Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 1 - 50 out of 4,683

Document Document Title
WO/2021/071890A1
The invention relates to methods of synthesizing 2'-deoxy-2',2'-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedu...  
WO/2021/072339A1
Disclosed is a continuous process for the purification of steviol glycosides such as Rebaudioside D and/or Rebaudioside M extracted from the dried stevia leaves or extracted from a fermentation broth using continuous simulated moving bed...  
WO/2021/069502A1
The present invention refers to a method for the production of a catalytically active DNA molecule resulting in a significantly decreased amount of impurities in the catalytically active DNA molecule, to a catalytically active DNA molecu...  
WO/2021/071130A1
Provided is a method for preparing a disodium 5'-guanylate heptahydrate crystal from an aqueous 5'-guanylate solution.  
WO/2021/062882A1
A method for synthesizing rosavin, comprising the steps of: using trimethylsilyl trifluoromethanesulfonate to catalyze 2,3,4-tri-O-acetyl-L-arabinofuranoside trichloroacetimide ester and ethyl 2,3,4-tri-O-acetyl-beta-D-thioglucopyranosid...  
WO/2021/067970A1
The present disclosure provides methods of sequencing polynucleotides and compounds, compositions for sequencing of polynucleotides, and synthesis of such compositions. The chemical compounds include nucleotides and their analogs which p...  
WO/2021/063075A1
The present invention relates to the technical field of biomedicine, and disclosed are an albiziae cortex lignan compound and an application thereof. The compound prepared by the present invention can effectively treat FFAs-induced lipid...  
WO/2021/064629A1
The present invention relates to the separation and isolation of neutral human milk oligosaccharides (HMOs) from the reaction milieu in which they are produced, preferably from a fermentation broth, comprising the steps of: i) optionally...  
WO/2021/056324A1
Provided is a green chemical preparation method for alpha-tri-O-acetyl glucuronic acid methyl ester bromo compound. The method uses sodium bromide, sulfuric acid and methyl tertiary ether system to replace the traditional hydrobromic aci...  
WO/2021/058483A1
The present invention relates to processes for producing, isolating and recovering various useful components from solid lignocellulosic biomass. More in particular, the invention provides a process for producing lignin components compris...  
WO/2021/056382A1
Provided is a preparation method for alpha-penta-O-acetyl mannose. A study is performed using natural mannose as a raw material on the basis of the conventional acetic anhydride acetylation process. A catalytic amount of cesium fluoride ...  
WO/2021/054474A1
In the present invention, a disaccharide unit for synthesizing a useful sugar chain for suppressing the development of dystroglycanopathy is obtained and used to reconstitute a post-phosphoryl sugar chain. Provided are: a disaccharide ...  
WO/2021/042922A1
Disclosed is a preparation method for tetragalloylglucose. The method comprises: using Camellia ptilophylla Chang as a raw material for extraction, purifying the Camellia ptilophylla Chang extract by using a macroporous adsorption resin,...  
WO/2021/043540A1
Disclosed are non-sporulating Bacillus cells for the production of a sialylated oligosaccharide wherein said Bacillus cell has been genetically engineered to possess a lactose permease, a CMP-NeuNAc biosynthesis pathway and a sialyltrans...  
WO/2021/043631A1
The present invention provides new chemical compositions, and methods for their preparation, which are industrially relevant in the manufacture of glycosaminoglycans, particularly fondaparinux.  
WO/2021/039935A1
Provided are: a nucleic acid compound manufacturing method that uses a nucleic acid compound that is preserved by a structure in which either one of the third position or fifth position of a ribose structure is represented by formula (1)...  
WO/2021/041728A1
The invention relates to a process for producing food ingredients from the Stevia rebaudiana plant and their use in food products, beverages and other consumables. The obtained compositions are useful as flavors, sweeteners, antioxidants...  
WO/2021/041756A1
The present invention relates to methods for synthesizing compounds useful as potent and stable RNA interference agents, derivatives thereof, and intermediates thereto.  
WO/2021/013795A3
The present invention relates to a method of making nicotinamide ribofuranosie salts, in particular pharmaceutically acceptable nicotinamide ribofuranoside salts. The invention further relates to the nicotinamide ribofuranoside salts as ...  
WO/2021/031594A1
Disclosed are a novel aromatic ring compound represented by general formula (I), an isomer, a prodrug, a solvate, a pharmaceutically acceptable salt and a pharmaceutical composition thereof, and use thereof for preparing medicaments for ...  
WO/2021/034962A1
Polymorphic forms of deoxycytidine and methods for preparing the same are provided herein. Also provided are compositions comprising polymorphic forms of deoxycytidine and at least one residual solvent, as well as methods of treating mit...  
WO/2021/034796A1
A process is provided for the synthesis of an intermediate of Formula 15 which is useful in the synthesis of E-selectin inhibitors. Also provided are useful intermediates obtained from the process.  
WO/2021/027614A1
A modified cytidine compound, that is, an aminooxy group is modified at the 4-position of a cytidine pyrimidine ring to produce derivative cytidine and nucleic acid containing the derivative cytidine, such as RNA. The expression level of...  
WO/2021/022565A1
A sucrose fatty acid ester, a preparation method and a quantitative analysis method therefor, and an application thereof. The preparation method comprises the following steps: (1) adding sucrose, a fatty acid methyl ester, a catalyst, an...  
WO/2021/022690A1
The present invention relates to the field of chemical synthesis, in relates particular to a nucleoside salt represented by formula (III) or formula (IV), and a preparation method therefor. The method provided by the present invention is...  
WO/2021/022819A1
The present invention relates to an isomerization feature-based purification and preparation method of punicalagin. The method uses a pomegranate peel extract as a raw material, avoids impurities contained in punicalagin on the basis of ...  
WO/2021/020879A1
The present disclosure provides the dinucleotide compounds which is useful for treating various cancers. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disc...  
WO/2021/019509A1
The present document relates to a process for the preparation of the crystalline form II of sotagliflozin from compound of formula (A), said process being continuously performed and comprising at least the steps of: a) performing in a re...  
WO/2021/019507A1
The present document relates to a process for the preparation of the crystallineform II of sotagliflozin, wherein said crystalline form II of sotagliflozin is directly obtained from the following compound of formula (A) and by using tolu...  
WO/2021/015622A1
The current invention concerns methods for the synthesis of 6-azido-6-deoxy-2-N-acetyl-monosaccharide-nucleoside diphosphate, in particular 6-azido-6-deoxy-2-N-acetyl-D- galactosamine-nucleoside diphosphate or 6-azido-6-deoxy-2-N-acetyl-...  
WO/2021/013795A2
The present invention relates to a method of making nicotinamide ribofuranosie salts, in particular pharmaceutically acceptable nicotinamide ribofuranoside salts. The invention further relates to the nicotinamide ribofuranoside salts as ...  
WO/2021/013155A1
Disclosed are a new glycosyl donor, a preparation method therefor, and an application thereof. Specifically, a glycosyl donor represented by formula (I), a preparation method therefor, and a use of the glycosyl donor represented by formu...  
WO/2021/008549A1
The present invention belongs to the field of pharmaceutical chemistry. Specifically, the present invention relates to a novel compound and a pharmaceutical composition. The novel compound has a structural formula represented by formula ...  
WO/2021/004388A1
Crystal form A of a compound represented by formula (I) and an application thereof in preparing a drug for treating an SGLT1/SGLT2-related disease.  
WO/2020/227618A3
The present disclosure describes a convergent liquid phase process for manufacturing oligonucleotides by coupling two or more oligonucleotide fragments, each of which have two or more nucleotides. Also provided by the present disclosure ...  
WO/2021/000598A1
Provided are a double specific nucleic acid aptamer, a derivative, a preparation method and use thereof, the nucleic acid aptamer comprises a first nucleic acid sequence and a second nucleic acid sequence; the first nucleic acid sequence...  
WO/2021/000380A1
The present disclosure relates to the technical field of nucleic acid medicines, in particular to a modified nucleoside, a nucleotide and a modified nucleic acid polymer, as well as a preparation method therefor and an application thereo...  
WO/2020/264055A1
The present invention relates to methods for purifying nucleic acids. In particular, the present invention relates to methods for purifying carbohydrate-conjugated oligonucleotides using a mixed-mode stationary phase and a mobile phase c...  
WO/2020/260028A1
The invention relates to a process for separating xylose in the liquid phase from a mixture of C5 and C6 sugars comprising at least xylose and glucose, by adsorbing the xylose on a zeolite adsorbent which is based on FAU zeolite crystals...  
WO/2020/260351A1
The present invention relates to a process for preparing a compound of formula (I), wherein said process is suitable for large scale synthesis.  
WO/2020/260027A1
The invention relates to a process for separating glucose in the liquid phase from a mixture of C5 and C6 sugars comprising at least xylose and glucose, by adsorbing the glucose on a zeolite adsorbent which is based on FAU zeolite crysta...  
WO/2020/227618A8
The present disclosure describes a convergent liquid phase process for manufacturing oligonucleotides by coupling two or more oligonucleotide fragments, each of which have two or more nucleotides. Also provided by the present disclosure ...  
WO/2020/254548A1
The invention comprises radiolabeled MOEM type oligonucleotide of the formula (I), (I) wherein n, X1, X2, the linker (1), the linker (2), Q* and the receptor targeting moiety are as defined (I) the description. The radiolabeled oligonucl...  
WO/2020/249571A1
The invention relates to a process for the production of a mixed P=O/P=S backbone oligonucleotide comprising a selective oxidation of an intermediary phosphite triester compound of formula I into a phosphodiester compound of formula II a...  
WO/2020/249584A1
Disclosed is a process for the purification of LNnT (lacto-N-neotetraose) from a fermentation broth, the process comprises subjecting a fermentation broth to a first step of membrane filtration, thereby providing a filtrated solution, su...  
WO/2020/244148A1
The present application relates to a doramectin polymorph. Specifically, the present application relates to doramectin crystal form A, crystal form B, and a preparation method thereof. The polymorph can be obtained by dissolving doramect...  
WO/2020/237836A1
Provided is a method for preparing 4-idarubicin hydrochloride. The method comprises the step of preparing compound B into compound C in the presence of tetrabutyl ammonium halide, and the 4-idarubicin hydrochloride can be further obtaine...  
WO/2020/243746A1
A method has now been found for the preparation of calcium, magnesium, and zinc salts of sugar acids, this being the object of the present invention, which is characterized in that the method may include providing a sugar and oxidizing t...  
WO/2020/238528A1
The invention relates to an intermediate TSL-1502M of a PARP inhibitor and a preparation method thereof. The structural formula of the intermediate is as shown. The preparation method includes the following step: under the action of sodi...  
WO/2020/239135A1
The present invention relates to a high anticoagulation activity compound, a preparation method and an application, said compound being formed from a monosaccharide unit D, a monosaccharide unit E, a 6-position carbon oxygen-substituted ...  

Matches 1 - 50 out of 4,683