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WO/2022/169206A1 |
The present invention relates to a method for purification of hemopexin and haptoglobin and provides a method in which a solution containing hemopexin and haptoglobin is titrated to a range of specific pH values without a step of precipi...
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WO/2022/167886A1 |
The invention relates to an improved process for the purification of proteins. More particularly, the invention pertains to a process for purification of Pegfilgrastim (PEG-GCSF). The invention further pertains to a purification process ...
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WO/2022/168135A1 |
The present invention relates to a method for extracting proteins, in particular enzymes, from an organic or inorganic matrix, such as, for example, soil or food matrices, the method being capable of providing a pure extract and a high e...
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WO/2022/165128A1 |
A system and method for treating whole stillage includes a stillage tank, a separation system (26) in communication with the stillage tank and configured to separate the whole stillage into a wet cake portion and a thin stillage portion,...
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WO/2022/164224A2 |
The present invention relates to a method for eluting a prokaryotic protein. In the present invention, a protein can be obtained in the intact form with no damages thereto by destructing cell walls of bacteria through a simple process of...
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WO/2022/160425A1 |
An anti-hepatoma and anti-liver fibrosis oligopeptide extracted from marine gastropod mucus. A total protein is extracted by using low-cost marine gastropod mucus as a raw material, and enzymolysis is performed on the extracted total pro...
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WO/2022/165001A1 |
The invention provides compositions of anti-PD-1 antibodies or antigen-binding fragments thereof with less than or equal to about 3.0 % oxidation of Met105 in the CDRH3 heavy chain region, and methods of obtaining the purified compositio...
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WO/2022/163041A1 |
Provided are: an indole-structure-selective reaction agent and an indole-structure-selective crosslinking agent which are capable of selectively modifying, under mild conditions, an indole structure of a molecule (e.g., tryptophan) conta...
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WO/2022/159783A1 |
A device for selectively capturing mycobacteria comprises a substrate and a capture polymer layer of poly-diallyldimethyl ammonium chloride, wherein the capture polymer layer is covalently linked onto the substrate via a UV-initiated pol...
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WO/2022/158889A1 |
The present invention provides a method for purifying an anti-4-1BB/anti-HER2 bispecific antibody, the method of which comprises carrying out affinity chromatography with a sodium acetate buffer containing a certain inorganic salt as an ...
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WO/2022/159234A1 |
Embodiments of the present disclosure pertain to methods of synthesizing a peptide by associating at least one isolated ribosomal RNA (rRNA) fragment with a plurality of transfer RNA fragments linked to amino acids (tRNA fragments). The ...
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WO/2022/157805A1 |
The present invention discloses a process for extracting biomolecules from biomass using an extraction apparatus. Further, the present invention provides an ultrasonic process that extracts lutein pigments from marigolds using an extract...
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WO/2022/154127A1 |
The present invention provides a desired antibody or antibody composition by modifying a thiol group chemically introduced into an antibody. More specifically, the present invention provides an antibody composition, etc., having desired ...
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WO/2022/149612A1 |
The present invention provides an industrially suitable, novel method for producing compound (1). The present invention relates to a method for producing compound (1) or a salt thereof, the method being characterized in that compound (...
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WO/2022/142978A1 |
The present invention relates to the field of biomedicine. Provided is the use of HrpW-type multi-mimotope ligandins in food products, cosmetics, health products or pharmaceuticals. The HrpW-type multi-mimotope ligandins comprise HrpWPsd...
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WO/2022/146036A1 |
Provided are a medium composition for culturing animal cells for producing a recombinant extracellular matrix protein, a method of producing the recombinant extracellular matrix protein with high purity, and a method of assaying a monome...
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WO/2022/141957A1 |
A preparation method and use of lentinus edodes oligopeptide. A lentinus edodes water extract is subjected to CTAB treatment, and then subjected to alkaline protease enzymolysis, flavourzyme enzymolysis, and activated carbon decoloration...
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WO/2022/146856A1 |
Methods are provided for isolation of immunoglobulin G (IgG) from plasma, where IgG is initially fractioned by salt precipitation, followed by successive ion exchange steps in which IgG appears in unbound, flow-through fractions of the i...
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WO/2022/145444A1 |
A problem addressed by the present invention is to provide a method for efficiently producing a high-purity peptide compound at a high yield. It was discovered that an amino acid can be supported efficiently by a resin for solid-phase sy...
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WO/2022/141615A1 |
A synthesis method for atosiban, relating to the field of polypeptide synthesis. The method comprises the following steps: synthesizing Fmoc-Pro-Orn-Gly-NH2 tripeptide, and taking a trityl resin as a starting resin to obtain Fmoc-Pro-Orn...
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WO/2022/143578A1 |
Disclosed is a biological sample processing system, more specifically, a plasmid or protein purification device. The system mainly comprises a rotating turntable device having a stirring function. A sample feeding device, a liquid absorp...
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WO/2022/081779A9 |
The present disclosure relates to the field of affinity chromatography, and more specifically to the provision of nucleic acid and polypeptide libraries encoding three-helix bundle protein domains suitable for selecting affinity ligands ...
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WO/2022/111642A9 |
The present disclosure provides a method for preparing an acylated derivative of insulin or of an analog thereof, comprising the step of reacting insulin or an analog thereof with the compound of formula (I), and also provides the compou...
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WO/2022/142976A1 |
Provided is the use of an HrpN-type multi-mimotope ligand protein in foods, cosmetics, health care products or pharmaceuticals. The HrpN-type multi-mimotope ligand protein comprises HrpNEcc, HrpNEca, HrpNEcb, HrpNEch, HrpNDaz, HrpNDada, ...
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WO/2022/144886A1 |
A large-scale process is described herein for preparing a cyclic peptide as described, comprising solid phase peptide synthesis of a linear peptide and cleaving it from the resin; oxidizing cysteine residues to form an intramolecular dis...
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WO/2022/141441A1 |
Provided is a follicle-stimulating hormone (FSH). The preparation thereof comprises the following steps: introducing a secretion signal peptide into the two subunits FSHα and FSHβ of the FSH, and then individually expressing same, foll...
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WO/2022/144860A1 |
The present invention provides for novel synthetic approach of solid phase synthesis of peptides with C-terminal Aspartic acid by anchoring the side chain carboxylic group of aspartic acid to the solid support to avoid the formation of v...
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WO/2022/143532A1 |
A method for synthesizing peptide thioesters and a head-to-tail amide cyclic peptide thereof, which belongs to the technical field of chemical pharmaceuticals and fine chemical preparation. The method comprises the following steps: (1) u...
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WO/2022/138718A1 |
The purpose of the present invention is to provide a polypeptide, which has excellent alkali stability and allows the elution of immunoglobulin or a fragment of the same, which has been bound thereto, in a weakly acidic region, by modify...
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WO/2022/138891A1 |
The present invention addresses the problem of providing a method for producing a high-purity peptide compound with high efficiency and high yield. It is found that the problem can be solved by supporting a peptide on a resin for solid-p...
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WO/2022/139631A1 |
The present application relates to the fields of biotechnology, immunology, virology, genetics, and molecular biology. More specifically, the present invention relates to an isolated codon-optimized nucleic acid encoding an isolated reco...
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WO/2022/138953A1 |
[Problem] To provide a method by which a lipid peptide compound and a salt thereof can be produced with a higher yield and a higher purity than conventional production methods. [Solution] A method for producing a lipid peptide compound r...
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WO/2022/136366A1 |
The present invention relates to a novel method for producing NCA compounds. The invention also relates to a novel use of a peptide coupling agent. The method according to the invention enables NCA compounds to be obtained from α-amino ...
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WO/2022/140389A1 |
The disclosure provides a method of producing etanercept from Chinese hamster ovary cells (CHO), the method comprising running an N-1 bioreactor system using a recirculating tangential flow filtration (RTF) or alternating tangential flow...
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WO/2022/140783A1 |
The present invention relates to method of purifying charge- shielded proteins from a cell lysate or periplasmic releasate using hydrophobic interaction chromatography as a first chromatography steps. Also provided herein are composition...
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WO/2022/140271A1 |
An in vitro release test (IVRT) method and system is provided for drug release testing. The IVRT method, referred to herein as adaptive perfusion, employ tangential-flow filtration (TFF), where released drug products that are smaller tha...
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WO/2022/138605A1 |
The present invention addresses the problem of providing a method for efficiently producing a peptide having a high purity, a reagent for forming a protective group having excellent deprotection properties, and a novel fused polycyclic c...
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WO/2022/133772A1 |
It relates to the medicinal chemistry field, particularly to a process for separating the isomeric compounds comprising a ring-opened thiosuccinimide group and a chiral moiety.
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WO/2022/134124A1 |
The present invention relates to the field of polypeptide synthesis, and provides a method for synthesizing the C-terminal protection fragment of a peptide. The method comprises the following steps: (1) preparing Resin-T-P; and (2) remov...
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WO/2022/138957A1 |
[Problem] To provide a practical method for producing a lipidic peptide compound, the method enabling a lipidic peptide compound to be mass produced inexpensively without the need for complicated operations. [Solution] A lipidic peptide ...
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WO/2022/133797A1 |
Provided is a long-acting glucagon derivative, the amino acid sequence thereof comprising the sequence shown in SEQ ID NO: 9. Animal experiments show that, when compared to the similar fatty acid-modified GLP-1R single agonist Semaglutid...
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WO/2022/131896A1 |
The invention relates to a method for producing human collagen structures with controlled characteristics comprising the steps of: a) preparing the tissue; b) pre-treatment; bl) washing with distilled water; c) extraction by enzymatic hy...
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WO/2022/129460A1 |
The present invention relates to new methods for the purification of Fc-peptide fusion protein (peptibodies) derived from inclusion bodies after prokaryotic expression. In particular, it relates to chromatographic methods of the fusion p...
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WO/2022/124096A1 |
The present invention analyzes an N-linked glycan linked to a protein in a blood-derived sample collected from a subject, and, on the basis of the structure of the N-linked glycan, predicts the structure of a glycan linked to immunoglobu...
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WO/2022/120916A1 |
A method for extracting synaptodendrosomes. The method for extracting synaptodendrosomes comprises at 2-8 ℃, sequentially acquiring a tissue homogenate, and performing primary density gradient centrifugation and secondary gradient cent...
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WO/2022/123240A1 |
This invention provides a method of purifying or isolating a heterologous protein or polypeptide comprising: (a) providing a sample containing the protein or polypeptide covalently or non- covalently attached to a magnetic nanoparticle b...
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WO/2022/121899A1 |
Disclosed is an antibody specifically binding to a Strep-Tag II tag, and further disclosed are an amino acid sequence of the antibody of the present invention, a cloning or expression vector, a host cell, and a method for expressing or s...
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WO/2022/124341A1 |
The present disclosure provides a design and synthesis of a useful carbon skeleton, a design and synthesis of a peptidomimetic molecule and applications and uses based thereon. More particularly, provided is a method for designing a comp...
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WO/2022/125592A1 |
The present disclosure relates to a polypeptide which is a variant of SEQ ID NO:1, fragment thereof, or fusion polypeptide, including: the variant of SEQ ID NO:1 or a fragment thereof, having an increased water solubility compared to SEQ...
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WO/2022/118894A1 |
The present invention provides a fractionation method for nuclear soluble proteins, said method achieving a high yield and being capable of preventing intranuclear soluble proteins from leakage outside nuclei due to diffusion, and a kit ...
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