| Document |
Document Title |
|
WO/2013/010650A1 |
A process is described for preparing acylglycinates of the formula (I) wherein R1 is a linear or branched, saturated alkanoyl group having 6 to 30 carbon atoms, or is a linear or branched, singly or multiply unsaturated alkenoyl group ha...
|
|
WO/2013/007103A1 |
A use of an organic framework porous solid acid, as a catalyst for a catalyzed esterification and acylation reaction. The preparation process thereof is: adding a divinylbenzene monomer to a mixed solvent containing azobisisobutyronitril...
|
|
WO/2013/008256A1 |
The present invention provides a cost effective, environmental friendly and efficient, one pot decarboxylative acylation of aromatic/heteroaromatic primary /secondary amine using diethyl malonate (DEM) to obtain corresponding homologated...
|
|
WO/2013/000255A1 |
Disclosed is a use of combination of polyphosphoric acid and metallic zinc, as well as combination of alkali metal salt of halogen anion, polyphosphoric acid and metallic zinc, in decoloring of tetraacetyl ethylene diamine mother liquid....
|
|
WO/2012/175903A1 |
A new compound, (S)-5-(2-acetoxypropanamido)-2,4,6-triiodoisophthalic acid, of formula II (S)-5-(2-acetoxypropanamido)-2,4,6-triiodoisophthalic acid. Said new compound is of use for the production of triiodinated contrast agent, especial...
|
|
WO/2012/176830A1 |
Provided are a novel 1,2-bis(dialkylphosphino)-4,5-(methylenedioxy)benzene derivative that forms a metal complex having particularly high asymmetry induction capacity and catalytic activity on β-dehydroamino acids, a method for manufact...
|
|
WO/2012/176715A1 |
The present invention relates to a 1-amino-2-vinyl cyclopropane carboxylic acid amide or a salt thereof. By obtaining an optically active 1-amino-2-vinyl cyclopropane carboxylic acid amide or a salt thereof by hydrolyzing an optically ac...
|
|
WO/2012/175049A1 |
Disclosed in the present invention is an amide compound, its preparation method and uses thereof, specifically, the compound of formula I or the pharmaceutically acceptable salts thereof, where R1, R2, R3, R4, R5, Q, X, N are defined as ...
|
|
WO/2012/176621A1 |
Provided is an industrially advantageous method for producing an unsaturated carboxylic acid amide composition with which it is possible to obtain an unsaturated carboxylic acid amide composition that can be used as a fine chemical such ...
|
|
WO/2012/175511A1 |
The invention relates to a simplified method for producing pyrazolylcarboxanilides by reacting pyrazolyl carboxylic acid esters with anilines in the presence of a base and removing at least one reaction product.
|
|
WO/2012/172387A1 |
The invention concerns a new process for the preparation of two crystalline forms of agomelatine, in particular a process for preparation of form I and a new form of agomelatine, here called form VII.
|
|
WO/2012/173572A1 |
The disclosure provides new methods for the oxidative Heck cross-coupling reaction with electron-rich alkenes such as substituted β-amidoacrylate and other related substituted enamides. Previously, functionalization of enamides under He...
|
|
WO/2012/168665A1 |
The invention relates to an agomelatine cocrystal consisting of: the agomelatine or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide of formula (I); and a solid organic acid.
|
|
WO/2012/163600A1 |
The present invention relates to a process for preparing methacrylic acid based on the hydrolysis of methacrylic esters.
|
|
WO/2012/164698A1 |
Provided is a 3-aminooxalylaminobenzamide derivative in which a difluoromethoxy group is introduced into a phenyl group in a benzamide group, and which can exhibit excellent effect as an insecticidal or miticidal agent. The 3-aminooxalyl...
|
|
WO/2012/165415A1 |
The present invention relates to a method for producing acrylamide by supplying a starting material water to a reactor, supplying acrylonitrile to the reactor, and hydrating the acrylonitrile using a biological catalyst. This method for ...
|
|
WO/2012/162409A1 |
The present invention is directed to biphenyl derivatives of Formula (I), pharmaceutical compositions containing them and their use in the treatment and / or prevention of disorders and conditions ameliorated by antagonizing one or more ...
|
|
WO/2012/157777A1 |
The present invention relates to a method for producing an acrylamide aqueous solution by generating acrylamide by hydrating a composition containing acrylonitrile, wherein the composition containing acrylonitrile contains 20-80 mg of me...
|
|
WO/2012/156888A1 |
The present invention relates to a novel manufacturing process of pharmaceutically active compound of formula (I) used as oral anti-diabetic drug. Starting from -aspartic acid derivate of formula (IV) the invention describes preparation ...
|
|
WO/2012/157504A1 |
Provided are: a β-lactam compound in which two adjacent carbon atoms present in a β-lactam ring are asymmetric carbon atoms respectively having four different substituents; a method for producing the β-lactam compound; a production in...
|
|
WO/2012/157776A1 |
The present invention pertains to an acrylamide aqueous solution containing the proportion of 2-100 mg of 2,2,6,6-tetramethylpiperidine 1-oxyl and 0.2-2.0 mg of manganese ions for every 1 kg of acrylamide. The present invention is able t...
|
|
WO/2012/153128A1 |
A method of removing a carboxylic acid from a liquid including a tertiary amide solvent includes the steps of: A) forming an extraction medium comprising an acid-extracting tin species and an extraction solvent that is immiscible with th...
|
|
WO/2012/152209A1 |
Provided are 4-carboxy phenyl retinamide ethanolate, a preparation method thereof, a pharmaceutical composition thereof, and uses thereof against cancers.
|
|
WO/2012/148555A1 |
This invention describes an amidation process whereby perfluorinated amino acids can be activated and treated with an amine in the presence of a coupling agent and a pyridine derivative to yield amides, without loss of optical purity.
|
|
WO/2012/145899A1 |
Compounds of the formula (I) or pharmaceutically acceptable salts thereof are disclosed. In the formula (I), R1, R2, R3, R4, R5 and n are defined as the specification. The preparation method for the compounds of the formula (I), the comp...
|
|
WO/2012/148624A1 |
Hydroxyamides are synthesized from esters. A process of making hydroxyalkyl amides comprises : reacting an ester with a hydroxyalkyl amine having the formula H2N-R3-OH wherein R3 is a substituted or unsubstituted C2 to C5 alkyl, in the p...
|
|
WO/2012/146085A1 |
Disclosed is an intermediate (structural formula I) for synthesizing prostaglandin medicines and preparation method therefor. The intermediate is used for synthesizing prostaglandin medicines, such as bimatoprost, travoprost, latanoprost...
|
|
WO/2012/146604A1 |
The invention relates to process for the continuous production of 4- chloroacetoacetyl chloride, comprising the steps of (a) feeding diketene and chlorine into a thin film reactor and (b) reacting the diketene and chlorine to obtain 4-ch...
|
|
WO/2012/142958A1 |
Provided are a Tigecycline crystalline hydrate, and a preparation method therefor and use thereof. The crystalline hydrate has high stability for storage, and is applicable to the preparation of medicaments for treating or preventing Gra...
|
|
WO/2012/139505A1 |
Provided are a linezolid intermediate and the preparation method thereof and a method for synthesizing linezolid. The structure of the intermediate is shown as formula F2, wherein the compound is prepared by a condensation reaction of (S...
|
|
WO/2012/137152A2 |
The present invention relates to a method for preparing formamide compounds using carbon dioxide, and to the use of said method for manufacturing vitamins, pharmaceutical products, adhesives, acrylic fibres, synthetic leathers, pesticide...
|
|
WO/2012/126386A1 |
The present invention provides a mixed crystal agomelatine (Form-VIII), the preparation method and use thereof and a pharmaceutical composition containing the same, wherein the mixed crystal mainly contains an agomelatine crystal form VI...
|
|
WO/2012/126385A1 |
The present invention provides a new crystal form VII of agomelatine, the preparation method and use thereof and a pharmaceutical composition containing the same. The new crystal form has a good purity, a stable crystal form and good rep...
|
|
WO/2012/123328A1 |
The invention relates to a novel process for preparing aromatic primary amides. The process involves reacting a compound of formula (II) with liquid ammonia in the presence of a solid Lewis acid catalyst to form a compound of formula (I)...
|
|
WO/2012/121179A1 |
A compound represented by formula (1), wherein X represents an n-valent group that is composed of C, H, N, O, S or a halogen; n represents an integer of 1-6; each of R1 and R2 represents H, a group represented by formula (2) or formula (...
|
|
WO/2012/121301A1 |
[Problem] To provide a process for producing a fluorine-containing substituted compound, which can produce the fluorine-containing substituted compound under temperature conditions that can be achieved industrially, using a simple appara...
|
|
WO/2012/116493A1 |
A chiral hydrogenation H8-BINOL bisphosphine compound is provided, with structural formula (I), wherein R1 and R2 are from halogen, H or C1-C10 fatty group; R3 is H or C1-C10 fatty group; R4 is from halogen, amino, nitro, H, C1-C10 fatty...
|
|
WO/2012/116577A1 |
The present invention relates to a compound of the following general formula (I) which has strong anti-oxidization activity, the preparation process thereof, an intermediate used, a composition and medical preparation comprising the comp...
|
|
WO/2012/114268A1 |
The invention relates to benzamide derivatives of formula (I),wherein R1, R2, R3, R4, R5, R6, n and Y are as defined in the description, their preparation and their use as pharmaceutically active compounds.
|
|
WO/2012/113999A1 |
A process for the industrial synthesis of the compound of formula (I) from the allyl cyanide of formula (II) and a compound of formula (III), wherein Xa is an -S-C(S)-OR group in which R is a linear or branched (C1-C6) alkyl group.
|
|
WO/2012/113738A1 |
The present invention relates to a chelating agent precursor that contains glutamic acid N,N-diacetic acid (GLDA) and/or methylglycine N,N-diacetic acid (MGDA) wherein at least one of the carboxylic acid groups is presentas a carboxylic ...
|
|
WO/2012/109749A1 |
The present application provides methods and catalysts for activation of carboxylic acids for organic reactions. In particular, methods are disclosed for direct nucleophilic addition reactions, such as, amidation reactions with amines, c...
|
|
WO/2012/103813A1 |
The present invention provides Danshensu derivatives containing a moiety of Chuanxiongqin (tetramethylpyrazine), and pharmaceutical compositions containing the Danshensu derivatives or their salts and pharmaceutically acceptable carriers...
|
|
WO/2012/103799A1 |
Disclosed are (2R,3R)-3-(3-substituted phenyl)-2-methyl-n-pentanamide compounds shown as formula I, their preparation methods thereof, wherein the substituents are described in the description, and their uses in the manufacture of Tapent...
|
|
WO/2012/103436A1 |
A method for preparing a compound of Formula (1) comprising contacting a compound of Formulae (2) and (3) in the presence of a palladium source, a ligand, a base and carbon monoxide wherein R1, R2, X and R3 are as defined in the disclosu...
|
|
WO/2012/102239A1 |
The present invention provides a process for producing an aromatic amidecarboxylic acid derivative represented by general formula (2), comprising a step of reacting an aromatic amidehalide derivative represented by general formula (1) wi...
|
|
WO/2012/098044A1 |
The invention concerns an improved process for the preparation of tolterodine (N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl propyl amine) and its salts, in particular for the preparation of the tartrate salt, and more particular...
|
|
WO/2012/097764A1 |
The invention provides a method for the preparation of chemically and polymorphously stable composition of agomelatine, based on a metastable form of agomelatine represented by the chemical formula (1), as well as a reproducible method o...
|
|
WO/2012/093402A1 |
The present invention relates to processes for the synthesis of N-[2-(7-methoxy-l - naphthethyl] acetamide, amorphous form of N-[2-(7-methoxy-l -naphthethyl] acetamide and pharmaceutical compositions thereof.
|
|
WO/2012/093411A2 |
The invention provides a process for resolution of R (±) - 3- (carbamoylmethyl)-5-methylhexanoic acid I to form enantiomerically pure form of compound of formula (I), the said process comprises resolution of racemic mixture of compound ...
|
