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WO/2023/234382A1 |
Provided is a means with which trioxane can be continuously produced at a high yield. Provided is a composition that contains (A) 58.5-65.5 mass% of formaldehyde, (B) 0.7-4.5 mass% of methanesulfonic acid, and (C) less than 0.007 mass%...
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WO/2023/156429A1 |
The present invention relates to the field of organic synthesis and more specifically it concerns a process for preparing compound of formula (I). The compound of formula (V), the compound of formula (VI) and the compound of formula (VII...
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WO/2023/111829A1 |
The present invention relates to novel drug delivery systems based on endoperoxide moieties such as 1,2,4,5-tetraoxanes, namely compounds of formula (I), appropriately modified to release active pharmaceutical ingredients (API) in the pr...
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WO/2023/110132A1 |
The invention is in the field of fragrances and relates to novel oxa-macrocyclic fragrance compounds according to general formula (I) with a musk-based note and improved biological degradability and further with improved chemical stabili...
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WO/2023/022204A1 |
Provided is a highly-safe cyclic peroxide. This cyclic peroxide is characterized by being represented by chemical formula (I). In chemical formula (I), R100 is a cyclic structure having 3 or more ring-forming members, may be saturate...
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WO/2022/258333A1 |
The invention relates to a process for the manufacture of a cyclic oligo(arylene ether ketone) wherein an aromatic compound such as diphenyl ether is caused to react with terephthaloyl chloride under pseudo-high dilution conditions. The ...
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WO/2022/258332A1 |
The invention relates to a process for the manufacture of a cyclic oligo(arylene ether) which can be a cyclic oligo(dichloromethylene arylene ether) or a cyclic oligo(arylene ether ketone); the process comprises the step of causing an ar...
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WO/2022/161490A1 |
1, 2, 4, 5-tetraoxane compounds and derivatives thereof that have anticancer properties are disclosed. Pharmaceutical compositions and pharmaceutical formulations in unit dosage form suitable for the delivery of the compounds to a subjec...
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WO/2022/147047A1 |
The present application discloses, in part, isolated, stable and biologically active menaquinol derivatives and their methods of use for the treatment of various diseases.
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WO/2022/144899A1 |
Polymeric ion conductors composed of a polymeric matrix associated with an isoindolinium moiety represented by Formula I as described in the specification are provided. Anion conducting compositions comprising an anion conducting polymer...
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WO/2022/095307A1 |
Provided in the present disclosure is a process for preparing trioxymethylene from methanol, comprising: step 1: preparing and obtaining formaldehyde from a mixture of methanol and methylal under the action of an oxidation catalyst, and ...
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WO/2022/071970A1 |
Compositions with supramolecular structures for use in agricultural methods include a source of micronutrients such as a fertilizer, a supramolecular host chemical or a supramolecular guest chemical configured to engage in host-guest che...
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WO/2022/044000A1 |
There is disclosed, a desalination apparatus making use of a particles including covalently bonded functionalized magnetic nanoparticles coupled to a complexing agent. For example, the complexing agent may include a crown ether. The part...
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WO/2021/247758A1 |
The present invention relates to anti-cancer agents comprising 1,2,4-trioxane compounds and anti-cancer agents comprising combinations comprising 1,2,4-trioxane compounds and chlorogenic acids. The invention further provides pharmaceutic...
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WO/2021/230185A1 |
Provided is a compound in which the hydroxy groups of a polyphenol are crosslinked within each molecule by a group containing a degradable bond that is degraded under acidic or alkaline conditions. The polyphenol is preferably a calixarene.
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WO/2021/219089A1 |
Provided herein are compounds, pharmaceutical compositions and methods for treating a SARS-CoV-2 infection.
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WO/2021/213663A1 |
The invention relates to a process for preparing aldehydes, characterized in that at least one 1,3,5 trioxane of the general formula (I) is reacted to the corresponding aldehyde(s) of the general formula (II) in the presence of at least ...
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WO/2020/243540A1 |
Disclosed are cationic lipids which are compounds of Formula I. Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly ca...
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WO/2020/240266A1 |
The present invention relates to new endoperoxide compounds and compositions, and to a process for producing them for prophylaxis and control of perkinsiosis in bivalves. Endoperoxide compounds with biological activity against Perkinsus ...
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WO/2020/203638A1 |
A hydride ion-containing composition which contains dissociative hydride ions and a solvent. It is preferable that the dissociative hydride ions are stabilized dissociative hydride ions. It is also preferable that the hydride ion-contain...
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WO/2020/188470A1 |
Provided herein are novel calixcrowns, such as those of Formula (I), which are useful for coating a solid substrate such as a protein chip, diagnostic kit or protein separation pack. Also provided herein are methods detecting protein-pro...
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WO/2020/131964A1 |
The present disclosure provides Molecular Recognition Technology (MRT) for selectively sequestering lithium from natural and synthetic brines, leachates, or other chemical mixtures. Also disclosed herein are MRT extractants, ligands, bea...
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WO/2020/119864A1 |
The invention relates to a compound which has a calixarene unit having n phenol units, where n is 4, 5, 6 or 8; an ether unit, which is bound to the calixarene unit, forming a crown ether; and at least one sulfonic acid amide unit of the...
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WO/2019/208723A1 |
A rotaxane compound including one or more cyclic molecules and an axial molecule that penetrates the inner hole portion of the cyclic molecule, the axial molecule having a cap structure arranged so that the cyclic molecule does not detac...
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WO/2019/195754A1 |
Cationic radial catenane comprising a central cationic ring and two or more radial cationic rings mechanically interlocked central cationic ring and methods for making the same are disclosed herein.
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WO/2019/181829A1 |
The present invention addresses the problem of providing a cyclic poly(arylene ether ketone) capable of being obtained in high yield. The cyclic poly(arylene ether ketone) of the present invention is represented by chemical formula (I), ...
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WO/2019/082516A1 |
[Problem] To provide a cyclopolymerized L-lactic acid having a pH of 6-7 as a single polymer. [Solution] In this method of producing a cyclopolymerized L-lactic acid, pressure is reduced and spraying of nitrogen gas is stopped while main...
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WO/2018/167315A9 |
Disclosed herein are compositions of a deep eutectic solvent with a host, such as a supramolecular host, and the use of the composition to form a composition comprising the host in complex with one or more guests. The deep eutectic solve...
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WO/2018/174574A1 |
The present invention relates to a method for preparing a fluorosulfonyl imide salt with a metal cation completely removed. The method of the present invention is a very efficient method in an economic view, and a fluorosulfonyl imide sa...
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WO/2018/167477A1 |
A salt of the general formula: Ca(L)x(PF6)2 wherein each L is a ligand selected from an ether or aza macrocyclic; a halomethane or a nitrile of the general formula R-C≡N. The method of making the salt comprises the steps: providing Ca ...
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WO/2018/068132A1 |
The present disclosure provides immunogenic compositions comprising: a) hepatitis C virus (HCV) E1E2 heterodimers, HCV E2, or HCV E1; and b) an adjuvant, where the adjuvant is a cyclic dinucleotide or an archaeosome. The present disclosu...
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WO/2017/102504A1 |
The present invention relates to a process for energy recovery in a process for the preparation of 1,3,5-trioxane.
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WO/2017/060418A1 |
The present invention provides novel cell-permeable carboxylic acid-based metabolites and cell permeable precursors thereof aimed at increasing ATP-production in mitochondria and thus, for use in medicine. The main part of ATP produced a...
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WO/2016/170015A1 |
Epoxy derivatives of ion chelating ligands, method for production and use thereof. Methods for producing polymers covalently linked with ion chelating ligands and their use as drug delivery and ion removal agents.
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WO/2016/104630A1 |
The present invention pertains to: a condensed heterocyclic compound having an inhibitory effect on enteropeptidase, the condensed heterocyclic compound being useful in the treatment or prevention of obesity, diabetes, and the like; and ...
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WO/2016/020592A1 |
The present invention concerns a method for preparing 1,3,5-trioxane by trimerisation of formaldehyde in the presence of methanesulfonic acid. The invention also concerns the use of at least one catalyst comprising methanesulfonic acid f...
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WO/2016/016446A1 |
A process comprising (i) providing a 2-fluoropropionic acid halide; (ii) hydrogenating the 2-fluoropropionic acid halide by contacting it with a heterogeneous hydrogenation catalyst in an atmosphere comprising hydrogen, obtaining a mixtu...
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WO/2015/155230A1 |
The present invention provides novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates fr...
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WO/2015/150588A1 |
The invention relates to complexes comprising a solid support and a material with a matrix structure comprising domains complexing rare earths or strategic metals. The invention also relates to the method for the production of said compl...
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WO/2015/135865A1 |
A composition comprising at least two trimeric cyclic ketone peroxides: a trimeric cyclic methyl ethyl ketone peroxide (3MEK-cp) of formula (I) and at least one peroxide satisfying formula (II) wherein R1 through R3 are independently sel...
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WO/2015/005169A1 |
The present invention provides a liquid-state trioxane composition having trioxane as a main component and including an antioxidant and at least one alkaline organic compound selected from the group consisting of an amine compound having...
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WO/2014/185205A1 |
Provided is a solid phosphoric acid catalyst which, when gas-phase synthesizing trioxane from formaldehyde, obtains trioxane at a high yield and at a high selection rate by markedly suppressing side reactions, and which reduces the adhes...
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WO/2014/183055A1 |
The present invention includes compositions and methods for the treatment of skin conditions by administration of a cyclolignan such as picropodophyllin and/or a derivative, metabolite, analog, prodrug, pharmaceutically acceptable salt, ...
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WO/2014/181068A1 |
Calixarene crown compounds of formula (I) in which R = COOH or OH and the salts of same, and compounds of this formula (I) and the salts of same in which the pyranone ring of each coumarin entity is replaced by a fluorophore chosen from ...
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WO/2014/053857A1 |
Disclosed herein are mono or di-succinate compounds where one or both of the acid groups in the succinate core are protected in the form of biologically labile moieties, and the use of said compounds to enhance mitochondrial function. Th...
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WO/2014/019501A1 |
A benzocrown ether graft polymer with a lithium isotopic separation effect and a preparation method thereof. The polymer is a chemical crosslinking benzocrown ether graft polymer having a polymer containing a chloromethyl group, acyl chl...
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WO/2014/017203A1 |
The objective of the present invention is to increase the yield and selectivity of trioxane and to minimize the amount of unreacted formaldehyde when producing trioxane from an aqueous formaldehyde solution. In this production method, fo...
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WO/2013/076286A1 |
The present invention relates to a process for producing cyclic acetal comprising i) preparing a liquid reaction mixture comprising a) formaldehyde source, b) an aprotic compound and c) a catalyst; and ii) converting the formaldehyde sou...
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WO/2013/076288A1 |
A process for producing cyclic acetals is described. A formaldehyde source is contacted with an aprotic compound in the presence of a catalyst to produce the cyclic acetals. The aprotic compound can increase conversion rates and/or effic...
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WO/2013/076290A1 |
A process for producing a cyclic acetal is disclosed. According to the process, a formaldehyde source is combined with an aprotic compound and contacted with a heterogeneous catalyst which causes the formaldehyde source to convert into a...
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