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WO/1999/043668A1 |
Novel $g(b)-diketone compounds represented by general formula (3); and coordination compounds obtained by modifying the $g(b)-diketone compounds with a metal through coordination. The compounds can be easily synthesized. The compounds ca...
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WO/1999/038828A1 |
A process for producing a butanetriol derivative represented by formula (1) useful as a material for medicines, characterized by reacting a compound represented by formula (3), wherein R?1¿ and R?2¿ represent different protecting group...
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WO/1999/038824A1 |
The invention relates to a simple method for obtaining purer optically active alcohols with a higher enantiomeric purity, in higher yields, at lower temperatures and in short reaction times by reducing the optically active carboxylic aci...
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WO/1999/036375A1 |
The present invention relates to a process for stereoselective cycloaddition reactions which generally comprises a cycloaddition reaction between a pair of substrates, each either chiral or prochiral, that contain reactive $g(p)-systems,...
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WO/1999/024410A1 |
The invention is drawn to novel transition metal catalysts for the pratical synthesis of important chiral molecules. The transition metal catalysts comprise chiral ligands based on chiral amine oxazolinyl ligands. The invention includes ...
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WO/1999/024443A2 |
This invention is to develop novel transition metal catalysts for the pratical synthesis of important chiral molecules. The invention emphasizes asymmetric catalysis based on chiral bidentate phosphine ligands with cyclic ring structures...
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WO/1999/021830A1 |
An improved method is described for making 9-deoxy-PGF¿1?-type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
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WO/1999/015481A1 |
A process for the preparation of an enantioenriched sulphone of formula (1), comprises asymmetric hydrogenation of a vinyl sulphone of formula (2) wherein R?1¿, R?2¿ and R?3¿ are each independently a hydrocarbon group of less than 20 ...
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WO/1999/015538A1 |
The invention relates to a method for selective production of racemic metallocene complexes through conversion of bridged or non-bridged transition metal complexes with cyclopentadienyl derivatives of alkali metals or alkaline-earth meta...
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WO/1999/014184A1 |
This invention is novel processes for the stereoselective preparation of gabapentin analogues.
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WO/1999/012877A1 |
The invention concerns a method for the enantioselective reduction of prochiral ketones into chiral alcohol's comprising the following steps: a) reacting a prochiral ketone with a silane agent, present in stoichimetric amount, in the pre...
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WO/1999/005100A1 |
The invention concerns an ionic compound of formula [R?1¿X?1¿(Z?1¿)-Q?-¿-X?2¿(Z?2¿)-R?2¿]¿m? M?m+¿ in which M?m+¿ is a cation of valence m, each of the X?i¿ is S=Z?3¿, S=Z?4¿, P-R?3¿ or P-R?4¿; -Q is N, CR?5¿, CCN or CSOÂ...
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WO/1998/058735A1 |
The present method provides a method of transferring oxygen to at least one oxidizable site on a target compound. The method includes the steps of selectively oxidizing an oxidizable site on a target compound by reacting in solution: the...
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WO/1998/054193A1 |
A chiral phosphorus-based ligand, in single enantiomer form, which is capable of complexing a transition metal atom and of acting as a ligand in asymmetric chemical catalysts, which comprises the partial structure (I): R?1�R?2�P-O-C-...
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WO/1998/051676A1 |
An efficient method for the preparation of key intermediate, in the synthesis of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihy
dro-2H-3,1-benzoxazin-2-one, a reverse transcriptase inhibitor is achieved using a chiral addit...
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WO/1998/046578A1 |
Allylic electrophiles are alkylated with oxazolones in the presence of a base and catalytic quantities of a transition metal complex incorporating a chiral phosphine ligand, to yield 4,4-disubstituted-5(4$i(H))-oxazolones. These precurso...
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WO/1998/039345A1 |
The invention concerns novel 6,6'-bis-(1-phosphanorbornadiene) diphosphines, the method for preparing them and their use in asymmetric catalysis. The novel diphosphines correspond to general formula (I) in which R�1?, R�2?, R�3?, R...
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WO/1998/039276A1 |
A novel process for producing optically active amines useful as an intermediate for physiologically active compounds such as medicines and agricultural chemicals or as a starting material for synthesizing functional materials, e.g., liqu...
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WO/1998/035934A1 |
A highly economical and efficient process for producing optically active homophenylalanine derivatives represented by general formula (IV); and intermediates therefor and a process for producing the same. The process comprises reacting a...
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WO/1998/030569A1 |
This invention relates to chiral heterocyclic compounds useful for asymmetric synthesis and catalysis. More particularly, the invention relates to chiral heterocyclic phosphine, sulfur, and nitrogen compounds for asymmetric synthesis and...
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WO/1998/030543A1 |
This invention relates to a process for the preparation of a key intermediate in the synthesis of an endothelin antagonist, having formula (I) by using a chiral additive to effect an asymmetric conjugate addition.
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WO/1998/028306A1 |
A process for the preparation of an aromatic organozinc compound is provided. The process comprises reacting a zinc chloride, bromide or iodide and an organometallic compoud of another metal comprising an aromatic moiety, producing a rea...
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WO/1998/022466A1 |
It is known that dihydroquinine or dihydroquinidine derivatives can be successfully used as ligands in the enantioselective dihydroxylation. The new disclosed ligand systems based on dihydroquinine/quinidine, unlike the prior art ligands...
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WO/1998/022484A1 |
Diphosphines of a mixed heteroarylic-arylic type, wherein the phosphine group carrying backbone is constituted by the interconnection of a five-atom heteroaromatic ring and a carbocyclic aromatic ring, forming an atropoisomeric chiral sy...
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WO/1998/015565A1 |
The invention relates to chiral ferrocenyls of formula (I), wherein R�a? is -P(R�10?R�11?) or -SR�12?; R�b? is -P(R'�10?R'�11?), -SR'�12?, -CH=NR�12?, -CH�2?-NH-R�12? or -CH�2?-O-P(R�10?R�11?); and the other s...
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WO/1998/015544A1 |
A compound and method for producing an enantiomerically enriched epoxide from an olefin using a chiral ketone and an oxidizing agent is disclosed.
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WO/1998/012202A1 |
Compounds of Formula (I) wherein R, R?1�, R?2� and R?9� are as herein defined, processes for their preparation and transition metal complexes comprising such compounds are disclosed. The complexes may be attached to insoluble suppo...
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WO/1998/012155A1 |
A process for preparing an optically active alcohol represented by general formula (IV), characterized by reducing a compound represented by general formula (I), preferably a compound represented by general formula (I'), with hydroborane...
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WO/1998/011057A1 |
A process for preparing in a good yield optically active erythro-3-amino-2-hydroxybutyric esters having a high purity and serving as an important intermediate of pharmaceuticals, particularly HIV protease inhibitors. The process is chara...
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WO/1998/011064A1 |
This invention is directed to methods for stereospecifically preparing [(1-optionally substituted aryl)- or (1-optionally substituted heteroaryl)]-2-substituted ethyl-2-amines, having chirality at the 2-position, and to intermediates to ...
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WO/1998/011053A1 |
The invention concerns a method for preparing an optically active alcohol of formula (I) in which the carbon atom indicated by the symbol * can have the configuration ($i(R)) or ($i(S)) and X represents an amino group not substituted or ...
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WO/1998/007685A1 |
The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates such as those having formulas (I)-(IV), such as those having formulas (I)-(IV), useful in the synthesis of neura...
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WO/1998/003272A1 |
4-Amino-5-chloro-6-(1-fluoroethyl)pyrimidine compounds of general formula (1) useful as pest-controlling agents for agricultural and horticultural use can be prepared industrially by reacting 5-chloro-6-(1-chloroethyl)-4-(2-phenylethylam...
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WO/1998/002445A1 |
A chiral compound of formula (I) or (II) wherein R?1�, R?2�, R?3� and R?4� are each independently H, alkyl, cycloalkyl, aryl, or alkaryl, provided that R?1� and R?2� are not both H; and X is any group capable of forming a sta...
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WO/1998/000375A1 |
The invention discloses an asymmetric hydrogenation method of a ketonic compound and derivative. It concerns the use of optically active metal complexes as asymmetric hydrogenation catalysts of a ketonic compound and derivative. The asym...
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WO/1997/049665A1 |
The invention concerns a new method for producing optically active 1-phenylethylamines of formula (I*), in which X stands for halogen or methyl and n stands for the digits 0, 1 or 2, wherein (a) racemic 1-phenylethylamines of formula (I)...
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WO/1997/048711A1 |
The invention relates to dendrimers comprising an initiator core with at least two functional groups and at least two saccharides. It also relates to the use thereof for various purposes e.g. as a catalyst in enantioselective syntheses, ...
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WO/1997/047633A1 |
The present invention relates to rigid chiral ligands useful in making catalysts for asymmetric synthesis. More particularly, the present invention relates to new monodentate and bidentate cyclic chiral phosphine ligands which are formed...
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WO/1997/047628A1 |
Chiral organoboranes of general formulae (I) and (II), wherein each of R1 and R2, which are the same or different, is a hydrogen atom or an alkyl or cycloalkyl radical, or R1 and R2, taken together, are a saturated divalent hydrocarbon g...
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WO/1997/042186A1 |
The present invention relates, first to a process for preparation of 5,6-dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-1,2,3,4-tet
rahydroisoquinolin-2-yl)pyrimidine represented by formula (I) and its acid addition salts, second, to a pro...
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WO/1997/040008A1 |
A process for producing pyrrolidine derivatives represented by general formula (2) or salts thereof in a simple and economical manner with a good productivity in a high yield. The process comprises conducting hydrogenolysis of a compound...
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WO/1997/035841A2 |
A method for preparing optically substantially pure (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phe
nyl]hydrazono]propanedinitrile from racemic 6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone intermediate is descri...
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WO/1997/034852A1 |
The invention concerns cycloalkyl derivatives of formula (I), where n is 0 to 4 and the other variables have the meaning given in claim 1. It also concerns a method for producing said derivatives and their use for producing compounds of ...
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WO/1997/029086A1 |
A method for the asymmetrical synthesis of S-acylated derivatives of 2-mercaptomethyl 3-phenyl propanoic acid of formula (I) is disclosed. The method comprises the steps of (a) preparing diol (VI) by reducing a malonic ester (V) in the p...
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WO/1997/028105A1 |
Processes for reducing carbonyl compounds into hydroxyl compounds easily under milder conditions, particularly a process for reducing an 'alpha'-aminohaloketone derivative stereoselectively. The above process comprises treating a carbony...
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WO/1997/019920A1 |
A process for preparing a compound of formula (IIa) or (IIb) wherein R2, R3, R4 and R5 independently represent hydrogen or C1-C4 alkyl; and A is an optionally substituted aromatic or heteroaromatic ring system; the process comprising the...
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WO/1997/017342A1 |
Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentano[b]pyridine derivatives. The most preferred compounds prep...
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WO/1997/017341A1 |
Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentanopyridine derivatives. The most preferred compounds prepare...
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WO/1997/016421A1 |
A process for producing optically active trans-vinyl sulfide alcohols represented by general formula (III), wherein R1 represents alkyl or aryl; which comprises reducing trans-vinyl sulfide ketones with a borane reducing agent in the pre...
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WO/1997/014669A1 |
This invention relates to a process for preparing optically active carboxylic acids by oxidizing an optically active aldehyde with a peracid in the presence of an amine and/or amine N-oxide catalyst selected from the group consisting of ...
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