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JP2843605B2 |
The invention relates to a process for the preparation of the 4 geometrical isomers of 4-(2-butenylidene)-3,5,5-trimethylcyclo- hex-2-en-1-one, a process which is characterised in that a compound of the formula in which R represents lowe...
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JPH10330356A |
To obtain the subject compound that is useful as an intermediate of pharmaceuticals, for example, vitamin A by reaction of a triphenylphosphine and an aldehyde with industitual advantage. A compound represented by formula I (R1 to R3 are...
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JP2835641B2 |
Compounds of formula I are useful as herbicides, effective against dicotyledonous weeds.
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JP2835195B2 |
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JPH10306073A |
To produce a natural carotenoid-containing granular composition having a color tone essential to the carotenoid and to provide a method for producing the natural carotenoid-containing granular composition having the consistent color tone...
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JP2801589B2 |
Compounds of the formula: wherein R2 and X are as described, are disclosed. The compounds are useful for treating dermatological disorders which are accompanied by epithelial lesions, e.g., acne and psoriasis, as well as malignant and pr...
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JP2795831B2 |
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JP2790212B2 |
PURPOSE: To obtain a substantially pure lutein suitable for use in humans by isolating the lutein from a saponified marigold extract, purifying the isolated lutein and crystallizing the purified luetin in a minimum of processing steps. C...
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JPH10226677A |
To provide a method which isomerizes vitamin A compound(s) or a mixture thereof into the corresponding whole-E-isomers in as high yield as possible, and isolates the isomers and 13-Z-isomer easily at low cost by use of nitrogen monoxide ...
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JPH10218855A |
To obtain the subject new compound useful for treating gastrointestinal ulcer such as duodenal ulcer and treating/preventing arrhythmia through its potent and specific blocking effect on K+ channel different from K+(ATP) channel. This ne...
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JPH10508320A |
PCT No. PCT/EP96/03848 Sec. 371 Date Apr. 21, 1997 Sec. 102(e) Date Apr. 21, 1997 PCT Filed Sep. 2, 1996 PCT Pub. No. WO97/09307 PCT Pub. Date Mar. 13, 1997The present invention relates to active derivatives of sphingoid bases. Specifica...
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JP2776787B2 |
Novel nonatetraenoic acid derivatives of the formula wherein the dotted bond is optional and R1 and R2 are as defined in the specific ation selectively bind to retinoic acid X-receptors (RXR) have anti-acne acitvity and potentiate the ac...
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JPH10182493A |
To obtain a stable solubilized carotenoid preparation having particle diameters in the range of 10-200nm, having the concentration of an active compound higher than 0.5wt.% useful for coloring food and medicine preparation. A suspension ...
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JP2770546B2 |
An optically active epoxycyclohexane derivative of general formula (I); and its enantiomers wherein R represents 4-oxycarbonyl-1-hydroxy-3-methyl-3(Z)-buten-1-yl or 4-hydroxycarbonyl-3-methyl-1(E), 3(Z)-butadien-1-yl; and R<1> and R<2> e...
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JP2772070B2 |
Novel phosphonate compounds of the formula are disclosed and claimed, as well as methods for manufacturing the phosphonates from C-14 through C-16 aldehydes. The phosphonate compounds of the present invention can be employed to form 13-c...
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JPH10155459A |
To obtain a drink and a medicine for preventing or suppressing arteriosclerosis, ischemic heart disease or ischemic encephalopathy through the mechnism protecting the oxidation of serum low-density lipoprotein(LDL). This drink having ant...
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JPH10147569A |
To simply and efficiently produce vitamin A in one pot by protecting the hydroxyl group of a hydroxysulfone compound as an intermediate with a specific compound. This method for producing vitamin A comprises treating a compound of formul...
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JP2740270B2 |
Process for the preparation of alpha , beta -unsaturated ketones of the general formula I in which R denotes an organic radical, by reaction of an appropriate aldehyde R-CHO with acetoacetic acid or one of its salts in the presence of an...
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JP2735600B2 |
Cycloaliphatic ketones of formula …… in which the wavy line denotes a C-C bond of cis or trans configuration, are prepared from an enolate of formula …… in which the wavy line has the meaning shown above and Me defines an alkali ...
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JPH1077225A |
To obtain an optically transparent aqueous-alcoholic solution of multivitamin containing β-carotene by dissolving the β-carotene in an aqueous- alcoholic solution of the multivitamin so as to be optically transparent. This optically tr...
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JPH1059996A |
To obtain the subject new oligonucleotide bound to all trans-retinoic acid inducing apoptosis of leukemic blast cells, useful as a side effect-free therapeutic agent for leukemia. This new oligonucleotide is a new anti-sense oligonucleot...
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JP2714598B2 |
New pyran derivatives and processes for their preparation and their uses. These derivatives are prepared by condensation of the lithium dienolate of prenal with an aldehyde or a ketone. The pyran derivative prepared from beta -io...
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JP2708126B2 |
Anti-ulcer agents containing isoprenoid derivatives are provided. The isoprenoid derivatives are represented by the formula: Wherein: R represents a group of formula In the above formula, R1, R2 and R3 may be the same or different each o...
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JPH10501232A |
(57) [Summary] Provided are methods for synthesizing 9-cis retinoids, novel intermediates and methods for synthesizing cyclohexadienin nitriles and 9-cis alkyl cisoid nitriles, as well as 9-cis retinoids prepared using such methods.
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JP2701133B2 |
PURPOSE: To obtain a novel intermediate useful in the preparation of vitamin A, carotenoids, or the like. CONSTITUTION: This novel intermediate is represented by formula I (wherein (n) is 1 or 2; R1-R3 are each H, a 1-4C alkyl, a 2-10C a...
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JPH09315976A |
To obtain the subject pharmaceutical preparation excellent in percutaneous absorbability, pharmacodynamic persistence and stability of a benzimidazole derivative capable of manifesting antagonistic actions on serotonin receptors in a pha...
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JP2672257B2 |
The invention provides a method for the solvent-extraction of beta -carotene from an aqueous algal biomass suspension, whereby a vegetable oil which is immiscible with water is mixed with an aqueous biomass suspension, the biomass contai...
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JP2647880B2 |
Esters and amides of 13-cis-retinoic acid are disclosed which are used for the treatment of acne and skin diseases.
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JP2640359B2 |
According to this process a stereospecific reduction of the two hydroxyl groups of an etherdiol is carried out using a mixture (titanium trichloride, lithium aluminium hydride) at a temperature of approximately between 5 DEG C and 40 DEG...
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JPH09202769A |
To obtain a dry carotenoid-oil powder resistant to degradation caused by exposure to oxygen, high in effectiveness and capable of being dispersed in water. Approximately 4.4wt.% of a carotenoid is dispersed in an oil, and the obtained ca...
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JPH09192493A |
To obtain a catalyst system having no corrosiveness or poisonousness, not polluting the environment and capable of exhibiting catalystic action on the objective reaction with high selectivity and a high yield by using a protonic acid cat...
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JP2620277B2 |
Preparation of pulverulent water-dispersible carotenoid preparations in which the carotenoid is present dissolved in an edible oil and the oil solution is present in the form of small droplets, by rapidly dissolving a carotenoid in a vol...
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JP2595036B2 |
Quaternary ammonium retinoate, characterized in that it corresponds to the formula: in which: X- denotes either an all-trans-retinoate of formula (I): or a 13-cis= retinoate of formula: (i) R1, R2 and R3, which may be identical or differ...
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JP2590254B2 |
The invention relates to mixtures of compounds of the formula in which R represents C1-4-alkyl, in a ratio of at least 1.1:1, in particular 2.2-3.0:1. The invention also relates to the use of such mixtures as odoriferous substances.
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JPH09500864A |
Compositions of high-purity natural beta-carotene and of the 9-cis isomer of beta-carotene are provided, as are methods for the production of these compositions from plant matter, conveniently algae such as Dunaliella species. Typically,...
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JPH09500641A |
This invention is directed to an efficient, mild, high yield process for the large scale synthesis of N-(4-hydroxyphenyl)-retinamide comprising the preferred steps of reacting retinoic acid with dimethylchloroformamidinium chloride to fr...
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JP2571230B2 |
A novel process and intermediates for the preparation of 5-amino-4-hydroxyvaleric acid derivatives of the formula in which R<1> represents hydrogen, optionally substituted alkyl, cycloalkyl, cycloalkyl(lower alkyl), aryl, aryl(lower alky...
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JP2572877B2 |
The process entails a suspension of a carotenoid in a high-boiling oil being contacted with superheated steam for a period not exceeding 30 seconds, subsequently the resulting mixture being emulsified in an aqueous solution of a colloid,...
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JPH0912538A |
To easily obtain a new 9(Z)-retinoic acid derivative important for cancer therapy while minimizing the toxic side effect of free 9(Z)-vitamin A acid. This new compound is expressed by the formula [Y is OCR12- CO-R2 (R1 is H, a 1-20C alky...
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JPH08333332A |
PURPOSE: To synthesize a 9-substituted retinoid useful as an analog, etc., of retinoic acids capable of manifesting cell differentiation inducing activities, etc. CONSTITUTION: A compound of formula I [R1 and R2 are each independently a ...
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JPH08311021A |
To easily produce the subject product through a chemical means by starting from a mother liquor for production of β- ionylideneethyltriarylphosphonium salts enriched in 9(Z)-isomer and by reacting the salts with a specific compound by W...
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JPH08311019A |
PURPOSE: To readily obtain β-carotene from an inexpensive raw material without using dangerous peroxide or iodine or urea requiring care of handling by reacting retinol with sulfur-introducing reagent in the presence of a base and react...
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JPH08311020A |
PURPOSE: To readily obtain β-carotene useful for a food additive, etc., through a stable intermediate in a short process at a high yield by subjecting two molecules of a specific sulfone compound to intermolecular coupling reaction and ...
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JPH08511027A |
Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to membe...
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JPH08291094A |
To obtain the subject new compound useful for curing and preventing diseases of coronary artery, protecting early atherosclerosis of coronary artery and curing cancers by increasing a high density lipoprotein level. This restricted 9-cis...
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JP2547581B2 |
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JP2547595B2 |
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JP2545289B2 |
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JP2542667B2 |
Process for the preparation of compounds of the formula in which R<1> denotes hydroxyl or an etherified hydroxyl group, and of zeaxanthine, characterised in that a compound of the formula in which R<1> has the above meaning, is converted...
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JP2540291B2 |
PURPOSE: To provide a new preparation process of vitamin A wherein a desirable stereoisomer is efficiently obtained. CONSTITUTION: Ethynyl-β-ionol is condensed with a chloroacetal of formula I (wherein n is 0 or 1; and when n=1, R is a ...
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