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WO/1996/032382A1 |
Substituted 1-phenylpyrazole-3-carboxamides of formula (I) are disclosed for use as compounds having high affinity for human neurotensin receptors.
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WO/1996/030036A1 |
Modified amino acid compounds useful in the delivery of active agents are provided. The active agents can be peptides, such as rhGH. Methods of administration, such as oral, subcutaneous, sublingual, and intranasal administration, are pr...
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WO/1996/030333A1 |
Compounds of formula (I), wherein X represents a single bond, O, S or CR9R10 where R9 and R10 each independently represent a hydrogen atom or a C1-4alkyl group; R1a, R1b and R1c each independently represent a substituent selected from: a...
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WO/1996/030320A1 |
The present invention relates to a novel process for preparing cis-4-O-protected-substituted-2-cyclopentenol derivatives comprising, (a) dissolving a 4-O-protected-2-cyclopentenone in a suitable organic solvent; and (b) treating the solu...
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WO/1996/030329A1 |
The invention relates to substituted benzenes and derivatives thereof, useful as neuraminidase inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral and other inf...
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WO/1996/028761A1 |
Certain N-alkylhydroxylamine derivatives are useful as antioxidants in photographic color developer compositions. These compounds stabilize the developer compositions, are highly water soluble and are essentially odorless.
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WO/1996/028491A1 |
Disclosed are poly-p-phenylenes which have perfluoroalkoxy and perfluoroalkyl substituents, their copolymers and the precursors to these polymers. Polymers produced herein are useful as membranes, coatings, fibers and articles.
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WO/1996/028417A1 |
The synthesis of phenol sulfonate esters of alkanoyl amino acids is conducted in the presence of aqueous base to provide bleach activator compounds. Thus, the acid chloride of N-nonanoyl-6-aminocaproic acid is reacted with the sodium sal...
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WO/1996/028418A1 |
Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors...
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WO/1996/027582A1 |
An improved process is disclosed for preparing 'alpha','beta'-diaminoacrylnitriles having the general formula (I) R3R2NC(R1)=C(NR2R3)CN, in which R1 stands for hydrogen, substituted or non-substituted aliphatic residues with 1 to 30 carb...
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WO/1996/026919A2 |
Low base number (LBN) sulphonates derived from high molecular weight sulphonic acids have low viscosity, are chloride free and are not skin sensitisers. In their preparation, neutralisation of high molecular weight sulphonic acids or par...
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WO/1996/026920A1 |
Magnesium low base number (LBN) sulphonates derived from high molecular weight sulphonic acids have low viscosity and are chloride free. The magnesium low base number sulphonates are not skin sensitisers. In their preparation neutralisat...
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WO/1996/025399A1 |
Aroylaniline derivatives which exhibit anti-retroviral activity, pharmaceutical compositions containing such aroylaniline derivatives, and methods for treating a retroviral-infected host comprising administering an antiviral effective am...
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WO/1996/025393A1 |
The invention concerns amphiphilic compounds of general formula (I) with at least two hydrophilic and at least two hydrophobic groups based on dicarboxylic acid diamides. The amphiphilic compounds according to the invention are mostly su...
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WO/1996/025388A1 |
The invention concerns amphiphilic compounds of general formula (I), in which R1 and R3 each represent a C1-C22 hydrocarbon residue, R2 is a spacer and X and Y are functional groups. The proposed compounds have at least two hydrophilic a...
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WO/1996/025157A1 |
This invention relates to the novel use of phenyl ureas in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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WO/1996/025389A1 |
Low-viscosity aqueous concentrates of betaine tensides of the formula (I) in which R1 is an aliphatic alkyl radical with 8 to 22 carbon atoms, R2 and R3 are mutually independently an alkyl and/or hydroxyalkyl radical with 1 to 4 carbon a...
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WO/1996/022154A2 |
An electrodialysis method using a bipolar membrane (BP) for regenerating acids, wherein a series of base (B), acid (A) and salt (S) compartments are provided between a positive electrode (anode) and a negative electrode (cathode), said c...
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WO/1996/022275A1 |
Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a c...
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WO/1996/021355A1 |
Pesticidal compounds having general formula (I) or a salt thereof is provided, in which n represents an integer from 0 to 4; m represents an integer 0 or 1; each R independently represents a halogen atom or a nitro, cyano, hydroxyl, alky...
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WO/1996/020930A1 |
Acetylenes substituted with a phenyl or heteroaryl group and with a 5,6,7,8-tetrahydronaphthyl or 7,8-dihydronaphthyl group have retinoid-like biological activity. The 5,6,7,8-tetrahydronaphthyl or 7,8-dihydronaphthyl group is substitute...
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WO/1996/020162A1 |
This invention relates to certain 1,4,4-(trisubstituted)cyclohex-1-ene dimers and related compounds which are useful in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).
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WO/1996/019978A1 |
This invention relates to certain 1,3,3-(trisubstituted)cyclohex-1-ene dimers and related compounds which are useful in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).
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WO/1996/019443A1 |
The invention relates to a process for the preparation of ortho-sulfocarboxylic acids of formula (I), which comprises: a) in a first reaction step, diazotising an aromatic ortho-aminosulfonic acid in the presence of an acid and nitrite i...
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WO/1996/019444A1 |
'beta'-Carboxy sulfonates of formula (I), wherein R1 is aryl, R3 and R4 are hydrogen or alkyl, Y is -O-, -S-, or -NR2-, and R5 is alkyl or aryl are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT) and are thus ...
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WO/1996/019445A1 |
Diaminoalkyl di(sulphosuccinate) (DDSS) compounds of formula (I) wherein M is an alkali metal or an alkaline earth metal or a mixture; and R1 is CH2 or CHOH and is optionally present, and when R1 is present R2 is hydrogen, and when R1 is...
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WO/1996/018609A1 |
The present invention is a method of protecting a sulfonic acid functional group in an organic molecule as a substituted or unsubstituted neopentyl sulfonate ester. The method allows the conversion of R-SO3-H to R'-SO3-H, wherein R and R...
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WO/1996/018715A2 |
Soil release agents which comprise: an ester backbone comprising (1) units selected from dihydroxy or polyhydroxy sulfonate (e.g., a sulfoethyl ether of glycerin), a unit which is at least trifunctional whereby ester linkages are formed ...
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WO/1996/018610A1 |
The invention concerns amphiphilic compounds of general formula (I) with at least two hydrophilic and at least two hydrophobic groups based on esters. The amphiphilic compounds according to the present invention are mostly surface-active...
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WO/1996/017832A1 |
Novel substituted alicyclic fused ring 2,3-quinoxalinediones, pharmaceutical compositions containing the same and the method of using the same, for the blockade of glutamate receptors, including either or both N-methyl-D-aspartate (NMDA)...
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WO/1996/017819A1 |
The object of the present invention is to provide asiatic acid derivatives (I), its pharmaceutically acceptable salts or esters. Asiatic acid, its trisaccharide asiaticoside and madecassic acid, extracted from Centella asiatica have been...
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WO/1996/017840A1 |
Compounds of formula (I) wherein Q is optionally substituted heterocyclyl; Z is optionally substituted hydroxy or mercapto; E is (i) CO--N(R2), (ii) CS--N(R2) or (iii) C(SR2) = N; W is O, N(R3), optionally substituted methylene or ethyle...
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WO/1996/016921A1 |
Nitroxyl inhibitors in combination with some oxygen reduce the premature polymerization of vinyl aromatic monomers during the manufacturing processes for such monomers. Even small quantities of air used in combination with the nitroxyl i...
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WO/1996/016008A1 |
The invention concerns compounds of formula (I) (A)n-B in which A is an extended cycloolefin group, B stands for a direct bond or an n-valent bridging group, and n is an integer from 2 to 8, with the exception of 1,2-bisnorbornenyl ethan...
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WO/1996/016032A1 |
The invention relates to a process for producing linear alkylbenzole sulphonic acid in which linear alkylbenzole is sulphonated in a first step up to a conversion of 60 to 80 % and in a second stage up to a conversion of 96 to 100 %. A b...
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WO/1996/016033A1 |
The invention relates to amphiphilic compounds of the general formula (I) with at least two hydrophilic and at least two hydrophobic groups based on di, oligo or polyolethers. The amphiphilic compounds of this invention are highly surfac...
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WO/1996/016015A1 |
The present invention provides anthraquinonyl and anthronyl dyes and dichroic light polarizers based on the dyes. The dichroic light polarizer includes two separate embodiments. In the first embodiment, the dye molecules are aggregated i...
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WO/1996/015106A1 |
The present invention provides a compound of formula (I), wherein Ar is (a) phenyl, naphthyl and biphenyl, each optionally substituted with C1-4 alkyl, C1-4 haloalkyl, C1-4 hydroxyalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C2-4 alkoxyalkoxy, C...
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WO/1996/015101A1 |
The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The com...
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WO/1996/015111A1 |
A method of preparing a korupensamine or an analog thereof comprising: (a) reacting a compound of formula (III), wherein each of R1 and R2 is CH3 or H, X is I, Y is (C1-C4)alkyl, benzyl or CHO, and each of R3 and R4 is (C1-C4)alkyl, benz...
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WO/1996/015092A1 |
Fluorine-containing liquid crystal compounds comprise a fluorocarbon terminal portion having at least one catenary ether oxygen and a hydrocarbon terminal portion, the terminal portions being connected by a central core. The compounds ha...
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WO/1996/014926A1 |
The invention relates to amphiphilic compounds of general formula (I), (R1, R3 = C1-C22 hydrocarbon radical, R2 = spacer, X, Y = functional groups, Z = 1 to 10) with at least two hydrophilic and at least two hydrophobic groups ont the ba...
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WO/1996/014294A1 |
A toner resin composition comprising a toner resin and an aromatic sulphonic acid salt of a guanidine such as the bis-diphenylguanidine salt of naphthalene-1,5-disulphonic acid. The diphenyl guanidine salts are novel.
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WO/1996/013509A1 |
Fluorinated alkene compounds having structure (I) wherein Q is -(C=S)-R1, -(C=W)-R2, or -(P=W)R3R4; wherein W is O or S; and R1 to R4 are as defined in claim 1; are useful for controlling nematodes, insects, and acarids that prey on agri...
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WO/1996/011181A1 |
A novel compound of formula (X) is prepared from L-lysine, and converted to Levobupivacaine by cyclisation.
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WO/1996/010610A1 |
Reactive dyes have the formula (I), in which n equals 1 or 2; R1 stands for hydrogen or hydroxylsulfonyl; R2 stands for hydrogen or hydroxy; R3 stands for substituted C1-C4-alkyl, C5-C7-cycloalkyl or substituted phenyl; R4 stands for hyd...
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WO/1996/010561A1 |
2-aroylcyclohexandiones have general formula (I), in which X, Y stand for O or S; Ar stands for phenyl or heteroaryl with 1 to 4 substituents; or two adjacent carbon atoms of the phenyl or heteroaryl ring may also be bridged by a chain; ...
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WO/1996/010560A1 |
A semicarbazone derivative of formula (I), wherein W is an oxygen atom or a sulfur atom; each of X, Y and Z which are independent of one another, is a halogen atom, a hydroxyl group, a cyano group, a nitro group, SCN, a trimethylsilyl gr...
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WO/1996/010004A1 |
A process for the purification of 2,6-diisopropylphenol (Propofol) by transformation of the crude Propofol into its ester with a carboxylic or sulphonic acid, crystallization and hydrolysis, is described.
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WO/1996/009278A1 |
In order to produce N-acylamino carboxylic and N-acylaminosulphonic acids and their alkaline metal salts from industrial alkaline metal salts of aminocarboxylic or aminosulphonic acids with an active content from 50 to 95 % by weight, in...
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