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WO/2010/015747A1 |
Process for obtaining the crystalline form V of the compound of formula (I), characterised in that a solution of agomelatine dissolved in one or two miscible solvents in all proportions and having a boiling temperature of less than 120°...
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WO/2010/015744A1 |
Process for the industrial synthesis of the compound of formula (I), characterised in that the (7-methoxy-1-naphtyl)acetonitrile of formula (II) is reacted and subjected to a hydrogen reduction in the presence of Raney nickel in a medium...
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WO/2010/015415A1 |
The present invention pertains to process for the amidation of a substituted 1-bromo-adamantane comprising a step (0) of reacting a substituted adamantane with an excess of bromine to obtain a 1-bromo-adamantane and a step (i) of reactin...
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WO/2010/015745A1 |
The invention relates to a method for the industrial synthesis of the compound of formula (I), characterised in that the 7-methoxy-1-naphtol of formula (II) is reacted.
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WO/2010/015746A1 |
The invention relates to a method for the industrial synthesis of the compound of formula (I), characterised in that the 3-methoxy acenaphtoquinone of formula (II) is reacted in the presence of a strong base.
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WO/2010/007408A2 |
The present invention relates to novel processes for the preparation of intermediate compounds which can be used to prepare therapeutic drugs. The invention relates to the intermediates 2-(2-Chloro-5-hydroxy-4-5 methylcarbamoylphenoxy)-2...
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WO/2010/007253A2 |
A method for preparing the compounds of formula (IV): in which R1, R2, R3 and R4, which may be identical or different, are each a hydrogen atom, a linear or branched (C1-C6) alkyl group, a linear or branched (C1-C6) alkoxy group, a fluor...
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WO/2010/005175A2 |
The present invention relates to a preparation method for novel crystalline cilastatin ammonium salts of chemical formula (1) which is used in the preparation of cilastatin sodium salts with high purity and the crystalline cilastatin amm...
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WO/2010/000856A1 |
The present invention relates to a method for producing substituted aminobiphenylene, in particular 2-aminobiphenylene, and a method for producing (het)acrylic acid amides of such aminobiphenyenes, in particular 2-aminobiphenyene.
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WO/2010/000964A1 |
Method for the microbiological production of cinnamoyl amide derivatives of amino acids, certain products that result therefrom and uses thereof, especially as antioxidants.
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WO/2009/157066A1 |
A process for producing an asymmetric catalyst Mannich reaction product, in which from an imine and acetaldehyde, a corresponding Mannich reaction product can be obtained with an asymmetric yield higher than in the prior art. The process...
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WO/2009/153206A2 |
The present invention relates to a process for the purification of crude bimatoprost to obtain pure bimatoprost comprising a chromatography, preferably a chromatography using an achiral stationary phase and an eluent comprising an alcoho...
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WO/2009/152474A2 |
The present invention relates to a process for the preparation of (2S,3S)-3-amino-N-cyclopropyl-2-hydroxyalkanamides as well as novel compounds prepared or used in the process.
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WO/2009/149344A2 |
The present invention describes a solid state of aliskiren free base, and process for the preparation thereof.
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WO/2009/147141A2 |
The invention relates to functionalised diols of diamondoids wherein one of the two hydroxy groups is masked by a protective group, and to methods for producing said functionalised diols. The protective group is a -CHR1R2 group, wherein ...
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WO/2009/147383A1 |
The present invention provides a process for preparing a compound of formula (Vl) or a salt thereof, the process comprising: (i) reacting 4-methoxyphenyl acetone with an amine of formula (VIII) under conditions of reductive amination to ...
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WO/2009/144736A1 |
A novel process for the preparation of 4-fluoro-α-[2-methyl-1-oxopropyl]-γ-oxo-N-β-diphenylbenze
nebutanamide also known as 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pe
ntanoic acid phenylamide of the formula (I) conta...
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WO/2009/144197A1 |
Method for producing aromatic and heteroaromatic carboxylic acids, carboxylic acid esters and carboxylic acid amides through the reacting of aromatic or heteroaromatic halogenides R-Xn, where n = a whole number from 1 to 6, R = a substit...
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WO/2009/146067A2 |
A novel monomer, 1,1,1-tri-[4-(methacryloxyethylaminocarbonyloxy)-phenyl] ethane (MPE) can be used in preparing dental compositions The MPE monomer can be combined into a dental adhesive with hydroxyethyl methacrylate (HEMA) and BisGMA (...
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WO/2009/144175A1 |
The invention relates to a process for preparing fatty acid amides by reacting a fatty acid and an amine, especially serotonin as well as tryptamine, tyramine and derivatives thereof, in the presence of a coupling reagent which is capabl...
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WO/2009/145263A1 |
Disclosed are a process suited to large scale synthesis with high yield for producing oseltamivir phosphate, in which a preparation of oseltamivir phosphate which is highly safe as a pharmaceutical product can be produced, and an interme...
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WO/2009/138778A1 |
A process for preparing a compound of formula (I) or a pharmaceutically acceptable salt thereof; wherein Qa is as defined in the specification, the compounds being useful in the preparation of therapeutic agents, in particular cytokine i...
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WO/2009/137916A1 |
The present application relates to processes for the preparation of oseltamivir and the H3PO4 salt of oseltamivir, Tamiflu®. The application further relates to novel intermediate compounds and to pharmaceutical compositions containing s...
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WO/2009/135598A1 |
The present invention relates to a process for preparing substituted biphenylanilides of the formula (I), wherein R1 is a protected amino group which comprises reacting a compound of formula (II), in the presence of a base and of a palla...
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WO/2009/135860A1 |
Method for manufacturing aryl carboxamides of the formula (I), with Ar = singly to triply substituted phenyl , pyridyl or pyrazolyl rings, wherein the substituents are selected from halogen, C1-C4 alkyl and C1-C4 halogen alkyl; M = thien...
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WO/2009/134030A1 |
The present invention relates to a novel process for preparing iopromide which is used as a contrast agent for X-ray, wherein 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-diacetoxypropyl)amide chloride of formula (19) and 5-me...
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WO/2009/131324A2 |
Disclosed herein are a method for synthesizing one-dimensional helical mesoporous structure, in which a self-assembled structure of a glycine-derived surfactant is used as a template at room temperature to synthesize the one-dimensional ...
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WO/2009/130075A2 |
The invention relates to a catalyst for reacting carboxylic acid nitriles with water, the catalyst comprising at least 60% by weight of manganese dioxide having the empirical formula MnOx, wherein x is in the range of 1.7 to 2.0, and at ...
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WO/2009/130735A1 |
The invention relates to novel derivatives of short-chain fatty acids, in particular derivatives of butyric acid, useful for all the known clinical applications of the latter, which show physicochemical characteristics suitable for an ea...
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WO/2009/127942A2 |
A process is described for the production of one or more of linear nitriles, amides and formamides which includes reacting a nitrogen containing compound, such as ammonia or NOx, and a synthesis gas over a catalyst at a temperature of be...
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WO/2009/125565A1 |
Disclosed is a novel ruthenium compound which is useful as an asymmetric reduction catalyst for a carbonyl compound. The ruthenium compound is represented by the following formula (I): Ru(X)2(Pxx)[R1R2C(NH2)-R3R4C(NH2)], and when the com...
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WO/2009/121486A1 |
The invention relates to a continuous method for producing amides, according to which at least one carboxylic acid of formula (I) R3-COOH (I), wherein R3 is an optionally substituted alkenyl group comprising between 2 and 4 carbon atoms,...
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WO/2009/121940A1 |
The present invention is directed to a novel process for the preparation of (4-chloro-phenyl)-(3-thfluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester, useful in the treatment of metabolic disorders and further to a process for t...
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WO/2009/121487A1 |
The invention relates to a continuous method for producing fatty acid amides, according to which at least one fatty acid of formula R3-COOH (I), wherein R3 is an optionally substituted aliphatic hydrocarbon radical, is reacted with at le...
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WO/2009/123241A1 |
Disclosed is a novel compound having an inhibitory activity on a plasminogen activator inhibitor-1 (PAI-1). Also disclosed is a PAI-1 inhibitor comprising the compound as an active ingredient. Further disclosed is a pharmaceutical compos...
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WO/2009/121484A1 |
The invention relates to a continuous method for producing amides of aromatic carboxylic acids, according to which at least one aromatic carboxylic acid of formula (I) Ar-COOH, wherein Ar is an optionally substituted aryl radical compris...
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WO/2009/121488A1 |
The invention relates to a method for producing carboxylic acid amides, according to which at least one carboxylic acid of formula (I) R3-COOH (I), wherein R3 is hydrogen or an optionally substituted hydrocarbon radical comprising betwee...
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WO/2009/121490A1 |
The invention relates to a continuous method for producing amides, according to which at least one carboxylic acid of formula (I) R3-COOH (I), wherein R3 is hydrogen or an optionally substituted alkyl group comprising between 1 and 4 car...
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WO/2009/121489A1 |
The invention relates to a continuous method for producing hydroxycarboxylic acid amides, according to which at least one hydroxycarboxylic acid of formula (I) HO-R3-COOH (I), wherein R3 is an optionally substituted aliphatic hydrocarbon...
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WO/2009/121485A1 |
The invention relates to a continuous method for producing fatty acid alkanol amides, wherein at least one fatty acid of the formula (I) R3-COOH, where R3 is an optionally substituted aliphatic hydrocarbon radical with 5 to 50 carbon ato...
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WO/2009/121788A1 |
A process for the preparation of a compound of formula (Ia): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds.
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WO/2009/118493A2 |
The invention relates to the continuous aqueous-phase synthesis of an N-acylated compound including a unit (M1) of the formula (I) in which n is 0, 1 or 2 and R1 is an aliphatic radical, wherein said synthesis comprises: the step A of re...
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WO/2009/118474A1 |
The invention relates to a method for preparing a combretastatin (A): formula (I) in the form of a base or of an addition salt with an acid, which comprises coupling, in the presence of a base and of T3P, the salt of the (Z)-amino compou...
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WO/2009/117317A1 |
A method of removing a carboxylic acid from a liquid that contains a tertiary amide solvent includes a step of contacting the liquid with an extraction medium comprising an amine. The amine is immiscible with both water and the tertiary ...
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WO/2009/115334A2 |
The present invention relates to a process for manufacturing N-Formyl-1-amino-3,5-dimethyladamantane, an intermediate product in the overall process of producing 1-Amino-3,5-dimethyladamantane hydrochloride (Memantine). Therein, the proc...
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WO/2009/114966A1 |
The process for preparing tamibarotene II type crystal of a single heat-absorptive peak near 233 oC in differential scanning thermal analysis. The process comprises the following steps: using low carbon organic acids (preferred acetic ac...
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WO/2009/112615A1 |
The invention applies to the field of pharmacology and medical chemistry and relates to novel molecules represented by general formula (I), especially referred to as FM19G11, and to pharmaceutical compositions containing same. Said pharm...
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WO/2009/113617A1 |
Disclosed is a method which can stabilize an aqueous acrylamide solution conveniently by using a stabilizer that can be separated and removed readily. Specifically disclosed is a method for stabilizing an aqueous acrylamide solution, whi...
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WO/2009/109792A1 |
New chiral stationary phases (CSPs) based on chiral selectors covalently bound on a solid support were prepared. Chiral selectors were obtained from enantiomerically pure aromatic amines and 3,5-dinitrobenzoic acid and then linked to the...
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WO/2009/110217A1 |
Provided is a hydroxyapatite with silver supported on the surface thereof, which is a novel compound useful as a catalyst in a reaction where a nitrile compound is hydrated to obtain a corresponding amide compound. The hydroxyapatite wit...
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