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WO/2022/200280A1 |
The invention relates to a device for a continuous virus inactivation during a protein production process, comprising a first and a second fluid inlet (2, 3), each of which is designed to introduce a liquid flow into the device (1), comp...
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WO/2022/198790A1 |
Provided are an oligonucleotide aptamer of cardiac troponin and the uses thereof, wherein the sequence of the aptamer is one of SEQ ID NOs: 1-10, or the aptamer is a variant which has a function equivalent to one of the sequences of SEQ ...
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WO/2022/202985A1 |
The present invention provides: a peptide that can be readily consumed on a daily basis and has various effects but few side effects; and a composition that contains the peptide as an active ingredient.　Provided is a peptide that compr...
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WO/2022/203512A1 |
The invention provides a method for providing a cargo to a C-terminal end (111) of a peptide (110), the method comprising a first stage and a second stage, wherein the first stage comprises reacting the C-terminal end (111) of the peptid...
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WO/2022/197184A1 |
The invention provides a method for providing a cargo to a C-terminal end (111) of a peptide (110), the method comprising a first stage and a second stage, wherein the first stage comprises reacting the C-terminal end (111) of the peptid...
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WO/2022/194257A1 |
A compound of formula (II) and a preparation method therefor, and a method for preparing a camptothecin derivative and an antibody drug conjugate from the compound of formula (II). The preparation method for the compound of formula (II) ...
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WO/2022/193482A1 |
The present application relates to a synthetic method for a cyclosporine derivative. The synthetic method comprises: pre-mixing a precursor fluid and an alkaline fluid to obtain a pre-mixed solution; inputting the pre-mixed solution into...
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WO/2022/197266A1 |
The present invention provides the beta-lactoglobulin protein and beta-lactoglobulin derived bioactive peptides from the whey fraction of goat milk and antiviral uses thereof, is preventive from infectious diseases and have effects of di...
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WO/2022/195000A1 |
The present invention relates to a composition comprising a solid carrier, a capture moiety, afunctional protein, a first linker connecting the capture moiety to the solid carrier, a second linker connecting the functional protein to the...
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WO/2022/196797A1 |
The present invention addresses the problem of providing: a highly efficient peptide production method by which a protecting group of a side chain can be de-protected via a weak acid; a reagent for forming a protecting group, the reagent...
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WO/2022/188628A1 |
Provided is a novel peripherally restricted multi-target cyclopeptide molecule for an opioid receptor and a neuropeptide FF (NPFF) receptor, or a pharmaceutically acceptable salt thereof. By using DN-9 as a chemical template, structural ...
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WO/2022/191223A1 |
The present invention addresses the problem of, in a method for extracting a target protein from prokaryotic cells expressing the target protein, preventing the contamination of the target protein with foreign substances and increasing t...
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WO/2022/192664A1 |
Provided are stapled antimicrobial peptides (i.e., StAMPs) and methods of using the same (e.g., for treating bacterial infections caused by Gram-negative bacteria). In certain embodiments, the stapled peptides are based on the amino acid...
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WO/2022/192504A1 |
Parallel chromatography systems and continuous manufacturing methods are described herein that utilize two or more chromatography column skids having columns operating in parallel with automation controls governing which column to load a...
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WO/2022/189620A1 |
The present disclosure provides transmembrane chimeric proteins derived from transposable element (TE)-exon fusion transcripts, as well as nucleic acids, antibodies, CARs, non-HLA restricted TCR and immune cells targeting such chimeric p...
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WO/2022/191158A1 |
Disclosed is a method for producing a fusion protein in which an antibody is fused with a lysosomal enzyme. This method for producing a fusion protein in which an antibody is fused with a human lysosomal enzyme comprises: (a) culturing m...
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WO/2022/190486A1 |
The present invention provides, as a novel compound that can be utilized for efficient synthesis or the like of a polypeptide comprising various amino acids, a silane-containing condensed cyclic dipeptide compound represented by formula ...
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WO/2022/191971A1 |
Parallel chromatography systems and continuous manufacturing methods are described herein that utilize two or more chromatography column skids having columns operating in parallel with automation controls governing which column to load a...
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WO/2022/184005A1 |
Provided herein are thiosuccinyl-crosslinked hemoglobin conjugates useful as blood replacement agents and therapeutic proteins, pharmaceutical compositions comprising the same and the methods of use and preparation thereof.
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WO/2022/183993A1 |
Provided is a compound targeting a prostate specific membrane antigen (PSMA). The compound has a structure as represented by formula (I), wherein R1 is a compound targeting a prostate specific membrane antigen; L1 is -(X)n-(CH 2)m-(Y)q-,...
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WO/2022/184163A1 |
Disclosed in the present invention is a modified nonapeptide, which is an alkyl acylated and/or phosphorylated nonapeptide. The amino acid sequence of the alkyl acylated nonapeptide is sequence I: R-Co-Trp-Ala-Gly-Gly-Phe-Ala-Ser-Gly-Glu...
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WO/2022/184165A1 |
Provided in the present invention are a polypeptide for inhibiting intracellular lipid accumulation and a synthesis method therefor. The polypeptide has a relatively high target affinity and reduces the activity of sterol O-acyltransfera...
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WO/2022/187273A1 |
Provided herein are, inter alia, bioreactive unnatural amino acids, compounds containing the unnatural amino acids, and methods of using same.
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WO/2022/186243A1 |
Provided is a protein folding agent able to fold a protein with high efficiency.　Provided is a protein folding agent including, as an active ingredient, at least one substance selected from among the compounds represented by formulas (...
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WO/2022/180264A1 |
Method for purifying a biomolecule (protein, DNA) of interest from a culture of gram-negative bacteria, comprising the use of polyoxyethylene (10) isooctylcyclohexyl ether to eliminate endotoxins, and use in chromatography of a solution ...
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WO/2022/182493A1 |
In some aspects, the present disclosure pertains to sample treatment methods that comprise: contacting an acidic elution solution that is free of primary amine, secondary amine and thiol groups with a sorbent having bound target antibody...
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WO/2022/182261A1 |
The present invention provides an artificial TRAP-cage comprising a selected number of TRAP rings which are held in place by cross-linkers, wherein the cross-linkers are selected for their specific characteristics whereby the cages are p...
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WO/2022/182388A1 |
Protein separation can be provided based on a High Performance Countercurrent Membrane Purification (HPCMP), which can exploit highly selective diffusive transport across thin walls of a hollow fiber membrane for separation of proteins. ...
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WO/2022/181672A1 |
The purpose of the present invention is to provide a modified milk protein that has high solubility in an acidic region, excellent foaming properties and high safety, and a method for producing the milk protein while minimizing the risk ...
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WO/2022/180117A1 |
The invention relates to a simple and very rapid method for simultaneously isolating nucleic acids from sedimentable and nonsedimentable biomolecules in water samples. The water samples can be, inter alia, drinking water, industrial wate...
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WO/2022/180062A1 |
The present invention relates to a method of processing or fractionating a sample comprising proteins, polypeptides and/or peptides, said method comprising (a) changing the physicochemical conditions of said sample; and (b) performing on...
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WO/2022/181717A1 |
The present invention addresses the problem of providing a simple oxytocin purifying method and measuring method and kit. The present invention pertains to an oxytocin purifying method, comprising treating a sample with an acid or a salt...
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WO/2022/182260A1 |
The present invention provides an artificial TRAP-cage decorated with particular molecules (proteins, peptides, small molecules, nucleic acids) on the exterior.
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WO/2022/182262A1 |
The present invention provides an artificial TRAP-cage comprising a selected number of TRAP rings and encapsulated therein a guest cargo.
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WO/2022/179970A1 |
Herein is reported a method for the purification or production of a therapeutic polypeptide using the same depth filter multiple times, i.e. a depth filter which has been used before and has been regenerated. Reported herein is a method ...
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WO/2022/178592A1 |
The disclosure provides methods for the solid phase synthesis of glutamate-urea-lysine derived (GUL derived) prostate-specific membrane antigen (PSMA) targeting conjugates. The disclosure also relates to key intermediates of this process...
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WO/2022/182003A1 |
The present invention relates to a method for purifying a target protein in high yield. More specifically, the present invention relates to a method for purifying a membrane protein in high yield. The purification method according to the...
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WO/2022/175863A1 |
Provided herein is a cell-free and aaRS-free protein translation systems, and uses thereof in the production of proteins and active enzymes.
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WO/2022/178124A1 |
The present disclosure is generally directed to gene editing in plant chloroplast and plant mitochondrial double-stranded DNA. Disclosed herein are cytosine base editors tailored for chloroplast and mitochondrial genomes in plants using ...
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WO/2022/178396A1 |
The present disclosure relates to the field of chromatography, and more specifically to novel affinity ligands and affinity agents which are suitable for use in isolation of adeno-associated virus (AAV). Thus, the disclosure encompasses ...
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WO/2022/172284A1 |
The disclosed invention relates to a method for purifying a recombinant protein produced in the bacterial protein expression system. Specifically, it relates to the efficient purification of a therapeutic recombinant protein by removing ...
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WO/2022/172295A1 |
The present invention relates to a process for purifying a protein of interest in a batch, integrated continuous or pseudo-continuous mode. Accordingly, the present invention relates to a process for purifying monoclonal antibodies, spec...
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WO/2022/167003A1 |
Provided is a method for using tangential flow ultrafiltration technology to prepare a controllable high concentration high molecular weight silk fibroin solution. The steps comprise: obtaining a silk fibroin inorganic salt solution; per...
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WO/2022/169206A1 |
The present invention relates to a method for purification of hemopexin and haptoglobin and provides a method in which a solution containing hemopexin and haptoglobin is titrated to a range of specific pH values without a step of precipi...
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WO/2022/167886A1 |
The invention relates to an improved process for the purification of proteins. More particularly, the invention pertains to a process for purification of Pegfilgrastim (PEG-GCSF). The invention further pertains to a purification process ...
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WO/2022/168135A1 |
The present invention relates to a method for extracting proteins, in particular enzymes, from an organic or inorganic matrix, such as, for example, soil or food matrices, the method being capable of providing a pure extract and a high e...
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WO/2022/165128A1 |
A system and method for treating whole stillage includes a stillage tank, a separation system (26) in communication with the stillage tank and configured to separate the whole stillage into a wet cake portion and a thin stillage portion,...
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WO/2022/164224A2 |
The present invention relates to a method for eluting a prokaryotic protein. In the present invention, a protein can be obtained in the intact form with no damages thereto by destructing cell walls of bacteria through a simple process of...
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WO/2022/160425A1 |
An anti-hepatoma and anti-liver fibrosis oligopeptide extracted from marine gastropod mucus. A total protein is extracted by using low-cost marine gastropod mucus as a raw material, and enzymolysis is performed on the extracted total pro...
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WO/2022/165001A1 |
The invention provides compositions of anti-PD-1 antibodies or antigen-binding fragments thereof with less than or equal to about 3.0 % oxidation of Met105 in the CDRH3 heavy chain region, and methods of obtaining the purified compositio...
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