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WO/2012/093225A1 |
Process for the industrial synthesis of the compound of formula (I).
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WO/2012/089177A1 |
The present solution relates to a method comprising, as a key step, production of optically pure or optically enriched tapentadol of formula I, in which optically pure or optically enriched (2R,3R)-amines of general formula V, wherein R ...
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WO/2012/089181A1 |
The compounds of general formula II are new and represent important intermediates in the synthesis of tapentadol. In the synthesis of tapentadol of formula I and its pharmaceutically acceptable salts, O-protected (2R,3R)-acids of general...
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WO/2012/088648A1 |
Disclosed are the deuterated acid salts of oseltamivir, namely, ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohex
ene-1-carboxylate, hydrates thereof and their preparation methods. More specifically, oseltamivir phosphat...
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WO/2012/084926A1 |
The invention relates to industrial preparation of contrast agents, and further to an improved process for the purification of contrast agents. In particular, it relates to a process for reducing the salt content of compositions comprisi...
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WO/2012/077221A1 |
Provided are: a 3-aminooxalylaminobenzamide derivative for use in an insecticidal and acaricidal agent; and an intermediate thereof. The 3-aminooxalylaminobenzamide derivative is represented by formula [1] [wherein R1 and R2 are each C1-...
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WO/2012/076560A1 |
The present invention provides a process for preparing primary amines, comprising the steps of A) providing a solution of a primary alcohol in a fluid, non-gaseous phase, B) contacting the phase with free ammonia and/or at least one ammo...
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WO/2012/078147A1 |
A process for preparing 4-[(2R)-2-X-methyl)-3-methylbutyl]-1 -methoxy-2-3(3- methoxypropoxy)-benzene wherein X is a leaving group and use of this compound in the synthesis of aliskiren.
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WO/2012/073910A1 |
Provided are a method for producing a sanshool, the method having a short process and being highly stereoselective, and an iron carbonyl complex compound which is a useful intermediate for the method of production. A diene iron complex c...
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WO/2012/070025A1 |
The present invention relates to a process for the manufacture of N-[2-(7-methoxy-1-naphthalenyl) ethyl]acetamide (Agomelatine) with improved yield and reduced level of N- acetyl-N-[2-(7-methoxy-1-naphthalenyl) ethyl]acetamide impurity.
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WO/2012/069423A1 |
The invention relates to a method for the preparation of 2-(6'-methoxy-2'-naphthyl)propionic acid chloride(naproxen chloride) using phosgene, and a method for the preparation of esters and amides derived from the thus prepared naproxen c...
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WO/2012/069855A1 |
There is provided a process for the preparation of Lacosamide (which is a useful medicament) of formula I, which comprises an enantioselective enzymatic acylation.
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WO/2012/069004A1 |
Disclosed are a preparation method for a key intermediate of tapentadol: (1R, 2R)-1-ethyl-2-methylbenzene ethane compound, and a method for applying the key intermediate in the preparation of tapentadol and a derivative thereof.
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WO/2012/067470A2 |
A method of preparing dialyl lactamides. The method of preparing dialkyl lactamides includes preparing ammonium lactate by reacting at least one compound selected from the group consisting of lactic acid and esters thereof with at least ...
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WO/2012/059933A1 |
The present invention relates to an improved and commercially, viable process for the resolution of racemic cis milnacipran of formula I and its pharmaceutically acceptable salts of formula II. The present invention comprises using racem...
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WO/2012/058866A1 |
Provided are a benzamide derivative as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the preparation method and use thereof for preparing a medicine for treating cancer, wherein the group definitions of formula ...
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WO/2012/053787A2 |
The present invention relates to a compound having HIF-1 inhibition activity, to a method for preparing same, and to a pharmaceutical composition containing same as an active ingredient. The compound of the present invention exhibits ant...
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WO/2012/053768A2 |
Disclosed are a compound inhibitory of HIF-1 activity, a method for preparing the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound has anticancer activity which is attributable to its inhib...
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WO/2012/052405A2 |
The invention relates to a method of the preparation of a cationic surfactant, derived from the condensation of fatty acids and esterified dibasic amino acids, having the formula (I): having a mean particle diameter of less than 300 μm;...
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WO/2012/047543A1 |
Disclosed are methods for preparing compounds of Formula 1 and 1A. The first method utilizes a benzyl carbamate amine protecting group and an intermediate of Formula 4. The second method utilizes a tert-butyl carbamate amine protecting g...
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WO/2012/042608A1 |
Provided is a novel 3-aminobenzoic acid derivative, said derivative being useful as an intermediate in the production of a 3-oxamoylaminobenzamide derivative which has a pesticidal and miticidal activity, and a method for producing the s...
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WO/2012/040922A1 |
A method for preparing N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl -L-lysine is provided. The method comprises: adding crude N2-[1-(S)-ethoxy carbonyl-3-phenyl-propyl]-N6-trifluoroacetyl-L-lysine to an organic solvent, ad...
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WO/2012/041986A1 |
The present invention relates to a process of manufacture of compounds of formula (B) wherein R1, R2 and R3 are as defined for compounds of formula (A), which process comprises hydrogenation of compounds of general formula (A). In partic...
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WO/2012/038515A1 |
The present invention relates to a process for preparing an N-acetyl-D,L-leucine mixture, and in particular a racemic mixture, which comprises the reaction consisting of racemisation of a base addition salt of N-acetyl-L-leucine or of N-...
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WO/2012/035557A1 |
The present invention discloses novel cationic amphiphiles containing mannose-mimicking shikimic and quinic acid head-groups and a process for preparing cationic amphiphiles with mannose-mimicking polar head-groups such as, shikimic and ...
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WO/2012/034991A1 |
The invention relates to a method for producing formamides by reacting carbon dioxide (1) with hydrogen (2) in a hydrogenation reactor I in the presence of: a catalyst, containing an element from group 8, 9 or 10 of the Periodic Table, a...
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WO/2012/016314A9 |
The present invention describes the production of arachidonic acid-derived coxib analogue-substituted compounds and salts thereof for use in treating pain. Furthermore, the invention relates to pharmaceutical compositions containing arac...
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WO/2012/034065A1 |
The present invention provides aliskiren intermediates and impurities, and processes for preparation thereof. The present invention also provides processes for preparing aliskiren using these intermediates and impurities. These impuritie...
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WO/2012/033091A1 |
Provided is an industrially more advantageous process for preparing novel pyridine derivatives which are expected to be utilized as drugs. A process for preparing high-quality 3-(6-hydroxy -1-methyl-1H-benzimidazol-2-yl)benzoic acid este...
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WO/2012/032084A1 |
The present invention relates to tripodal catechol derivatives having an adamantyl basic framework for functionalizing surfaces, to methods for the production and to the use thereof. The remaining fourth bridgehead position can easily be...
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WO/2012/032085A1 |
The present invention relates to tripodal catechol derivatives having a flexible basic framework for functionalizing surfaces, to methods for the production and to the use thereof. The central atom of the flexible frameworks is a tertiar...
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WO/2012/031573A1 |
Provided is a compound as shown in general formula (I), wherein the definitions for the various substituents are as stated in the specification. Also provided are a method for preparing the compound, use of the compound in the preparatio...
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WO/2012/029276A1 |
The present invention addresses the problem of providing a recording material or sheet which is excellent not only in the whiteness of non-image areas but also in the storage of non-image areas and images and which exhibits excellent col...
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WO/2012/020483A1 |
A 3-aminooxalyl aminobenzamide derivative used in an insecticide and miticide is provided. The 3-aminooxalyl aminobenzamide derivative is represented by the following formula. (In the formula, R1 represents a C1 to C3 halo alkylthio grou...
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WO/2012/020484A1 |
A 3-aminooxalyl aminobenzanilide derivative used in an insecticide and miticide is provided. The 3-aminooxalyl aminobenzanilide derivative is represented by the following formula. (In the formula, R1 and R2 are both halogen atoms; R3 and...
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WO/2012/021446A2 |
The present application relates to a process for the preparation of aliskiren and its pharmaceutically acceptable salts. In particular, the present application relates to a process for the preparation of intermediates for aliskiren, and ...
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WO/2012/017966A1 |
The invention addresses the problem of providing complex compound catalysts that have high catalytic activity, are inexpensive and do not have the theoretical production limitations of solid catalytic methods (problems of contamination w...
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WO/2012/014760A1 |
Disclosed is a method for producing a carboxylic acid amide, which involves a step in which a carboxylic acid ester represented by formula (1) (in the formula, R1 represents an optionally substituted C1-20 hydrocarbon group or an optiona...
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WO/2012/014226A1 |
The present invention discloses novel process for the preparation of (2R)-2-acetamido-N- benzyl-3-methoxypropanamide of Formula I involving novel intermediates of Formula - XIX and Formula - XX.
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WO/2012/010651A2 |
The present invention relates to method for the preparation of an ω-amino-alkane(thio)amide having the formula (3). Furthermore, novel intermediates and partial reaction steps of the claimed method are disclosed.
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WO/2012/010923A1 |
The subject of the present invention is a process for preparing acrolein and/or acrylic acid by dehydration of glycerin in the presence of molecular oxygen in an amount chosen so as to be outside the flammability range at any point in th...
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WO/2012/007547A1 |
The present invention relates to a process for the preparation of 5-[(2- hydroxyacyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamidic derivatives comprising the Smiles rearrangement of a suitable precursor, by contact of an aqueous solution...
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WO/2012/005182A1 |
A rare earth metal extractant containing, as the extractant component, dialkyldiglycol amide acid which is excellent in breaking down light rare earth elements is reacted in diglycolic acid (Xmol) and an esterification agent (Ymol) at a ...
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WO/2012/005183A1 |
A rare earth metal extractant containing, as the extractant component, dialkyldiglycol amide acid which is excellent in breaking down light rare earth elements is reacted in diglycolic acid (Xmol) and an esterification agent (Ymol) at a ...
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WO/2012/005317A1 |
Provided are: a methylenebis(fatty acid amide) composition which exhibit stable adhesive characteristics and peeling characteristics under various environmental conditions and which can minimize the stains of an adherend; a pressure-sens...
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WO/2012/005200A1 |
An industrially advantageous method for producing an optically active 1,2-bis(dialkylphosphino)benzene derivative, wherein borane is removed from a phosphine-borane compound (1), followed by lithiation, then the reaction product is react...
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WO/2012/001710A1 |
The present invention relates to a novel and improved process for the preparation of lacosamide, wherein the process is a sequential one-pot process.
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WO/2011/157670A2 |
The present invention relates to a process for the preparation of benzamide derivatives which are useful as intermediates in the preparation of pharmaceutically active compounds.
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WO/2011/158249A1 |
Disclosed is a process for the preparation of milnacipran intermediate, a compound of formula ΙII, and its use in the preparation of pure milnacipran.
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WO/2011/157986A1 |
The present invention relates to a process for the preparation of substantially pure nateglinide of formula (I), substantially free from the cis-isomer and L-enantiomer and preparation of enantiomerically pure nateglinide form B, directl...
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