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WO/2023/215883A1 |
In certain embodiments, the present disclosure provides adhesive compositions and medical graft materials comprising adhesive compositions. In some forms, such adhesive compositions comprise are photocurable and comprise one or more phen...
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WO/2023/215872A1 |
Described are photocurabie liquid adhesives, kits for preparing photocurabie liquid adhesives, and methods for their preparation and use. Kits can include first and second components that can be mixed to prepare a photocurabie liquid adh...
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WO/2023/213385A1 |
The invention relates to novel biocompatible Ta-Nb-Ti alloys, methods for preparing the same, and uses thereof.
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WO/2023/212160A1 |
This disclosure relates to drug releasing implants. In certain embodiments, the implants release drugs from a biodegradable material. In certain embodiments, the implant is a low swelling hydrogel. In certain embodiments, the drug is an ...
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WO/2023/210403A1 |
The present invention provides a method for evaluating the hair regeneration ability of dermal sheath cup (DSC) cells using the expression level of a gene related to smooth muscle differentiation as an indicator. The present invention al...
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WO/2023/210775A1 |
The problem to be solved by the present invention is to provide: an immunoisolation device which can achieve both of the reduction in diffusion distance effective for the improvement in permeability of a substance such as a physiological...
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WO/2023/210609A1 |
The purpose of the present invention is to provide a simple method for producing a cell sheet, wherein the cell sheet produced by the method is easily handled. The present invention provides a method for producing a cell sheet, the metho...
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WO/2023/208607A1 |
A first aspect of invention relates a method for preparing a biodegradable biological tissue, preferably a collagen containing tissue. The (decellularized) biological tissue is first stabilized by a tissue water replacing material and th...
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WO/2023/210765A1 |
The present invention addresses the problem of providing an immunoisolation device: that realizes both a reduction in diffusion distance, which is effective for improving the permeation of physiologically active substance, nutrients, etc...
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WO/2023/209738A1 |
Provided in the present disclosure are biopolymer formulations comprising thiolated gelatin and methacrylated hyaluronic acid. Said formulations are useful for corneal applications, by way of example for treatment of disease of or damage...
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WO/2023/212124A1 |
Biologics, including peptides, proteins, antibodies, nucleic acids (DNA and RNA), oligonucleotides, vaccines, or complex combinations of these substances, are important for treating various types of diseases and tissue and organ regenera...
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WO/2023/206055A1 |
Provided are a modification and the use of silk fibroin. Calcium in silk fibroin or fibroin fibers is partially or completely removed, so as to obtain the modified silk fibroin with a broad-spectrum antioxidant effect. A method for prepa...
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WO/2023/211147A1 |
The present invention relates to a method for preparing an extracellular matrix-induced self-assembly-based 3D printed artificial tissue, and artificial tissue prepared thereby, and provides: a method in which a self-assembly, formed by ...
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WO/2023/210402A1 |
The present invention provides a method for evaluating the hair regeneration ability of dermal sheath cup (DSC) cells using a mitochondrial respiration level as an indicator. The present invention also provides a composition for hair reg...
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WO/2023/212126A1 |
The present invention provides a soft tissue composite. The soft tissue composite comprises a first collagen fiber bundle of a first soft tissue isolated from a first donor and a polymeric material, and the first collagen fiber bundle in...
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WO/2023/211728A1 |
Methods of promoting healing of a wound in a dermal location of a subject are provided. Aspects of the methods may include administering an effective amount of a Piezo inhibitor composition to the wound to promote healing of the wound, e...
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WO/2023/208566A1 |
The present invention, inter alia, relates to a method for preparing a biological material for a medical application comprising exposing the biological material to a first liquid, for example comprising, by at least 10%, a component othe...
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WO/2023/212637A1 |
Systems, methods, and devices include techniques for healing a bone void and/or regenerating a portion of bone by forming an exosome solution with one or more cell-derived exosomes and one or more cellular components. The one or more cel...
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WO/2023/212416A1 |
Disclosed herein are various bioreactor devices that mimic the mammalian joint. The bioreactor device includes a series of bioreactor chambers that contain different components of the joint, such as bone, cartilage, synovium, and ligamen...
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WO/2023/205854A1 |
The present invention relates to biocompatible hydrogels, in particular, biocompatible hydrogels for delivering a cell to a subject, wherein the hydrogel comprising a scaffold and an oxygen carrier.
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WO/2023/211909A1 |
Compositions for local delivery of a drug to an intracranial region, such as brain tissue or a brain tumor. Methods for locally delivering drug or therapy to an intracranial region. Compositions may include a hydrogel in which a chemothe...
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WO/2023/208968A1 |
The present invention relates to a guided bone regeneration device that is intended for the reconstruction of a buccal bone defect and is composed of an optionally micro-perforated smooth wall which is made of titanium and has a shape th...
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WO/2023/204122A1 |
[Problem] The purpose of the present invention is to provide a method for producing a hydroxyl-group- and (meth)acryl-group-containing siloxane at high purity and high yield. [Solution] The present invention provides a method for purifyi...
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WO/2023/205265A1 |
The present disclosure provides improved polymer compositions, such as GelMA polymer compositions. In certain embodiments, the improved polymer compositions can be used for delivering one or more therapeutic agents, such as cells, to a t...
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WO/2023/205051A1 |
Compositions, methods, and applications for single component systems for the formation of in situ hydrogels are described. The single component systems are effective for forming stable, single solutions containing precursors providing bo...
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WO/2023/205370A1 |
Disclosed herein are apparatuses comprising one or more channels defining a luminal space, wherein the luminal space is defined by an inner wall of fibrous basement membrane material, as well as methods of their manufacture and use.
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WO/2023/204434A1 |
According to the present invention, a decellularized tissue supplement is prepared by: a preparation step for preparing tissue of a non-human mammal; a pretreatment step for pretreating the tissue; a first inactivation step for inactivat...
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WO/2023/204424A1 |
The present invention relates to a technology relating to an implant abutment and, more specifically, to an implant abutment absorbing external shock and a manufacturing method thereof, wherein when an implant abutment made of titanium (...
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WO/2023/205141A1 |
Disclosed are compositions and kits useful for bone repair and reconstruction of bone defects such as bone voids and fractures. The compositions can include two reactive components that when mixed together form a polythiourethane that cu...
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WO/2023/205519A1 |
A method for producing a microfluidic device, the method comprising: producing a first housing portion and a second housing portion; securing the second housing portion to the first housing portion; enclosing a three-dimensional biomater...
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WO/2023/204749A1 |
A method of forming a cross-linked hydrogel, comprising to provide a) a polymer composition comprising polymer molecules provided with thiol-containing moieties, wherein the one or more thiol groups of a thiol-containing moiety are prote...
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WO/2023/205163A1 |
Disclosed herein are systems and methods for coating an implant with a therapeutic agent in a sterile clinical setting. The systems and methods disclosed herein can provide for coating implants or other prosthetic components with one or ...
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WO/2023/205127A1 |
In an embodiment, the present disclosure pertains to a multi-network hydrogel composed of a first network, a second network, and a third network. In some embodiments, the first network, the second network, and the third network form a po...
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WO/2023/203235A1 |
Provided is a composite material used for promoting innervation, osteogenesis and angiogenesis.
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WO/2023/204435A1 |
A decellularized mammal-derived tissue matrix according to the present invention is prepared through: a preparation step of preparing tissues of a mammal that excludes humans; a pretreatment step of pre-treating the tissues; a primary in...
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WO/2023/201397A1 |
Disclosed herein is a bioactive polymer for forming a tissue scaffold, the polymer comprising a first monomer for binding water, a second monomer for imparting mechanical properties to the scaffold; optionally, a third monomer for bindin...
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WO/2023/201684A1 |
The present application provides a porous material and a preparation method therefor, a current collector, a secondary battery and a device. The porous material has pores having a first pore diameter and pores having a second pore diamet...
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WO/2023/199586A1 |
An artificial skin (1) comprises a collagen layer (2), which is mainly composed of collagen, and a silicone layer (3), which is mainly composed of silicone and covers one surface of the collagen layer (2). Of the collagen layer (2) and t...
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WO/2023/198555A1 |
There is provided an object, wherein there are particles on the surface of the object, wherein the amount of particles is in the interval 0.041 - 6 μg/cm2, wherein the particles comprise palladium in an amount corresponding to 0.02 - 2 ...
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WO/2023/200847A1 |
Anti-biofilm osseointegrating and/or tissue-integrating implantable biomaterial devices that optionally can elute therapeutic ions such as magnesium, silver, copper and/or zinc. In certain embodiments, the devices are subjected to a surf...
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WO/2023/200731A1 |
A method for 3D printing a patient-specific bone implant having variable density, in various aspects, comprises: (1) providing a thermoplastic polymer composition comprising: (A) between about 20% and about 50% bioactive agent by weight;...
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WO/2023/199814A1 |
The present invention addresses the problem of providing a method for producing an octacalcium phosphate molded article compounded with a biocompatible polymer. Provided is a method for producing an octacalcium phosphate molded article...
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WO/2023/200098A1 |
The present invention relates to an artificial structure for preventing or treating lymphedema and a construction method therefor. According to the artificial structure for preventing or treating lymphedema and the construction method th...
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WO/2023/197881A1 |
The present invention relates to a nanotube capable of promoting selective nerve self-repair. The nanotube comprises a hollow nanotube body and a slidable cover plate. The side wall of the nanotube body is provided with a side wall openi...
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WO/2023/199855A1 |
The purpose of the present invention is to provide: a copolymer that can impart excellent biocompatibility to the surface of a medical device by a simple process and enables the biocompatibility to be kept for a long period of time; a me...
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WO/2023/197248A1 |
The present invention belongs to the technical field of cell biology. Disclosed are a biological agent, use of a QF-1 compound in the preparation of a biological agent for promoting adipogenic differentiation of mesenchymal stem cells an...
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WO/2023/197419A1 |
An injectable hyaluronic acid microsphere, a preparation method therefor and use thereof. The method comprises: adding cross-linked hyaluronic acid into an aqueous solvent to prepare a first liquid phase, the concentration of the cross-l...
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WO/2023/199794A1 |
A cervical stenosis prevention device (1) comprises: a composite thread portion (2) that is formed by twisting a membrane-like dried vitrigel body and includes a thread-like core material; and a fixing part (3) that is used for indwellin...
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WO/2022/159878A9 |
The present disclosure provides compositions and methods related to the delivery of therapeutic medicines to the heart for treating a cardiac injury, such as those that occur due to a myocardial infarction (MI). In particular, the presen...
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WO/2023/196970A1 |
Compositions are disclosed herein that include an extracellular matrix (ECM) hydrogel and matrix bound nanovesicles (MBV). These compositions provide a synergistic effect and are of use for treating subjects.
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