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Matches 1 - 50 out of 3,908

Document Document Title
WO/2024/077111A3
An aspect of the present disclosure provides an engineered nucleotide molecule. The engineered nucleotide molecule can comprise a pentose sugar. The engineered nucleotide molecule can comprise a base coupled to the pentose sugar, wherein...  
WO/2024/114485A1
The present invention relates to a fluorescence turn-on nucleoside, a preparation method therefor and a use thereof. The structural formula of the fluorescence turn-on nucleoside is as shown in formula (1). The preparation method can obt...  
WO/2024/112800A1
The present disclosure provides methods for deprotecting and purifying an oligomeric compound. The method provides for deprotection of a protecting group, which may be a trityl protecting group, and removal of a byproduct by diafiltratio...  
WO/2024/112637A1
Described herein are novel methods of preparing sphingosines and glycosylated sphingosines. A method of preparing a glycosylated sphingosine as described herein includes an efficient, four-step route for synthesizing lactosylsphingosine ...  
WO/2024/112877A1
Methods are disclosed for making a targeting ligand-conjugated nucleotide phosphoramidite known as adem-A-GalNAc phosphoramidite, which can be used in the synthesis of oligonucleotides such as therapeutic oligonucleotides.  
WO/2024/112865A1
Methods are disclosed for making a 4'-phosphate analog phosphoramidite known as MeMOP, which can be used in the synthesis of oligonucleotides such as therapeutic oligonucleotides.  
WO/2024/105051A1
The present invention relates to a method for preparing an at least partially acetal-protected sugar involving the step of reacting a sugar or a sugar derivative selected from the group consisting of an aldopentose, an aldohexose, an ald...  
WO/2024/098964A1
Provided in the present invention are a vinylphosphonic acid-modified mRNA cap analogue, and a preparation method therefor and the use thereof. The vinylphosphonic acid-modified mRNA cap analogue of the present invention has a more stabl...  
WO/2024/099487A1
The invention relates to oligosaccharides composed of alternating glucose and N- acetylglucosamine units with a double bond in position 4 of the terminal non-reducing saccharide (glucose) and with the primary hydroxyl group in position 1...  
WO/2024/102605A1
The present disclosure relates generally to improved methods of preparing glycoconjugates. The methods comprise using a reducing mixture containing acetoxyborohydrides prepared in-situ for conjugating a saccharide to a carrier protein.  
WO/2024/094607A1
The present invention generally relates to the field of isotope labeled and non-labeled gentamicin congeners and synthetic methods for the preparation of such congeners. In particular, the present invention relates to isotope labeled gen...  
WO/2024/092506A1
A sample processing module (100), comprising a first lifting/lowering plate (120), a fixing plate (140), a hollow threaded tube (160) and a first driving member (180). The first lifting/lowering plate (120) is coupled to the first drivin...  
WO/2024/087720A1
Provided in the present invention are a compound for a TLR8 inhibitor, and a preparation method therefor and the use thereof, which relate to the technical field of small molecule pharmaceutical compounds. The compound of the present inv...  
WO/2024/089953A1
The present invention provides a method for producing oligonucleotide by a solid-phase synthesis technique, wherein said method for producing oligonucleotide comprises a step for reacting, in the presence of a thiol, an acid with an olig...  
WO/2024/083491A1
The invention relates to an oligosaccharide of formula I derived from rare sugars, wherein R, X and n have the meanings defined in the specification. The invention also relates to its process to obtain it and to its use as a prebiotic an...  
WO/2024/082175A1
The present invention provides a preparation method for a sucralose refined product, and relates to the technical field of fine chemical engineering. In the present invention, by means of subjecting a sucralose crude product to ethyl ace...  
WO/2024/082158A1
Provided in the present invention is a method for preparing a sucralose crude product by using a sucralose-6-acetate crystallization mother liquor. In the present invention, by using an alkali metal hydroxide for alkaline hydrolysis, suc...  
WO/2024/083746A1
The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents S...  
WO/2024/082156A1
The present invention provides a method for preparing a sucralose crude product by using an alcohol-water alkaline hydrolysis system, and relates to the technical field of fine chemical engineering. In the present invention, an aqueous s...  
WO/2024/082154A1
The present invention provides a method for preparing a sucralose crude product by using an alcohol-water alkaline hydrolysis system, and relates to the technical field of fine chemical engineering. In the present invention, an aqueous s...  
WO/2024/082157A1
The present invention relates to the technical field of fine chemical engineering, and provides a method for preparing a crude sucralose by using an alcohol-water alkaline hydrolysis system. According to the present invention, a sucralos...  
WO/2024/086623A1
A method of separating and recovering a first carbohydrate from a feed solution comprising two or more carbohydrates and salts using a chromatography separation system which comprises one or more strong acid cation exchange resin, and re...  
WO/2024/082177A1
The present invention provides a method for preparing a sucralose crude product by using an alcohol-water alkaline hydrolysis system, and relates to the technical field of fine chemical engineering. In the present invention, an aqueous s...  
WO/2024/077410A1
The present application relates to the technical field of metal ion chemistry, and provides a method for reducing an azide methoxy group, a sequencing method, and a kit. The method for reducing an azide methoxy group provided by the pres...  
WO/2024/075760A1
The present invention addresses the problem of providing: a novel method for producing a N-acetyl-D-galactosamine ligand-oligonucleotide conjugate, particularly a novel method for producing a N-acetyl-D-galactosamine unit; and a novel in...  
WO/2024/075025A1
The present invention relates to an industrial process for the preparation of 2,3-O-Isopropylidene-D-ribofuranose of formula (I). The intermediate of formula (I) is used for the preparation of Varitriol, Carbovir, Abacavir, Sapropterin d...  
WO/2023/280934A9
The present invention relates to a 5'-cap analog according to formula (I) or salts thereof, wherein the 5'-cap analog comprises a photocleavable group fused via a carbamate moiety to the 5'-cap structure.  
WO/2024/066250A1
The present invention provides an immobilized 4,5-dicyanoimidazole, a preparation method therefor, and use thereof. The immobilized 4,5-dicyanoimidazole is obtained by a free radical copolymerization reaction of a first comonomer, a seco...  
WO/2024/065048A1
The present disclosure relates to sweetened fibers, compositions thereof, and products comprising the sweetened fiber of the present disclosure, and uses thereof. The present disclosure also relates to methods of preparing the sweetened ...  
WO/2023/212134A9
The disclosure provides methods for synthesis of peracetylgalactosamine-1-pentanoic acid, also called peracetylated D-galactosamine C5 linker or GalNAc C5 linker, using a vegetal source as a starting material, such as vegetal-sourced D-g...  
WO/2024/061842A1
A method for the solid-phase synthesis of a target oligonucleotide OT is disclosed, wherein said method comprises a step of incubating a nucleoside or oligonucleotide, which is covalently linked to a solid support and comprises a backbon...  
WO/2024/061271A1
Disclosed is a biotinylated heparin pentasaccharide capable of being neutralized, which has a structure as represented by formula (I). The anti-coagulation activity of the biotinylated heparin pentasaccharide capable of being neutralized...  
WO/2024/058256A1
Provided is a method for dissolving a polysaccharide such as cellulose under acidic and mild conditions using a solution containing hydrochloric acid and zinc chloride, wherein the hydrogen chloride concentration in the hydrochloric acid...  
WO/2024/055758A1
The present invention relates to the technical field of biological medicines. Disclosed are a cyclic dinucleotide metal compound, and a preparation method therefor and a use thereof. The structural formula of the compound is [M(cyclic di...  
WO/2024/059258A1
Click-labeled uridine bases, nucleosides, and phosphoramidites are provided, including improved methods of synthesis, oligonucleotides comprising the click-labeled nucleosides, methods of synthesizing spin-labeled oligonucleotides using ...  
WO/2024/053574A1
[Problem] The present invention addresses the problem of providing a novel oligosaccharide that is a two-branched glycan that has an α2,6-sialic acid structure at the non-reducing end, a production method for the oligosaccharide, an int...  
WO/2024/051696A1
The present invention relates to a compound for RNA capping and use thereof and belongs to the technical field of genetic engineering. The compound has a structure represented by formula I. The compound is used for capping an mRNA5' end,...  
WO/2024/050809A1
Provided is a method for the glycosylation modification of proteins and/or polypeptides, belonging to the technical field of medicinal chemistry. Using glycosyl sulfinate as a raw material, a method for the glycosylation modification of ...  
WO/2024/047122A1
The invention relates to a process for the preparation of a particulate allulose composition, the process comprising the steps of providing an aqueous allulose syrup; evaporating water from the allulose syrup; adding seed crystals of all...  
WO/2024/046993A1
Disclosed is a process for the production of a human milk oligosaccharide (HMO) derived by a microbial fermentation method, the process comprising the steps of: a) providing a fermentation broth comprising at least one HMO and biomass; b...  
WO/2024/047096A1
The present invention relates to processes for the purification of an oligosaccharide from a solution, a product of such processes, and the use of a product of such processes.  
WO/2024/049312A2
The first object of the invention is a method for the synthesis and purification of a nucleotide and/or a nucleoside. The second object of the invention is a modified nucleoside and/or a nucleotide, being a mono-, di- or triphosphate, co...  
WO/2024/047121A1
The invention relates to a process for the preparation of a particulate allulose composition, the process comprising the steps of providing an aqueous allulose syrup; evaporating water from the allulose syrup; allowing the composition to...  
WO/2024/044741A2
Described herein are highly pure, chemically synthesized, stabilized, 5'-capped oligonucleotides. Additionally, described herein are methods for making and using said oligonucleotides.  
WO/2024/044792A1
Disclosed herein are chemical preparation of oligonucleotides, chemical entities useful in such preparation, processes for such preparation, and methods of use relating to the chemical preparation of oligonucleotides. Further disclosed h...  
WO/2024/036768A1
A method for extracting stevioside RD. The method comprises the following steps: providing a solution containing stevioside RD, wherein the pH of the glycoside solution is 5 to 6; at 20-25℃, causing a macroporous neutral adsorption res...  
WO/2024/040091A1
Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.  
WO/2024/038195A1
The present invention relates to new specific 2'-fucosyllactose propionate compounds, to a new and improved synthesis of specific 2'-fucosyllactose propionates as well their use. Propionate compounds are very useful compounds.  
WO/2024/036254A2
The present invention relates to a process for producing compounds of formula I and/or formula I'. The present invention also relates to a process of selectively cleaving the main ring of a compound of formula IV to provide the starting ...  
WO/2024/036275A1
The present disclosure provides a method of producing cyclic dinucleotides (CDNs) on a commercial scale. Also provided are pharmaceutical compositions comprising a purified CDN preparation and use thereof to stimulate the immune system i...  

Matches 1 - 50 out of 3,908