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Matches 101 - 150 out of 1,313

Document Document Title
WO/2003/015793A1
The invention relates to the controlled release of preparations of therapeutic agents, for example a steroid; formulations comprising said preparations; and the use of said formulations to treat diseases such as those diseases which woul...  
WO/2003/014141A1
17$g(a),21-Dihydroxypregna-4,9-diene-3,20-dione and 17$g(a),21-dihydroxypregna-4-ene-3,20-dione 17 and/or 21 esters of having remarkable antiandrogenic activity, and the processes for the preparation thereof.  
WO/2003/010181A1
The invention relates to 6$g(a)-fluoropregnanes (I), wherein: the line of points between positions 1 and 2 represents a single or double bond; R¿1? denotes OH, OCOR¿2?, X, SO¿3?R¿3? or a (R¿7?)(R¿8?)(R¿9?)SiO-group, wherein X is h...  
WO/2003/000696A1
The present invention relates to pharmaceutical compositions and methods using such compositions for the treatment of inflammatory disease. Such compositions contain a catalyst for the dismutation of superoxide, including superoxide dism...  
WO/2002/102827A1
The present invention is a novel process for the transformation of 11$g(b), 17$g(a) dihydroxy-6$g(a)-methylpregna-1,4-diene-3,20-dione 17-acetate (III), to 11$g(b), 17$g(a),21-trihydroxy-6$g(a)-methylpregna-1,4-diene-3,20-dio ne 21-aceta...  
WO/2002/102826A1
The present invention is a novel process for the transformation of 17$g(a)-hydroxy-6$g(a)-methylpregn-4-ene-3,20-dione 17-acetate (Formula (I)) to 11$g(b),17$g(a),21-trihydroxy-6$g(a)-methylpregna-1,4-diene- 3,20-dione 21-acetate (Formul...  
WO/2002/100437A2
Ophthalmic compositions comprising an ophthalmic drug, e.g. ketotifen, and a linear polysaccharide compound, e.g. a hyaluronic acid compound, are useful for topical once-a-day administration to the eye.  
WO/2002/100878A1
A process for preparing flumethasone (6a,9a-diffluoro-11$g(b),17a,21-trihydroxy-16a-methyl-pregna -1,4-diene-3,20-dione), fulmethasone 21-acetate or its 17-carboxyl androsten analogue which process comprises reacting a compound of formul...  
WO/2002/094758A1
The present invention provides methods of making 21-[4'-(nitrooxyalkyl)benzoate] corticosteroid derivatives according to the following general reaction scheme. The invention also provides intermediates useful in making such 21-[4'-(nitro...  
WO/2002/089814A1
17-Methylene-androstan-3α-ol analogs are useful as corticotropin releasing hormone (CRH) inhibitors, and especially as anti-depressants, when administered to the vomeronasal organ. An improved synthesis of 17-methyleneandrost-4-en-3α-o...  
WO2002051385A8
The invention relates to solid dispersions of nitrate active principles in at least one polymer chosen from the group consisting of polyvinyl pyrrolidone, cellulose derivatives or polyethylene glycol, their production processes and pharm...  
WO2002053577A3
The present invention relates to novel steroid derivatives that ace on the gamma-aminobutyric acid receptor-chloride ionophore (GR) complex as well as methods for making the same and their applications to induce anesthesia, in the treatm...  
WO2002036106A3
The invention relates to novel medicament compositions based on anticholinergics and corticosteroids, a method for the production thereof and the use thereof for treating respiratory conditions.  
WO2002041925B1
A method of sterilising a pharmaceutical composition containing a suspension of a pharmaceutical comprises rapidly heating the pharmaceutical composition from ambient temperature to an elevated temperature, maintaining it at or above the...  
WO/2002/058634A2
The present invention relates to analogs of estradiol, which, in their most preferred embodiment, act as locally active estrogens without significant systemic action. A series of 16$g(a)-carboxylic acid substituted steroids sand their es...  
WO/2002/053577A2
The present invention relates to novel steroid derivatives that ace on the gamma-aminobutyric acid receptor-chloride ionophore (GR) complex as well as methods for making the same and their applications to induce anesthesia, in the treatm...  
WO/2002/051385A1
The invention relates to solid dispersions of nitrate active principles in at least one polymer chosen from the group consisting of polyvinyl pyrrolidone, cellulose derivatives or polyethylene glycol, their production processes and pharm...  
WO/2002/051422A1
Preventives and/or remedies for inflammatory airway diseases which contain as the active ingredient steroid derivatives represented by the following general formula (1): (1) wherein R represents hydrogen, halogeno, hydroxy or -OCOR?1¿ (...  
WO2001072293A3
The present invention features methods of inhibiting progestin activity in a cell or in a subject in need of such inhibition, and methods of treating or preventing progestin-dependent conditions in a subject in need of such treatment or ...  
WO2002007683B1
The present invention relates to a composition comprising a) at least one antimycotic agent and b) at least one film forming agent wherein component b) is a derivative of chitosan selected from hydroxyalkylchitosans and carboxyalkylchito...  
WO/2002/041925A1
A method of sterilising a pharmaceutical composition containing a suspension of a pharmaceutical comprises rapidly heating the pharmaceutical composition from ambient temperature to an elevated temperature, maintaining it at or above the...  
WO/2002/036606A1
This invention is directed to a method for treating an inflammatory condition, treating haematological and other malignancies, causing immunosuppression, or preventing or treating transplant rejection in man or other animals which compri...  
WO/2002/036106A2
The invention relates to novel medicament compositions based on anticholinergics and corticosteroids, a method for the production thereof and the use thereof for treating respiratory conditions.  
WO2001074840A3
The present invention relates, inter alia, to compounds having the general formula (I) in which: R<1> is a member selected from the group consisting of -OCH3 -SCH3, -N(CH3)2, -NHCH3, -NC4H8, -NC5H10, -NC4H8O, -CHO, -CH(OH)CH3, -C(O)CH3, ...  
WO2001040253A3
The invention concerns a 3-methylene steroid derivative having general formula (1) wherein R<1> is H or together with R<3> forms a beta -epoxide or R<1> is absent if there is a 5-10 or 4-5 double bond; R<2> is (C1-C5)alkyl or CF3; R<3> i...  
WO2001058919A3
Syntheses of steroids such as 3-hydroxy-7 alpha -methyl-21-[2'-methoxy-4'-(diethylaminomethyl)-phenoxy]-19-n orpregna-1,3,5(10)triene citrate ("SR 16234") and analogs thereof are provided, wherein 21-hydroxy-19-norpregna-4-en-3-one serve...  
WO/2002/024206A1
A unit dose formulation comprises less than 2.5 mg of prednisolone or an equivalent, equipotent amount of another corticosteroid. Once daily administration of the unit dose formulation between midnight and 6 a.m. for the treatment of rhe...  
WO/2002/020552A1
A process for the preparation of pregnane derivatives which comprises reacting a compound (I) with an alkali metal or an alkaline earth metal in the presence of ammonia or an amine to obtain a compound (II), protecting the hydroxyl group...  
WO/2002/007683A1
The present invention relates to a composition comprising a) at least one antimycotic agent and b) at least one film forming agent wherein component b) is a derivative of chitosan selected from hydroxyalkylchitosans and carboxyalkylchito...  
WO/2002/008243A1
The present invention relates inter alia to a novel oxidation process for the synthesis of a known intermediate, useful in the preparation of anti-inflammatory steroids, the known intermediate being of formula (I).  
WO2001058919A9
Syntheses of steroids such as 3-hydroxy-7 alpha -methyl-21-[2'-methoxy-4'-(diethylaminomethyl)-phenoxy]-19-n orpregna-1,3,5(10)triene citrate ("SR 16234") and analogs thereof are provided, wherein 21-hydroxy-19-norpregna-4-en-3-one serve...  
WO/2001/098322A1
The present invention comprises the design, synthesis and development of a new class of chemotherapeutic agents for prophylactic and therapeutic treatments in a mammal, particularly a human, believed to be at risk of suffering from a hor...  
WO/2001/096293A1
Provided are vitamin D derivatives which exhibit excellent physiologic activities suitable for drugs, particularly remedies for dermatoses such as psoriasis, and are lowered in the calcium increasing activity. The derivatives are represe...  
WO/2001/087923A1
Synovial CRH functions in a paracrine manner to induce the nuclear transcription factor NURR1, which is abundantly expressed in the inflammatory cells of both rheumatoid arthritis and psoriatic arthritis synovium. This induction is suppr...  
WO/2001/074840A2
The present invention relates, $i(inter alia), to compounds having the general formula (I) in which: R?1¿ is a member selected from the group consisting of -OCH¿3? -SCH¿3?, -N(CH¿3?)¿2?, -NHCH¿3?, -NC¿4?H¿8?, -NC¿5?H¿10?, -NC¿...  
WO/2001/072293A2
The present invention features methods of inhibiting progestin activity in a cell or in a subject in need of such inhibition, and methods of treating or preventing progestin-dependent conditions in a subject in need of such treatment or ...  
WO2001022959A3
The present invention provides methods for treating inflammatory conditions, including but not limited to, inflammatory bowel disease (ulcerative colitis, Crohn's disease, and proctitis), other noninfectious, inflammatory conditions of t...  
WO/2001/058919A2
Syntheses of steroids such as 3-hydroxy-7$g(a)-methyl-21-[2'-methoxy-4'-(diethylaminomethy l)-phenoxy]-19-norpregna-1,3,5(10)triene citrate ('SR 16234') and analogs thereof are provided, wherein 21-hydroxy-19-norpregna-4-en-3-one serves ...  
WO/2001/040253A2
The invention concerns a 3-methylene steroid derivative having general formula (1) wherein R?1¿ is H or together with R?3¿ forms a $g(b)-epoxide or R?1¿ is absent if there is a 5-10 or 4-5 double bond; R?2¿ is (C¿1?-C¿5?)alkyl or C...  
WO/2001/022959A2
The present invention provides methods for treating inflammatory conditions, including but not limited to, inflammatory bowel disease (ulcerative colitis, Crohn's disease, and proctitis), other noninfectious, inflammatory conditions of t...  
WO1999046279A3
Novel methods of medical treatment and/or inhibition of development of diseases are disclosed for diseases that are sensitive to androgenic or estrogenic activity. The treatments utilize inhibitors of type 5 and/or type 3 17 beta -hydrox...  
WO/2000/062735A2
The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumor...  
WO/2000/063229A1
Novel steroid derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, useful as anti-inflammatory agents wherein R¿1? is a corticosteroid bonded through an ester linkage formed from the alcoholic hy...  
WO2000029088A3
The present invention provides, in one aspect, a novel method for recovering an organic solute from a predominantly aqueous solution. In one embodiment, the solution is contacted with a dry, non-conditioned sorbent medium held by a suppo...  
WO/2000/053619A1
The disclosed invention relates to the unexpected finding of steroids for use as androgens which are characterized by a configuration opposite to that of natural steroids, viz. 14$g(a), 17$g(b). These steroids according to the invention ...  
WO/2000/034306A1
The invention is directed to a novel class of 17$g(b)-acyl-17$g(a)-propynyl steroids which exhibit potent antiprogestational activity.  
WO/2000/029088A2
The present invention provides, in one aspect, a novel method for recovering an organic solute from a predominantly aqueous solution. In one embodiment, the solution is contacted with a dry, non-conditioned sorbent medium held by a suppo...  
WO/2000/023460A1
The invention pertains to a process for the preparation of a high purity composition of (7$g(a),17$g(a))- 17-hydroxy- 7-methyl- 19-nor-17-pregn- 5(10)-en-20-yn-3-one. The process provides for a composition with less than 0.5 % of (7$g(a)...  
WO/2000/021977A1
This invention provides 5$g(a)-pregnane-3$g(b), (20S), 21-triol, 20-O-$g(b)-glucuronide and 5$g(a)-pregnane-3$g(b),20R-diol, 20-O-$g(b)-glucuronide and pharmaceutically acceptalbe salts thereof which are useful as progestational agents.  
WO/1999/046279A2
Novel methods of medical treatment and/or inhibition of development of diseases are disclosed for diseases that are sensitive to androgenic or estrogenic activity. The treatments utilize inhibitors of type 5 and/or type 3 17$g(b)-hydroxy...  

Matches 101 - 150 out of 1,313