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WO/2011/159564A1 |
Processes include producing hexamethylenediamine (HMD), adiponitrile (ADN), adipamide (ADM) and derivatives thereof from fermentation broths containing diammonium adipate (DAA) monoammonium adipate (MAA) and/or adipic acid (AA).
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WO/2011/159557A1 |
Processes for producing nitrogen containing compounds include producing hexamethylenediamine (HMD), adiponitrile (ADN), adipamide (ADM) and derivatives thereof from adipic acid (AA) obtained from fermentation broths containing diammonium...
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WO/2011/154500A1 |
The present invention relates to a process for the preparation of iodinated phenols; in particular; it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted phenol compounds to the cor...
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WO/2011/154292A1 |
The present invention relates to a process for preparing esteramide compounds. More particularly, the invention relates to a process for preparing esteramide compounds by reaction between a diester and an amine, in the presence of a basi...
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WO/2011/154661A1 |
The present invention relates to a process for preparing esteramide compounds. More particularly, the invention relates to a process for preparing esteramide compounds by reaction between a diester and an amine, in the presence of a basi...
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WO/2011/153939A1 |
Intermediate compounds for preparation of agomelatine and preparation methods thereof are provided. Also provided are two novel intermediate compounds. The method is simple to manipulate, well-controlled, suitable for industrial producti...
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WO/2011/151442A2 |
A new route of synthesis of the compound Aliskiren of formula (I), used in the treatment of hypertension, is described.
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WO/2011/148392A1 |
The present invention relates to a process for the preparation of (2S,4S,5S,7S)-N-(2- Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-
8-[4-methoxy-3-(3-methoxy propoxy )phenyl]-octanamide compound of formula- 1 and its pharm...
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WO/2011/146440A1 |
Processes include providing a clarified diammonium succinate (DAS)- or monoammonium succinate (MAS)- containing fermentation broth; distilling the broth of an overhead that includes water and ammonia, and a liquid bottoms that includes S...
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WO/2011/146009A1 |
An improved process for the preparation of aryl substituted olefinic amines such as (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-
amine and (2S)-(4E)-N- methyl-5-[3-(5-methoxypyridin)yl]-4-penten-2-amine and new intermedia...
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WO/2011/144983A2 |
The present invention relates to an improved process for the preparation of Lacosamide of Formula (I), comprising: O-methylating a compound of Formula (V) or a compound of Formula (XX) or a compound of Formula XXII; in the presence of a ...
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WO/2011/146556A1 |
Processes that make nitrogen-containing compounds include converting succinic acid (SA) or monoammonium succinate (MAS) derived from a diammonium succinate (DAS)- or MAS-containing fermentation broth to produce such compounds including d...
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WO/2011/145687A1 |
Provided is a method for preserving, in a stable state, an amide compound having an unsaturated bond, which is industrially very important but very easily undergoes polymerization and, therefore, is very hard to handle, without adding a ...
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WO/2011/141923A2 |
The present invention is directed towards synthesis of (S) - 3-cyano-5-methyl-hexanoic acid ethyl ester. A cost effective, eco-friendly process for preparation of enantiomerically pure (S)-3-cyano-5-methyl-hexanoic acid alkyl ester, inte...
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WO/2011/134763A1 |
The invention relates to a new process for the production and/or purification of the salt of the compound (S)-2-[4-(2-fluorobenzyloxy) benzylamino]propanamide, i.e. ralfinamide, or the respective R-enantiomer, with methanesulfonic acid i...
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WO/2011/135586A2 |
The present invention provides a process for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof, having the R-configuration, of formula (IA), or S-configuration of formula (IB), selectively over the other ...
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WO/2011/127797A1 |
Aliskiren intermediates and their preparation methods are provided. Specifically aliskiren intermediates present by formula (I), formula (II) and formula (III) and their preparation methods are provided. The nitro-aldol reaction of the i...
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WO/2011/130615A2 |
Processes for preparing lacosamide, for use in pharmaceutical compositions comprising lacosamide.
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WO/2011/128413A1 |
The invention provides a process for the preparation of the polymorph from I of agomelatine, characterized by the following crystal data: C15H17N02 Mr = 243.30 Orthorhombic Pca21 a = 31.501 (4) Å b = 9.5280 (10) Å c = 17.906 (2) Å ...
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WO/2011/123444A1 |
A method for generating a radiolabeled tracer. The method includes providing a phosphine molecule having at least one carbocyclic, aromatic, or pyrrolidinyl ring with an OH substitute. The OH of this phosphines molecule is then condensed...
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WO/2011/120314A1 |
Biphenyl compounds and their preparation method are provided. These compounds have antitumor activity in vivo and in vitro, which may be used in the treatment of cancer.
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WO/2011/120313A1 |
Biphenyl compounds and their preparation method are provided. These compounds have antitumor activity in vivo and in vitro, which may be used in the treatment of cancer.
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WO/2011/117535A1 |
The present invention relates to a method for continuously preparing a betaine aqueous solution, said method including the reaction of an amine with an ω-halocarboxylic acid in the presence of water and a base. Said method is characteri...
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WO/2011/113362A1 |
An agomelatine hydrochloride hydrate of formula (I), preparation, use, and pharmaceutical composition thereof are provided. Said hydrate obtained through the present method has significant increased solubi1ity than agomelatine, and there...
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WO/2011/113363A1 |
An agomelatine hydrobromide hydrate of formula (I), in which X is Br, preparation method and use thereof as well as pharmaceutical composition containing it are provided. The solubility of the agomelatine hydrobromide hydrate obtained by...
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WO/2011/110624A2 |
The invention relates to novel β-hydroxyalkylamides, to a method for their production and to the use thereof.
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WO/2011/111802A1 |
Provided is a crosslinkable composition which can yield a crosslinked product that exhibits excellent retort resistance and causes little bleeding and that can attain excellent interlaminar adhesion in the form of a multilayer structure....
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WO/2011/108717A1 |
Disclosed are: an amide compound production catalyst which can be used in the production of an amide compound by the hydration of a nitrile compound and is highly efficient; and a production process using the catalyst. Specifically discl...
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WO/2011/103933A1 |
The present invention relates to a process for the preparation of a compound of the general Formula (I), comprising: a) reacting a compound of the general Formula (II) with a compound of the Formula III R2COOH and a compound of the gener...
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WO/2011/102510A1 |
A method for stabilizing an aqueous acrylamide solution is provided. Also provided is a stable aqueous acrylamide solution which contains acetaldehyde in an amount of 1.5-4 mg per kg of the acrylamide.
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WO/2011/097797A1 |
Disclosed are a kind of polyphenol acrylic acid derivative, its preparation, and use in preparing medicine. The compound can be used as an inhibitor of protein kinase or cytokine, tranquilizer, and also can be used to treat eczema, psori...
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WO/2011/098258A1 |
The present invention relates to new salts of the renin inhibitor Aliskiren in a crystalline or amorphous form, processes for the manufacture of the new Aliskiren salts in a crystalline form, and a process for forming salts of Aliskiren ...
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WO/2011/098545A1 |
New 2-methyl-1,4-naphthoquinone derivatives with vitamin K activity are provided having the general formula (1): wherein R is a aliphatic group with 12 to 50 carbon atoms. Preferably, R is a straight or branched C12-50 alkylgroup or a st...
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WO/2011/099033A1 |
Processes for preparing and purifying (R)-2-acetamido-N-benzyl-3-methoxy- propionamide of formula-1 and intermediates thereof are provided.
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WO/2011/095110A1 |
Intermediate compounds which can be used for preparing Lacosamide as well as preparation methods of Lacosamide are provided. The present preparation methods can avoid using expensive CH3I and AgO and can also avoid using Pd-C catalyst.
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WO/2011/094897A1 |
A surfactant consisting of polyalkoxyl hydroxyethyl fatty acid amide composition and the preparation method thereof are provided. The polyalkoxyl hydroxyethyl fatty acid amide comprises groups derived from one or more saturated or unsatu...
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WO/2011/091677A1 |
Industrial preparation method of 3-amino-2,2-dimethyl propanamide is provided which is a key intermediate of high blood pressure rennin inhibitor Aliskiren, ie., 3-amino-2,2-dimethyl propanamide is obtained by making cyanoacetic acid der...
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WO/2011/092672A2 |
The present invention relates to processes for reducing impurities in lacosamide during the preparation of lacosamide. The invention provides processes for minimizing or removing impurities such as (2R)-2-(acetylamino)-3-(benzylamino)-3-...
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WO/2011/092559A1 |
A novel process for the synthesis of Lacosamide using D,L-serine as starting material is described, where the methylation reaction of hydroxyl is carried out using an inexpensive base such as NaOH and an inexpensive alkylating agent, non...
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WO/2011/091427A1 |
The invention provides a method for producing amides via the reaction of aldehydes and amines with oxygen adsorbed on a metallic silver or silver alloy catalyst. An exemplary reaction is shown in Scheme 1 : (I), (II), (III)
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WO/2011/086565A1 |
A process for preparation of enantiomerically enriched and/or racemic γ-amino acids, particularly those useful for preparing γ-amino acids that exhibit binding affinity to the human α2δ calcium channel subunit, including pregabalin a...
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WO/2011/082506A1 |
A method for preparing Aliskiren and intermediate thereof, which comprises the following steps: reacting 4-bromo-1-methoxy-2-(3-methoxypropoxy)benzene with magnesium isopropyl chloride and n-BuLi to obtain the compound of formula XXII; r...
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WO/2011/075943A1 |
Agomelatine crystal, which is a drug useful for treating depression, and pharmaceutical compositions thereof are provided. The X-ray powder diffraction spectra of such agomelatine crystal, which is irradiated by Cu-Kα and showed by 2θ(...
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WO/2011/076086A1 |
Chiral amino compounds, methods of preparation and uses thereof. Tamiflu can be obtained from the said compounds. Multi-substituted chiral tetrahydropyrrolyl amine which can be used as intermediate compounds of medicament can also be pro...
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WO/2011/078172A1 |
A process for producing an optically active 3-substituted glutaric acid monoamide, characterized by mixing a mixed solution of an optically active 3-substituted glutaric acid monoamide represented by formula (2) (wherein * represents an ...
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WO/2011/077463A1 |
Processes for preparing pregabalin and its intermediate such as 3-(carbamoylmethyl)-5-methylhexanoic acid are provided. The process for preparing pregabalin mainly comprises reacting 3-(carbamoylmethyl)-5-methylhexanoic acid with (+)-phe...
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WO/2011/070028A1 |
Whilst methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols (i.e., R-SH). The present invention relates to a ...
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WO/2011/071058A1 |
Disclosed is an efficient industrial preparation method for an optically active 2-hydroxycycloalkane carboxylic acid ester that is useful as an intermediate for the production of pharmaceutical products. Specifically disclosed is a metho...
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WO/2011/070459A1 |
The present invention relates to a novel manufacturing process and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially rennin inhibitors such as Aliskiren. The invention describes a preparation of...
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WO/2011/067278A1 |
The invention relates to a method for producing formamides by converting aromatic amines and a formic acid ester in the presence of a catalyst, the method being characterized in that the catalyst is a phosphoric acid or a Lewis acid meta...
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