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WO/2010/105983A1 |
The present invention relates to a process for the preparation of given carboxamido compounds, in particular of 2,4,6-triiodoisophthalic acid derivatives, as useful intermediates for the preparation of X-ray contrast media among which is...
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WO/2010/101299A1 |
Provided is a method for producing a halogen-substituted benzene dimethanol, including a first step for reacting a compound represented by formula (1) and a compound represented by formula (2) to obtain a dicarboxamide compound represent...
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WO/2010/097052A1 |
Agomelatine hydrohalide complex and preparation method thereof are disclosed. Compared with agomelatine, agomelatine hydrohalide complex obtained by the present method has improved solubility, and is suitable for application need of prep...
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WO/2010/092546A1 |
The present invention concerns compounds of general formula (I) : Method of preparation and uses thereof.
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WO/2010/094029A2 |
Cobalt(ll) complexes of the D 2-symmetric chiral porphyrins are effective catalysts for asymmetric cyclopropanation reactions with succinimidyl diazoacetate. The Co-catalyzed reaction is suitable for various olefins, providing the corres...
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WO/2010/093059A1 |
Disclosed is a method for producing a phenylacetamide compound represented by formula (1) (wherein Q, R2, R4 and Ar are as defined below; and when R2 is a hydrogen atom, R5 represents R4, but when R2 is an alkyl group having 1-4 carbon a...
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WO/2010/089881A1 |
Disclosed is a 3-aminooxalylaminobenzamide derivative used for a pesticide/miticide. The 3-aminooxalylaminobenzamide derivative is represented by formula [1]. (In the formula, R1 and R2 independently represent a hydrogen atom, a halogen ...
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WO/2010/090031A1 |
Disclosed is a method for producing an optically active succinimide derivative which is a key intermediate of (3R)-2'-(4-bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'(1'H)-
pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone. The method for pr...
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WO/2010/090282A1 |
Provided are 3-aminoxalylaminobenzamide derivatives which are intended to be used in insecticidal and miticidal agents. The 3-aminoxalylaminobenzamide derivatives are represented by general formula [1] [wherein R1 and R2 are each a C1-C3...
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WO/2010/086429A2 |
(S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid or (S)-pregabalin is an anticonvulsive drug. In addition to its use as an anticonvulsive agent, pregabalin has also been indicated as a medicament in the treatment of anxiety, neuropathic pa...
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WO/2010/086394A1 |
The present invention relates to a method for synthesizing a pharmaceutically acceptable acid addition salt of (1S, 2R)-milnacipran comprising the following successive steps: (a) reaction of phenylacetonitrile and of (R)-epichlorhydrin i...
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WO/2010/084325A2 |
The present invention provides a process for isolating tigecycline which process comprises the step of spray drying a solution of tigecycline in a solvent. Preferably the solvent is water or an organic solvent. In another aspect, there i...
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WO/2010/081788A1 |
The present invention relates to a new process for the preparation of N-[5-(3-dimethylamino-acryloyl)-2-fluoro-phenyl]-N-methyl-ac
etamide (I) in a high yield and high purity, which is an intermediate in the synthesis of compounds with a...
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WO/2010/081410A1 |
Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid and intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors.
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WO/2010/079405A2 |
The present invention relates to an improved process for preparing 1-(pentanoylamino)cyclopentanecarboxylic acid formula (I) which is useful intermediate for the preparation of Irbesartan.
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WO/2010/079774A1 |
An N-(1-hydroxyethyl)carboxamide compound represented by general formula (1), a process for producing the compound, a process for producing an N-(1-alkoxyethyl)carboxamide compound, a process for producing an N-vinylcarboxamide compound,...
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WO/2010/072480A1 |
A novel method is described, which allows n-isopropyl(meth)acrylamide to be obtained in a simple way in high purity and high yield in that methacrylic acid anhydride is reacted with isopropylamine, optionally in a solvent.
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WO/2010/072543A1 |
The invention relates to a method for producing N-vinylcarboxamides by pyrolyzing a compound of the formula (I), in which R and R1 stand for H or C1 to C6 alkyl, in the presence of solids that are doped with alkali metal or alkaline-eart...
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WO/2010/072632A1 |
The present invention relates to methods of initiating a reaction represented by scheme (1), wherein Q is optionally substituted aryl or optionally substituted heteroaryl; X is halogen or a sulphonate; P is an organic radical; R is hydro...
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WO/2010/069778A1 |
Methods for producing a compound of formula (k1) or (k2) by reducing a dihydronapthalene amide compound of formula (i); with hydrogen gas in the presence of a ruthenium catalyst of formula (j1) or (j2); Ru(Z)2(L) = (j1), Ru(E)(E')(L)(D) ...
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WO/2010/067252A1 |
The present invention relates to an improved process for the preparation of 1-bromo-3,5-dimethyl adamantane of formula (III), which is an useful intermediate for synthesis of 1-amino-3,5-dimethyl adamantane of formula (I) or pharmaceutic...
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WO/2010/068649A1 |
The invention provides crystalline solid forms of (S)-4-((2S,3S)-7-carbamoyl-1,1-diethyl-3-methoxy-1,2,3,4-tet
rahydronaphthalen-2-ylamino)-2-cyclohexylmethyl-butyric acid. The invention also provides pharmaceutical compositions comprisi...
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WO/2010/067589A1 |
A method for producing a β-alkoxypropionamide comprising synthesizing a transesterified polyol of a β-alkoxypropionic acid ester by subjecting a β-alkoxypropionic acid ester represented by formula (I) and a polyol having two or more O...
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WO/2010/064785A2 |
The present invention relates to a method for selectively crystallizing Z isomer of iopromide of formula (I) comprising a) dissolving a crude iopromide comprising a mixture of E and Z isomers or a concentrate thereof in an alcohol, and b...
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WO/2010/063080A1 |
Amphiphilic prodrugs of general formula A-X are disclosed, wherein A is a biologically active agent or may be metabolised to a biologically active agent; and X is selected from the group consisting of R, or up to three R moieties attache...
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WO/2010/063276A1 |
The present invention relates to processes for the production of lactams such as ε-Caprolactam, ω-Laurolactam, or of carboxylic acid amides such as acetaminophenol and benzanilide by Beckman rearrangement from the corresponding oximes ...
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WO/2010/060624A2 |
The invention relates to dry processes for producing tablets containing lacosamide and adhesive agent. The invention further relates to compacted intermediates containing lacosamide and an adhesive agent, as well as to a pharmaceutical f...
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WO/2010/061097A1 |
The invention relates to a method for producing methyl methacrylate by reacting alpha-hydroxyisobutyramide with methyl formate in order to obtain methyl alpha-hydroxyisobutyrate and formamide, said methyl alpha-hydroxyisobutyrate being d...
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WO/2010/060801A1 |
A process for removing by-products from N-vinylamide-rich product mixtures (crude N-vinylamide), characterized in that an extraction of the crude N-vinylamide is performed with an organic solvent as the extractant.
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WO/2010/061621A1 |
Disclosed is a method for manufacturing, efficiently and with high yield, a trans-{4-[(alkyl amino) methyl] cyclohexyl} acetic ester which is useful as a starting material compound for the manufacture of medicines and the like, said meth...
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WO/2010/057765A1 |
The present invention relies on a process for the preparation of non ionic iodinated contrast agents and, in more details, it relates to a process for the preparation of Iopamidol in high yields and with a high degree of purity. In more ...
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WO/2010/057874A1 |
The present invention relates to a process for preparing secondary amides with good selectivity by carbonylating a corresponding tertiary amine with carbon monoxide in a reaction mixture in the presence of a metal catalyst and in the pre...
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WO/2010/058577A1 |
Disclosed is a method for producing an unsaturated aminocarboxylic acid derivative, which is useful as a pharmaceutical raw material, at low cost. Specifically, an unsaturated aminocarboxylic acid derivative is produced by hydrolyzing a...
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WO/2010/058206A1 |
A method of making a phenylethylamine of formula (B): wherein R2, R3, R4, R5, R6, Rα, Rβ and Rn are each independently selected from hydrogen, alkyl, acyl, aryl, amido, amino acids, sugars and nucleotides. The method includes the reduc...
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WO/2010/058004A1 |
The present invention relates to a method for preparation of carboxamides using alcohols and amines as starting materials in a dehydrogenative coupling reaction catalyzed by a ruthenium N-heterocyciic carbene (NHC) complex, which may be ...
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WO/2010/055005A1 |
The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates...
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WO/2010/055162A1 |
Provided is an enantioselective, palladium-catalyzed method for the preparation of γ-amino-α,β-unsaturated carboxylic acid derivatives having the formulas II, III, IV and VIII.
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WO/2010/052011A1 |
The present patent application relates to an alternative process for the preparation of amino derivatives. In particular, the present application relates to an improved process for the manufacture of Lacosamide (LCM), (R)-2-acetamido-N-b...
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WO/2010/041739A1 |
The issue is to provide a method to obtain optically active vinyl-cyclopropane carboxylic acid derivatives with high yield and high optical purity using starting materials that are safe and easily acquired at a low cost. An additional is...
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WO/2010/038633A1 |
Disclosed is a production process which can produce a trans-dicyclohexane derivative in high yield. The production process comprises hydrogenating a specific phenyl-trans-cyclohexane derivative in the presence of a rhodium catalyst to pr...
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WO/2010/038765A1 |
Provided are a novel type I natural ceramide derivative composed of sphingosine and ω-acyloxy long-chain carboxylic acid and having a structure closer to that of type I natural ceramide; and a method for producing the same. The derivat...
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WO/2010/037776A1 |
The present invention pertains to a process for manufacturing dialkyl lactamide comprising the steps of reacting lactide and dialkylamine selected from one or more of dimethylamine, diethylamine, and methylethylamine to form a reaction m...
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WO/2010/034236A1 |
A novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active N-acylbiphenyl alanine compounds, in particular neutral endopeptidase (NEP) inhibitors.
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WO/2010/032129A1 |
The invention relates to a method for producing a compound of formula (I) wherein R is selected from the groups comprising hydroxy, amino, and C1-C6 alkoxy or a salt thereof. Said method comprises a step of solvolysis of adamantoyl cyani...
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WO/2010/032219A1 |
The present invention relates to an improved process for the preparation of tigecycline. The process comprises treating minocycline hydrochloride with nitrating agent at low temperature followed by reduction in presence of catalyst to pr...
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WO/2009/137448A9 |
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WO/2010/021956A2 |
Methods of producing the N-alkyl (alkyl)acrylamides. In a general embodiment, the present disclosure provides a method of producing an N-alkyl (alkyl)acrylamide comprising providing an aqueous solution comprising an N-alkyl amine and add...
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WO/2010/018023A1 |
The present invention relates to a process for producing an aqueous methacrylamide solution, where water is passed through a fixed bed which comprises methacrylamide as solid. The present invention further describes a solids container an...
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WO/2010/018047A2 |
The invention relates to compositions comprising at least one oil from the fruit of a sumac plant.
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WO/2010/019730A1 |
The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example w...
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