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WO/2000/017133A2 |
The invention concerns LTA¿4? hydrolase inhibiting compounds of formula (I). It also concerns their therapeutic, in particular anti-inflammatory, applications.
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WO/2000/015603A1 |
Benzene derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof; and AP-1 activation inhibitors, NF-kappa B activation inhibitors, inflammatory cytokine production inhibitors, matrix metalloprotease pr...
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WO/2000/015607A1 |
The present invention is a process for the preparation of calcium hydroxy alkane sulphonates from a mixture comprising at least 20 % by weight paraffins and at least 10 % by weight olefins, comprising reacting the mixture with a sulphona...
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WO/2000/012451A1 |
Processes for making particularly branched, especially monomethyl-branched or nongeminal dimethyl-branched surfactants used in cleaning products; preferred processes comprising particular combinations of two or more adsorptive separation...
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WO/2000/010967A1 |
The present invention relates to novel aryl sulphonamides and analogues, methods for the production and use thereof in the prophylaxis and treatment of neurodegenerative diseases, especially in the treatment of apoplexia cerebri, cranioc...
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WO/2000/010968A2 |
The present invention relates to novel aryl sulphonamide amino acid esters and analogues, methods for the production and use thereof in the prophylaxis and treatment of neurodegenerative diseases, especially in the treatment of apoplexia...
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WO/2000/010966A1 |
The present invention relates to a method for the production of compounds of general formula (I) from compounds of general formula (II) and sulfite salts with subsequent halogenation. The solvent used in halogenation is an organic solven...
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WO/2000/010972A1 |
Compounds of fomulae (I), (II) or (III), wherein m is zero or 1; n is 1, 2 or 3; R¿1? inter alia is unsubstituted or substituted phenyl, or naphthyl, anthracyl, phenanthryl, a heteroaryl radical, or C¿2?-C¿12?alkenyl; R'¿1? inter ali...
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WO/2000/009471A1 |
A description is given of divinylstilbenesulfonic acid derivatives of formula (1), wherein X is (a); (b); -CN; or (c); Y¿1? and Y¿2? are each independently of the other hydrogen or -SO¿3??-¿M?+¿; at least one Y¿1? or Y¿2? being -S...
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WO/2000/008025A1 |
Novel intermediates and improvements in the synthesis of acyclic guanine nucleoside prodrugs of the formula (R)-9-[(2-alkanoylmethyl)-4-(aminoacyloxy)butyl]guanine (for example valtamociclovir stearate), including purine salts amenable t...
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WO/2000/007709A1 |
The present invention relates to surfactants useful in life science and industrial formulations. More particularly, the invention relates to surfactants of alkoxylated amine neutralized by aromatic sulfonic acid and pesticide formulation...
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WO/2000/008525A1 |
A chemical amplification type radiation-sensitive composition comprising a film-forming resin based on a hydroxystyrene in combination with an onium salt precursor capable of generating a fluorinated alkanesulfonic acid as a radiation-se...
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WO/2000/007979A2 |
Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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WO/2000/005956A1 |
The present invention relates to novel herbicidal phenoxypropionic acid N-alkyl-N-2-fluorophenyl amides represented in formula (1), a method for preparing thereof, their use to control barnyard grass produced from rice and composition as...
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WO/2000/003034A2 |
The subject invention provides compounds useful as fluorogenic substrates for the hydrolytic enzymes. Upon hydrolysis of the hydrolyzable group, a halo-pyrene substituted molecule is developed which is highly fluorescent, water soluble a...
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WO/2000/002455A1 |
Hypericin has been shown to specifically inhibit T-type calcium channel activity. $i(Hypericum) extract containing hypericin also inhibits T-type calcium channel activity. Moreover, other chemicals in $i(Hypericum) extract showed a syner...
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WO/2000/001668A2 |
The present invention relates to N-Acetylated $g(a)-Linked Acidic Dipeptidase (NAALADase) inhibitors enzyme activity, pharmaceutical compositions comprising such inhibitors, and methods of their use to inhibit NAALADase enzyme activity, ...
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WO/1999/067304A1 |
A class of unsaturated compounds including containing a fluoroether-substituted aromatic ring, polymers, including ionomers, formed therefrom, and processes for forming them. The compositions of the invention have particular suitability ...
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WO/1999/065703A1 |
Metallic salts useful for inkjet receptor media are disclosed. The metallic salt can be a multivalent metal derivative of an aromatic carboxylic, sulfocarboxylic, sulfophenolic, or combination thereof. The aromatic moiety can be a simple...
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WO1999054280B1 |
The present invention relates to therapeutically active cubane compounds, a method of preparing the same, and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases of the central ner...
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WO/1999/064391A1 |
There is provided lower alkanesulphonate salts of cyanobenzylamines, which salts may be produced via a selective recrystallisation process. The salts may be produced advantageously following the selective hydrogenation of a dicyanobenzen...
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WO/1999/062870A1 |
A novel compound 3-{4-[2-(4-$i(tert)-Butoxycarbonylaminophenyl)ethoxy]phenyl}
-(S)-2-ethoxy propanoic acid having formula (I) and pharmaceutically acceptable salts, solvates, and crystalline forms thereof, a process and intermediates for...
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WO/1999/062872A1 |
A novel 3-aryl-2-hydroxypropionic acid derivative, having formula (I) and pharmaceutically acceptable salts, solvates, and crystalline forms thereof, a process and intermediate for its manufacture, pharmaceutical preparations containing ...
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WO/1999/062871A1 |
Novel 3-aryl proprionic acid derivatives and analogs, having general formula (I) and stereo- and optical isomers and racemates thereof as well as pharmaceutically acceptable salts, solvates and crystalline forms thereof, process for thei...
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WO/1999/061410A1 |
This invention provides compounds of Formula (I) having structure (I) wherein: B and D are each, independently, hydrogen, halogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, aryl, heteroaryl, aralkyl of 6-12 carbon atoms,...
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WO/1999/061415A1 |
An improved process for sulphonation of organic compounds, notably hydroxybenzene and alkylbenzene compounds, comprises reacting them with sulphuric acid or oleum in the presence of an organic solvent, notably an n-alkane or a cycloalkan...
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WO/1999/061403A1 |
Compounds represented by general formula (I) and salts thereof, which are useful as glaucoma remedies, wherein R?1¿ is H, lower alkyl or phenyl, the phenyl being optionally substituted with lower alkyl, hydroxyl, lower alkoxy, halogeno,...
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WO/1999/057123A1 |
The invention is directed to the process of purifying 4'-chloro-4-biphenylcarboxaldehyde.
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WO/1999/055663A1 |
The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well ...
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WO/1999/055666A1 |
The present invention provides a method of converting a hydroxy group in alcohols containing an electron withdrawing group into perfluoroalkanesulphonate and fluorosulphonate esters, which are good leaving groups, with inversion of confi...
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WO/1999/055668A1 |
3-Arylphenyl sulfide derivatives represented by general formula (I) and insecticides and miticides containing these derivatives as the active ingredient, wherein R represents C¿2?-¿6? alkyl, C¿2?-¿6? alkenyl, C¿2?-¿6? alkynyl, etc....
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WO/1999/054292A1 |
The invention concerns novel sulphonated and oxy- or polyalkylene diphenol derivatives and their corresponding salts corresponding to general formulae (Ia and Ib) wherein Y¿1? and Y¿2? are such as defined in Claim 1.
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WO/1999/050246A1 |
Disclosed are novel compounds represented by structural formula (I); and physiologically acceptable salts thereof. X¿1? and X¿2? are independently -NH-, -O-, -S- or -C=C-. Z¿1? and Z¿2? are independently -O- or formula (II). A is a l...
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WO/1999/047488A1 |
A process for producing L-valine benzyl ester p-toluenesulfonate which involves the steps of reacting L-valine with benzyl alcohol in at least one aromatic solvent selected from among toluene, monochlorobenzene and xylene in the presence...
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WO/1999/047495A1 |
A process for the preparation of sulphonated distyryl-biphenyl compounds of formula (1), in which R¿1? and R¿2?, independently, are hydrogen, C¿1?-C¿5?-alkyl, C¿1?-C¿5?-alkoxy or halogen, and M represents Li, K, an alkaline earth m...
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WO/1999/047496A1 |
The present invention relates to compounds having utility as surfactants which are derived from intermediates produced in petroleum biodesulfurization processes. The compounds of the invention include acyloxybiphenylsulfinates, acyloxybi...
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WO/1999/041292A1 |
This invention concerns substantially fluorinated, but not perfluorinated, ionomers consisting of a polyethylene backbone having pendant groups of fluoroalkoxy sulfonic acids and metal salts thereof. Such ionomers are useful for electroc...
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WO/1999/040096A1 |
A method for the synthesis of certain N-silylated cyclopentaphenanthrene (Group IV metal) complexes is disclosed.
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WO/1999/040080A1 |
Use of a compound for the manufacture of a medicament for the treatment or prevention of a condition associated with matrix metalloproteinases or that is mediated by TNF $g(a) or enzymes involved in the shedding of $i(L)-selectin, CD23, ...
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WO/1999/038828A1 |
A process for producing a butanetriol derivative represented by formula (1) useful as a material for medicines, characterized by reacting a compound represented by formula (3), wherein R?1¿ and R?2¿ represent different protecting group...
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WO/1999/039245A1 |
The present invention provides for process of preparing a photoactive ester compound of high purity using a solid base catalyst, preferably an anionic exchange resin. The invention further provides for preparing and imaging a photosensit...
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WO/1999/038855A1 |
Highly pure optically active threo-3-amino-1,2-epoxy compounds appropriate for materials for manufacturing drugs and a process for producing the same on an industrial scale. An optically active threo-3-amino-1,2-diol derivative is subjec...
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WO/1999/037606A1 |
The invention relates to new derivatives of sulfonic, phosphonic or phosphinic aminoalkane acids, corresponding to formula (I), where X is selected from among (a), (b), (c) and (d), where R is a C¿1?-C¿7? alkyl radical, R¿1?, R¿2? an...
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WO/1999/036397A1 |
The invention relates to novel bis(perfluoro-n-alkyl sulfonates) of formula (I), wherein n means 3, 4, 5, 6, 7, 8, 9 and A and B have the meanings given in the claims, and to the use thereof for producing diphosphanes of formula (III), w...
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WO/1999/036381A1 |
Fluorine containing oxyvinyl compounds characterized by having one or more oxyvinyl groups separated from fluorine containing groups by at least one alkylene group having 2-8 carbon atoms and by at least one oxygen atom in addition to th...
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WO/1999/033781A1 |
Compounds represented by formulae (I, II or III), wherein U is CH, O, or S; Z is -C(R¿2?)(R¿3?), -CH-N(R¿2?)(R¿3?), C(R¿3?)[(CH¿2?)nR¿2?], CH-C(R¿3?)(R¿8?)(CH¿2?)nR¿2?, C[(CH¿2?)nR¿2?]-[CH(R¿3?)(R¿8?)], C[(R¿3?)][CH[(CH¿...
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WO/1999/032438A1 |
A process for producing a naphthoquinone diazide ester of a phenolic compound that is useful in a photoresist composition, which process comprises providing a naphthoquinone diazide ester solution in an organic polar solvent; adding the ...
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WO/1999/032463A1 |
This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.
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WO/1999/031047A1 |
Novel compounds of Formula (I) are described. R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ and R?6¿ are described in this specification. Synthetic intermediates and pharmaceutical compositions comprising the inhibitors of the invention are also de...
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WO/1999/031074A2 |
Novel amines of formulas (1A) and (1B) or a pharmaceutically acceptable salt thereof wherein: n is an integer of from 0 to 2; R is sulfonamide, amide, phosphonic acid, heterocycle, sulfonic acid, or hydroxamic acid; A is hydrogen or meth...
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