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WO/2002/000167A2 |
In accordance with the present invention, there are provided modified forms of nonsteroidal anti-inflammatory drugs (NSAIDs). Modified NSAIDs according to the invention provide a new class of anti-inflammatory agent which provides the th...
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WO/2001/098263A1 |
The invention relates to a method for producing aliphatic sulfonic acid chlorides by reacting aliphatic sulphonic acids with phosgene in the presence of dimethyl formamide. The inventive method is characterised in that catalytic quantiti...
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WO/2001/096348A1 |
3-Substituted benzotrifluorides are selectively deprotonated and functionalized in the 2-position. The selectively is achieved by equilibrating the mixture of lithiobenzotrifluorides initially formed in the presence of a primary or secon...
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WO/2001/094303A2 |
The invention relates to a process for isolating a phenyl ester salt from a mixture comprising sulfolane (tetrahydrothiophene-1,1-dioxide). The invention includes adjusting the temperature of a mixture comprising a phenyl ester salt and ...
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WO/2001/094304A1 |
A process for the production of sulfonic ester derivatives of the general formula (4) or (5) by reacting an amino alcohol of the general formula (1) or (2) with an organic sulfonyl halide of the general formula (3) in a mixed solvent of ...
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WO/2001/094295A1 |
The present invention relates to chemical compounds, pharmaceutical compositions comprising said compounds, methods of treatment administering these compounds to mammalian hosts, and processes for their preparation. Specifically, the inv...
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WO/2001/094302A2 |
A process for the purification and isolation of a chemical compound, by extractive solution crystallization. The process comprises combining in any order a first solvent, a second solvent, and a mixture comprising a chemical compound wit...
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WO/2001/094509A2 |
The present invention relates to a process for preparing an aqueous solution of a C¿14?-C¿16? alpha olefin sulfonate, wherein the aqueous solution has a Klett color of less than 12, when diluted with water to a 5% solution.
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WO/2001/094305A1 |
The present invention provides a monomer having the formula A-B, wherein A is represented by Formula I:wherein B is selected from -OCF=CF2 and -A; wherein, when B is -OCF=CF2, the orientation of B is meta or para to the trifluorovinyloxy...
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WO/2001/092216A2 |
The invention relates to a process for purifying and decolorizing a phenyl ester salt. The process combines a phenyl ester salt with a solvent to form a mixture and then stirs the mixture to form a slurry. The phenyl ester salt is substa...
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WO/2001/092217A2 |
The present invention relates to a process for the preparation of amidostyrylstilbene-disulphonic acid derivatives represented by formula (1) in which X represents a group of formula (2), (3) or (4), whereby, in formula (2), R¿1? is hyd...
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WO/2001/089457A2 |
Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a huma...
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WO/2001/089472A1 |
The present invention includes a composition comprising an enriched mixture of $g(a)-sulfofatty acid esters. Increasing the concentration of specific chain length $g(a)-sulfofatty acid esters, relative to the proportions of the other cha...
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WO/2001/087838A1 |
The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and (e); and R?1¿, R?2¿, R?3¿, R?4¿, R?5¿,...
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WO/2001/087900A1 |
The invention provides a phosphonium salt of formula I wherein R?1¿, R?2¿, R?3¿, and R?4¿ are C¿1-20? hydrocarbyl groups and X is an anion, except halide, provided that (i) R?1¿, R?2¿, R?3¿, and R?4¿ are not all the same; and (i...
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WO/2001/087814A2 |
The present invention discloses a process for the semi-synthesis of 4-demethoxydaunomycinone, (8s-cis)-acetyl-10-hydroxy-7,8,9,10-tetrahydro-6,8,11-trihyd
roxy-5,12-naphthacenedione, of formula (I).
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WO/2001/085678A1 |
The invention relates to a method for the production of $g(V)-aminoalkylsulphonic acids of general formula (I), where R1 and R2 = optionally substituted alkyl groups with 1 20 C atoms and n = a whole number from 2 6, whereby an amine of ...
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WO/2001/083421A1 |
A process for the preparation of 2-halobenzoic acids of the general formula (I), characterized by reacting a benzoic acid of the general formula (II) with a halogenating agent in the presence of a Pd catalyst. [In the formulae, A is -OH,...
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WO/2001/081365A2 |
A metal chelating composition having the formula: wherein Q is a carrier; S?1¿ is a spacer; L is -A-T-CH(X)- or -C(&equals O)-; A is an ether, thioether, selenoether, or amide linkage; T is a bond or substituted or unsubstituted alkyl o...
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WO/2001/081349A1 |
A novel, optically active, quaternary ammonium salt with axial asymmetry which is useful as a phase-transfer catalyst with which a glycine derivative is stereoselectively alkylated to convert it into an optically active $g(a)-amino acid ...
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WO/2001/079151A1 |
The invention relates to the production of nitro benzoic acids by oxidation of special nitro toluenes, nitro benzyl alcohols, esters and/or ethers in the presence of nitric acid at a high temperature and high pressure. The special nitro ...
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WO/2001/077071A1 |
The invention relates to a method for producing ditaurine and salts thereof from taurine or its salts or from mixtures thereof by heating the starting material to temperatures ranging from 130 °C to 300 °C in the presence of a reaction...
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WO/2001/077668A2 |
The present invention provides methods for analyzing proteomes, as cells or lysates. The analysis is based on the use of probes that have specificity to the active form of proteins, particularly enzymes and receptors. The probes can be i...
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WO/2001/077684A2 |
The present invention provides methods for analyzing proteomes, as cells or lysates. The analysis is based on the use of probes that have specificity to the active form of proteins, particularly enzymes and receptors. The probes can be i...
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WO/2001/074764A1 |
Intermediates for the synthesis of 1$g(a)-hydroxyvitamin D derivatives useful as drugs; and processes for the preparation of the same. Specifically, a process for the preparation of a compound of the general formula (5), which comprises ...
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WO/2001/074976A2 |
The present invention relates to an emulsifier composition suitable for mixing with oil to form lubricants comprising at least one non-extracted salt of a natural petroleum sulfonic acid having about 15 wt-% to about 30 wt-% active conte...
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WO/2001/074762A2 |
One aspect of the present invention relates to compounds, comprising at least two moieties selected from the group consisting of aryl sulfonates and aryl sulfates. A second aspect of the present invention relates to combinatorial librari...
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WO/2001/074763A1 |
The invention relates to novel aryl and heteroaryl sulfonates of formula (Ia) and to methods for producing them and to novel aryl and heteroaryl sulfonates of formula (I) for treating and/or preventing diseases, especially for treating p...
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WO/2001/072692A1 |
The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula (I), which are useful in the treatment of obesity, overweight condition, hyperlipidemia...
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WO/2001/072693A1 |
Aminophenol derivatives of the general formula (1) useful as intermediates in the production of drugs, agricultural chemicals and so on can be prepared at a low cost by condensing an amine of the general formula (2) with an ester of the ...
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WO/2001/072694A1 |
Zofimarin derivatives of the general formula (I), pharmacologically acceptable esters of the same, or salts thereof, exhibiting excellent antimycotic activity: (I) wherein X is formyl or cyano; and A is CH=N-O-R?a¿, -CH¿2?-S(=O)¿g?-R?...
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WO2001014576B1 |
Efficient synthetic routes for the preparation of rhinovirus protease inhibitors of formula (I), particulary (I'), key intermediates useful in those synthetic routes, as well as a continuous membrane reactor useful for those synthetic ro...
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WO/2001/070667A1 |
A compound represented by the formula (I) or a salt or solvate thereof; and a composition and a kit both containing any of these. In said formula X represents CH, sulfur, or nitrogen; Y represents CH, sulfur, or nitrogen or is absent; (a...
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WO2000071506A9 |
Compounds of formula (I), wherein R<1> and R<2> are substituents on the A rings and are, independently, -SO2NR<7>2, -C(O)NR<7>2, -NR<7>SO2R<7>, -NR<7>C(O)R<7>, -SO2OR<7>, -C(O)OR<7>, -OSO2R<7>, or -OC(O)R<7>, R<3> and R<4> are, independe...
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WO/2001/068595A1 |
The invention aims at providing novel sulfur compounds, molecular compounds containing the same as the component compound, and so on. The above aim is achieved by using sulfur compounds of the general formula (I) wherein Rs are each inde...
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WO/2001/068657A1 |
A novel triphenylphosphine derivative which is synthesized from triphenylphosphine and a hydroxylated lactone; a palladium/nickel complex having the derivative as a ligand; and a process for producing a biaryl derivative which comprises ...
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WO/2001/066516A1 |
Disclosed is a process for the preparation of trifluoromethanesulfonic acid anhydride by the steps of (1) forming a mixed anhydride comprising a trifluoromethanesulfonyl acyl residue and a carboxyl residue by contacting trifluoromethanes...
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WO/2001/064695A1 |
The invention concerns a method for preparing bismuth tris-trifluoromethanesulphonate, characterised in that it consists in reacting CF¿3?SO¿3?H trifluoromethanesulphonic acid with Bi¿2?O¿3? bismuth trioxide in a medium consisting of...
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WO/2001/064629A1 |
A process for preparing organic sulfur acids or salts thereof, which comprises reacting an organic substrate with a sulfur oxide in the presence of a metal compound catalyst in the absence of N-hydroxy- and N-oxo-cyclic imide compounds t...
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WO/2001/064610A1 |
An integrated process for producing alkylbenzenes, sulfonated alkylbenzenes and/or alkylcyclohexanes from syngas is disclosed. The process involves subjecting syngas to Fischer-Tropsch conditions. Fractions rich in C¿6-8? and C¿18-26? ...
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WO/2001/062707A1 |
The invention relates to a method of producing 3-aminoalkanoic acid esters of the general formula (I), wherein R represents C¿1-6? alkyl, and R?1¿ represents hydrogen, C¿1-6? alkyl or phenyl, or the salts thereof, by catalytically hyd...
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WO/2001/060809A1 |
6-Substituted-4,5-epoxy-6-hydroxy-2-cyclohexen-1-one derivatives represented by the general formula (I), wherein R?1¿ represents optionally substituted lower alkyl, optionally substituted lower aryl or optionally substituted aralkyl. Th...
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WO/2001/059067A2 |
Compounds containing a specific branched chain end terminal group, which is isopropyl, sec.-butyl, or tert.-butyl; a polar leading group; and long-chain aliphatic, non-cyclic, saturated or unsaturated, hydrocarbon group linking them; and...
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WO/2001/058862A1 |
The invention relates to a method for producing diaryliodonium sulfonates in high yields and with a high degree of purity and then isolating the same, by reacting special diaryliodonium salts with an aliphatic or aromatic sulfonic acid o...
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WO/2001/058863A1 |
A compound having the formula: R¿1?OOC-(CH¿2?)¿n?-CH(CH¿2?CH¿2?SO¿3?X)-(CH¿2?)¿m?-C
OOR¿2? where n is an integer from 1 to 10, m is an integer from 1 to 10, X is an alkali metal selected from the group consisting of lithium, sod...
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WO/2001/056962A1 |
Perfluoroisopropylbenzene derivatives of the general formula (I) or salts thereof, useful as intermediates or raw materials in the synthesis of various industrial materials including agricultural chemicals, drugs and surfactants, wherein...
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WO/2001/051461A1 |
An integrated process for preparing $g(a)-(2,4-disulfophenyl)-N-tert-butylnitrone and its salts is disclosed in which N-tert-butylhydroxylamine acid addition salt is incompletely neutralised so as to leave catalytic amounts of acid and t...
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WO/2001/051459A1 |
Solid aryl sulfonates are purified by preferentially dissolving impurities into an aqueous liquid phase.
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WO/2001/051460A1 |
A process for the preparation of $g(a)-(2-4-disulfophenyl)-N-tert-butylnitrone and pharmaceutically acceptable salts thereof by the reaction of the corresponding disulfophenyl aldehyde with N-tert-butylhydroxylammonium acetate is disclosed.
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WO/2001/049275A2 |
Methods and therapeutic compounds for treating pain, mitigating inflammation, effecting analgesia and/or effecting sedation in a subject are described. A subject is administered an effective amount of a therapeutic compound which is a ni...
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