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Matches 1 - 50 out of 4,430

Document Document Title
WO/2024/121013A1
The present invention provides new derivatives having the general formula (I), (I) wherein R1, R2, R3, R4, R5, R6, R7, X1, X2, X3, X4, and X5 are as defined herein, compositions including the compounds, processes of manufacturing the com...  
WO/2024/040350A8
The present disclosure relates to pyridazinone compound of the Formula (I) for the treatment of respiratory diseases, such as, chronic obstructive pulmonary disease (COPD), cystic fibrosis, cancer, Long QT syndrome or Dravet syndrome, wh...  
WO/2024/114635A1
The present disclosure belongs to the field of medicinal chemistry; and relates to a dihydrophthalazine-containing compound, a preparation method therefor, a pharmaceutical composition containing same, and the use thereof in the treatmen...  
WO/2024/109922A1
Disclosed are a bridged ring pyridazine compound and the use thereof, which compound and use belong to the technical field of chemical medicine. Provided is a bridged ring pyridazine compound as represented by formula I, which compound c...  
WO/2024/104345A1
Provided are a pyridazinone derivative and use thereof. The pyridazinone derivative is represented by general formula (I). The compound of general formula (I) has activity on various fungal diseases and bacterial diseases in the agricult...  
WO/2024/106438A1
The present invention provides a superior novel pest control agent for agriculture and horticulture. The present invention pertains to: compounds represented by general formula [I] (each symbol is as described in the description) or salt...  
WO/2024/100545A1
The present invention proposes novel derivatives of phthalazinium dicyanomethanides (I), a process for manufacturing same, and the use thereof in the functionalization of peptides and proteins, in the attachment of biological polymers to...  
WO/2024/094185A1
The present invention belongs to the technical field of medicine, relates to an NLRP3 inflammasome inhibitor and a use thereof, and specifically relates to a compound represented by a general formula (A') or a pharmaceutically acceptable...  
WO/2024/095012A1
The invention relates to a compound of formula (Ia) and related aspects.  
WO/2024/084491A1
The present invention discloses a process for synthesis of Res metirom and its intermediates thereof. More particularly, the invention discloses process for synthesis of a key intermediate, 6-(4-amino, 2,6-dichlorophenoxy)4- isopropylpyr...  
WO/2024/083257A1
Provided in the present invention are an SOS1 protein degradation agent and a use thereof. Specifically, provided in the present invention is a formula (I) for a S-L-E compound, and a stereoisomer, enantiomer, diastereomer, deuterated co...  
WO/2024/086361A1
Described herein are molecular glue degrader compounds that bind to both a target protein and a RING E3 Ubiquitin Ligase, as well as related compositions and methods of use, e.g., for degradation of the target protein and/or the treatmen...  
WO/2024/079733A1
The present invention provides a process for the preparation of aminopyridazine derivatives, and novel pyridazine-based and pyrazole-based compounds which are useful as either starting materials or intermediates in said process.  
WO/2024/079072A1
The present invention relates to a compound of formula (I) or any of its acceptable salts (I) wherein W, X, Y and Z each independently represents =CH- or -N=, provided that at most two of W, X, Y and Z both represent a -N= group, R1 repr...  
WO/2024/067676A1
Provided are a compound represented by general formula (1), a preparation method therefor, and use of the compound represented by general formula (1) and isomers, crystal forms, pharmaceutically acceptable salts, hydrates or solvates the...  
WO/2024/040350A1
The present disclosure relates to pyridazinone compound of the Formula (I) for the treatment of respiratory diseases, such as, chronic obstructive pulmonary disease (COPD), cystic fibrosis, cancer, Long QT syndrome or Dravet syndrome, wh...  
WO/2024/037558A1
The present invention relates to novel forms of Compound I, preparation thereof, pharmaceutical composition containing the same and use thereof, wherein, the compound is (S) -5- ( (1- (3- (5-methyl-3- (trifluoromethyl) -8, 9-dihydropyrid...  
WO/2024/028782A1
The present invention relates to novel pyridazin-3-yl phenol compounds of formula (I): wherein R1, R2, R3, R4 and R5 are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relat...  
WO/2024/022186A1
The present invention relates to a methylpyrazole compound, a pharmaceutical composition comprising same, a preparation method therefor, and use thereof. In particular, the present invention relates to a compound represented by formula (...  
WO/2024/008176A1
A nitrogen-containing heterocyclic compound represented by formula (I-a), or a stereoisomer, a deuterated compound, a solvate, a pharmaceutically acceptable salt or a eutectic crystal thereof, a pharmaceutical composition comprising same...  
WO/2024/010963A1
The present disclosure provides phosphonate-containing heterocycle compounds with TYK2/JAK1 inhibitory activities, pharmaceutical compositions comprising the same, and applications thereof. The present disclosure provides compounds of Fo...  
WO/2024/002318A1
The present invention relates to the technical field of medicines, and in particular to a pyridazopyridone derivative used as an SOS1 protein inhibitor and a use thereof. The provided compound has an obvious inhibition effect on the acti...  
WO/2024/002375A1
Disclosed are a compound or a pharmaceutically acceptable salt thereof which function as a SMARCA2/4 inhibitor, said compound having the structural formula shown in formula I. Further disclosed are a pharmaceutical composition containing...  
WO/2023/246867A1
The present invention provides a Nav1.8 inhibitor. Specifically, the present invention provides a compound represented by formula I, a tautomer, a stereoisomer, a hydrate, a solvate, a pharmaceutically acceptable salt or a prodrug thereo...  
WO/2023/243677A1
The present invention provides a plant disease control method having an excellent efficacy for controlling plant diseases, the method comprising treating plants or soil used for plant cultivation with a compound represented by formula (I...  
WO/2023/239675A1
The present disclosure is related to STING agonists, pharmaceutical compositions thereof, and the use of the agonists and pharmaceutical compositions to induce a STING-mediated immune response and/or to treat diseases and disorders media...  
WO/2023/231997A1
Provided in the present invention are a pyridazine compound represented by formula (II), and a preparation method therefor and the use thereof. Further disclosed in the present invention is the use of the compound of the present inventio...  
WO/2023/223055A1
This invention relates to compounds that can be used to treat viral infections. The compounds of the present invention are papain-like protease (PLpro) inhibitors.  
WO/2023/217989A1
Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.  
WO/2023/220741A1
The present disclosure provides small molecule compounds and pharmaceutical compositions for the modulation of alpha 4 beta 7 integrin, useful for the treatment of inflammatory conditions such as inflammatory bowel disease, including ulc...  
WO/2023/213626A1
The present invention relates to the use of (5S)-3-[3-( -chloro-2-fluorophenoxy)-6-methylpyridazin-4-yl] 5-(2-chloro-4-methylbenzyl)-5,6-dihydro-4H-1,2,4-oxadiazine according to formula (I) for controlling unwanted microorganisms causing...  
WO/2023/209086A1
The specification relates to compounds of Formula (I): (I) and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in th...  
WO/2023/209090A1
The specification relates to compounds of Formula (I): (I) and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in th...  
WO/2023/204124A1
The present invention addresses the problem of providing: a pyridazinone compound having excellent bactericidal/antibacterial activities and excellent safety and capable of being synthesized industrially advantageously; an agricultural a...  
WO/2023/202626A1
The present invention provides a PRMT5 inhibitor as shown in formula (I), or a pharmaceutically acceptable salt, an isotopic variant, a tautomer, a stereoisomer, a prodrug, a polymorph, a hydrate or a solvate thereof. The present inventi...  
WO/2023/193759A1
Described herein are HPK1inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with HPK1.  
WO/2023/194496A1
A process for the preparation of compound of formula (I) is provided: where R, R1, R2, R3 and R4 are as defined in the description.  
WO/2023/186102A1
The present invention provides a Nav1.8 inhibitor. Particularly, the present invention provides a compound represented by formula I, or a tautomer, a stereoisomer, a hydrate, a solvate, a pharmaceutically acceptable salt or a prodrug the...  
WO/2023/190015A1
In the production of crops in agriculture, horticulture, etc., damages caused by pests, etc., are still significant, and it has been required to develop a new agricultural and horticultural pesticide due to factors such as the emergence ...  
WO/2023/192989A2
The present disclosure relates to phthalazinone compounds and related compounds and their use in treating a disease or condition responsive to inhibition of PARP7.  
WO/2023/192864A2
This invention provides a PARP16 inhibiting compound of Formula (I): (I) wherein: R1 is selected from the group of H, halo, -OH, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, -O-alkyl,-O-alkenyl,-O-alkynyl, -O-cycl...  
WO/2023/178130A1
Provided herein are SOS1 protein degraders, e.g., a compound of Formula (I) comprising an E3 ubiquitin ligase binding moiety, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing...  
WO/2023/177568A1
The application relates to compounds of the general Formula (I) which act as cannabinoid receptor modulators useful for the treatment of complications arising from metabolic, inflammatory and fibrotic disorders.  
WO/2023/172112A1
The present specification relates to a compound represented by chemical formula 1 and an organic light-emitting device comprising the compound.  
WO/2023/166067A1
A compound of Formula (I) wherein the substituents are as defined in claim 1, useful as pesticides, especially as fungicides.  
WO/2023/165574A1
Disclosed are a compound used as a TYK2 inhibitor, a preparation method therefor, and pharmaceutical use thereof. Specifically, the compound has a structure represented by formula (I), wherein the definitions of the groups and substituen...  
WO/2023/158602A1
Disclosed are compounds of Formula I including all geometric and stereoisomers, tautomers, N-oxides, and salts thereof, wherein G, Z, L, J, A and T are as defined in the disclosure. Also disclosed are compositions containing the compound...  
WO/2023/158708A1
The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NLRP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodru...  
WO/2023/158795A1
Provided are compounds of the Formula (I): or pharmaceutically acceptable salts thereof, which are useful for the inhibition of DHX9 and in the treatment of a variety of DHX9 mediated conditions or diseases, such as cancer.  
WO/2023/152182A1
Present invention relates to a compound according to formula (II): and all stereoisomers, racemic mixtures, tautomers, pharmaceutically acceptable salts, prodrugs, hydrates, solvates and polymorphs thereof, as well as pharmaceutical comp...  

Matches 1 - 50 out of 4,430