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WO/2024/044987A1 |
The present invention provides a monooxygenase mutant and use thereof. The monooxygenase mutant comprises (a) a protein having an amino acid sequence set forth in SEQ ID NO: 1; or (b) a protein that undergoes an amino acid mutation at at...
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WO/2024/038903A1 |
There is a problem in the supply of ovothiol A and related substances. The present disclosure provides a method for manufacturing ovothiol A or a related substance. This method for manufacturing ovothiol A or a related substance or a m...
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WO/2023/232233A1 |
The invention relates to a process for producing L-cysteic acid, comprising the reaction of O-phospho-L-serine (OPS) with a salt of sulfurous acid (sulfite) and a cysteate synthase (CS-enzyme) of enzyme class EC 2.5.1.76 in a biotransfor...
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WO/2023/094011A1 |
The invention relates to a method for preparing L-cysteic acid, in which method O-acetyl-L-serine (OAS) is reacted with at least one enzyme selected from the class of O-acetyl-L-serine-sulfhydrylases (OAS sulfhydrylases, EC 4.2.99.8) in ...
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WO/2023/094010A1 |
The invention relates to a process for producing taurine from O-acetyl-L-serine (OAS) by way of biotransformation. In a first process step (biotransformation 1), L-cysteic acid is produced from O-acetyl-L-serine (OAS) using an enzyme sel...
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WO/2023/052490A1 |
The invention relates to uses and methods implementing a non-naturally occurring mutated arylsulfotransferase comprising (i) an amino acid substitution in at least one amino acid position selected among positions 6, 7, 8, 9, 11, 17, 20, ...
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WO/2023/280382A1 |
The invention relates to a method for enzymatic oxidation of sulfinic acids of formula H2N-CH(R)-CH2-SO2H to form sulphonic acids of formula H2N-CH(R)-CH2-SO3H using an enzyme chosen from the class of H2O2-generating oxidases in the pres...
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WO/2022/202952A1 |
The present invention pertains to a modified (mutant) nicotinamide phosphoribosyltransferase and a method for producing nicotinamide mononucleotide using the same. The modified nicotinamide phosphoribosyltransferase (Nampt) according to ...
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WO/2022/150596A1 |
The present invention relates to processes for preparing linkers that are useful in the conjugation of therapeutic molecules (e.g., cytotoxic agents) with targeting moieties (e.g., proteins, peptides, antibodies, nanoparticles, nucleic a...
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WO/2022/089572A1 |
The present disclosure relates to synthesis of enantiomerically rich key drug intermediates as a means for manufacturing of thiocarbamate derivatives as A2A adenosine receptor (A2AR) inhibitors. More particularly, the present disclosure ...
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WO/2021/181029A1 |
The present invention relates to a chemoenzymatic process for coproducing a disulfide and a sulfoxide or a sulfone from a composition M comprising: 1) a sulfide, 2) optionally an oxidizing agent, 3) an organic compound bearing at least o...
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WO/2021/177896A1 |
The present invention provides for a method to increase the free lipoic acid production in an isolated genetically engineered bacteria or yeast cell. The method involves culturing in a cysteine supplemented culture medium the engineered ...
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WO/2021/071356A1 |
The invention relates to the field of enzyme engineering and biocatalysis, in particular to alcohol oxidases and their application in the selective oxidation of diols for the production of industrially useful oxidation products thereof, ...
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WO/2021/050634A1 |
In order to produce chondroitin sulfate in an animal-free manner, engineered E. coli host cells were modified so as to reduce expression of an endogenous gene for fructosyltransferase (kfoE); reduce expression of an endogenous gene for 3...
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WO/2021/038095A1 |
The present invention relates to methods for the preparation of α-hydroxyacyl compounds, and peptides for the catalyzed formation of α-hydroxyacyl compounds as well as their use in the preparation of α-hydroxyacyl compounds.
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WO/2020/254745A1 |
The present invention relates to a selective process for the preparation of sulfones from sulfides by enzymatic catalysis, as well as to a composition comprising a symmetrical sulfide, an oxidoreductase enzyme catalyzing the oxidation of...
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WO/2020/254744A1 |
The present invention relates to a selective process for preparing sulfoxides from sulfides by enzymatic catalysis, as well as to a composition comprising a symmetrical sulfide, wherein an oxidoreductase enzyme catalyzes the oxidation of...
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WO/2020/237313A1 |
A process for harvesting and preparing green garlic leaves and shoots ( green tops) for the production of ajoene and garlic oil for use in medicine and foods, the method including the steps of garlic green top separation from bulbs durin...
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WO/2020/152314A1 |
The invention relates to a method for producing a water-insoluble lignosulfonate polymer from a solution containing a lignosulfonate precursor, in particular from raw liquor, comprising the steps of: a. separating the lignosulfonate prec...
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WO/2020/127208A2 |
The present disclosure concerns the large-scale manufacture of pharmaceutical compounds, and novel intermediates for use in the manufacture. International Patent Application WO2011154737 discloses morpholine pyrimidines useful for treati...
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WO/2020/108462A1 |
Provided is a monooxygenase of which the acid sequence is obtained by mutation of an amino acid sequence shown in SEQ ID NO: 2. The monooxygenase may be used for preparing chiral sulfoxide drugs and used for producing proton pump inhibit...
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WO/2020/093191A1 |
Provided are a monooxygenase mutant and an application thereof. The amino acid sequence of the monooxygenase mutant is a mutated version of the amino acid sequence shown in SEQ ID NO: 1. The mutation comprises a mutation at at least one ...
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WO/2020/090016A1 |
A method for producing an α-keto acid, said method comprising a step of culturing a microorganism, which contains a gene encoding an enzyme catalyzing an aldol reaction between pyruvic acid and a carbonyl compound, in the presence of a ...
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WO/2020/058493A1 |
The present invention discloses a method to produce amino sugar (containing) products using metabolically engineered microorganisms wherein the conversion of UDP-N- acetylglucosamine to cell envelope precursors and molecules is reduced b...
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WO/2020/058444A1 |
A process for producing a bio-based surfactant comprising an alkyl disulphate salt comprises the steps of methanolysis of medium chain length polyhydroxyalkanoic acid (mcl-PHA) to provide hydroxy fatty acid methyl ester monomers (HFAME's...
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WO/2020/013346A1 |
A method for enzymatic sulfurylation of a substrate is provided which includes the steps of reacting the substrate with 3'-phosphoadenosine-5'-phosphosulfate (PAPS) in a medium containing a bacterium belonging to the family Enterobacteri...
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WO/2019/169695A1 |
A bradyrhizobium monooxygenase, a gene for encoding the monooxygenase, a recombinant expression vector comprising the gene, a recombinant expression transformant, a method for preparing the monooxygenase by using the recombinant expressi...
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WO/2019/171207A1 |
The present invention relates to an allicin-based formulation having high stability, non-phytotoxic at the doses of use, easily injectable into vascular plants, phytopharmaceutical compositions or kits comprising said formulation and use...
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WO/2019/060963A1 |
The present invention relates to methods for producing isothiocyanate containing products from Brassicaceae material and lactic acid bacteria for use in such methods. The present invention also relates to isothiocyanate containing produc...
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WO/2018/144088A1 |
Disclosed is a therapeutic regimen which includes S-adenosyl methionine, or a salt thereof; folic acid, or a metabolite thereof, or a salt thereof; and a compound of Formula (I), or salt thereof, useful in the treatment of a variety of c...
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WO/2018/122511A1 |
The invention relates to the field of organic polysulphides, more particularly to a method for synthetising functionalised organic polysulphides of formula (I): R2-X-(NR1R7)C*H-(CH2)n-Sa-(CH2)n-C*H(NR1R7)-X-R2, in which the various subst...
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WO/2017/213142A1 |
Provided is a method for producing hypotaurine and/or taurine. Hypotaurine and/or taurine are produced by: incubating in culture medium a microorganism capable of producing L-cysteine, the microorganism being modified so as to increase c...
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WO/2017/190056A1 |
Described herein are biotechnological methods for the production of industrially relevant chemicals. In particular, methods for the biological production of products containing at least one terminal alcohol, carboxyl group, amine or alky...
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WO/2017/144670A1 |
The present invention relates to the production of hydrolyzates from a lignocellulose-containing material, and to fermentation of the hydrolyzates. More specifically, the present invention relates to the detoxification of phenolic inhibi...
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WO/2017/144671A1 |
The present invention generally relates to the field of biotechnology as it applies to the production of aryl sulfates using recombinant host cells. More particularly, the present invention pertains to recombinant host cells comprising (...
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WO/2017/096310A1 |
This document describes biochemical pathways for producing 7-aminoheptanoic acid using a β-ketoacyl synthase or a β-ketothiolase to form either a 5-amino-3-oxopentanoyl-[ACP] or 5-amino-3-oxopentanoyl-CoA intermediate. 7-aminoheptanoic...
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WO/2017/096260A1 |
This document describes biochemical pathways for producing 7-aminoheptanoic acid using a β-ketoacyl synthase or a β-keioihiolase to form an N-acetyl-5-amino-3- oxopentanoyl-CoA intermediate. 7-aminoheptanoic acid can be enzymatieally c...
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WO/2017/087488A1 |
A process for production and extraction of dihydrolipoic acid (DHLA) relates to the biotransformation of R-lipoic acid to dihydrolipoic acid. The process ferments the lipoic acid with bacteria selected from the genus of any of the follow...
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WO/2017/083656A1 |
This document describes polypeptides with dual CoA transferase and β-ketothioiase activities and variants thereof, use of such polypeptides in biosynthetic methods, and non-naturally occurring hosts comprising such polypeptides.
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WO/2017/083493A1 |
This document describes biochemical pathways for biosynthesizing a 3-oxo-7-hydroxyheptanoyl-CoA intermediate using a β-ketothiolase, and enzymatically converting 3-oxo-7-hydroxyheptanoyl-CoA to 7-hydroxyheptanoic acid. - 7-hydroxyheptan...
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WO/2017/069267A1 |
The present invention pertains to recombinant eukaryotic micro-organisms into which genes that encode acyl-CoA dehydroquinases have been introduced, and a method for producing methacrylic acid esters such as MMA and MMA-CoA, and precurso...
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WO/2017/055753A1 |
The invention relates to a method for producing mercaptans from disulfides and hydrogen by enzyme catalysis, and in particular for producing methylmercaptan from dimethyl disulfide and hydrogen.
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WO/2017/055752A1 |
The invention relates to a method for producing mercaptans from disulfides by enzyme catalysis, and in particular for producing methylmercaptan from dimethyl disulfide.
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WO/2017/050874A1 |
Herein is reported a method for the enzymatic production of a thioester comprising incubating i) a first polypeptide comprising the amino acid sequence LPXTG (SEQ ID NO: 01, wherein X can be any amino acid residue), ii) a second polypept...
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WO/2016/154124A1 |
Provided are Ybt analogs and derivatives thereof and compositions comprising Ybt and Ybt analogs and derivatives thereof. Methods of making Ybt and Ybt analogs and methods of using Ybt and Ybt analogs are also provided. The methods use m...
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WO/2016/111675A1 |
A wastewater treatment method and apparatus removing suspended solids from wastewater inflow streams and/or conventional process liquid streams to reduce loads on bioreactors, sulfurous acid treat the removed solids containing heavy meta...
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WO/2016/097293A1 |
Described is a method for the production of 2-pentenoic acid comprising the enzymatic conversion of 2-pentenoyl-CoA into 2-pentenoic acid comprising two enzymatic steps comprising (i) first enzymatically converting 2-pentenoyl-CoA into 2...
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WO/2016/069929A1 |
An engineered microbe that contains a designed platform for the conversion of one-carbon substrates to chemical products is described. The designed platform embodies a new metabolic architecture that consolidates carbon fixation, central...
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WO/2016/026976A1 |
The present invention generally relates to the field of biotechnology as it applies to the production of aryl sulfates using polypeptides or recombinant cells comprising said polypeptides. More particularly, the present invention pertain...
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WO/2016/017631A1 |
The problem to be solved by the present invention is to provide a method for producing glutathione and γ-glutamylcysteine, which is a precursor of glutathione, at high yield. This method for producing glutathione includes, as a means fo...
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