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WO/2000/036134A1 |
The invention relates to a method for the enantioselective reduction of 3,5-dioxocarboxylic acid derivatives and their syntheses. According to the invention, compounds of formula (4) are reacted with an alcohol dehydrogenase which prefer...
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WO/2000/031064A1 |
Disclosed is a process for preparing a compound of formula (I) wherein X?1¿, X?2¿, X?3¿, X?4¿ and X?5¿ are independently selected from the group consisting of H, halo, alkyl, alkoxy, aryl, and aryloxy, and R is a protecting group, i...
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WO/2000/031016A1 |
A process for producing an ester comprises the steps of: (a) feeding to a first vessel a feed that comprises organic acid, alcohol, and water, whereby organic acid and alcohol react to form monomeric ester and water, and whereby a first ...
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WO/2000/031010A2 |
The invention relates to methods for producing chiral aldehydes by the enantioselective hydroformylation of prochiral substrates using a catalyst comprised of a transition metal and of a chiral ligand. The invention is characterized in t...
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WO/2000/031003A1 |
A process for preparing a fluoride from its corresponding alcohol comprises the steps of (a) forming a mixture comprising (i) at least one fluorinated, saturated aliphatic or alicyclic sulfonyl fluoride (for example, perfluorobutanesulfo...
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WO/2000/029371A1 |
The present invention relates to compounds of formula (a) in which R?1¿ is defined in the specification, and non-toxic metabolically labile esters and amides thereof are useful as modulators of metabotropic glutamate receptor function.
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WO/2000/029370A1 |
The present invention describes a process for the industrial production of L-carnitine, comprising the enantioselective reduction of an alkyl 4-chloro-3-oxobutyrate or 4-chloro-3-oxobutyramide. The optically active 3-hydroxy derivative t...
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WO/2000/027786A1 |
A process for preparing an alkyl phenylglycolic acid is disclosed. It follows the sequence of condensing a substituted acetaldehyde with mandelic acid to provide a 5-phenyl-1,3-dioxolan-4-one, which is condensed with an alkyl ketone or a...
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WO/2000/027855A1 |
An enantiomerically enriched compound of formula (4) or the opposite enantiomer thereof, wherein R is C¿1-10? alkyl. This compound, in the form of a transition metal complex, is useful as a catalyst for stereoselective hydrogenation.
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WO/2000/027799A1 |
New esters derived from substituted phenyl-cyclohexyl compounds, derived from tramadol, process for obtaining such esters and use of said compounds for the fabrication of a medicament having analgesic properties. These new products havin...
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WO/2000/026220A1 |
A non-symmetrical diphosphine of the formula R?1¿R?2¿P-(Z)-PR?3¿R?4¿ wherein Z represents a chain of 2 to 4 carbon atoms which may be substituted, which chain may be saturated or unsaturated, and R?1¿, R?2¿, R?3¿ and R?4¿, which ...
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WO/2000/024919A1 |
The invention described herein relates to coenzymes useful for the synthesis of L-carnitine, particularly a compound of coenzyme A, and more particularly gamma-butyrobetainyl-coenzyme A and crotonobetainyl-coenzyme A, to procedures for t...
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WO/2000/024510A1 |
Functionalized amine derivatives are prepared by reacting an amine, a carbonyl derivative, and an organoboron compound under mild conditions. Organoboronic acids (4) react with amines (2) and alpha-hydroxy aldehydes (3) to give $i(anti)-...
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WO/2000/021910A2 |
Compounds of Formula (I), wherein the substituents are as described in the specification or pharmaceutically acceptable salts or stereochemically isomeric forms thereof, useful for treating diseases related to calcium imbalance and metab...
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WO/2000/018708A1 |
A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal neutral hydrocarbyl complex which is coordinated to defined bidentate ligands. Preferred metals include rhodium, ruthenium and iridiu...
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WO/2000/017228A2 |
The invention relates to an improved stereoselective heterogenous catalytic reductive amination between ethyl 2-oxo-4-phenylbutyrate and alanylproline using hydrogen, a catalyst and one or more additives to produce the ACE inhibitor, ena...
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WO/2000/015599A1 |
The present invention relates to producing stereoselective nitro compounds by reacting a dicarbonyl compound with a nitrostyrene compound in the presence of a catalyst complex and a base.
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WO/2000/014033A1 |
Nucleophilic oxygen species, such as primary alcohols, carboxylates, and water, are added to vinyl epoxides in a highly regioselective and enantioselective manner, providing a convenient route to enantiomerically enriched 2,2-diols and o...
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WO/2000/014051A1 |
The compounds of formula (I) in which the symbols R?1¿, R?2¿, R?3¿ and R?4¿ represent independently from each other a hydrogen atom or a methyl or ethyl group, the symbol X represents an oxygen atom or an alkylene group of formula (A...
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WO/2000/014034A1 |
Microwave heating of a transition metal-catalysed organic reaction, in which a catalyst complex between a transition metal and an auxiliary ligand or ligands, the ligand being asymmetric or symmetric, monodentate or bidentate, results in...
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WO/2000/014096A1 |
The present invention relates to novel chiral 1,1' ferrocylene diphosphonites and the synthesis thereof, in addition to complexes of said compounds with metals from groups VIIb, VIIIb and Ib of the periodic table and to the use thereof f...
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WO/2000/012449A1 |
An allylic compound is reacted with an organozinc compound Zn(R?6¿)¿2? to eliminate a group (the leaving group) from the allylic compound and to add a group from the organozinc compound to it in the presence of a copper salt catalyst a...
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WO/2000/012467A1 |
Compounds of the formula (I): R?1¿-CO-N(OH)-CR?2¿R?3¿-CR?4¿R?5¿-CONH-CR?6¿R?7¿-CONR
?8¿R?9¿, wherein R?1¿ is C¿1-6?alkyl, aryl or aryl C¿1-6?alkyl; R?2¿ is hydrogen, C¿1-6?alkyl, C¿3-8?cycloalkyl, aryl or arylC¿1-6?alkyl;...
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WO/2000/010992A2 |
The invention relates to a water-dispersible or water-soluble compound having structure (I) wherein, R?1¿, R?2¿, and R?3¿ are, independently hydrogen or methyl, and R?4¿ is -(CH¿2?CH¿2?O)¿n?CH¿2?CH¿2?OH, wherein n is from 10 to ...
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WO/2000/011008A1 |
Chiral phosphine ligands derived from chiral natural products including D-mannitol and tartaric acid. The ligands contain one or more 5-membered phospholane rings with multiple chiral centers, and provide high stereoselectivity in asymme...
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WO/2000/010968A2 |
The present invention relates to novel aryl sulphonamide amino acid esters and analogues, methods for the production and use thereof in the prophylaxis and treatment of neurodegenerative diseases, especially in the treatment of apoplexia...
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WO/2000/009463A1 |
The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile, selected from the group consisting of water, alcohols, carboxylic acids, and thiols, an...
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WO/2000/009483A2 |
The present invention relates to a new process for the preparation of acetylcholinesterase inhibitors of formula (I) or a salt thereof, wherein: R?1¿ is N-acyl-4-piperidyl; N-alkoxycarbonyl-4-piperidyl; 4-piperidyl; N-alkyl-4-piperidyl;...
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WO/2000/007978A1 |
The present invention relates to aminomethylcarboxylic acid derivatives having general formula (I), wherein Z is (CH¿2?)¿n?, O, S, SO, SO¿2? or N-R¿5?; n is 0, 1 or 2; X represents 1-3 substituents independently selected from hydroge...
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WO/2000/008025A1 |
Novel intermediates and improvements in the synthesis of acyclic guanine nucleoside prodrugs of the formula (R)-9-[(2-alkanoylmethyl)-4-(aminoacyloxy)butyl]guanine (for example valtamociclovir stearate), including purine salts amenable t...
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WO/2000/006532A2 |
A process is described for the preparation of R-(-)-carnitine comprising the following steps: (a) conversion of (S)-3-hydroxy-4-butyrolactone [1] to alkyl (S)-4-halogen-3-hydroxy-butyrate [2] by reaction with a linear or branched C¿1?-C...
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WO/2000/005402A1 |
The present invention relates to a continuous process for preparing optically pure (S)-3,4-dihydroxybutyric acid derivatives expressed by Formula (1) and more particularly, to the continuous process which enables preparing optically pure...
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WO/2000/005399A1 |
The present invention relates to a process for preparing optically pure ($i(S))-3-hydroxy-$g(g)-butyrolactone expressed by the Formula (1) and more particularly, to a process that enables preparing optically pure ($i(S))-3-hydroxy-$g(g)-...
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WO/2000/005398A1 |
The present invention relates to a process for preparing $g(a)-(1,4) linked oligosaccharide, and more particularly, to a process for preparing oligosaccharide expressed by Formula (1) by reacting amylose, easily available from the natura...
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WO/2000/005401A1 |
The present invention relates to a continuous process for preparing optically pure ($i(S))-3-hydroxy-$g(g)-butyrolactone expressed by formula (1) and more particularly, to a process which enables preparing optically pure ($i(S))-3-hydrox...
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WO/2000/005400A1 |
The present invention relates to a process for preparing optically pure (S)-3,4-dihydroxybutyric acid derivatives expressed by Formula (1) and more particularly, to a process that enables preparing optically pure (S)-3,4-dihydroxybutyric...
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WO/2000/002834A1 |
A composition and method for the catalytic conversion of a racemic mixture of dienes to a cyclic olefin by a ring-closing metathesis (RCM) reaction are disclosed. The composition, a transition metal complex with an M=C reaction site, con...
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WO/2000/002848A1 |
Novel salts of $i(N-tert)-butylhydroxylamine with lower carboxylic acids are disclosed, together with processes for their preparation. The salts possess advantageous properties that render them useful in synthesis.
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WO/2000/002843A1 |
A process for the preparation of optically active 1-arylalkylamines represented by general formula (4), (wherein R?1¿ is C¿2?-C¿6? lower alkyl; R?2¿ and R?3¿ are each independently hydrogen, halogeno, lower alkyl or lower alkoxy, wi...
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WO/2000/001641A1 |
The present invention describes a chiral surface comprising a non-McFadden-type kink.
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WO/1999/062917A1 |
The invention relates to phospholanes and diphospholanes of general formula (I), whereby R represents H, C¿1?-C¿6?-alkyl, aryl, alkyl aryl, SiR?2¿¿3?, R?2¿ represents alkyl or aryl, A represents H, C¿1?-C¿6?-alkyl, aryl, Cl, or (a...
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WO/1999/059721A1 |
Novel transition metal catalysts with conformationally rigid chiral phosphines and phosphites are developed for asymmetric carbon-hydrogen and carbon-carbon bond formation. The invention emphasizes synthesis of chiral amines, $g(b)-amino...
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WO/1999/056699A2 |
The present invention relates to a method and catalysts for the stereoselective addition of a nucleophile to a reactive $g(p)-bond of a substrate. The chiral, non-racemic catalysts of the present invention constitute the first examples o...
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WO/1999/052886A1 |
A method for kinetically resolving a stereoisomer mixture of compounds using asymmetric epoxidation is provided. Compounds contain an olefin moiety providing one stereoisomer to be epoxidized at a higher rate than the other stereoisomer ...
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WO/1999/052915A1 |
Described herein are new atropo-isomeric chiral phosphorated ligands having C¿1? symmetry, the procedure for their preparation, the organometallic complexes containing said ligands in optically active form, and the use of said complexes...
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WO/1999/052840A1 |
The asymmetric production of pure diastereomeric (2R, 3R), (2R, 3S), (2S, 3R) and (2S, 3S)-2-aryl-1-substituted butan-2,3-diols from the derivatives of lactic acid.
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WO1999032225A9 |
Complexes of a selected class of chiral ligands with molybdenum, tungsten or chromium, preferably molybdenum, are effective as catalysts in highly enantioselective and regioselective alkylation of allylic substrates. Such compositions pr...
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WO/1999/047530A1 |
The invention concerns a compound of formula (I) wherein: R¿1?, R¿2?, R¿3?, R¿4?, R¿5? and X are such as described in Claim 1.
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WO/1999/047475A1 |
The invention concerns a method for separating $i((d/l)) and $i((meso)) diastereoisomers of bis-[1-phospha- 2,3-diphenyl- 4,5-dimethylnorbornadiene]. The invention also concerns a method for preparing optically active diphosphines of bis...
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WO/1999/046252A1 |
A process for industrially producing oxazolidin-2-one derivatives represented by general formula (3) characterized by reacting a 1,3-dioxolan-2-one derivative with a carbamate derivative or a urea derivative in the presence of a fluorine...
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