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WO/2020/103916A1 |
Provided is a separation and purification method for uridine triphosphate. The separation and purification method comprises the following steps: 1) loading: filtering crude uridine triphosphate and then loading same into a chromatography...
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WO/2020/104492A1 |
The present invention relates to a method for preparing stereodefined phosphorothioate oligonucleotides, especially locked stereodefined phosphorothioate oligonucleotides with a high yield, using pyridinium acidic salts as a coupling act...
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WO/2020/106636A1 |
Provided are 13-membered macrolides for the treatment of infectious diseases. The 13- membered macrolides described herein are azaketolides. Also provided are methods for preparing the 13-membered macrolides, pharmaceutical compositions ...
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WO/2020/102980A1 |
Proposed is a preparation method for a nucleotide for sequencing, i.e. a preparation method for a compound represented by formula (I), comprising (1) performing a first nucleophilic substitution reaction on a compound represented by form...
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WO/2020/099599A1 |
The invention relates to apparatus and a method for the extraction of one or more components from a biomass material, said apparatus including means to allow the biomass material to be pre-processed, which may include extraction and/or c...
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WO/2020/098659A1 |
The present invention relates to a method for removing impurities in a xylose mother liquor. A xylose mother liquor produced during xylose production is used as a raw material, and the xylose mother liquor is pretreated by using a lytic ...
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WO/2020/090948A1 |
A freeze-dried product of cyclic-di-AMP requires special production facilities and, therefore, is not suitable for large-scale production. A free acid crystal of cyclic-di-AMP is unstable under severe conditions at 105°C. Under these ci...
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WO/2020/092543A1 |
Provided are methods for non-enzymatically synthesizing nucleic acids. The methods include submerging a first portion of the outer surface of a cylinder in a non-enzymatic nucleic acid synthesis reaction mixture. The reaction mixture has...
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WO/2020/091423A1 |
The present invention provides a novel phytochemical-fructooligosaccharide conjugate having a structure in which a phytochemical in the form of phenolic acid is conjugated to a portion of saccharides constituting a fructooligosaccharide ...
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WO/2020/086366A1 |
The present disclosure provides methods for separating nucleic acids in a sample based on the length of the nucleic acids using a capillary electrophoresis device with formamide as a denaturing agent and a non-aqueous separation matrix c...
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WO/2020/083898A1 |
The invention relates to a new process for the purification of oligonucleotides which comprises the removal of the acid labile 5'hydroxy protecting group at the 5'- O- oligonucleotide terminus of the oligonucleotide by way of tangential ...
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WO/2020/086559A1 |
Methods of isolating dihydrochalcone compounds of Formula (I) from Balanophora harlandii are provided herein. Compositions and consumables comprising at least one sweetener and at least one dihydrochalcone compound described herein are a...
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WO/2020/083871A1 |
The present invention relates to novel oligogalacturonans having a degree of methylation of 0 and a degree of polymerisation of 1 to 10, and to the use thereof for stimulating defence responses of plants against pathogenic microorganisms.
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WO/2020/079114A1 |
The present invention relates to a method for obtaining crystalline 2'-fucosyllactose from a 2'-FL raw material, which contains 2'-FL as a main constituent and at least 0.5% by weight, frequently at least 1% by weight, in particular at l...
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WO/2020/079146A1 |
Crystalline form II of 2'-O-fucosyl lactose having an X-ray powder diffraction pattern comprising three reflections at 2θ angles (13.65 ± 0.20)°, (16.98 ± 0.20)° and (18.32 ± 0.20)°, determined at a temperature of 25 °C with Cu-K...
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WO/2020/077970A1 |
Provided in the present invention is a highly efficient stevioside mixture preparation method, the preparation method comprising the following steps: (1) placing crude stevioside into a sealed pressure-resistant system or apparatus, and ...
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WO/2020/078000A1 |
1,3-disubstituted-2H-imidazolyl-2-carbene is a common type of azacyclocarbene, which may be used in a plurality of fields, comprising catalyzing organic reactions, acting as a transition metal ligand, and acting as a supporting ligand in...
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WO/2020/063894A1 |
An industrialization method for comprehensive utilization of stevia rebaudiana. The major improvement is in that the stevia rebaudiana is extracted by using a high-concentration alcohol solution, then the extracted solution is purified b...
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WO/2020/064787A1 |
The present disclosure relates generally to terpene glycosides, such as certain such compounds extracted from Stevia rebaudiana Bertoni, Rubus suavissimus, or Siraitia grosvenorii. The disclosure also provides for the use of such compoun...
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WO/2020/063892A1 |
Disclosed is an industrial method for simultaneously preparing stevia rebaudiana chlorogenic acid and stevioside. The industrial method includes carrying out alcohol extraction on stevia rebaudiana which is used as a raw material, and th...
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WO/2020/064788A1 |
The present disclosure relates generally to terpene glycosides, such as certain such compounds extracted from Stevia rebaudiana Bertoni, Rubus suavissimus, or Siraitia grosvenorii. The disclosure also provides for the use of such compoun...
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WO/2020/062156A1 |
Disclosed by the present application is a continuous flow catalytic reactor, an assembling method therefor and an application thereof. The continuous flow catalytic reactor comprises a reaction container, a filler material packaged in th...
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WO/2020/056713A1 |
A method for preparing high-purity NAD, comprising: adjusting a pH value to 6.0-8.0, removing insoluble substances, heating to 35 ± 1°C, adding ethanol, cooling to 6 ± 0.5°C, crystallizing, filtering, heating a filtrate to 25-30°C, ...
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WO/2020/057561A1 |
A method for preparing D-psicose from starch. The starch is used as a raw material, and D-psicose with the purity being 98-99% is obtained by means of saccharification treatment, isomerization treatment, and concentration and chromatogra...
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WO/2020/057562A1 |
A method for producing concentrated D-psicose, including vaporization and concentration using a mechanical vapor recompression evaporator and utilizing flash steam to obtain high-concentration D-psicose.
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WO/2020/057560A1 |
Disclosed is a process for producing D-psicose using starch, comprising the steps of subjecting starch to liquefaction and saccharification to obtain a first mixture; adding enzymatic metal ions into the mixture for isomerization to obta...
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WO/2020/053207A1 |
The invention relates to an improved method for producing isomalt from a carbohydrate mix containing isomaltulose and saccharose.
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WO/2020/050462A1 |
The present invention relates to a naphthopyrone derivative and a composition comprising, as an active ingredient, a Cassia obtusifolia shoot extract including the naphthopyrone derivative. A composition according to an aspect of the pre...
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WO/2020/050663A1 |
The present invention relates to a method for chemical production of 3,6-anhydro-L-galactitol (L-AHGol), which is a novel sugar alcohol, and agarobititol (ABol), which is a disaccharide having the same agarobititol as a reductant end the...
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WO/2020/042729A1 |
Disclosed are a 6-disulfide-substituted-2'-deoxyguanosine compound and a preparation method therefor and a use thereof in an anti-tumor drug. Using 2'-deoxyguanosine as a structure mother nucleus, the present invention designs and synthe...
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WO/2020/043846A1 |
The invention relates to a method for preparing 3 ' -O-amino-2' -deoxyribonucleoside-5 ' - triphosphate. It also relates to a solid support functionalized with at least one N- hydroxyphthalimide moiety and uses thereof for protecting 3 '...
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WO/2020/040433A1 |
The present invention relates to a method for preparation of a dapagliflozin precursor, which is a SGLT-2 inhibitor and, particularly, to a method for preparation of the dapagliflozin precursor, which is the compound of chemical formula ...
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WO/2020/041793A1 |
The present invention provides, among other things, methods for purifying mRNA based on normal flow filtration for therapeutic use.
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WO/2020/040233A1 |
The present invention provides a method for obtaining a specifically-shaped crystal (specifically, spherocrystal) of a compound with good reproducibility. This method for producing a specifically-shaped crystal (specifically spherocrysta...
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WO/2020/035553A1 |
The present invention is directed to a process for purifying natamycin, to an epoxide polyene amphoteric macrolide, to a composition comprising said polyene amphoteric macrolide and to a process for preparing said polyene amphoteric macr...
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WO/2020/036382A1 |
The present invention relates to a method for producing an intermediate useful for the synthesis of a diphenylmethane derivative that can be used as a SGLT inhibitor. A method for synthesizing a compound of formula 7 according to the pre...
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WO/2020/035552A1 |
The present invention is directed to a process for purifying natamycin, to an all-trans polyene amphoteric macrolide, to a composition comprising said polyene amphoteric macrolide and to a process for preparing said polyene amphoteric ma...
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WO/2020/032152A1 |
Current synthesis methods for 4'-substituted nucleoside derivatives include a step in which stereoisomers are produced and therefore have problems such as decreased yield and complication of a refinement step. Thus, a synthesis method ha...
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WO/2020/032272A1 |
The present invention provides a production method for sugar fatty acid esters. The production method is characterized in that a weakly basic ion exchanger that has a pKb of 3–7 is used as a catalyst to react a fatty acid ester and a s...
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WO/2020/029168A1 |
A natamycin superfine powder, a preparation method therefor and the use thereof. The natamycin superfine powder is a solid powder, and has no fixed shape under a transmission electron microscope, and no less than 95% of the shape size is...
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WO/2020/029647A1 |
Provided in the present invention is a method for synthesizing a nucleoside compound and an intermediate thereof, wherein the method is carried out by introducing a protective group at position 6 of guanine ketocarbonyl, causing only 9 N...
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WO/2020/025527A1 |
The present invention relates to an oligonucleotide comprising at least one phosphorotrithioate intemucleoside linkage of formula (I) as defined in the description and in the claim. The oligonucleotide of the invention can be used as a m...
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WO/2020/025925A1 |
Lignocellulosic biomass (11) is processed to produce organic chemicals by (a) subjecting the biomass to a first hydrolysis (14) to hydrolyse hemicellulose, to form a liquid component comprising the products of hemicellulose hydrolysis in...
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WO/2020/028360A1 |
A fructose in solid form containing a matrix and a plurality of carbohydrate crystals within said matrix, the matrix containing amorphous fructose and water, wherein the carbohydrate crystals comprise fructose and optionally one or more ...
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WO/2020/020208A1 |
The present application relates to a method for preparing trifluridine, comprising reacting a compound of formula III with a compound of formula IV in a first solvent in the presence of an acid to obtain a compound of formula II, and per...
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WO/2020/012307A1 |
A method for manufacturing an anhydrosugar or anhydrosugar alcohol, said method comprising the steps:a) subjecting a sugar or sugar alcohol in aqueous solution to a dehydration reaction to form a mixed solution comprising a sugar or suga...
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WO/2020/009702A1 |
Aspects of the present disclosure include methods for double coupling a nucleoside phosphoramidite during synthesis of an oligonucleotide. The method can include coupling a free hydroxyl group of a nucleoside residue with a first sample ...
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WO/2020/003723A1 |
This catalyst for hydrolysis, which is for hydrolyzing a polysaccharide contained in a biomass material, is a carbon material, said catalyst having, in terms of a phenolic hydroxyl group, at least 0.4 mmol/g of a functional group capable...
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WO/2020/001166A1 |
Disclosed are a glycoside compound represented by formula (III) and a preparation method therefor, a composition, an application, and an intermediate. The provided glycoside compound is simple in preparation method, can remarkably improv...
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WO/2020/002469A1 |
The present invention relates to new reagents and methods for modifying nucleic acids where an azide-containing nucleoside or nucleotide derivative is applied to living cells followed by a nitrogenous derivative of dibenzo-1,5-cyclooctad...
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