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WO2002030415A9 |
The present invention provides pravastatin sodium substantially free of pravastatin lactone and epiprava, the C-6 epimer of pravastatin. The present invention further provides a novel process for recovering pravastatin sodium from a ferm...
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WO/2002/083713A2 |
This invention relates to an improved process for the minimization of acid-catalyzed reactions of certain echinocandins of the kind disclosed in U.S. Patent No. 5,378,804. The process involves the use of a boronic acid.
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WO/2002/083612A1 |
A process for producing (S)-1-(4-phenoxyphenoxy)-2-propanol having a high optical purity, characterized by reacting a sulfonic ester compound represented by the formula (1): (1) (wherein R?1¿ represents halogeno, nitro, or C¿1-4? alkyl...
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WO/2002/083694A1 |
A method of synthesizing 7-silyl camptothecins and 7-silyl homocamptothecins includes the step of mixing a camptothecin or a homocamptothecin having hydrogen at the C7 position with a silyl radical generator and a silyl radical precursor...
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WO/2002/081475A1 |
The present invention provides novel compounds of formula (I) and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and...
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WO/2002/079136A1 |
A method of forming a cyclopropane having enhanced chirality said method comprising reacting together (1), a symmetrical 1,2-dioxine of the formula (1), wherein X and Y are the same and are groups in which a carbon atom is bonded to the ...
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WO/2002/076997A1 |
Non-chiral and in particular optically active alcohols are produced from a carbonyl compound using hydrogen in the presence of a catalyst, a base and optionally a diamine. The method is advantageous if a catalyst containing both a suppor...
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WO/2002/074050A2 |
The present invention provides methods for the asymmetric synthesis of (S.S.R)-(-)-actinonin and its analogs and the compounds thereby synthesized having a structural formula: where R?1¿ is an optionally substituted or halogenated alkyl...
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WO/2002/072514A1 |
This invention provides methods and catalysts systems for catalyzing enantioselective oxidation reactions, including cyclization reactions and enantioselective oxidation reactions of secondary alcohols and other similarly reactive organi...
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WO/2002/072259A1 |
A support for osmium oxide supporting which comprises an aromatic polyolefin having a group represented by the general formula [1] -A'-O(-A-O)¿n?-R [1] (wherein A represents alkylene; A' represents a bond or alkylene; R represents aryl;...
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WO/2002/072542A2 |
NMDA receptor blockers, including pH-sensitive NMDA receptor blockers, are provided as neuroprotective drugs that are useful in stroke, traumatic brain injury, epilepsy, and other neurologic events that involve acidification of brain or ...
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WO/2002/072531A1 |
An oligolactic acid ester having a specific chain length is produced and isolated as a single compound. It is a compound represented by the general formula (1) or a salt thereof: (1) wherein X represents hydrogen or a hydroxyl-protecting...
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WO/2002/070492A1 |
An asymmetric synthesis of diarylmethylpiperazines is described. The synthetic route enables preparation of a variety of enatiomerically pure amines with different N-alkyl groups. The invention includes an asymmetric addition of organome...
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WO/2002/070441A1 |
Optically active, cyclohexene, cyclohexenone and cyclohexene oxide compounds are provided, which are represented by the general formulae (1) to (4): (1) (2) (3) (4) wherein R is hydrogen or CH¿2?R?2¿ (wherein R?2¿ is hydrogen, or line...
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WO/2002/069909A2 |
This invention encompasses a process for making a compound of Formula A AThese compounds are intermediates useful in the preparation of certain non-steroidal anti-inflammatory agents.
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WO/2002/066410A1 |
A process is provided for the preparation of mandelic acid derivatives. The process comprises the steps of: (a) stereoselectively cyanating a compound of Formula (2) to yield the corresponding cyanohydrin; (b) hydrolysing the product of ...
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WO/2002/066432A1 |
The invention relates to substituted propane-1,3-diamine derivatives of general formula (I), to methods for producing said derivatives, to medicaments and pharmaceutical compositions containing the same, and to the use thereof for produc...
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WO/2002/064643A1 |
A polymer-supported allylsilane compound with high stereoselectivity which comprises a polymer support and an allylsilyl compound fixed thereto and which is represented by the general formula (I) (I) (wherein the part located on the left...
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WO/2002/062809A1 |
A ruthenium complex functioning as a catalyst for heterogeneous catalysis which is represented by (R,RR)-ruthenium complexes of the polymer-bonded type. It is almost equal to ruthenium complexes having a binaphthyl group not bonded to a ...
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WO/2002/060850A1 |
A method of efficiently synthesizing an $g(a)-ketol unsaturated fatty acid having a double bond at the $g(b)-position of the ketone moiety. The method is characterized by reacting a mono-substituted acetylene (2) with an epoxy compound (...
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WO/2002/057278A1 |
A compound of general formula 4 wherein each of W, X, Y and Z is any substituent where a heteroatom is bonded to phosphorus, optionally linked in pairs X/Y and Z/W to form a ring, or W=X=Y=Z=H, is new. Complexes thereof can be used in as...
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WO/2002/055477A1 |
A ruthenium (Ru) compound which is useful as a catalyst for asymmetric hydrogenation; a diamine ligand; and a process for highly stereoselectively producing an optically active alcohol in high yield. The process comprises using a rutheni...
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WO/2002/055195A2 |
Improved hydrogenation catalysts, catalyst formulations and methods employing them. Activity of Ru (II) complexes as hydrogenation catalysts is enhanced by addition of Lewis acid as a cocatalyst, preferably potassium ions or borate ester...
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WO/2002/053517A2 |
An improved method is described for making 9-deoxy-PGF¿1?-type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
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WO/2002/051781A1 |
A process for producing an optically active halohydrin compound, characterized by subjecting an $g(a)-haloketone compound to asymmetric hydrogen transfer reduction in the presence of a Group 9 transition metal compound having an optional...
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WO/2002/048161A1 |
P-chiral bisphospholane ligands and methods for their preparation are described. Use of metal/P-chiral bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is ...
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WO/2002/048162A1 |
The present invention relates to chiral salen catalysts and a process for preparing chiral compounds from racemic epoxides by using them. More particularly, the present invention is to provide a chiral polymeric salen catalyst and its us...
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WO/2002/044111A1 |
A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal hydrocarbyl complex which is coordinated to defined bidentate ligands substituted with at least one group selected from an optionally...
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WO/2002/044161A2 |
A process for the preparation of the compound 13-(N-Boc-$g(b)-isobutylisoserinyl)-14$g(b)-hydroxybaccatine
III 1,14-carbonate.
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WO/2002/043667A2 |
The present invention provides a process for preparing atorvastatin hemi-calcium from an atorvastatin ester derivative with calcium hydroxide. The process is conveniently incorporated into a process for preparing atorvastatin hemi-calciu...
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WO/2002/041984A2 |
Methods and compositions are provided for the direct catalytic asymmetric aldol reaction of aldehydes with donor molecules selected from ketones and nitroalkyl compounds. The reactions employ as catalyst a Group 2A or Group 2B metal comp...
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WO/2002/042258A1 |
N-protected-L-homocysteine disulfide of the formula (I) or an activated form thereof is reacted with (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester to give the disulfide intermediate of the formula (II). The disulfide intermediate ...
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WO/2002/042346A1 |
The invention concerns an optically active polymer obtainable by free radical or anionic polymerisation of an optically active ethylene monomer with epoxide function bearing at least a chiral centre with a copolymerisable ethylene monome...
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WO/2002/040491A1 |
3,3'-substituted chiral biaryl phosphine and phosphinite ligands and metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The metal complexes are useful as catalysts in asymmetric reactions, such as,...
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WO/2002/040492A1 |
The invention concerns novel chiral diphosphines (R) or (S), and their use as optically active ligand for preparing diphosphino-metallic complexes. The invention also concerns the diphosphino-metallic complexes containing said chiral dip...
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WO/2002/040438A1 |
The present invention relates to a process for the preparation of compounds of formula (1), wherein R¿1? is unsubstituted or substituted C¿1?-C¿8?alkyl or a radical of formula -COOR¿3?, wherein R¿3? is hydrogen or unsubstituted or s...
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WO/2002/040573A1 |
Solid-supported optically active binaphthyls, a process for preparing the binaphthyls or intermediates thereof, and an efficient process for preparing asymmetric amino nitriles by using the same. The solid-supported optionally active bin...
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WO/2002/040493A1 |
The invention concerns asymmetric metal complexes based on a transition metal and comprising as ligand of said metal at least an optically active form of a compound of general formula (I). The invention also concerns the preparation and ...
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WO/2002/038544A2 |
The present invention relates to a $g(b);3 adrenergic receptor agonist of formula I: (I);or a pharmaceutical salt thereof; which is useful for treating Type II diabetes and/or obesity.
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WO/2002/038535A1 |
Optically active cobalt (II) complexes represented by the general formulae (1) and (1'): (1) (1') wherein R?1¿ and R?2¿ are each independently hydrogen, linear or branched alkyl, linear or branched alkenyl, aryl, acyl, alkoxycarbonyl, ...
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WO/2002/038543A2 |
The present invention relates to a Beta 3 adrenergic receptor agonist of formula (I) or a pharmaceutical salt thereof; which is useful for treating Type II diabetes and/or obesity.
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WO/2002/038565A2 |
The invention relates to 7-(R) aminotriazolopyrimidines of formula (I), in which the substituents and index have the following definitions: R?1¿ represents hydrogen or methyl; R?2¿ represents methyl; R?3¿ represents C¿2?-C¿10? alkyl...
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WO/2002/036594A1 |
The present invention relates to a cost effective and commercially viable process for the preparation of crystalline N-formimidoyl thienamycin monohydrate (Imipenem monohydrate) of Formula I.
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WO/2002/030919A1 |
Process for the synthesis of R(+)$g(a)-lipoic acid comprising the following stages: a) Salifying of racemic 6,8-halo-octanoic acid with S(-)$g(a)-methylbenzylamine; b) separation by filtration of the crystallized diastereoisomeric salt o...
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WO/2002/030356A2 |
The present invention relates to methods for use in producing epothilones and analogs and derivatives thereof. A general method according to the present invention broadly comprises performing an aldol condensation of a first compound wit...
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WO/2002/028840A1 |
A novel process is provided for the preparation of chiral intermediates useful in the asymmetric syntheses of $g(a)v$g(b)3 integrin receptor antagonists. Also provided are the enantiomerically enriched intermediates that are obtained fro...
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WO/2002/026695A2 |
Disclosed are processes for the preparation of enantiomerically-enriched cyclopropylalanine derivatives by the hydrogenation of certain enamides in the presence of a catalyst comprising a transition metal and a substantially enantiomeric...
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WO/2002/024671A1 |
The invention concerns a process for the production of optically active epoxides useful as pharmaceutical intermediates, particularly in the field of HIV protease inhibitors. The optically active epoxides are produced in commercially acc...
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WO/2002/024705A1 |
A process for preparing (1R,3S)-3-(9-chloro-3-methyl-4-oxo-5H-(isoxazoloquinolin-5-y
l))cyclohexanecarboxylic acid and esters thereof, as represented by formulas II and III, wherein R is a lower alkyl groups, and A and B are N or O, prov...
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WO/2002/022569A1 |
The invention relates to a method for producing chiral compounds according to the condition of a 1.4 Michael reaction in addition to a compound of general formula (31) and the use thereof as an antalgic.
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