| Document |
Document Title |
|
WO/2022/007478A1 |
Provided are a protein antigen subjected to site-directed mutation and site-directed modification, and a method for the site-directed mutation and site-directed modification of the protein antigen. The method comprises: introducing unnat...
|
|
WO/2022/008858A1 |
A method of determining the presence or absence of an antibody in a sample, the method comprising the steps of: (a) contacting the sample with a lysis composition comprising: (i) a quaternary ammonium compound; and (ii) a non-ionic surfa...
|
|
WO/2022/008658A1 |
A method for preparing a composition of human plasma-derived immunoglobulin M (IgM) including the steps of (a) PEG precipitation of the IgM; (b) resuspension of the precipitated IgM; (c) performing an adsorption chromatography; (d) remov...
|
|
WO/2022/003565A1 |
Provided herein is an environmentally compatible detergent for use in purification of a recombinantly produced biotherapeutic. The environmentally compatible detergent includes Laureth-9 and can be used for viral clearance, cell lysis, a...
|
|
WO/2022/006548A1 |
Disclosed herein are synthesis and use of covalent inhibitors selective for Transcriptional Enhancer Factor TEF-1 (TEAD1), which can be used for treatment of cancers such as glioblastoma, gastric cancer, colorectal cancer, pancreatic duc...
|
|
WO/2022/001818A1 |
Provided is a modified recombinant human nerve growth factor (rhNGF), which is obtained by reacting a polymer of formula A with an rhNGF. The polymer of formula A is an N-disubstituted amino acetamidoaldehyde polymer. Compared with an un...
|
|
WO/2021/260772A1 |
Provided are an aluminum phosphate compound exhibiting an excellent ability to purify, a method for producing the same, a carrier for purifying protein, and a method for purifying protein which uses the same. This aluminum phosphate co...
|
|
WO/2021/262041A1 |
The invention relates to the field of biotechnology, specifically to the problem of creating effective technologies for producing highly purified protein drugs for medical use. Proposed is a new scheme for purifying a recombinant inhibit...
|
|
WO/2021/260038A1 |
The invention concerns a method for the separation of potato proteins from one or more first salts and phenolic and/or glycoalkaloid compounds in potato fruit juice, said method comprising the steps of: (i) providing a potato fruit juice...
|
|
WO/2021/260039A2 |
The present invention concerns a method for separation of (a) potato proteins and insoluble fibers from (b) first salts and phenolic and/or glycoalkaloid compounds in potato fruit juice or a derivative thereof, said method comprising the...
|
|
WO/2021/262710A1 |
Disclosed are various prodrugs of L-Phe-D-Arg-L-Phe-L-Lys-NH2.
|
|
WO/2021/262708A1 |
Disclosed are various prodrugs of Elamipretide.
|
|
WO/2021/261509A1 |
A method for cleaving a disulfide bond in a protein, the method comprising: a cleavage step for cleaving a disulfide bond in a protein present in a reaction system by reducing the disulfide bond using a reduced redox protein (step S104);...
|
|
WO/2021/260041A2 |
The present invention concerns a method for separation of (a) potato proteins and optionally insoluble fibers from (b) first salts and phenolic and/or glycoalkaloid compounds in potato fruit juice or a derivative thereof, said method com...
|
|
WO/2021/261451A1 |
Provided is a method for evaluating clogging of a filtration membrane for a protein-containing solution, the method comprises the following: a) a step for passing the protein-containing solution through the filtration membrane; b) a step...
|
|
WO/2021/262985A1 |
The present invention relates to compositions comprising biologically active proteins, such as cytokines, linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells cont...
|
|
WO/2021/261511A1 |
This method of inactivating an allergen comprises: an inactivation step (S104) for using a reduced redox protein to reduce and thereby inactivate an allergen that is present in a reaction system; and a reduction step (S103) for donating ...
|
|
WO/2021/258641A1 |
A preparation method for a near-infrared fluorescent tracer used for diagnosing a metastatic lymph node, as follows: 6-aminocaproic acid (Fmoc-acp-OH) is used with cRGDyK to produce Fmoc-acp-cRGDyK; when deprotected, the amino group prod...
|
|
WO/2021/260074A1 |
Disclosed are methods and kits for producing a conformationally constrained peptide, such as a helix constrained peptide, in a cell. In some cases, the methods comprise contacting a cell comprising an intracellularly-localised recombinan...
|
|
WO/2021/253136A1 |
Disclosed are plant protein compositions prepared from hemp plant material. Hemp seeds are deconstructed and separated into heavy protein-rich fractions and light oil-rich fractions. The deconstruction processes avoid the use of organic ...
|
|
WO/2021/253645A1 |
Provided are a Hansenula engineered bacterium efficiently expressing a CA10 virus-like particle and use thereof. Said engineered bacterium comprise a recombinant vector carrying CA10 virus P1 and a 3CD genes. An original strain of the en...
|
|
WO/2021/252782A1 |
The present disclosure provides improved systems and methods for purifying and/or concentrating lentiviral compositions.
|
|
WO/2021/252236A2 |
Provided are a Native Cell Membrane Nanoparticle (NCMN) system and methods of using the NCMN polymers to extract and/or purify one or more membrane proteins. The NCMN system includes at least one NCMN polymer and one or more membrane pro...
|
|
WO/2021/252986A1 |
Human regulatory T cells (hTregs) proliferation or amphiregulin production is induced by treatment with a TLR 7/8 agonist, and formulations of the treated hTreg cell may be introduced into persons in need thereof as ex vivo cell therapy ...
|
|
WO/2021/248244A1 |
Methods and reagents to obtaining a sample enriched in peptides comprising the third complementarity-determining region of the heavy chain (CDRH3) of immunoglobulins, such as IgGs, are described. These methods are based on the use of tar...
|
|
WO/2021/252990A1 |
A method for characterizing a target peptide through a detection approach such as mass spectrometry is provided, including: introducing at least one guard molecule to mix with the target peptide; and applying the detection approach for t...
|
|
WO/2021/252829A1 |
The present invention provides processes and compounds for the preparation of glucagon and GLP-1 co-agonist compounds that are useful in the treatment of type 2 diabetes, obesity, nonalcoholic fatty liver disease (NAFLD) and/or nonalcoho...
|
|
WO/2021/249564A1 |
Provided are a semaglutide derivative and a preparation method therefor. Specifically, provided is a fusion protein comprising a green fluorescent protein folding unit and a semaglutide precursor or an active fragment thereof. The expres...
|
|
WO/2021/246471A1 |
The present invention allows condensation reaction to proceed efficiently even when an amino acid having a high steric hindrance is included and allows a desired peptide compound to be obtained with high yield and high purity, as a resul...
|
|
WO/2021/246910A1 |
The invention relates to biotechnology. Claimed are a genetic construct for the expression of SARS-CoV-2 virus RBD recombinant protein, and a Chinese hamster ovary cell strain CHO-S-RBD for producing recombinant protein of the receptor b...
|
|
WO/2021/247537A1 |
The present disclosure relates to metal di-amino acid chelates and metal tri-amino acid chelates.
|
|
WO/2021/247475A1 |
Provided herein is a method to produce relaxin or relaxin analogues or variants and their use in methods of treatment, e.g., in the treatment of a stiffened fibrotic joint.
|
|
WO/2021/245089A1 |
In isoelectric focusing (IEF) separation, the resolution and focusing time is positively correlated to physical length of the separation channel. Thus, an increase in IEF resolution by means of increasing the length of the separation cha...
|
|
WO/2021/241965A1 |
The present invention relates to: a novel fusion protein for analyzing the crystal structure of IL-33; a method for producing same; and a crystallizing method. According to the present invention, it is possible to obtain a crystal having...
|
|
WO/2021/241915A1 |
The present invention relates to: a proteinaceous antibacterial substance having lytic activity against Actinobacillus pleuropneumoniae, which infects the respiratory system; and a method for producing same. More specifically, the presen...
|
|
WO/2021/238302A1 |
Provided are an interleukin 29 (IL29) mutant protein, a fusion protein containing the mutant protein, a conjugate, a pharmaceutical composition, a product and a kit. The provided IL29 mutant protein has good activity and stability, and c...
|
|
WO/2021/242674A1 |
The present disclosure describes a highly sensitive immunoassay method capable of detecting small changes in the amount of dystrophin in a biological sample. The immunoassay method may be used to comparatively quantify the amount dystrop...
|
|
WO/2021/237280A1 |
This invention relates to polypeptides, including variants of inhibin, and related therapeutics and compositions. Further, the invention relates to the use in the treatment or prevention of conditions associated with reduced levels of in...
|
|
WO/2021/243285A1 |
Disclosed herein are systems and methods of use thereof for coupling affinity reagents (e.g., in solution affinity reagents such as proteins, peptides, and nucleic acids and libraries of affinity reagents) with particles having coronas f...
|
|
WO/2021/233330A1 |
Provided is a method for biosynthesis of a protein heterogeneous catenane. The basic structure of a protein precursor sequence of the protein heterogeneous catenane comprises from an N-terminal to a C-terminal: L1-1-X-L1-2-(in situ enzym...
|
|
WO/2021/235767A1 |
The present invention relates to a method for obtaining a collagen peptide from starfish, an elastic liposome comprising the starfish-derived collagen peptide, and a cosmetic composition comprising same. According to the present inventio...
|
|
WO/2021/233312A1 |
Disclosed is a fully-automatic protein purification system device, comprising a chromatography device (0), a first driving device, a connection pipeline (2), a positioning device (3), a second driving device, a first container (5), a sec...
|
|
WO/2021/235591A1 |
A method for preparing low-molecular gelatin according to the present invention can effectively remove off-favor of fish-derived collagen and prepare low-viscosity collagen whereby a low-molecular weight gelatin having lowered stickiness...
|
|
WO/2021/233094A1 |
Disclosed in the present invention is an interferon-κ mutant. On the basis of wild-type interferon-κ, free cysteine residues are mutated to amino acids other than cysteine, and/or methionine residues which can be oxidatively modified a...
|
|
WO/2021/232846A1 |
Disclosed are a zwitterionic polypeptide and derivatives thereof, and a nano-drug based on same, having blood compatibility, being capable of accelerating the release of drugs inside cells, and being used for targeted treatment of tumours.
|
|
WO/2021/235806A1 |
The present invention relates to a novel method for preparing liraglutide by means of an ionic liquid and a eutectic solvent, which are environment-friendly solvents. More specifically, the present invention is characterized in that frac...
|
|
WO/2021/232791A1 |
Provided is a method for preparing an efficient anti-tumor active polypeptide Tubulysin M. The method comprises the steps of: S1, providing compound 2; and S2, preparing the active polypeptide Tubulysin M by taking the compound 2 as a ke...
|
|
WO/2021/231463A1 |
Methods for viral clearance using low pH hold based on a statistical design of experiment are provided. Several factors are evaluated to characterize the impacts of a low pH hold step for virus inactivation, including the factors of pH c...
|
|
WO/2021/229885A1 |
The present invention makes it possible to obtain a highly pure protein by contacting activated carbon particles. A method for purifying protein according to one embodiment of the present invention involves: contacting a protein solution...
|
|
WO/2021/227512A1 |
Provided is a novel method for preparing natural active polypeptide Tubulysin U, the synthetic route of the preparation method satisfies the Green Chemistry standard and utilizes as much as possible renewable and recyclable resources, th...
|
