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WO/2000/048446A2 |
The use of compounds that are antagonists of the pain enhancing effects of E-type prostaglandins for the treatment or prevention of neuropathic pain are described. The use of a compound that is an antagonist of the pain enhancing effects...
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WO2000012076A9 |
Disclosed are nitrosated and/or nitrosylated compounds of formulae (I)-(XIX) which are phosphodiesterase inhibitors and compositions comprising them. The invention also provides methods for treating or preventing sexual dysfunctions in m...
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WO/2000/046184A1 |
The invention provides fungicidal compounds of formula (I) and salts thereof wherein: R?1¿ is alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted, or hydrogen; R?2¿ and R?3¿, which may be the same or...
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WO/2000/044726A1 |
Poly(ADP-ribose)polymerase inhibitors containing as the active ingredient 2H-phthalazin-1-one derivatives represented by general formula (I) (wherein each symbol is as defined in the description) or salts thereof. The compounds of the ge...
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WO/2000/042061A1 |
The invention concerns a method for preparing compounds of formula (I) wherein: R = H, alkyl, aryl, aralkyl containing up to 18 carbon atoms and the amine function may be free or protected, from a compound of formula (IA). The invention ...
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WO/2000/040539A1 |
Novel 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives, use of substituted 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives as Matrix Metalloprotease Inhibitors for the Treatment of Respiratory Diseases, pharmaceutical compos...
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WO/2000/040657A1 |
Hydrazam imides of general formula (I), wherein R?1¿ and R?2¿ are each independently of the other (a) hydrogen or nitro, at least one of which radicals being nitro, or R?1¿ and R?2¿ together are (b) one of the radicals: (a), (b), (c)...
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WO/2000/039100A1 |
The invention refers to novel phthalazine derivatives of formula (I), a process for the preparation thereof, and a pharmaceutical composition containing the same. The novel compounds have positive or negative AMPA/kainate receptor modula...
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WO/2000/037429A2 |
The present invention relates to small molecules according to formula (I) which are potent inhibitors of a $g(a)¿4?$g(b)¿1? mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing $g(a)¿4?$g(b)¿1? ad...
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WO/2000/034249A1 |
A pyridazin-3-on derivative of formula (1) in which R2 is a hydrogen atom or a C¿1?-C¿3? alkyl group, R?3¿ is a hydrogen atom or a C¿1?-C¿3? alkyl group, and Q is an optionally substituted phenyl group can be prepared at a high yiel...
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WO/2000/032573A1 |
The present invention relates to a meta-nitro phenol derivative of formula (I) wherein X is halogen, cyano, nitro, C1-6haloalkyl or C1-6haloalkoxy; Y is hydrogen, halogen, cyano, nitro, C1-6haloalkyl or C1-6haloalkoxy; Z is oxygen, sulfu...
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WO/2000/032584A2 |
The invention relates to the use of compounds of general formula (I), wherein A, B, A, Ar, R?1¿, R?2¿ and R?3¿ have the meanings detailed more closely in the description, for producing medicaments with an antiinflammatory action. The ...
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WO/2000/029385A1 |
A compound of formula (I) wherein A¿5? is N, N(O) or N(S); E¿1? is(CR¿1?R¿1?)¿m1?W¿1?; G¿1? is N¿3?,CN,OH,OR¿6a?, NO¿2?, or(CR¿1?R¿1?)¿m1?W¿2?; T¿1? isNR¿1?W¿3?, H,R¿3?,R¿5?, or a heterocycle; U¿1? is X¿1?W¿6?; J¿1...
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WO/2000/026201A1 |
The invention relates to benzoyl pyridazine derivatives of formula (I), wherein R?1¿, R?2¿, R?3¿ and Q have the meaning defined in claim 1. Said derivatives have a phosphodiesterase IV inhibiting effect and can be used in the tr...
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WO/2000/024719A1 |
The present invention describes pyridazinone compounds of formula (I) which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with infl...
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WO/2000/024718A1 |
The invention relates to a serine protease inhibitor having formula (I), in which J is H, R?1¿, R?1¿-O-C(O)-, R?1¿-C(O)-, R?1¿-SO¿2?-, R?3¿OOC-(CHR?2¿)¿p?-, (R?2a¿, R?2b¿)N-CO-(CHR?2¿)¿p?- or Het-CO-(C...
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WO/2000/023421A1 |
This invention is directed to novel (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in t...
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WO/2000/021935A1 |
Phenylpyridazinone derivatives represented by general formula (I), or pharmacologically acceptable salts thereof; and drug compositions characterized by containing as the active ingredients the above derivatives or salts, and medicinally...
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WO/2000/021920A1 |
Compounds of the formula (1a), wherein R1 is a group of the formula (2) where R1, R2, A, B, U, V, W, X, Y, Z, k and n have the significance given in the specification, are useful to treat rheumatoid arthritis, psoriasis, multiple scleros...
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WO/2000/015230A1 |
A method is provided for treating atherosclerosis and related diseases, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antiatherosclerotic agent, for example, an HMG CoA reductase inhibitor such as pravastatin.
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WO/2000/015229A1 |
A method is provided for treating diabetes and related diseases, especially Type II diabetes, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antidiabetic agent such as metformin, glyburide, troglitazone and/o...
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WO/2000/015614A1 |
The invention relates to novel pyridyl derivatives (I), their use as medicaments, pharmaceutical formulations including them and methods for their preparation.
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WO/2000/012084A1 |
The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treat...
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WO/2000/010569A1 |
Nitrogenous heterocyclic carboxamide derivatives represented by general formula (I), or salts thereof are useful as preventives and therapeutic agents for infections with viruses, particularly influenza virus. In said formula A is an opt...
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WO/2000/009488A1 |
Pyridazinone derivatives represented by general formula (1); medicinally acceptable salts of them; and drug compositions containing the same as the active ingredient, wherein R?1¿ is optionally substituted phenyl or an aromatic heterocy...
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WO/2000/005218A1 |
Compounds of formula (I), wherein ------ is a single or double bond; Z is NH, methylene, a (C¿2?-C¿6?)alkylene chain optionally branched and/or unsaturated and/or interrupted by a (C¿5?-C¿7?)cycloalkyl residue; A is phenyl or heteroc...
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WO/2000/005221A1 |
The invention relates to substituted benzoylcyclohexandiones of general formula (I), wherein A represents a single bond or alkane diyl (alkene) and Z represents an optionally substituted 4-12 membered, saturated on unsaturated, monocylic...
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WO/2000/005219A1 |
Compounds of formula (I) wherein B is NH, methylene, a C¿2-6? alkylene chain optionally branched and/or unsaturated and/or interrupted by a C¿5-7? cycloalkyl residue; A is phenyl or heterocycle optionally substituted; R represents two ...
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WO/2000/001666A1 |
This invention is directed to novel oxamyl depeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatm...
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WO/2000/000473A1 |
The invention concerns a compound of formula (I) wherein: n is equal to 0 or 1; R¿1?, R¿2?, R¿3?, R¿4? represent a hydrogen or an alkyl group, or R¿1? and R¿3? together form a cycloalkyl group; R¿5? represents a hydrogen, an alkyl...
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WO/1999/067206A1 |
Compounds of general formula (I) are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular...
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WO/1999/067231A1 |
Nitric acid salts with medicines having an antihypertensive activity.
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WO/1999/066912A2 |
Levosimendan, or (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phe
nyl]hydrazono]-propanedinitrile, which has been previously suggested for the treatment of congestive heart failure is useful in the treatment of pulmonary hype...
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WO/1999/066932A1 |
A method for the treatment of neurohumoral imbalance caused by alterations of cardiac function to prevent the development of heart failure or a method of increasing calcium sensitivity of contractile proteins of cardiac muscle comprises ...
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WO/1999/065871A2 |
This invention pertains to the discovery of a novel family of thiolesters and uses thereof. Also provided for are viricidal compounds and pharmaceutical formulations comprising these novel thiolesters. The invention also provides thioles...
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WO/1999/065888A2 |
The present invention relates to a pyridazinyl derivative (I) and its use as a reference compound in the determination of potentially genotoxic impurities in levosimendan samples. The invention also relates to an analytic method for the ...
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WO/1999/065880A1 |
The invention relates to aryl alkanoylpyridazine derivatives of the formula (I) and their physiologically compatible salts and solvates, where R?1¿, R?2¿, Q and B have the meanings given in claim 1. Said compounds have a phosphodiester...
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WO/1999/064402A1 |
The invention relates to novel processes for the preparation of 5-chloro-4- {3-[N- [2-(3,4- dimethoxyphenyl)- ethyl]-N- methylamino]- propylamino}- 3(2H)- pyridazinone of formula (I) and the pharmaceutically acceptable acid addition salt...
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WO/1999/062506A1 |
The use of compounds of formula (I), and salts thereof; and pharmaceutically acceptable $i(in vivo) cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said compound or said prodrugs; in formula (...
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WO/1999/057099A1 |
The invention relates to heterocyclic derivatives of formula (I), or pharmaceutically-acceptable salts thereof, which possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or ani...
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WO/1999/054310A2 |
The invention relates to cysteine protease inhibitors of the general formula (I), in which A is -(CH¿2?)¿p?-R?1¿, where R?1¿ can be pyrrolidine, morpholine, piperidine, -NR?5¿R?6¿ and formula (a) and p can be 1 or 2; B can be possi...
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WO/1999/052878A1 |
The invention relates to novel substituted phenyl pyridazinones of formula (I), wherein R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ and R?6¿ have the meanings cited in the description. The invention also relates to the production and use thereof ...
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WO/1999/051578A1 |
This invention concerns compounds of formula (I), stereochemically isomeric forms thereof, acid or base addition salts thereof, $i(N)-oxides thereof, or quaternary ammonium derivatives thereof, wherein the dotted line is an optional bond...
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WO/1999/050248A1 |
The present invention relates to a 3/2-hydrochloride of 4-chloro-5-[3- (4-benzylpiperazin-1- yl)carbonylmethoxy-4- methoxybenzylamino]- 3(2H)-pyridazinone, and also relates to a method for producing the 3/2- hydrochloride of 4-chloro-5-[...
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WO/1999/047505A1 |
The compounds of formula (I) in which R1, R2, R3, R4, R5, X and Y have the meanings as given in the description are novel effective bronchial therapeutica.
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WO/1999/046268A1 |
The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) such as P...
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WO/1999/044612A1 |
The invention relates to novel quinazolines and heterocycles which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and fo...
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WO/1999/044987A1 |
Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are of general formula (I), where X¿1?, X¿2?, Y, and Z are defined variables. Such compounds and their pharmaceutically acceptable salts, multim...
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WO/1999/044995A1 |
Pyridazine derivatives represented by general formula (1) or salts thereof, wherein R?1¿ represents lower alkoxy, lower alkylthio or halogeno; R?2¿ represents H, lower alkoxy, lower alkylthio or halogeno; R?3¿ represents OH, CN, halog...
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WO/1999/042442A1 |
Compounds represented by general formula (I) or salts thereof having preventive and therapeutic effects on ischemic heart diseases, etc., and being useful as preventives/remedies for ischemic heart diseases such as heart infarction and a...
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