxy-2',2'-difluorocytidine hydrochloride), to the silylated cytosine analogs 4c and 4d as intermediate...  
WO/2009/136158A1
The present invention relates to a process for preparing a compound of formula 682-4, said process comprising the steps of: (i) converting a compound of formula 682-1 into a compound of formula 682-2'; (ii) converting said compound of fo...  
WO/2009/073506A3
This application provides compositions or compounds as disclosed herein that are suitable for treating hepatic viral diseases, such as hepatitis C (HCV).  
WO/2009/135035A1
Kit and method for measuring potassium ions using the NAD(P)H analogs Ac-NAD(P)H, thio-NAD(P)H, and Ald-NAD(P)H. The analogs allow liquid stable enzymatic potassium reagents to be prepared which have greatly extended stabilities in aqueo...  
WO/2009/133147A1
The present invention relates to novel compounds of formula (A): in the form of a free base or of an addition salt with an acid. The invention also relates to process of preparation of compounds of formula (A), to composition comprising ...  
WO/2009/134469A1
Nucleotide analogs that can sustain the enzymatic synthesis of double-stranded nucleic acid from a nucleic template are described. The nucleotide analogs include: (i) a base selected from the group consisting of adenine, guanine, cytosin...  
WO/2009/132135A1
Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the I ' position of ...  
WO/2009/132123A1
Provided are imidazol [1,5-f] [1,2.4]triazinyl, imidazol [1,2,4]triazinyl, and [1,2,4] triazolo [4,3-f] [1,2,4] triazinyl nucleosides of formula I nucleoside phosphates and prodrugs thereof. The compounds, compositions, and methods provi...  
WO/2009/102820A3
The invention relates generally to functionalized sugars and methods of making and using such sugars. The novel sugars described herein are used as substrates to make glyco conjugates with therapeutic and diagnostic applications.  
WO/2009/125841A1
Disclosed is a process for producing 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, which is a compound useful as a pharmaceutical agent, with high efficiency and in an industrially advantageous manner. Specifically disclosed is a process...  
WO/2009/125042A1
Glycosylated indolecarbazoles, method for obtaining same and uses thereof. This invention relates to rebeccamycin and staurosporine derivatives obtained by means of fermentation of recombinant bacterial strains. The invention also relate...  

Matches 1,101 - 1,150 out of 12,335