Heterocyclic Compounds

Matches 1,101 - 1,150 out of 53,986	< 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 >

Document	Document Title
WO/2023/083247A1	INTERMEDIATE COMPOUND OF QUINOXALINE AND PREPARATION PROCESS THEREOF Disclosed are an intermediate compound of quinoxaline of formula A, the use in the preparation of intermediates and bulk medicines thereof, and a synthesis method. The method avoids cumbersome separation and purification steps, reduces c...
WO/2023/085785A1	ISOINDOLINONE DERIVATIVE HAVING GLUTARIMIDE MOTHER NUCLEUS, AND USE THEREOF The present invention relates to an isoindolinone derivative compound having a glutarimide mother nucleus, and the application thereof and, more specifically, to an isoindolinone derivative compound having a glutarimide mother nucleus ha...
WO/2023/083209A1	LIGAND COMPOUND TARGETING PSMA ANTIGEN, AND CHELATE AND USE THEREOF IN DIAGNOSIS AND TREATMENT OF PROSTATE CANCER Disclosed are a ligand compound targeting a PSMA antigen, and a chelate and the use thereof in the diagnosis and treatment of prostate cancer. The ligand compound is a compound of formula (I) or a salt, ester or solvate thereof. The pres...
WO/2023/081967A1	COMPOUNDS AND USES THEREFOR Provided herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising said compounds. Also provided are uses of the compounds for sensitising bacterial cells expressing EptA...
WO/2023/083201A1	AMINOPYRAZOLE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF Provided in the present disclosure are an aminopyrazole derivative, and a preparation method therefor and the use thereof. Specifically, provided in the present disclosure is a compound as represented by formula I or a pharmaceutically a...
WO/2023/086319A1	6-HE TERO ARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.
WO/2023/079294A1	PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS The invention relates to compounds of formula (Ia) and to their use in treating or preventing an inflammatory disease, a disease associated with an undesirable immune response, cancer, obesity, a diabetic disease or a blood disorder: whe...
WO/2023/081312A1	SMALL MOLECULE INDUCERS OF AUTOPHAGY The present disclosure provides compounds or salts of Formula (I) which modulate Beclin-l/Bcl-2 protein- protein interactions. These interactions induce autophagy and are useful for treating a variety of indications, including cancer, in...
WO/2023/078252A1	PPARG INVERSE AGONISTS AND USES THEREOF Provided are compounds of Formula (I) : and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with PPARG.
WO/2023/080732A1	COMPOUND HAVING BTK PROTEIN DEGRADATION ACTIVITY, AND MEDICAL USES THEREOF The present disclosure provides: a compound of a specific chemical structure, having excellent activity with respect to BTK degradation; or a pharmaceutically acceptable salt thereof. The present disclosure also provides a composition co...
WO/2023/078410A1	COMPOUND HAVING ACTIVITY OF DEGRADING GSPT1 AND APPLICATION THEREOF Disclosed in the present application are a compound having the activity of degrading GSPT1 and an application thereof. The compound disclosed in the present application has the activity of degrading GSPT1, and can be used for preparing d...
WO/2023/078813A1	HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS Compounds of the formula (I) Q1-Q2-Q3 (I) in which Q1, Q2 and Q3 have the meanings indicated in Claim 1, degrade target proteins, and can be employed, inter alia, for the treatment of diseases and conditions mediated by such target prote...
WO/2023/081209A1	PI3K INHIBITORS AND METHODS OF TREATING CANCER Compounds of Formula (I) and pharmaceutically active salts thereof are provided, where the variables in Formula (I) are described herein. Such compounds and salts are PI3K inhibitors that are useful for treating conditions characterized ...
WO/2023/077294A1	COMPOUND, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Disclosed are a compound as represented by formula (I), and a preparation method therefor and an application thereof. The definitions of groups of the compound are as described in the claims and the description. The compound as represent...
WO/2023/078333A1	SUBSTITUTED PHENYLPROPIONIC ACID DERIVATIVE AND USE THEREOF The disclosure provides a substituted phenylpropionic acid derivative and a use thereof. Specifically, the disclosure provides a compound as shown in formula II or a medicinal salt thereof, which can be used in the preparation of a drug ...
WO/2023/078207A1	6-POSITION-SUBSTITUTED INDOLINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF Disclosed are a 6-position-substituted indolinone derivative, a preparation method therefor, and a medical use thereof. The present invention belongs to the field of medicinal chemistry; the 6-position-substituted indolinone derivative o...
WO/2023/078451A1	COMPOUND USED AS CDK7 KINASE INHIBITOR AND USE THEREOF The present invention relates to a compound used as a CDK7 kinase inhibitor and a use thereof. Specifically, the compound of the present invention has the structure shown in formula I, the definitions of the groups and substituents being...
WO/2023/078461A1	HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF A heterocyclic compound as shown in formula I, a tautomer, stereoisomer, solvate, pharmaceutically acceptable salt or prodrug thereof, a preparation method therefor, and the use thereof. The heterocyclic compound has a better 15-PGDH inh...
WO/2023/081720A1	USES OF PAN BET INHIBITORS The present disclosure relates to methods for the treatment, amelioration, or prophylaxis of an inflammatory and/or an autoimmune disease or disorder or a disease or disorder related thereto (e.g., wounds, pigmentation or pigmentation re...
WO/2023/078238A1	SARS-COV-2 INHIBITORS FOR TREATING CORONAVIRUS INFECTIONS Provided herein are compounds, pharmaceutical compositions and methods for treating a SARS-CoV-2 infection.
WO/2023/077218A1	PHOTOCATALYSTS, PREPARATION AND USE THEREOF There is provided a process for alkylating a substrate with a photocatalytic system. The process comprises providing a mixture containing an acid, and a substrate (an organic compound). Then, an organophotoredox catalyst of formula Ia is...
WO/2023/078231A1	SARS-COV-2 INHIBITORS FOR TREATING CORONAVIRUS INFECTIONS Provided herein are compounds, pharmaceutical compositions, and methods for treating a SARS-CoV-2 infection.
WO/2023/081854A1	AKT3 MODULATORS Compounds of Formula la, lb, Ic, Ila, lIb, lIc, Illa, Illb, IIIc, IVa, IVb, or IVc, or, are described, where the various substituents are defined herein. The compounds can modulate a property or effect of Akt3 in vitro or in vivo, and ca...
WO/2023/077678A1	SMALL MOLECULE COMPOUND TARGETING SRSF6 PROTEIN AND PREPARATION METHOD THEREFOR AND USE THEREOF Disclosed in the present invention are a small molecule compound targeting an SRSF6 protein and a preparation method therefor and a use thereof. The compound is as represented by formula (I). A molecule can selectively inhibit abnormal c...
WO/2023/081224A1	SUBSTITUTED N-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-4- YL)METHYL)BENZAMIDE ANALOGS AS MODULATORS OF CEREBLON PROTEIN In one aspect, the disclosure relates to substituted N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)methyl) benzamide analogs that useful as modulators of cereblon (CRBN) activity, methods of making same, pharmaceutical composition...
WO/2023/079556A1	COMPOSITIONS AND METHODS FOR CANCER TREATMENT The present invention provides compounds and pharmaceutical compositions comprising thereof. Further, methods for increasing or prolonging the therapeutic efficacy of a chemotherapeutic agent in a subject in need thereof, and methods for...
WO/2023/072273A1	POLYCYCLIC COMPOUND AS CBL-B INHIBITOR The present application describes a polycyclic compound represented by general formula (I) as a Cbl-b inhibitor, or a stereoisomer or pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the compound of gener...
WO/2023/072248A1	PYRIDYL-CONTAINING COMPOUND Provided are a pyridyl-containing compound represented by formula I and a preparation method therefor, and the use thereof in the preparation for a drug for treating tumors.
WO/2023/072962A1	SUBSTITUTED QUINOLINES AS IMPROVED NF-KB-INDUCING KINASE (NIK) INHIBITORS The present invention provides novel compounds of formula (I) and pharmaceutical compositions containing these compounds. The compounds of formula (I) can act as NF-κB-inducing kinase (NIK) inhibitors and, in particular, can induce the ...
WO/2023/073082A1	CCR6 RECEPTOR MODULATORS The present invention relates to compounds of Formula (I), their synthesis and use as CCR6 receptor modulators for the prevention or treatment of e.g. inflammatory/autoimmune diseases/disorders and cancer.
WO/2023/077070A1	RXFP1 AGONISTS The disclosure relates to compounds of Formula (I), which are RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such ...
WO/2023/070605A1	METHODS OF PREPARING 6-MEMBERED AZA-HETEROCYCLIC CONTAINING DELTA-OPIOID RECEPTOR MODULATING COMPOUNDS The present embodiments are directed, in part, to processes and compositions that can, for example, be used in the preparation compounds of Formula (XIV), or a pharmaceutically acceptable salts thereof.
WO/2023/074847A1	NOVEL SPIRO COMPOUND The present invention provides: a novel spiro compound having a TRH-DE inhibition activity and useful for the prevention/treatment of various diseases associated with TRH and/or symptoms associated with the diseases, or a pharmacological...
WO/2023/073502A1	METHODS FOR PREPARATION OF ANTHRANILAMIDE AND PYRAZOLE-CARBOXYLATE INTERMEDIATE COMPOUNDS The present invention relates to methods for preparation of 2-amino-5-chloro-N-3-dimethylbenzamide compound of Formula (IV) and pyrazole-carboxylate compound of Formula (VI), an intermediates useful for preparation of certain anthranilam...
WO/2023/072246A1	PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITORS AND USES THEREOF Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with PHD.
WO/2023/072849A1	PESTICIDALLY ACTIVE PYRIDAZINONE COMPOUNDS Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides.
WO/2023/071314A1	SYNTHESIS, PREPARATION METHOD AND USE OF SHP2 AND CDK4/6 DUAL-TARGET INHIBITORY COMPOUND The present invention belongs to the field of medicinal chemistry, and particularly relates to synthesis, a preparation method and the use of an inhibitor containing dual targets SHP2 and CDK4/6, wherein the inhibitor comprises three com...
WO/2023/072966A1	IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 The present invention relates to a compound of formula (I) wherein R1 represents a (C4-C6)alkyl group, a (C3-C8)cycloalkyl group, a bridged (C6-C10)cycloalkyl group, a fused phenyl group, a substituted phenyl group, a R'-L- group, wherei...
WO/2023/077046A1	INHIBITORS OF HIF-2ALPHA AND METHODS OF USE THEREOF The present disclosure is directed to compounds that are inhibitors of HIF-2α having a structure according to Formula I, and compositions containing those compounds. Methods of using the compounds for the treatment of diseases, disorder...
WO/2023/072257A1	PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITORS AND USES THEREOF Described herein are PHD inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of inflammatory bowel disease.
WO/2023/072794A1	PIPERAZINYLSULFONYLARYL COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS The present invention relates to compounds of formula (I), wherein R1, R2, R3, R4, Y, Q1, Q2, Q3, Q4 and Q5 are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods...
WO/2023/073574A1	PROCESS FOR THE PREPARATION OF PIPERIDINE CARBOXAMIDES SALT FORMS AND THEREOF The present invention relates to commercially viable and industrially advantageous process for the preparation of salts of amino amide anesthetics. The invention explicitly discloses industrially applicable process for the preparation of...
WO/2023/072263A1	5-SUBSTITUTED PYRIDINE-2(1H)-KETONE COMPOUND AND USE THEREOF The present invention relates to a class of 5-substituted pyridine-2(1H)-ketone compounds and a use thereof, and specifically relates to a compound as shown in formula (X) or a pharmaceutically acceptable salt thereof.
WO/2023/077117A1	CRYSTALLINE FORMS OF N-((1R,3S)-3-(4-ACETYLPIPERAZIN-1-YL)CYCLOHEXYL)-4-FLUORO-7-METHYL-1H-INDOLE-2-C ARBOXAMIDE This disclosure provides crystalline forms of N-((1R,3S)-3-(4-acetylpiperazin-1-yl)cyclohexyl)-4-fluoro-7- methyl-1H-indole-2-carboxamide, N‑((1R,3S)-3-(4-acetylpiperazin-1-yl)cyclohexyl)-4-fluoro- 7-methyl-1H-indole-2-carboxamide hydr...
WO/2023/072969A1	IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 The present invention relates to a compound of formula (I) wherein A, B, C, D and E are selected from the group consisting of =CH- and -N=, R2 is selected from a hydrogen atom, a (C1-C4)alkyl group and a (C3-C6)cycloalkyl group, R1 repre...
WO/2023/071601A1	DESLORATADINE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Disclosed in the present application is a compound as represented by formula (A), wherein-R is-R' or -Y-(CH2)n-R', Y is O or NH, n is 1, 2, 3, 4, 5 or 6, and -R' is diethylamino, pyrrolidinyl, piperazinyl, N-morpholinyl, bis(2-methoxyeth...
WO/2023/072913A1	BENZO[H]QUINAZOLINE-4-AMINE DERIVATIVES FOR THE TREATMENT OF CANCER The invention provides compounds of formula (I) (I)and pharmaceutically acceptable salts thereof; whereinRa and Rb are both -CH3 or Ra and Rb together form a -CH2-CH2-CH2- or a -CH2-CH2-CH2-CH2-bridging moiety;A is -CH2- or -C(=O)-;T is ...
WO/2023/072197A1	PIPERIDINYL INDOLE DERIVATIVES, PREPARATION METHODS AND MEDICINAL USES THEREOF Compounds of formula (I) as piperidinyl indole derivatives, the preparation method thereof, pharmaceutical compositions comprising the compounds, and the pharmaceutical uses for the treatment a disease or disorder mediated by complement ...
WO/2023/076665A1	METHODS FOR TREATING CARDIOVASCULAR CONDITIONS AND METHODS OF INCREASING THE EFFICIENCY OF CARDIAC METABOLISM The invention provides methods of treating cardiovascular conditions and methods of increasing the efficiency of cardiac metabolism.
WO/2023/072924A1	CCR6 RECEPTOR MODULATORS The present invention relates to compounds of Formula (I), their synthesis and use as CCR6 receptor modulators for the prevention or treatment of e.g. inflammatory/autoimmune diseases/disorders and cancer.

Matches 1,101 - 1,150 out of 53,986	< 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 >