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WO/1999/031075A1 |
Novel amines of formulas (1), (1C), (1F), (1G) and (1H) or a pharmaceutical acceptable salt thereof wherein n is an integer of from 0 to 2; m is an integer of from 0 to 3; R is sulfonamide, amide, phosphonic acid, heterocycle, sulfonic a...
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WO/1999/031057A1 |
Novel amines of formulas (1D) and (1E), or a pharmaceutically acceptable salt thereof, wherein: n is an integer of from 0 to 2; R is sulfonamide, amide, phosphonic acid, heterocycle, sulfonic acid, or hydroxamic acid; and X is -O-, -S-, ...
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WO/1999/029640A2 |
Aromatic acids and pharmaceutical compositions of aromatic acids of formula Ar-M-Y and methods for using the pharmaceutical compositions for modulating the activity of the FGF family of peptides are provided. Methods for inhibiting the b...
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WO/1999/028292A1 |
The invention concerns ionic compositions with high ionic conductivity, comprising a salt with delocalized anionic charge. An ionic composition comprises a salt dissolved in a solvent and has a conductivity higher than 10?-5¿ S.cm?-1¿ ...
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WO/1999/024604A1 |
The invention concerns a method for detecting and identifying and/or quantifying an enzymatic activity such as deaminase of a micro-organism, which consists in contacting an inoculum capable of containing a micro-organism with a deaminas...
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WO/1999/024139A1 |
A process for separating a compound from a mixture of different compounds is disclosed for compounds comprising at least two negatively charged groups connected by a linker group. The process comprises treating the mixture with a materia...
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WO/1999/022858A1 |
A method of reacting an aromatic compound with an immiscible reacting agent involves the passage of the reactant along a flow path having a width of from 10 to 1000 $g(m)m in such a way that essentially laminar flow of the reactant takes...
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WO/1999/023079A1 |
The invention relates to compounds of formula (I) or the salts thereof, wherein R?1¿, R?3¿ = H, (substituted) hydrocarbon radical (KW) or (substituted) heterocyclyl, which comprise inclusive substituents 1-30 C-atoms, R?2¿ = R?0¿-Q?0...
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WO/1999/020640A2 |
Oligonucleotides and other biomolecules are immobilized in high density on solid substrates through covalent forces using either a permanent thioether bond, or a chemoselectively reversible disulfide bond to a surface thiol. Substrates w...
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WO/1999/018110A1 |
The invention concerns (R)-sulphonyloxyacetic ester derivatives of general formula (I) in which R¿1? represents a benzyl group, C¿1?-C¿4? alkyl optionally substituted by one or several halogen atoms, or phenyl optionally substituted b...
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WO/1999/018064A1 |
The invention concerns a method for functionalizing a phenolic compound bearing an electron-donor group, in said group para position, inter alia a method for the amidoalkylation of a phenolic compound bearing an electron-donor group, and...
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WO/1999/016742A1 |
The present application relates to a series of novel sulfonic acid metal cation salts of formula (I) which are useful intermediates to prepare antifolate 5-substituted pyrrolo[2,3-d]pyrimidines. The present invention also relates to a no...
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WO/1999/016746A1 |
Novel aminoalkylphenols, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction utilizing the aminoalkylphenols or compositions thereof are disclosed.
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WO/1999/016743A1 |
The present invention relates to a process for preparing $i(o)-(carboalkoxy) phenylmethanesulfonyl chloride derivatives and more particularly to a novel process for preparing $i(o)-(carboalkoxy)phenylmethanesulfonyl chloride expressed by...
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WO/1999/014293A1 |
The invention concerns a stable oil-in-water microemulsion, whereof the drop dimension ranges substantially between 10 and 100 nm. Said microemulsion contains a) between 25 and 50 wt. % of C¿12-22? fatty acid methylester; b) between 10 ...
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WO/1999/014192A1 |
The salt of a sulfonated succinic acid is cyclized, then converted to novel sulfonated hydroxamic acids by reaction with hydroxylamine (which is added or formed $i(in situ)), and the novel hydroxamic acid is then cyclized to the sulfo-N-...
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WO/1999/009004A2 |
The present invention relates to a process for the preparation of a purified salt of 4-sulfophenyl-[(1-oxyalkanoyl)amino] alkanoate. The process comprises the steps of: (a) providing a source of 4-sulfophenyl-[(1-oxyalkanoyl)amino] alkan...
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WO/1999/007793A1 |
Various classes of dyes are provided having acid, ester or amide groups for covalent linking to biomolecules. The dyes may be prepared by use of a compound of formula (I) where R?1¿ comprises a linker and a carboxy including acid, salt,...
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WO/1999/008299A1 |
Improved nonaqueous electrolytes for application in electrical storage devices such as electrochemical capacitors or batteries are disclosed. The electrolytes of the invention contain salts consisting of alkyl substituted, cyclic delocal...
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WO/1999/007656A2 |
Processes for making particularly branched, especially monomethyl-branched or nongeminal dimethyl-branched surfactants used in cleaning products; preferred processes comprising particular combinations of two or more adsorptive separation...
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WO/1999/006363A1 |
The invention relates to a method for sulfochlorinating acetanilide, characterised in that the acetanilide is introduced into a reaction vessel in fused form and then reacted with chlorosulfonic acid and thionyl chloride. The intermediat...
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WO/1999/005356A1 |
The invention relates to mixtures of optical brighteners, consisting of non-ionic polyester brighteners and anionic or non-ionic polyamide brighteners which have a synergistic effect. The inventive brighteners are suitable for polyamide ...
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WO/1999/005244A1 |
A surfactant composition comprising: alkylarylsulfonate surfactant system comprising at least two isomers of the alkylarylsulfonate surfactant of formula (I) wherein: L is an acyclic aliphatic hydrocarbyl of from 6 to 18 carbon atoms in ...
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WO/1999/005082A1 |
The present invention is in the field of processes for making alkylbenzenesulfonate surfactants. The processes herein include a combination of two essential steps, delinearization and alkylation. The delinearization step selected herein ...
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WO/1999/005084A1 |
The present invention is in the field of processes for making modified alkylbenzenesulfonate surfactants and of the products of such processes, including the surfactant compositions and consumer cleaning products, especially laundry dete...
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WO/1999/005241A1 |
Cleaning compositions, especially laundry detergents and the like comprising: (i) modified alkylarylsulfonate surfactants, e.g., modified alkylbenzenesulfonates, which are the product of particular processes and (ii) cleaning adjuncts su...
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WO/1999/005189A1 |
Olefins containing selected functional groups such as silyl, ether and alkenyl, and often containing a blocking group, may be copolymerized with unsubstituted olefins such as ethylene and propylene in the presence of certain coordination...
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WO/1999/002146A1 |
Compounds represented by general formula (I), salts thereof and type N calcium channel inhibitors containing the same as the active ingredient, wherein R?1¿ represents optionally substituted alkyl, alkoxy or phenyl, a heterocyclic group...
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WO/1999/001419A1 |
A process for producing 2-aminomalonic acid derivatives of general formula (1) (wherein A is linear or branched alkylene having 1 to 10 carbon atoms; R?1¿ is linear or branched alkyl having 2 to 20 carbon atoms; R?2¿ and R?3¿ may be t...
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WO/1999/001429A1 |
New oximsulfonate compounds of formulae (I) or (II), wherein m is 0 or 1; x is 1 or 2; R¿1? is, for example phenyl, which is unsubstituted or substituted or R¿1? is a heteroaryl radical that is unsubstituted or substituted, or, if m is...
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WO/1999/001423A1 |
Non-peptide compounds comprising a central hydrazide motif and methods for the synthesis thereof. The compounds act to antagonize the action of the glucagon peptide hormone.
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WO/1999/001420A1 |
A process for the preparation of 2-aminomalonic acid derivatives of general formula (1), characterized by deacylating compounds of general formula (2), halogenating the resulting compounds, reacting the resulting halogenated compounds wi...
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WO/1998/051661A1 |
New aminium compounds having an excellent solubility in solvents, being highly safe in handling and for the environment, and represented by general formula (1), (wherein R�1? is a substituted or unsubstituted alkyl group; and A�2? is...
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WO/1998/050367A1 |
The invention relates to processes and intermediates for preparing compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R, R?1�, R?2�, and R?3� are as defined herein. The above compounds of formula (I) ar...
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WO/1998/050389A1 |
Aluminum compounds represented by formula (1): Al(R?1�-SO�3?)�l?(R?2�)�m?(R?3�)�n? (wherein R?1� represents an optionally substituted hydrocarbon group; R?2� represents an optionally substituted hydrocarbon group, an op...
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WO/1998/050347A1 |
The present invention relates to a novel class of compounds that are potent inhibitors of HIV reverse transcriptase and HIV integrase. In addition to being multienzyme inhibitors, the inventive compounds of the present invention are rema...
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WO/1998/049137A1 |
Compounds represented by general formula (I) wherein R?1� and R?2� are each independently C�1?-C�6? alkyl; R?3� and R?4� are each independently hydrogen or C�1?-C�6? alkyl; and R?5� and R?6� are each independently hyd...
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WO/1998/047473A1 |
The invention relates to the use of unsaturated aldehydes of formulae (Ia) or (Ib), wherein R?1�, R?2�, R?3� and R?4� independently mean hydrogen, halogen, a C�1?-C�4?-alkoxy, C�1?-C�4?-alkyl, aryl radical or a C�1?-Cï¿...
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WO/1998/047879A1 |
A compound having formula (I) or a pharmaceutically acceptable salt thereof wherein one of R?1�, R?2� and R?3� is a cyclic or heterocyclic acidic functional group having a pKa value below 8 or a group which is convertible in vivo t...
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WO/1998/047865A1 |
The invention relates to amphiphilic compounds with at least two hydrophilic and at least two hydrophobic groups on a di- oligo- or polyene base, to a method for producing said amphiphilic compounds, and to the use of said amphiphilic co...
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WO/1998/047523A1 |
The present invention is directed to novel peptidyl-2-amino-1-hydroxyalkanesulfonic acid inhibitors of cysteine proteases. Methods for the use of the protease inhibitors are also described.
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WO/1998/046711A1 |
The invention relates to a method for producing sulfated fatty acid esters with a reduced electrolyte content, whereby a) unsaturated fatty acid esters are saturated with low alcohols or glycerin with sulfuric acid or fuming sulfuric aci...
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WO/1998/045265A1 |
The invention provides a process for covalently coupling organic compounds which comprises reacting an aromatic ring compound having a halogen or halogen-like substituent at a coupling position with a diboron derivative in the presence o...
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WO/1998/043952A1 |
A compound represented by the general formula (1): FSO�2?CFXCF�2?O(CFXCF�2?O)�n?CF(CF�2?Y)COF, wherein X is a fluorine or chlorine atom or trifluoromethyl; Y is a fluorine, chlorine, bromine, or iodine atom; and n is 0, 1, or 2...
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WO/1998/043946A1 |
Processes for preparing compounds of the formula (I) are described: P?1�OOC-CH(OH)-CHR?1�-CONH-Z wherein P?1� is hydrogen or a protecting group, Z is a group -CHR?2�COOP?2� or -CHR?2�CONR?3�R?4� wherein P?2� is hydrogen...
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WO/1998/043945A1 |
Stable and non hygroscopic salts of L-carnitine or lower alkanoyl-L-carnitine with 2-aminoethanesulfonic acid are disclosed suitable for preparing solid compositions useful as dietary/nutritional supplements for human use and as fodder s...
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WO/1998/043953A1 |
The invention relates to a compound of formula (I) wherein the groups N(R?3�) and R?4� are separated by at least 4 ring carbon atoms; R?1� represents a phenyl, naphthyl, phenoxymethyl, thiazolyl, pyridyl or pyrimidyl group, optiona...
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WO/1998/043632A1 |
A compound of formula (I), wherein A and C are independently H, alkyl of 1-6 carbon atoms, hydroxy, or alkoxy of 1-6 carbon atoms; B is hydroxy, alkoxy of 1-6 carbon atoms, -CO�2?Z, -O(CH�2?)�m?CO�2?Z, -SO�3?Z, -OPO�3?Z�2?;...
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WO/1998/042658A1 |
A process is provided for preparing a fatty acyl isethionate salt of the formula R?1�C(O)OR?2�SO�3?M which comprises reacting at least one fatty acid of the formula R?1�C(O)OH with at least one hydroxyalkanesulfonic acid salt of ...
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WO/1998/042660A1 |
A process for producing halogenoalkylsulfonamide derivatives represented by general formula (I); intermediates thereof; and a process for producing these intermediates; wherein R?1� represents alkyl, hydroxyalkyl, cycloalkyl or phenyl ...
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