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WO/2011/064790A1 |
A novel process for making Renin inhibitors like Aliskiren is disclosed. Its novel intermediate compounds and method of making them are also disclosed.
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WO/2011/066156A1 |
A method for preparing highly fluorinated carboxylic acids and theirs salts and the precursors thereof comprising subjecting a highly fluorinated olefin of the general formula (I) : Rf(O)n-(CF2)m-CF=CF2 to a derivative of formic acid acc...
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WO/2011/063551A1 |
An improved synthesis method for preparation of iodixanol, and a purification process through macroporous adsorption resin chromatographic column and recrystallization are provided. The synthesis method relates to dimerization of 5-aceta...
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WO/2010/063520A9 |
The invention relates to a method for producing a carboxylic acid amide from a carbonyl compound and hydrocyanic acid, comprising the steps of A) reacting a carbonyl compound with hydrocyanic acid to produce a hydroxycarboxylic acid nitr...
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WO/2011/063110A1 |
The present invention generally relates to a process for preparing 2,2- dibromomalonamide from 2,2-dibromo-3-cyanoacetamide.
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WO/2011/061610A2 |
The present invention relates to processes for the preparation of crystalline polymorphic forms of lacosamide (Formula I), including processes for inter-conversion among such polymorphic forms.
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WO/2011/060302A1 |
The embodiments described herein provide a reduction of an aldehyde or a ketone, such as a Meerwein-Ponnorf-Verley (MPV) reaction of an aldehyde or ketone. In some embodiments, the reaction occurs in the presence of A1[OC(CH3)3]. In some...
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WO/2011/054616A1 |
The invention relates to a process for the preparation of compounds of formula (III) wherein R1, R2, R3, R4 and R5 are independently selected from C1-6 alkyl or hydrogen, comprising reacting an aniline of formula (IV) with a carboxylic a...
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WO/2011/054436A2 |
The invention relates to halogen-substituted amide derivatives of general formula (I), in which R1 to R6, Q1 to Q8, A, V, W, X, Y, n and m are defined as cited in the description. The invention also relates to a method for producing same...
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WO/2011/054917A1 |
The invention provides a process for the preparation of the polymorph from I of agomelatine, characterized by the following crystal data: C15H17NO2 Mr = 243.30 Orthorhombic Pca21 a = 31.501 (4) A b = 9.5280 (1 O) A C = 17.906 (2) A Z = 1...
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WO/2011/052601A1 |
Provided are a novel ionic organic compound represented by general formula (I), which is effective as a carbon nanotube dispersant, and a method for producing said compound by means of simple processes. (In the formula, R1, R2, and R3 re...
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WO/2011/051853A1 |
The invention describes a novel technical process and novel intermediates useful for the manufacture of enantiomerically pure 8- aryloctanoic acids of the formula (I) which are pharmaceutically active compounds as rennin inhibitors.
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WO/2011/048091A1 |
A novel process for the preparation of a phenylalanine derivative of formula (I):
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WO/2011/041275A1 |
The present disclosure is directed to a process for preparing an alkylated triiodo-substituted arylamide, such as iodixanol, the process comprising contacting a triiodo-substituted arylamide, such as 5-acetamido-N,N'-bis(2,3-dihydroxylpr...
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WO/2011/041276A1 |
The present disclosure generally relates to an improved process for alkylating a triiodo-substituted arylamide to form a compound suitable for use as an X-ray contrast agent. More particularly, the present disclosure is directed to such ...
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WO/2011/039781A1 |
The invention relates to improved processes for the preparation of lacosamide. The invention also relates to a novel intermediate useful in the preparation of lacosamide. The invention also relates to process for the purification of laco...
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WO/2011/035569A1 |
A novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors.
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WO/2011/034506A1 |
A process is provided for the synthesis of an amide. A primary or secondary amine and a primary alcohol, with the amine and the alcohol being either moieties of different reactants or moieties of the same molecule, are contacted in the p...
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WO/2011/023324A1 |
The present invention relates to a process for producing substituted biphenyls by reacting aryl halides with tetraarylborates in the presence of palladium catalysts.
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WO/2011/019789A1 |
The present invention provides a novel process for opening a lactone and/or a lactam ring. More particularly, the present invention provides a process that employs a novel catalyst in the opening of a lactone ring and/or a lactam ring. A...
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WO/2011/011865A1 |
The present invention provides compounds of formula (I): in which T is L or -A-NH-C(O)-L-; L is -(CH2)n- or -(CH2)p-Z-; A is -(CH2)m- or an alkyl component of a naturally occurring amino acid; R is -CO2R1, -CH2OH, -C(O)NH(hydroxyphenyl) ...
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WO/2011/012319A1 |
The present invention relates to method for the preparation of an ω-amino-alkane(thio)amide having the general formula (6): Furthermore, novel intermediates and partial reaction steps of the claimed method are disclosed.
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WO/2011/010610A1 |
Provided is a catalyst precursor, which has excellent safety and stability, has a high stable activity retention rate, is capable of repeated use, has a high reaction recovery rate, and is easily worked into various shapes. The catalyst ...
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WO/2011/010677A1 |
Provided is a process for economically producing from 2-hydroxybutyronitrile a 2-aminobutylamide inorganic acid salt which is useful as a starting material for medicines, etc. 2-Hydroxybutyronitrile is reacted with ammonia to obtain a li...
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WO/2011/007807A1 |
Provided is an amide ester that is useful as an intermediate manufacturing product for an aroma compound such as spilanthol or the like. Also provided is a spilanthol manufacturing method using said amide ester. High-purity spilanthol ca...
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WO/2011/006387A1 |
The preparing process of agomelatine is provided, which comprises reacting 7-methoxy-1-tetralone with a cyano compound in presence of n-butyllithium (n-BuLi) to obtain 2-(1,2,3,4-tetrahydro-1-hydroxyl-7-methoxy-1-naphthyl)aceton
itrile, ...
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WO/2011/004980A2 |
The present invention relates to a method for preparing tricyclic derivatives, and more particularly, to a method for preparing intermediates of novel tricyclic derivatives having a superior yield rate and purity, wherein the method invo...
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WO/2011/003116A2 |
The present invention relates to an electrolyte for the electroless deposition of a metal layer on a substrate, wherein the electrolyte is free of heavy metal stabilizers, cyanides, selenium compounds and sulfur compounds comprising sulf...
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WO/2011/000462A1 |
The invention relates to a continuous method for producing amides of aliphatic carboxylic acids by reacting at least one carbonic acid ester of formula (I) R3-COOR4 (I), wherein R3 represents hydrogen or an optionally substituted aliphat...
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WO/2011/000461A2 |
The invention relates to a continuous method for N-acylating amino group-carrying organic acids by reacting at least one carboxylic acid of formula (I) R1-COOH (I), wherein R1 represents hydrogen or an optionally substituted hydrocarbon ...
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WO/2011/000459A1 |
The invention relates to a continuous method for producing amides of aromatic carboxylic acids by reacting at least one carbonic acid ester of formula (I) R3-COOR4, wherein R3 represents an optionally substituted aromatic hydrocarbon gro...
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WO/2011/000537A1 |
Method of preparing 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane, an intermediate in the synthesis of 1-amino-1,3,3,5,5-pentamethylcyclohexane (Neramexane) or a pharmaceutically acceptable salt thereof, comprising step (iii): (iii)...
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WO/2011/003061A2 |
Methods of producing compositions of trans-4-amino-2-cyclopentene-1-carboxylic acid derivatives are described. Also described is an amine salt of a compound having formula A, having components present in both cis and trans structures.
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WO/2010/149952A2 |
A novel, branched, saturated, primary fatty acid amide is disclosed. Applications areas are as a slip and/or antiblocking agent or mould release agent. The branched, saturated, primary fatty acid has a formula R-CO-NH2 where R is a satur...
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WO/2010/151489A1 |
A chlorinating agent such as a chloroiminium species is used to remove or neutralize tertiary acetamide present as a contaminant in a tertiary formamide solvent. Tertiary formamide solvent purified or treated in this manner can be used a...
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WO/2010/147286A1 |
The present invention relates to a synthesis method of glycine alkyl amides which are used as a template for preparing a nanopore structure, by reacting glycine combined with an amine protecting group compound and an alkyl amine. The syn...
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WO/2010/145024A1 |
The present disclosure provides a process for the mono-reduction of one or more imide moieties in a compound comprising contacting the compound with hydrogen gas and a catalyst comprising a transition metal hydride in the presence of a b...
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WO/2010/141334A1 |
A process for synthesis of a compound of Formula (X) wherein R1 is an aryl group substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, aminocarbonyl, alkylaminocarbonyl, dial...
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WO/2010/139090A1 |
N-Phenyl dichloroacetamide and their derivatives which belong to pharmaceutical chemistry and organic synthesis fields are provided. These compounds have the structures of general formula I, in which N-{3-chloro-4-[(trifluoromethyl)sulfo...
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WO/2010/141328A2 |
A process for synthesis of a compound of Formula (X) wherein R1 is an aryl group substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, aminocarbonyl, alkylaminocarbonyl, dial...
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WO/2010/130696A1 |
The present invention provide a process for the production of compounds of general formula (I), Y-CH2CH2-Z (I) wherein Y and Z are functional groups independently selected from the group consisting of a hydroxyl group and R1R2N and where...
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WO/2010/126086A1 |
Disclosed is a technique for efficiently producing a large amount of an amide compound at low cost, using an α,β-unsaturated carboxylic acid as a starting material, said amide compound being suitable for solvents and cleaning agents.
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WO/2010/117258A1 |
A method of producing an amide ester derivative of azelaic acid comprising treating an amino acid hydrohalide of the general formula (I): wherein R' is a substituted or unsubstituted alkyl, and R" is a substituted or unsubstituted side c...
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WO/2010/115906A1 |
The invention relates to 2-{2-amino-3-[hydroxy(phenyl)methyl]phenyl} acetamide, a process for its preparation, and its use as a reference marker and reference standard for analyzing the purity of nepafenac.
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WO/2010/115666A1 |
The invention relates to a method for continuously producing alkylamino(meth)acrylamides by reacting alkyl(meth)acrylates with high-boiling amines. A catalyst activation and special regeneration technique allow for product qualities that...
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WO/2010/114680A1 |
The invention in one embodiment is directed to a method of preparing a compound of formula (1), or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are each independently chosen from hydrogen, (C1-C6)alkyl, and cycloalkyl, R...
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WO/2010/112482A1 |
The present invention discloses a process for dimethylation of active methylene groups. Specifically, the invention discloses aprocess for preparing3-amino-2,2- dimethylpropanamide. Compounds produced by the present dimethylation process...
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WO/2010/111849A1 |
A solid basic catalyst for synthesizing alkanolamide compounds has the following general formula [Mg1-xAlx(OH-)2]x+(OH-)x·mH2O, wherein 0.2≤x≤0.33 and 0.1
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WO/2010/108814A1 |
The invention relates to a method for producing N,N`-lactic acid dialkylamide from lactic acid and dialkylamine under pressure.
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WO/2010/108817A1 |
The invention relates to a method for producing N,N`-lactic acid dialkylamides in a one-pot reaction, said N,N'-lactic acid dialkylamides being obtained from an ionic liquid.
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