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WO/2021/044437A1 |
The invention provides certain cocrystals of Olaparib and provides novel polymorphic forms of certain cocrystals of Olaparib. In particular, cocrystals of Olaparib with fumaric acid and 3,5-dihydroxybenzoic acid are described. The invent...
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WO/2021/035257A1 |
The invention provides compounds having STimulator of INterferon Genes (STING) agonistic bioactivity that can be used in the treatment of tumors in patients afflicted therewith. The compounds are of formula (IA), formula (I), and formula...
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WO/2021/032161A1 |
Disclosed in the present invention are a halogen-substituted phenylate compound and applications thereof. Particularly provided are a compound shown in formula (I) or an optical isomer thereof, and pharmaceutically acceptable salts, prod...
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WO/2021/032033A1 |
The present invention belongs to the technical field of pesticides, and in particular relates to a pyridazinol compound, a derivative thereof, a preparation method therefor, a herbicidal composition and the use thereof. The pyridazinol c...
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WO/2021/032074A1 |
The present disclosure relates to a benzamide fused aromatic ring derivative, a preparation method therefor and an application thereof in medicine. Specifically, the present disclosure relates to a benzamide fused aromatic ring derivativ...
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WO/2021/020362A1 |
Provided is a compound which has a glucosylceramide synthase-inhibiting activity and is expected to be useful as a prophylactic or therapeutic agent for a lysosomal storage disease (e.g., Gaucher disease, Fabry disease, GM1-gangliosidosi...
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WO/2021/018834A1 |
The present invention relates to compounds of Formula (I), wherein R1, R2, R3, R4x, R4y, m, n and G are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), to their use fo...
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WO/2021/009334A2 |
The present invention relates to herbicidal substituted phenyl-pyridazine-diones and substituted phenyl-pyridazinone derivatives of formula (I), as well as to processes and intermediates used for the preparation of such derivatives. The ...
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WO/2021/009335A1 |
The present invention relates to herbicidal substituted phenyl- pyridazine-diones and substituted phenyl-pyridazinone derivatives of formula (I), as well as to processes and intermediates used for the preparation of such derivatives. The...
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WO/2021/004535A1 |
Compounds of Formula (I) or (Ia), pharmaceutically acceptable salts, stereoisomers, tautomers, solvates or prodrugs, and their use as HPK1 inhibitors are described herein, and also described are methods for preparing the compounds, and m...
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WO/2020/256636A1 |
In certain aspects, the invention provides a novel crystalline form of olaparib (4-[(3-[(4-cyclopropylcarbonyl)piperazin-4-yl]carbonyl)-4-fl
uorophenyl]methyl(2H)phthalazin-1-one). In related aspects, the invention provides a processe fo...
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WO/2020/250223A1 |
The invention relates to a novel substituted amino acids, agricultural compositions comprising the novel substituted amino acids, and their use for controlling undesired plant growth alone or in combination with crop protection agents su...
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WO/2020/248065A1 |
The present application is directed to compounds of Formula (I), (II), (III) or (IV) compositions comprising these compounds, methods for their preparation and their uses, for example, as acyl hydrazone linkers, which can link two chemic...
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WO/2020/252414A1 |
Disclosed herein are naphthoquinone derivative compounds of the formula shown below, compositions thereof, and methods of using such compounds and compositions for treating or suppressing oxidative stress disorders and/or neurodegenerati...
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WO/2020/242245A1 |
The present invention relates to: a phthalazinone compound, or a racemate, stereoisomer, or pharmaceutically acceptable salt thereof; a pharmaceutical composition for the prevention or treatment of Sirt6-associated diseases, comprising, ...
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WO/2020/239076A1 |
Pyridazinone derivatives as thyroxine receptor-β agonists, and application thereof in preparing medicines for diseases related to thyroxine receptor-β agonists. Specifically disclosed is a compound represented by formula (I), or a phar...
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WO/2020/234715A1 |
The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I): (I), wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention furth...
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WO/2020/228577A1 |
Provided are a pyridazinone derivative and the use thereof. By selecting specific modification groups of the pyridazinone derivative provided in the present invention having a structure as shown in formula (I), the results show that the ...
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WO/2020/228823A1 |
The present invention relates to novel amide compounds of formula (I), pharmaceutical compositions thereof, methods for preparing thereof, and uses thereof, wherein the symbols are as defined in the specification.
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WO/2020/221276A1 |
The present invention relates to a salt of 5-((2-ethynyl-5-isopropylpyridin-4-yl)oxy)pyrimidine-2,4-dia
mine and a solid form thereof, a method for preparing the solid form and a pharmaceutical composition comprising the solid form, as w...
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WO/2020/214999A1 |
The present disclosure relates to compounds for the use of treating neurodegenerative diseases and, in particular, to compounds targeting the Abelson non-tyrosine kinase (c-Abl) protein for such treatment. The neurological disorders and ...
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WO/2020/210626A1 |
Disclosed are spray-dried formulations of 4-chloro-5-(4-(4-fluoro-2- (trifluoromethyl)phenoxy)-5,8-dihydropyrido[3,4-d]pyrimidin-
7(6H)-yl)pyridazin-3(2H)-one, methods and compositions for making the same, and solid dosage forms comprisi...
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WO/2020/198526A2 |
The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associ...
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WO/2020/169042A1 |
Specifically, the present invention relates to the 6-oxo-1,6-dihydropyridazine prodrug derivative shown in general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, a use thereof as a NaV...
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WO/2020/164970A1 |
The present invention relates to herbicidally active cinnolinium derivatives of formula (I), as well as to processes and intermediates used for the preparation of such derivatives. The invention further extends to herbicidal compositions...
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WO/2020/163541A1 |
Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treati...
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WO/2020/163647A1 |
Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treati...
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WO/2020/163375A1 |
Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treati...
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WO/2020/161248A1 |
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.
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WO/2020/160151A1 |
A compound having one of formula (1), formula (2), formula (3) and formula (4) or a pharmacologically acceptable salt thereof.
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WO/2020/156571A1 |
Provided is a pyridazine derivative as shown in formula (I), and a use thereof in preparing a drug for the prevention and/or treatment of indications related to HIF modulation. The pyridazine derivative is an ideal, highly-effective HIF-...
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WO/2020/159904A1 |
Compounds having the following formula (I): (Formula (I)) or a stereoisomer or pharmaceutically-acceptable salt thereof, are useful in the modulation of IL-12, IL-23 and/or IFNa, by acting on Tyk-2 to cause signal transduction inhibition.
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WO/2020/157199A1 |
The present invention includes name compounds of general formula (I) : (I), in which R1, R2, R3 and A are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical ...
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WO/2020/140959A1 |
A 6-oxo-1,6-dihydropyridazine derivative, a preparation method therefor and medical use thereof, in particular, a 6-oxo-1,6-dihydropyridazine derivative represented by general formula (I), a preparation method therefor, and a pharmaceuti...
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WO/2020/127168A1 |
Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.
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WO/2020/127780A1 |
The present disclosure relates to heterocyclyl pyridazine compounds, processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.
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WO/2020/122092A1 |
The present invention provides a heterocyclic compound having orexin receptor type 2 agonist activity. A compound represented by formula (I) [in the formula, each symbol is as described in the description] or a salt thereof has orexin ...
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WO/2020/115548A1 |
Combination therapies comprising administering radioimmunoconjugates and DNA damage response inhibitors.
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WO/2020/114869A1 |
The present invention relates to the use of herbicidal substituted phenyl-pyridazinediones and substituted phenyl-pyridazinone derivatives of formula (I), in combination with herbicidal pyrrolidinone derivatives of the formula (II) to co...
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WO/2020/109039A1 |
The present invention relates to the compounds of formula (I), and the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof wherein the variables are defined according to the description formula ...
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WO/2020/109391A1 |
The present disclosure relates to pyridazine (thio)amide compounds, processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.
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WO/2020/102572A1 |
Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are ...
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WO/2020/099367A1 |
Use of the compounds of the formula (I) wherein the substituents are as defined herein as herbicides. Compounds of formula (I) are also claimed.
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WO/2020/097258A1 |
Substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne Muscular Dystrophy (DMD), are disclosed herein. The disclosed compounds are useful, amon...
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WO/2020/093272A1 |
The present application belongs to the technical field of organic chemistry, and particularly relates to a sulfonyl fluoride-containing compound with high affinity to a PARP receptor, or a pharmaceutically acceptable salt, isomer, prodru...
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WO/2020/097265A1 |
Substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne Muscular Dystrophy (DMD), are disclosed herein. The disclosed compounds are useful, amon...
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WO/2020/089098A1 |
The present invention relates to novel pyridazines, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of diseases and disorders mediated...
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WO/2020/081971A1 |
The present disclosure provides a method for treating a cancer or refractory caner and/or inhibiting cancer metastasis, recurrence or progression in a subject or increasing the likelihood of survival over a relevant period in a subject d...
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WO/2020/076123A1 |
The present invention relates to a compound, a photoresist composition comprising same, a photoresist pattern comprising same, and a method for manufacturing a photoresist pattern.
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WO/2020/069056A1 |
Disclosed is a compound of Formula I, including N-oxides, and salts thereof, wherein R1, R2 and R3 are defined as set forth in the disclosure. Also disclosed is a process for preparing a compound of Formula I. A compound of Formula I can...
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